DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek1 and lrfn4b

DIOPT Version :9

Sequence 1:	NP_001303320.1	Gene:	kek1 / 34688	FlyBaseID:	FBgn0015399	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	XP_021333806.1	Gene:	lrfn4b / 100149980	ZFINID:	ZDB-GENE-070705-473	Length:	1131	Species:	Danio rerio

Alignment Length:	156	Identity:	34/156 - (21%)
Similarity:	57/156 - (36%)	Gaps:	29/156 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 IREAVFLVLTLLPGMILGTRYNQLHLYANGGASSSGPGGYR---PAPSSQNEVYSIADSQPMTED 64
            :.:.|:|....||..:...:.:|..:.....|....|..||   |.....|..:.::..:|:...
Zfish   984 VGQRVWLATKNLPLRVESRKLSQRFIGPFRIARKVNPVSYRLYLPRSLRINPTFHVSLLKPVLSS 1048

  Fly    65 GYMPPSQHFPP-----------THSDLDPPAQQQSTCQTVCACKWKG-GKQTVECIDRHLIQIPE 117
            .:.||.:..||           .|..||....|.|....|   .|:| |.:     :|..|...:
Zfish  1049 PFAPPRRPPPPPRIIDGQPAYTVHRILDSRRVQNSLQYLV---DWEGYGPE-----ERSWIPAKD 1105

  Fly   118 HIDP------NTQVLDMSGNKLQTLS 137
            .:||      :||....||..:::.|
Zfish  1106 ILDPSLIREFHTQRPGCSGRNVRSRS 1131

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek1	NP_001303320.1	leucine-rich repeat	103..122	CDD:275380	4/24 (17%)
		LRR_RI	<119..277	CDD:238064	7/25 (28%)
		leucine-rich repeat	123..148	CDD:275380	5/15 (33%)
		LRR_8	148..207	CDD:290566
		leucine-rich repeat	149..172	CDD:275380
		leucine-rich repeat	173..196	CDD:275380
		LRR_8	195..255	CDD:290566
		leucine-rich repeat	197..220	CDD:275380
		leucine-rich repeat	221..244	CDD:275380
		leucine-rich repeat	245..268	CDD:275380
		LRRCT	277..327	CDD:214507
		IG_like	338..429	CDD:214653
		Ig	346..426	CDD:143165
lrfn4b	XP_021333806.1	retropepsin_like	58..144	CDD:133136
		RT_LTR	253..429	CDD:238825
		RNase_HI_RT_Ty3	525..646	CDD:260006
		zf-H2C2	716..749	CDD:324145
		rve	772..885	CDD:307008
		Chromo	1069..1116	CDD:306815	13/54 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26535
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910