Protein Alignment kek1 and kek2

DIOPT Version :10

• Sequence 1: NP_523559.3
• Gene: kek1 / 34688
• FlyBaseID: FBgn0015399
• Length: 880
• Species: Drosophila melanogaster
• Sequence 2: XP_061512480.1
• Gene: kek2 / 1280097
• VectorBaseID: AGAMI1_010202
• Length: 877
• Species: Anopheles gambiae
• Alignment Length: 930
• Identity: 258/930 - (27%)
• Similarity: 380/930 - (40%)
• Gaps: 224/930 - (24%)

  Fly    82 PPAQQQSTCQT-VCACKWKGGKQTVECIDRHLIQIPEHIDPNTQVLDMSGNKLQTLSNEQFIRAN 145
            |||   :.|.. ||.||||||||||||..|.|.::|:.:||.||||:.|||.|..|.:|:|.:..
Mosquito    23 PPA---TGCPAEVCVCKWKGGKQTVECGGRFLNRLPDGMDPGTQVLNFSGNSLTILQSERFRKME 84

  Fly   146 LLNLQKLYLRNCKIGEIERETFKGLTNLVELDLSHNLLVTVPSLALGHIPSLRELTLASNHIHKI 210
            |:||||:||...::.:|....|:|||||||||||.|.|..||:.......:|..|:|:.|.|..:
Mosquito    85 LINLQKIYLARNQLVKIHDRAFRGLTNLVELDLSDNTLSEVPTETFQDYAALMRLSLSGNPIRAL 149

  Fly   211 ESQAFGNTPSLHKLDLSHCDIQTISAQAFGGLQGLTLLRLNGNKL-----SELLPKTIETLSRLH 270
            .:.||.....|..|:||:|.|:.:..:||.|:..|..|||:||::     :.:||::      ||
Mosquito   150 RASAFKQLSYLTTLELSNCQIELVEDEAFIGMDNLEWLRLDGNRIATIRGAHVLPES------LH 208

  Fly   271 GIELHDNPWLCDCRLRDTKLWLMKRNIPYPVAPVCSGGPERIIDRSFADLHVDEFACRPEMLPIS 335
            ||.|..|.|.|||.|.|...||...|:|......|| ||.|:...:...|.:|:.||.|.:.|.:
Mosquito   209 GINLQSNRWHCDCHLTDVYTWLNSFNVPQREEIKCS-GPARLAGETVKTLTLDDLACLPVVTPET 272

  Fly   336 HYVEAAMGENASITCRARAVPAANINWYWNGRLLANNSAFTAYQRIHM---LEQVEGGFEKRSKL 397
            .|.|.|.|.|.|:.||..|.|...:.|.:.|::|.|:|..:  ..:|:   :::::|.  |.|:|
Mosquito   273 SYREIAEGRNISLDCRIVATPEPTVAWLFQGQVLLNDSFLS--PNLHLYYFVDELDGA--KHSEL 333

  Fly   398 VLTNAQETDSSEFYCVAENRAGMAEANFTLHVSMRAAGMASLGSGQ------IVGLSAALVALIV 456
            .:.|....|:..:.|||||.||..:.|:||||.::...:....:..      ||..|||...|:.
Mosquito   334 FIYNINADDNGTYSCVAENSAGRVQTNYTLHVIVKEEPVVEQVTFSEEYFLAIVAASAATAVLLA 398

  Fly   457 FALGVIMCLLLRVKRQPYVDSKTPNHMEVITSVNHQNSITNKTQPATGNGSIGGVVIANGAVANI 521
            ....::.|...|.:|.....:|.|                ...:.||.:|.: ||.......|:|
Mosquito   399 LLCCIVACKCARARRASGSGAKKP----------------RGAKGATADGLV-GVPAGQQKCASI 446

  Fly   522 -------IDGGVVQGGTLERKSSGRGGVPHGVHDQRSANPVQKPPRLTDLPYSTQGYD----NNG 575
                   :..|.:.|..    ..|.|..|..:....:|||              .|.|    ||
Mosquito   447 THDLGEPLTAGKLNGAL----GLGDGSNPQDIVLYLNANP--------------NGLDKAALNN- 492

