DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek1 and lrrc4bb

DIOPT Version :9

Sequence 1:	NP_001303320.1	Gene:	kek1 / 34688	FlyBaseID:	FBgn0015399	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	XP_003201401.1	Gene:	lrrc4bb / 100535350	ZFINID:	ZDB-GENE-091116-44	Length:	726	Species:	Danio rerio

Alignment Length:	709	Identity:	156/709 - (22%)
Similarity:	240/709 - (33%)	Gaps:	251/709 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 AQQQSTCQTVCACKWKGGKQTVECIDRHLIQIPEHIDPNTQVLDMSGNKLQTLSNEQFIRANLLN 148
            |:....|..:|:|..:..:  |.|..:.|.::|:.|..||:.|::..|.:|.:.::.|...|  :
Zfish    33 AEASPACPALCSCSNQASR--VICTKKSLNEVPQSISSNTRYLNLQENSIQVIRSDTFKHLN--H 93

  Fly   149 LQKLYLRNCKIGEIERETFKGLTNLVELDLSHNLLVTVPSLALGHIPSLRELTLASNHIHKIESQ 213
            |:.|.|...:|.:||...|.||.||:.|:|..|.|..|||.|..::..||||.|.:|.|..:.:.
Zfish    94 LEILQLSKNQIRQIEVGAFNGLPNLITLELFDNRLPLVPSQAFEYLSKLRELWLRNNPIETLPAY 158

  Fly   214 AFGNTPSLHKLDLSHC-DIQTISAQAFGGLQGLTL----------------------LRLNGNKL 255
            ||...|||.:|||... .:..||..||.||..|..                      |.|:||:|
Zfish   159 AFHRVPSLRRLDLGELRKLSFISEAAFEGLLNLRFLNLGMCGLKDVPNLTPLVRLEELELSGNQL 223

  Fly   256 SELLP------------------------------KTIETLSRLHG------------------I 272
            ..:.|                              |.:|.|:..|.                  :
Zfish   224 GVVRPGSFQGLVSLRKLWLMHSRISVIERNAFDDLKNLEELNLSHNSLHSLPHDLFTPLQQLERV 288

  Fly   273 ELHDNPWLCDCRLRDTKLWL---MKRNIPYPVAPVCS--GGPERIIDRSFADLHVDEFAC-RPEM 331
            .|:.|||:|:|.:    |||   :|..:| ..:..|:  ..|.....|...||...:|.| .|.:
Zfish   289 HLNHNPWVCNCDV----LWLSWWLKETVP-DNSTCCARCHAPPGTKGRYIGDLDQRDFTCYAPVI 348

  Fly   332 LPISHYVEAAMGENASITCRARAVPAANINWYW-NGRLLANNSAFTAYQ-RIHMLEQVEGGFEKR 394
            :.....:....|..|.:.||. .....::||.. ||.|:.:.    ||: ||.:|..
Zfish   349 VEPPTDLNVTEGMAAELKCRT-GTSMTSVNWLTPNGTLMTHG----AYKVRISVLHD-------- 400

  Fly   395 SKLVLTNAQETDSSEFYCVAENRAGMAEANFTLHVSMRAAG------------------------ 435
            ..|..||....|:..:.|:..|.||...|...|:||....|
Zfish   401 GTLNFTNVTMQDTGPYTCMVTNSAGNTTATAVLNVSAPDPGNGYSYFTTVTVETVETGQEGHDSP 465

  Fly   436 ----------------MASLGSGQ----------------------------------------- 443
                            .||..:|.
Zfish   466 ARQFVNETFISFPGPTAASTSAGPTGSMLSSLSPRATRAPDRPFTVSITDVANLSGLEDVMKTTK 530

  Fly   444 -IVGLSAALVALIVFALGVIMCLLLRVKRQPYVDSKTPNHMEVITSVNHQNSITNKTQPATGNGS 507
             |:|...|    |.|...|::.:..::::|..: .|.......|..:|.::.|          ||
Zfish   531 IIIGCFVA----ITFMAAVMLVVFYKLRKQHQL-HKHHGPARAIEIINVEDEI----------GS 580

  Fly   508 IGGVVIANGAVANIIDGGVVQGGTLERKSSGRGG----VPHGVHDQRSANPVQKPPRLTDLP--- 565
            .||   |:|          :.||:.....:|.||    .|. :||          |.:..||
Zfish   581 AGG---ASG----------ITGGSTVHTGAGTGGGSGQSPR-IHD----------PEIMTLPSVG 621

  Fly   566 --------YSTQGYDNN--GSVLSTASCFISPS------------GSTGNGGNNPDLIN 602
                    |....::||  |..::|......|:            |..|:.|.||..|:
Zfish   622 QADHLNHYYKAHHFNNNVLGLNMTTGMLNNKPNPSSQNQASTLKMGPAGDLGPNPGSIS 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek1	NP_001303320.1	leucine-rich repeat	103..122	CDD:275380	5/18 (28%)
		LRR_RI	<119..277	CDD:238064	60/228 (26%)
		leucine-rich repeat	123..148	CDD:275380	6/24 (25%)
		LRR_8	148..207	CDD:290566	25/58 (43%)
		leucine-rich repeat	149..172	CDD:275380	9/22 (41%)
		leucine-rich repeat	173..196	CDD:275380	9/22 (41%)
		LRR_8	195..255	CDD:290566	26/82 (32%)
		leucine-rich repeat	197..220	CDD:275380	9/22 (41%)
		leucine-rich repeat	221..244	CDD:275380	10/23 (43%)
		leucine-rich repeat	245..268	CDD:275380	10/74 (14%)
		LRRCT	277..327	CDD:214507	16/54 (30%)
		IG_like	338..429	CDD:214653	24/92 (26%)
		Ig	346..426	CDD:143165	22/81 (27%)
lrrc4bb	XP_003201401.1	LRRNT	38..72	CDD:214470	10/35 (29%)
		LRR_8	68..128	CDD:290566	21/61 (34%)
		leucine-rich repeat	70..93	CDD:275380	6/24 (25%)
		LRR_RI	85..293	CDD:238064	54/209 (26%)
		leucine-rich repeat	94..117	CDD:275380	9/22 (41%)
		leucine-rich repeat	118..141	CDD:275380	9/22 (41%)
		LRR_8	140..196	CDD:290566	22/55 (40%)
		leucine-rich repeat	142..165	CDD:275380	9/22 (41%)
		leucine-rich repeat	166..190	CDD:275380	10/23 (43%)
		leucine-rich repeat	191..212	CDD:275380	1/20 (5%)
		LRR_8	212..271	CDD:290566	10/58 (17%)
		leucine-rich repeat	213..236	CDD:275380	6/22 (27%)
		leucine-rich repeat	237..260	CDD:275380	0/22 (0%)
		leucine-rich repeat	261..282	CDD:275380	3/20 (15%)
		TPKR_C2	293..343	CDD:301599	16/54 (30%)
		IG_like	352..435	CDD:214653	24/95 (25%)
		Ig	360..435	CDD:299845	24/87 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I12164
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8422
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910