DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek1 and lrfn2

DIOPT Version :9

Sequence 1:	NP_001303320.1	Gene:	kek1 / 34688	FlyBaseID:	FBgn0015399	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	XP_031758515.1	Gene:	lrfn2 / 100491687	XenbaseID:	XB-GENE-6035533	Length:	765	Species:	Xenopus tropicalis

Alignment Length:	872	Identity:	172/872 - (19%)
Similarity:	298/872 - (34%)	Gaps:	266/872 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 STCQTVCACKWKGGKQTVECIDRHLIQIPEHIDPNTQVLDMSGNKLQTLSNEQFIR--------- 143
            ::|...|.|:.........|..:.|:.:|..||..|..|.:.||.:.:::.:.|..
Frog    18 NSCPKYCVCQNLSESLGTLCPTKGLLFVPMDIDRRTVELRLGGNFIISINRQDFANMTGLVDLTL 82

  Fly   144 -------------ANLLNLQKLYLRNCKIGEIERETFKGLTNLVELDLSHNLLVTVPSLALGH-I 194
                         .:|.:|:.|:|.:.::..:..:.|:||.||..|.:::|.|.::...|... :
Frog    83 SRNTISYIQPYSFIDLESLRSLHLDSNRLTNLGDDVFRGLINLQHLIMNNNQLNSIAEDAFEDLL 147

  Fly   195 PSLRELTLASNHIHKIESQAFGNTPSLHKLDLSHCDIQTISAQAFGGLQGLTLLRLNGNKLSELL 259
            .:|.:|.|:.|::..:...|.....:||:|.|.|..|..|:...|..|..|..|.|..|:|.:|.
Frog   148 QTLEDLDLSYNNLKTVPWDAVRRMVNLHQLSLDHNLIYYITEGTFQDLNKLARLDLTSNRLQKLP 212

  Fly   260 PKTIETLSRLH-----------GIELHDNPWLCDCRLRDTKLWLMKRNIPYPVAPVCSGGPERII 313
            |..|...|::.           .:....||..|:|.|    |||.:.:....:....|  |..:.
Frog   213 PDPIFARSQISMTSATPFSPPLSLSFGGNPLHCNCEL----LWLRRLDREDDMETCAS--PSALK 271

  Fly   314 DRSFADLHVDEFACRPEMLPISHYVEAAM---GENASITCRARAVPAANINWYW-NGRLLANNSA 374
            .|.|..:..:||.|.|.:  |:.|.:..:   |:.||:.|:|...|...|:|.. :|||:.|:|.
Frog   272 GRYFWYVREEEFVCEPPL--ITQYTQRLLVLEGQTASLKCKAVGDPLPVIHWVAPDGRLIGNSSR 334

  Fly   375 FTAYQRIHMLEQVEGGFEKRSKLVLTNAQETDSSEFYCVAENRAGMAEANFTLHVSMRAAGMASL 439
            .|.|.        .|..:    :::|.::  |...|.|:|.|.||  |....:.:|:......|.
Frog   335 TTVYD--------NGTLD----ILITTSK--DYGTFTCIAANAAG--ELTAPVELSIVQIPHVSN 383

  Fly   440 GSGQIVGLSAALVALIVFALGVIMCLLLRVKRQPYVDSKTPNHMEVITSVNHQNSITNKTQPATG 504
            |:|:                                .:...:.:..|||....|....||.|..
Frog   384 GTGR--------------------------------TAPPKSRLSDITSSTKSNRGEVKTAPEK- 415

  Fly   505 NGSIGGVVIANGAVANIIDGGVVQGGTLERKSSGRGGVPHGVHDQRSANPVQKPPRL----TD-- 563
                 .||::.          |.....|.:.|..:            |.|..|..:|    :|
Frog   416 -----AVVVSE----------VTSSTALVKWSVSK------------AAPKVKMYQLQYNCSDDE 453

  Fly   564 ------LPYSTQGYDNNGSVLSTA--SCFISPSGSTGNGGNNPDLINDTKRFGSDEFADLKIPPI 620
                  :|.|.:.:..|..|..||  .|.::....|.......:::...:.|..:::...:....
Frog   454 VLIYRMIPASNKAFVVNNLVSGTAYDLCVLAIWDDTATTLTATNIVGCAQFFTQEDYQQCQSMHS 518