  Fly   576 SVLSTASCFISPSGSTGNGGNNPDLINDTK------------------RFGSDEFADLKIPPISG 622
              ::..:.|.||..:......|||||||.:                  ...|||        .|.
Mosquito   493 --MTAMAQFCSPPSARSYQDQNPDLINDAESGQHKARPRPDAIDSDLGEKDSDE--------QSS 547

  Fly   623 VGVGGS-------------GEYSRANGCDSLYP-----------SGLWEHGAPVGTTSA---DDL 660
            |..|||             .:..:..|....||           |.|  ...|.|.|:|   .||
Mosquito   548 VQDGGSEVSFQQQQQHQQQQQQQQGQGQGPYYPPMVLRGPRFASSAL--STLPRGGTAALGGKDL 610

  Fly   661 FMKRYTDKTPIIDSTQLY--------DLHERTAAT----DYFSKTFP----RSHLQQGMMTGGGG 709
              ..|..:..|..|...:        ||....|.:    :|: :|.|    :..|||.....||.
Mosquito   611 --SAYQHQVDIHLSPGCFLDQNGYPVDLSLMAAPSGPPVNYY-RTLPHKKHQQQLQQQQQQPGGP 672

  Fly   710 G------TSTASTVTTNLSGGSSSGY-PNDY-----GLPLVPGAEHQH--------NHQLQMHPL 754
            |      .:.|..:....|..:...| |.|.     |.|     :|:|        .::.::||:
Mosquito   673 GKPIARYANDAEFINRTQSPAAYQMYAPTDVRYTAEGYP-----QHEHGQFPSPPDGYKGEVHPV 732

  Fly   755 QQLQQQLTSTLNHQKQEGSSTGSS-----------PHFSSRTLPRLHEGSGGGGSSRSSP-TPAV 807
            ..:.....::      .|...|.:           |.|..:.:|.:   :..||:..:|| .|:.
Mosquito   733 AYMSSAAAAS------AGFCVGPAPGPPQQWPTFLPGFHPQLIPIM---APAGGALLASPMMPSP 788

  Fly   808 SGGHANQ---AANPSTSSSS----CSILPNGQPINAKTIRVWQK-------------GGVPVLPP 852
            ||....|   .::|.|...|    ||:......::...|...::             ||
Mosquito   789 SGQQQQQQQLLSSPQTQPGSALKKCSVGAQTSELDKDVIPEQREEEEEEEDEQDGGGGG------ 847

  Fly   853 VTALKRALISSSRNSPDEGY 872
            .|...|.|.....:||||||
Mosquito   848 STVKLRHLTGPLADSPDEGY 867

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kek1	NP_523559.3	leucine-rich repeat	103..122	CDD:275380	9/18 (50%)
		LRR	<122..>277	CDD:443914	64/159 (40%)
		leucine-rich repeat	123..148	CDD:275380	12/24 (50%)
		leucine-rich repeat	149..172	CDD:275380	9/22 (41%)
		leucine-rich repeat	173..196	CDD:275380	11/22 (50%)
		leucine-rich repeat	197..220	CDD:275380	7/22 (32%)
		leucine-rich repeat	221..244	CDD:275380	9/22 (41%)
		leucine-rich repeat	245..268	CDD:275380	8/27 (30%)
		LRRCT	277..327	CDD:214507	18/49 (37%)
		IG_like	338..429	CDD:214653	31/93 (33%)
		Ig strand B	346..350	CDD:409353	1/3 (33%)
		Ig strand C	359..363	CDD:409353	0/3 (0%)
		Ig strand E	395..399	CDD:409353	2/3 (67%)
		Ig strand F	409..414	CDD:409353	1/4 (25%)
		Ig strand G	422..425	CDD:409353	0/2 (0%)
kek2	XP_061512480.1	None