DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek1 and lrrc4c

DIOPT Version :9

Sequence 1:	NP_001303320.1	Gene:	kek1 / 34688	FlyBaseID:	FBgn0015399	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	XP_002938986.1	Gene:	lrrc4c / 100188921	XenbaseID:	XB-GENE-5772259	Length:	639	Species:	Xenopus tropicalis

Alignment Length:	504	Identity:	133/504 - (26%)
Similarity:	196/504 - (38%)	Gaps:	112/504 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 TCQTVCACKWKGGKQTVECIDRHLIQIPEHIDPNTQVLDMSGNKLQTLSNEQFIRANLLNLQKLY 153
            ||.:||:|..:..|  |.|..|:|.::|:.|..||:.|::..|::|.:..:.|  .:|.:|:.|.
Frog    46 TCPSVCSCSNQFSK--VICTRRNLREVPDGISTNTRQLNLHENQIQIIKVDSF--KHLRHLEVLQ 106

  Fly   154 LRNCKIGEIERETFKGLTNLVELDLSHNLLVTVPSLALGHIPSLRELTLASNHIHKIESQAFGNT 218
            |....|..||...|.||.||..|:|..|.|.|:|:.|..::..|:||.|.:|.|..|.|.||...
Frog   107 LSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFEYLSKLKELWLRNNPIESIPSYAFNRI 171

  Fly   219 PSLHKLDLS-------------------------------------------------------- 227
            |||.:|||.
Frog   172 PSLRRLDLGEMKRLSYISEGAFEGLSNLKYLNLGMCNLRDIPNLTPLVKLDELDLSGNHLSVLRP 236

  Fly   228 ---------------HCDIQTISAQAFGGLQGLTLLRLNGNKLSELLPKTIET-LSRLHGIELHD 276
                           |..||.|...||..||.|..|.|..|.|: |||..:.| |..|..|:||.
Frog   237 GSFQGLTHLQKLWIMHSQIQVIERNAFDDLQSLVELNLAHNNLT-LLPHDLFTPLHNLQRIQLHH 300

  Fly   277 NPWLCDCRLRDTKLWLMKRNIPYPVAPVCS--GGPERIIDRSFADLHVDEFAC-RPEMLPISHYV 338
            |||.|:|.:.....||  :.|....:..|:  ..|..:.....|:|..:.|.| .|.::.....:
Frog   301 NPWNCNCDILWLSWWL--KEIVTTGSTCCARCSTPPSLKGTHIAELDHNYFTCYAPVIVEPPADL 363

  Fly   339 EAAMGENASITCRARAVPAANINWYW-NGRLLANNSAFTAYQ-RIHMLEQVEGGFEKRSKLVLTN 401
            ....|..|.:.||| :.....::|.. ||.::.:.|    |: ||.:|..        ..|..||
Frog   364 NVTEGMAAELKCRA-STSLTYVSWITPNGTIMTHGS----YKVRISVLND--------GTLNFTN 415

  Fly   402 AQETDSSEFYCVAENRAGMAEANFTLHVSMRAAGMASLGSGQIVGLSAALVALIVFALGVIMCLL 466
            ....|:..:.|:..|.||...|:.||:|:....|...        .|...|..:..:........
Frog   416 VTVRDTGLYTCIVSNSAGNTTASATLNVTASDTGYTY--------FSTVTVETMEPSQDEARTTE 472

  Fly   467 LRVKRQPYVDSKTPNHMEVITSVNHQNS-ITNK--TQPAT-GNGSIGGV 511
            ..|...|.:|.:|.|   ..||:..|:: .|.|  |.|.| .|..:.|:
Frog   473 THVGPTPVIDWETTN---ATTSLMPQSTRFTEKTVTVPVTDANNGMPGI 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek1	NP_001303320.1	leucine-rich repeat	103..122	CDD:275380	6/18 (33%)
		LRR_RI	<119..277	CDD:238064	64/229 (28%)
		leucine-rich repeat	123..148	CDD:275380	6/24 (25%)
		LRR_8	148..207	CDD:290566	23/58 (40%)
		leucine-rich repeat	149..172	CDD:275380	9/22 (41%)
		leucine-rich repeat	173..196	CDD:275380	8/22 (36%)
		LRR_8	195..255	CDD:290566	28/130 (22%)
		leucine-rich repeat	197..220	CDD:275380	10/22 (45%)
		leucine-rich repeat	221..244	CDD:275380	11/93 (12%)
		leucine-rich repeat	245..268	CDD:275380	10/23 (43%)
		LRRCT	277..327	CDD:214507	13/51 (25%)
		IG_like	338..429	CDD:214653	24/92 (26%)
		Ig	346..426	CDD:143165	21/81 (26%)
lrrc4c	XP_002938986.1	LRRNT	47..78	CDD:214470	11/32 (34%)
		LRR	<77..302	CDD:227223	63/227 (28%)
		leucine-rich repeat	78..101	CDD:275380	6/24 (25%)
		leucine-rich repeat	102..125	CDD:275380	9/22 (41%)
		leucine-rich repeat	126..149	CDD:275380	8/22 (36%)
		leucine-rich repeat	150..173	CDD:275380	10/22 (45%)
		leucine-rich repeat	174..198	CDD:275380	4/23 (17%)
		leucine-rich repeat	199..220	CDD:275380	0/20 (0%)
		leucine-rich repeat	221..244	CDD:275380	0/22 (0%)
		leucine-rich repeat	245..268	CDD:275380	7/22 (32%)
		leucine-rich repeat	269..290	CDD:275380	9/21 (43%)
		LRRCT	301..351	CDD:214507	13/51 (25%)
		Ig	354..443	CDD:416386	25/101 (25%)
		Ig strand A	354..357	CDD:409353	1/2 (50%)
		Ig strand A'	361..364	CDD:409353	0/2 (0%)
		Ig strand B	370..377	CDD:409353	2/6 (33%)
		Ig strand C	383..388	CDD:409353	1/4 (25%)
		Ig strand C'	391..393	CDD:409353	1/1 (100%)
		Ig strand D	402..406	CDD:409353	2/3 (67%)
		Ig strand E	409..413	CDD:409353	1/3 (33%)
		Ig strand F	423..430	CDD:409353	1/6 (17%)
		Ig strand G	433..443	CDD:409353	4/9 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm49155
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910