  Fly   621 SGVG------VGG------------------------------SGEYSRANGCDSLYPSGLWEHG 649
            ..:|      :||                              :..||:.||.:::      ::|
Frog   519 QFLGGTMILVIGGIIVATLLVFIVILMVRYKICNHSQGKMANVTNVYSQTNGGNTV------QNG 577

  Fly   650 APVGTTSADDLFMKRYTDKTPIIDSTQLYDLHERTAATDYFSKTFPRSHLQQGMMTGGGGGTSTA 714
            ||..|.                                   .|...|:.|.:...     |::.:
Frog   578 APPQTN-----------------------------------PKVVVRNELMEFQC-----GSAHS 602

  Fly   715 STVTTNLSGGSSSGYPNDYGLPLVPG---------AEHQHNHQLQMHPLQQLQQQLTSTLNHQKQ 770
            |..:::.|..|..|  :||.|...|.         :..:||....|.....|:      |..||:
Frog   603 SVSSSSSSVNSPDG--DDYSLHSNPSTLSNKWRPVSRSKHNIDRLMGAFASLE------LRCQKK 659

  Fly   771 E---GSSTGSSPHFSSRTLPRL--HEGSG--------GGGSSRSSPTPAVSGGHANQAANPSTSS 822
            |   .|.|.::.|.|.:. |.|  ||...        .|.:.||         |:....:.||
Frog   660 EDTVDSRTSTTAHQSDKE-PLLGHHESKVRSLLMLPLEGKAKRS---------HSFDMGDFST-- 712

  Fly   823 SSCSILPNGQPINAKTIRVWQKGGVPV 849
            :.|...|.      |...:|.:..:.|
Frog   713 TQCCSYPR------KISNIWTRRSLSV 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek1	NP_001303320.1	leucine-rich repeat	103..122	CDD:275380	5/18 (28%)
		LRR_RI	<119..277	CDD:238064	43/191 (23%)
		leucine-rich repeat	123..148	CDD:275380	6/46 (13%)
		LRR_8	148..207	CDD:290566	16/59 (27%)
		leucine-rich repeat	149..172	CDD:275380	6/22 (27%)
		leucine-rich repeat	173..196	CDD:275380	5/23 (22%)
		LRR_8	195..255	CDD:290566	18/59 (31%)
		leucine-rich repeat	197..220	CDD:275380	5/22 (23%)
		leucine-rich repeat	221..244	CDD:275380	9/22 (41%)
		leucine-rich repeat	245..268	CDD:275380	8/22 (36%)
		LRRCT	277..327	CDD:214507	14/49 (29%)
		IG_like	338..429	CDD:214653	25/94 (27%)
		Ig	346..426	CDD:143165	24/80 (30%)
lrfn2	XP_031758515.1	LRR_8	51..111	CDD:404697	9/59 (15%)
		leucine-rich repeat	53..76	CDD:275380	5/22 (23%)
		leucine-rich repeat	77..100	CDD:275380	1/22 (5%)
		LRR_8	100..160	CDD:404697	16/59 (27%)
		leucine-rich repeat	101..124	CDD:275380	6/22 (27%)
		leucine-rich repeat	125..148	CDD:275380	5/22 (23%)
		LRR_8	148..208	CDD:404697	18/59 (31%)
		leucine-rich repeat	150..173	CDD:275380	5/22 (23%)
		leucine-rich repeat	174..197	CDD:275380	9/22 (41%)
		LRRCT	241..285	CDD:214507	14/49 (29%)
		Ig	288..375	CDD:416386	27/104 (26%)
		Ig strand A	288..291	CDD:409353	0/4 (0%)
		Ig strand A'	295..298	CDD:409353	0/2 (0%)
		Ig strand B	304..312	CDD:409353	3/7 (43%)
		Ig strand C	318..323	CDD:409353	2/4 (50%)
		Ig strand C'	326..328	CDD:409353	1/1 (100%)
		Ig strand D	334..338	CDD:409353	1/3 (33%)
		Ig strand E	341..345	CDD:409353	1/7 (14%)
		Ig strand F	355..362	CDD:409353	3/6 (50%)
		Ig strand G	365..375	CDD:409353	2/11 (18%)
		fn3	417..485	CDD:394996	17/89 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910