DRSC/TRiP Functional Genomics Resources

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Protein Alignment kek1 and Lingo1

DIOPT Version :9

Sequence 1:NP_001303320.1 Gene:kek1 / 34688 FlyBaseID:FBgn0015399 Length:880 Species:Drosophila melanogaster
Sequence 2:XP_006511149.1 Gene:Lingo1 / 235402 MGIID:1915522 Length:647 Species:Mus musculus


Alignment Length:494 Identity:110/494 - (22%)
Similarity:165/494 - (33%) Gaps:175/494 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    90 CQTVCACKWKGGKQTVECIDRHLIQIPEHIDPNTQVLDMSGNKLQTLS---------------NE 139
            |...|.|  ....:.|.|..:..:.:||.|...|::||:..|:::||:               ||
Mouse    69 CPPRCEC--SAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNE 131

  Fly   140 QFIRA-------NLLNLQKLYLRNCKIGEIERETFKGLTNLVELDLSHNLLV------------- 184
            ..:.|       ||.||:.|.||:.::..|....|.||:||.:||:|.|.:|             
Mouse   132 NIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNL 196

  Fly   185 -----------------------------------TVPSLALGHIPSLRELTLASNHIHKIESQA 214
                                               ::|:.||.|:..|..|.|...:|:.|...:
Mouse   197 KSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYS 261

  Fly   215 FGN------------------TP------SLHKLDLSHC-------------------------- 229
            |..                  ||      :|..|.::||                          
Mouse   262 FKRLYRLKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPI 326

  Fly   230 ---------------DIQTISAQ-------AFGGLQGLTLLRLNGNKLSELLPKTIETLSRLHGI 272
                           :||.:..|       ||.||..|.:|.::||:|:.|......::..|..:
Mouse   327 GTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESAFHSVGNLETL 391

  Fly   273 ELHDNPWLCDCRLRDTKLWLMKRNIPYPV---APVCSGGPERIIDRSFAD----LHVDEFACRPE 330
            .|..||..|||||    ||:.:|......   .|.|: .||.:..:.|.|    |..:.|.||..
Mouse   392 ILDSNPLACDCRL----LWVFRRRWRLNFNRQQPTCA-TPEFVQGKEFKDFPDVLLPNYFTCRRA 451

  Fly   331 ML--PISHYVEAAMGENASITCRARAVPAANINWYWNGRLLA---NNSAFTAYQRIHMLEQVEGG 390
            .:  ..:..|....|......|||...|...|.|....:.|.   :|...|.:.        :|.
Mouse   452 HIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFP--------DGT 508

  Fly   391 FEKRSKLVLTNAQETDSSEFYCVAENRAGMAEANFTLHV 429
            .|.|      .||..|:..:.|:|.|..|.......|||
Mouse   509 LEVR------YAQVQDNGTYLCIAANAGGNDSMPAHLHV 541

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek1NP_001303320.1 leucine-rich repeat 103..122 CDD:275380 5/18 (28%)
LRR_RI <119..277 CDD:238064 59/299 (20%)
leucine-rich repeat 123..148 CDD:275380 11/46 (24%)
LRR_8 148..207 CDD:290566 23/106 (22%)
leucine-rich repeat 149..172 CDD:275380 8/22 (36%)
leucine-rich repeat 173..196 CDD:275380 10/70 (14%)
LRR_8 195..255 CDD:290566 23/131 (18%)
leucine-rich repeat 197..220 CDD:275380 8/46 (17%)
leucine-rich repeat 221..244 CDD:275380 11/70 (16%)
leucine-rich repeat 245..268 CDD:275380 6/22 (27%)
LRRCT 277..327 CDD:214507 18/56 (32%)
IG_like 338..429 CDD:214653 22/93 (24%)
Ig 346..426 CDD:143165 19/82 (23%)
Lingo1XP_006511149.1 LRRNT 68..102 CDD:214470 9/34 (26%)
LRR <93..398 CDD:227223 62/304 (20%)
leucine-rich repeat 100..123 CDD:275380 6/22 (27%)
leucine-rich repeat 124..147 CDD:275380 5/22 (23%)
LRR_8 147..206 CDD:338972 16/58 (28%)
leucine-rich repeat 148..171 CDD:275380 8/22 (36%)
leucine-rich repeat 172..219 CDD:275380 6/46 (13%)
leucine-rich repeat 220..243 CDD:275380 4/22 (18%)
leucine-rich repeat 244..291 CDD:275380 8/46 (17%)
leucine-rich repeat 292..315 CDD:275380 4/22 (18%)
leucine-rich repeat 316..339 CDD:275380 0/22 (0%)
leucine-rich repeat 340..363 CDD:275380 7/22 (32%)
leucine-rich repeat 364..384 CDD:275380 6/19 (32%)
PCC 368..>448 CDD:188093 24/84 (29%)
Ig 466..541 CDD:386229 21/88 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - mtm8825
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.000

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