DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek1 and Rtn4r

DIOPT Version :9

Sequence 1:	NP_001303320.1	Gene:	kek1 / 34688	FlyBaseID:	FBgn0015399	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	NP_446065.1	Gene:	Rtn4r / 113912	RGDID:	620810	Length:	473	Species:	Rattus norvegicus

Alignment Length:	466	Identity:	110/466 - (23%)
Similarity:	159/466 - (34%)	Gaps:	116/466 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 CQTVCACKWKGGKQTVECIDRHLIQIPEHIDPNTQVLDMSGNKLQTLSNEQFIRANLLNLQKLYL 154
            |...|.| :...|.|.....:.|..:|..|..::|.:.:.||::..:....|  .:..||..|:|
  Rat    27 CPGACVC-YNEPKVTTSRPQQGLQAVPAGIPASSQRIFLHGNRISYVPAASF--QSCRNLTILWL 88

  Fly   155 RNCKIGEIERETFKGLTNLVELDLSHN--LLVTVPSL--ALGHIPSLR----------------- 198
            .:..:..|:...|.|||.|.:||||.|  |.|..|:.  .|||:.:|.
  Rat    89 HSNALAGIDAAAFTGLTLLEQLDLSDNAQLRVVDPTTFRGLGHLHTLHLDRCGLQELGPGLFRGL 153

  Fly   199 ----------------------------ELTLASNHIHKIESQAFGNTPSLHKLDLSHCDIQTIS 235
                                        .|.|..|.|..:...||....||.:|.|....:..:.
  Rat   154 AALQYLYLQDNNLQALPDNTFRDLGNLTHLFLHGNRIPSVPEHAFRGLHSLDRLLLHQNHVARVH 218

  Fly   236 AQAFGGLQGLTLLRLNGNKLSELLPKTIETLSRLHGIELHDNPWLCDCRLRDTKLWLMK-----R 295
            ..||..|..|..|.|..|.||.|..:.:..|..|..:.|:||||:||||.|....||.|     .
  Rat   219 PHAFRDLGRLMTLYLFANNLSMLPAEVLVPLRSLQYLRLNDNPWVCDCRARPLWAWLQKFRGSSS 283

  Fly   296 NIPYPVAPVCSGGPERIIDRSFADLHVDEF----------------------------ACRPEML 332
            .:|       |..|:|:..|....|...:.                            .|:|:..
  Rat   284 GVP-------SNLPQRLAGRDLKRLATSDLEGCAVASGPFRPFQTNQLTDEELLGLPKCCQPDAA 341

  Fly   333 PISHYVEAAMGENASITCRARAVPAANINWYWNGRLLANNSAF-----TAYQRIHMLEQVEGGFE 392
            ..:..:|.....:.....:.|..|........:|....|:|.|     :|...:..|.  .||.|
  Rat   342 DKASVLEPGRPASVGNALKGRVPPGDTPPGNGSGPRHINDSPFGTLPGSAEPPLTALR--PGGSE 404

  Fly   393 KRSKLVLTNAQETDSSEFYCVAENRAGMAEANFT-LHVSMRAAGMASLGSGQIVGLSAALVALI- 455
            ... |..|..:            .|.|.:..|.| .|..:..||..|.|:|...| |.||.||.
  Rat   405 PPG-LPTTGPR------------RRPGCSRKNRTRSHCRLGQAGSGSSGTGDAEG-SGALPALAC 455

  Fly   456 -VFALGVIMCL 465
             :..||:.:.|
  Rat   456 SLAPLGLALVL 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek1	NP_001303320.1	leucine-rich repeat	103..122	CDD:275380	4/18 (22%)
		LRR_RI	<119..277	CDD:238064	50/206 (24%)
		leucine-rich repeat	123..148	CDD:275380	4/24 (17%)
		LRR_8	148..207	CDD:290566	25/107 (23%)
		leucine-rich repeat	149..172	CDD:275380	7/22 (32%)
		leucine-rich repeat	173..196	CDD:275380	12/26 (46%)
		LRR_8	195..255	CDD:290566	18/104 (17%)
		leucine-rich repeat	197..220	CDD:275380	7/67 (10%)
		leucine-rich repeat	221..244	CDD:275380	6/22 (27%)
		leucine-rich repeat	245..268	CDD:275380	8/22 (36%)
		LRRCT	277..327	CDD:214507	17/82 (21%)
		IG_like	338..429	CDD:214653	18/96 (19%)
		Ig	346..426	CDD:143165	16/84 (19%)
Rtn4r	NP_446065.1	LRR 1. /evidence=ECO:0000255	56..79		4/24 (17%)
		LRR_8	60..115	CDD:290566	18/56 (32%)
		leucine-rich repeat	60..82	CDD:275380	4/23 (17%)
		LRR 2. /evidence=ECO:0000255	80..103		6/22 (27%)
		LRR_RI	81..>261	CDD:238064	46/179 (26%)
		leucine-rich repeat	83..106	CDD:275380	7/22 (32%)
		LRR 3. /evidence=ECO:0000255	105..128		10/22 (45%)
		leucine-rich repeat	107..131	CDD:275380	10/23 (43%)
		LRR 4. /evidence=ECO:0000255	129..152		4/22 (18%)
		LRR_8	131..190	CDD:290566	5/58 (9%)
		leucine-rich repeat	132..155	CDD:275380	1/22 (5%)
		LRR 5. /evidence=ECO:0000255	153..176		0/22 (0%)
		LRR_4	156..195	CDD:289563	4/38 (11%)
		leucine-rich repeat	156..179	CDD:275380	0/22 (0%)
		LRR 6. /evidence=ECO:0000255	178..200		6/21 (29%)
		LRR_8	179..238	CDD:290566	17/58 (29%)
		leucine-rich repeat	180..203	CDD:275380	6/22 (27%)
		LRR 7. /evidence=ECO:0000255	202..224		6/21 (29%)
		leucine-rich repeat	204..227	CDD:275380	6/22 (27%)
		LRR 8. /evidence=ECO:0000255	225..248		8/22 (36%)
		leucine-rich repeat	228..251	CDD:275380	8/22 (36%)
		LRR 9. /evidence=ECO:0000255	250..273		11/22 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	346..446		24/114 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910