DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek1 and lingo1

DIOPT Version :9

Sequence 1:	NP_001303320.1	Gene:	kek1 / 34688	FlyBaseID:	FBgn0015399	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	NP_001093719.1	Gene:	lingo1 / 100101739	XenbaseID:	XB-GENE-921957	Length:	606	Species:	Xenopus tropicalis

Alignment Length:	506	Identity:	109/506 - (21%)
Similarity:	167/506 - (33%)	Gaps:	195/506 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 STCQTVCACKWKGGKQTVECIDRHLIQIPEHIDPNTQVLDMSGNKLQTLSNEQF----------I 142
            |.|...|.|..:  .::|.|..:..:.:||.|..:|::||:|.|:::.|:.::|          :
Frog    26 SGCPQRCDCSPQ--DRSVLCHRKRYLDVPEGIPTDTRLLDLSKNRIKALNQDEFSAFPYLEELEL 88

  Fly   143 RAN------------LLNLQKLYLRNCKIGEIERETFKGLTNLVELDLSHNLLV----------- 184
            ..|            |.||:.|.||:.::..|....|.||:||.:||:|.|.:|
Frog    89 NENIVSIIEPGAFNGLFNLRSLGLRSNRLKLIPLGVFTGLSNLTQLDISENKIVILLDDMFQDLY 153

  Fly   185 -------------------------------------TVPSLALGHIPSLRELTLASNHIHKIES 212
                                                 :||:.||.|:..|..|.|...:|:.|..
Frog   154 NLKSLEVGDNDLVYISHRAFRGLNSLEELTLEKCNLTSVPTEALSHLHGLITLKLRYLNINVIRD 218

  Fly   213 QAFGNTPSLHKLDLSHC------------------------------------------------ 229
            .:|.....|..|:::|.
Frog   219 YSFKRLYRLKNLEIAHWPYLDTMTSNGLYGLNLTSLSITHSNLSSIPYVAIRHLVYLRFLNLSYN 283

  Fly   230 ------------------------DIQTISAQAFGGLQGLTLLRLNGNKLSELLPKTIETLSRLH 270
                                    .:..:...||.||..|.:|.::.|.||.|...:..::..|.
Frog   284 PITAVEGSMLYELLRLQEFHLVGGQLSVVEPYAFRGLNHLKVLNVSSNYLSTLEESSFHSVGNLE 348

  Fly   271 GIELHDNPWLCDCRLRDTKLWLMKRNIPYPVA---PVCSGGPERIIDRSFAD----LHVDEFACR 328
            .:.|..||..|||||    ||:.:|......:   |.|| .||.:..:.|.|    |..:.|.||
Frog   349 TLILDKNPLACDCRL----LWIFRRRWRLNFSRQQPSCS-SPEYVQGKEFKDFPDVLQPNYFTCR 408

  Fly   329 PEMLPISH-----YVEAAMGENASITCRARAVPAANINWY----------WNGRLLANNSAFTAY 378
            ...:. .|     ||:.  |......|||...|...|.|.          .||||       |.:
Frog   409 RARIQ-DHSAQVVYVDE--GHTVHFFCRADGDPPPTILWQSPRKTFITSKSNGRL-------TVF 463

  Fly   379 QRIHMLEQVEGGFEKRSKLVLTNAQETDSSEFYCVAENRAGMAEANFTLHV 429
            .        :|..|.|      .||..|:..::|:|.|..|...:...|||
Frog   464 P--------DGTLEVR------YAQVQDNGTYHCIASNAGGNDTSLAHLHV 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek1	NP_001303320.1	leucine-rich repeat	103..122	CDD:275380	5/18 (28%)
		LRR_RI	<119..277	CDD:238064	52/299 (17%)
		leucine-rich repeat	123..148	CDD:275380	9/46 (20%)
		LRR_8	148..207	CDD:290566	24/106 (23%)
		leucine-rich repeat	149..172	CDD:275380	8/22 (36%)
		leucine-rich repeat	173..196	CDD:275380	11/70 (16%)
		LRR_8	195..255	CDD:290566	16/131 (12%)
		leucine-rich repeat	197..220	CDD:275380	6/22 (27%)
		leucine-rich repeat	221..244	CDD:275380	7/94 (7%)
		leucine-rich repeat	245..268	CDD:275380	6/22 (27%)
		LRRCT	277..327	CDD:214507	19/56 (34%)
		IG_like	338..429	CDD:214653	24/100 (24%)
		Ig	346..426	CDD:143165	21/89 (24%)
lingo1	NP_001093719.1	LRRNT	27..61	CDD:214470	9/35 (26%)
		LRR 1	58..79		7/20 (35%)
		leucine-rich repeat	59..82	CDD:275380	7/22 (32%)
		PLN00113	62..>381	CDD:215061	60/322 (19%)
		LRR 2	82..103		1/20 (5%)
		leucine-rich repeat	83..106	CDD:275380	2/22 (9%)
		LRR_8	106..165	CDD:338972	16/58 (28%)
		LRR 3	106..127		7/20 (35%)
		leucine-rich repeat	107..130	CDD:275380	8/22 (36%)
		LRR 4	130..151		7/20 (35%)
		leucine-rich repeat	131..154	CDD:275380	6/22 (27%)
		LRR 5	154..175		0/20 (0%)
		leucine-rich repeat	155..178	CDD:275380	0/22 (0%)
		LRR 6	178..199		4/20 (20%)
		leucine-rich repeat	179..250	CDD:275380	14/70 (20%)
		LRR 7	202..223		6/20 (30%)
		leucine-rich repeat	203..226	CDD:275380	6/22 (27%)
		LRR 8	250..271		0/20 (0%)
		leucine-rich repeat	251..274	CDD:275380	0/22 (0%)
		LRR 9	274..295		0/20 (0%)
		leucine-rich repeat	275..298	CDD:275380	0/22 (0%)
		LRR 10	298..319		2/20 (10%)
		leucine-rich repeat	299..322	CDD:275380	4/22 (18%)
		LRR 11	322..343		6/20 (30%)
		leucine-rich repeat	323..343	CDD:275380	6/19 (32%)
		Ig	425..500	CDD:386229	23/95 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910