DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MRP and ABCC12

DIOPT Version :9

Sequence 1:NP_723772.2 Gene:MRP / 34686 FlyBaseID:FBgn0032456 Length:1549 Species:Drosophila melanogaster
Sequence 2:NP_001380726.1 Gene:ABCC12 / 94160 HGNCID:14640 Length:1359 Species:Homo sapiens


Alignment Length:1397 Identity:478/1397 - (34%)
Similarity:712/1397 - (50%) Gaps:174/1397 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly   225 PELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHHWNQNVRKNYKNKA 289
            |...|..||..|:.|...:.:||||..|....|..|...||.......|...|::.|       |
Human    45 PVDDAGLLSFATFSWLTPVMVKGYRQRLTVDTLPPLSTYDSSDTNAKRFRVLWDEEV-------A 102

  Fly   290 RVEP-KAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQV 353
            ||.| ||..|:....|:...                            .||.:..:.|......:
Human   103 RVGPEKASLSHVVWKFQRTR----------------------------VLMDIVANILCIIMAAI 139

  Fly   354 LSLIISFVEAQDAE----PEWKGILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAIYR 414
            ...::.....|..|    ..|.||...:.||.....:.|.....:...:...:|::.||...::.
Human   140 GPTVLIHQILQQTERTSGKVWVGIGLCIALFATEFTKVFFWALAWAINYRTAIRLKVALSTLVFE 204

  Fly   415 KALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGL 479
            ..  :|..|....:|||::|:::.|:....|...:..:..:.|:.:.....:.:..|||:.|.|:
Human   205 NL--VSFKTLTHISVGEVLNILSSDSYSLFEAALFCPLPATIPILMVFCAAYAFFILGPTALIGI 267

  Fly   480 AVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKE 544
            :|.:|.|||...:|.....::...:...|:||:.|||.|:.|:::|:||||.||...:.|||.:|
Human   268 SVYVIFIPVQMFMAKLNSAFRRSAILVTDKRVQTMNEFLTCIRLIKMYAWEKSFTNTIQDIRRRE 332

  Fly   545 IATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVLTSEANQLSVEKVLVSIALFDLMKLPLTILP 609
            ...|....::.:|.|.|......:..::|.:.::|.  ..:|:.......||:|::||..:.|||
Human   333 RKLLEKAGFVQSGNSALAPIVSTIAIVLTLSCHILL--RRKLTAPVAFSVIAMFNVMKFSIAILP 395

  Fly   610 MLSVDIAETQVSVNRINKFL--------NSEELDPNSVL----------HDSS-KPHPMSIEN-- 653
            .....:||..||:.|:.|.|        .::..||::||          |::| |..|..::|  
Human   396 FSIKAMAEANVSLRRMKKILIDKSPPSYITQPEDPDTVLLLANATLTWEHEASRKSTPKKLQNQK 460

  Fly   654 -----------------------GEFSWGDEI--TLRNINIEVKKGSLVALVGTVGSGKSSVVQA 693
                                   |.....|.:  .|.:|:..|:||.::.:.|.|||||||::.|
Human   461 RHLCKKQRSEAYSERSPPAKGATGPEEQSDSLKSVLHSISFVVRKGKILGICGNVGSGKSSLLAA 525

  Fly   694 FLGEMEKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSA 758
            .||:|:...|||...|.||||.|||||.:..||:|||||:.||.:||...:..|.|:.|:..|..
Human   526 LLGQMQLQKGVVAVNGTLAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPY 590

  Fly   759 GDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARK 823
            ||||||||:|:||||||:||||||||||||..||||||||||||||||||:|||.|  |..|..|
Human   591 GDLTEIGERGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECI--KKTLRGK 653

  Fly   824 SRVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKR 888
            :.|||||.:.||...|.:.:::.|||.|.||..:|::.:|.:|..|  |...|.:.::       
Human   654 TVVLVTHQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLI--HNLRGLQFKD------- 709

  Fly   889 QISSTADVPELLGTVEKAIKLARTESLSDSISVTSADSLMGGGGSLRRRTKRQDSHDSVASAASL 953
                    ||.|      ...|..|:..:|.:....|:   |...|....::.:..:|...:..:
Human   710 --------PEHL------YNAAMVEAFKESPAEREEDA---GIIVLAPGNEKDEGKESETGSEFV 757

  Fly   954 KKKQEVEGKLIETEKSQTGGVEFAVYKHYIK-SVGIFLSVATLVLNFVFQAFQIGSNLWLTQWAN 1017
            ..|.. |.:||:||..|.|.|.:..|..||| |.|..||:.|:.|..:.......||.||..|. 
Human   758 DTKVP-EHQLIQTESPQEGTVTWKTYHTYIKASGGYLLSLFTVFLFLLMIGSAAFSNWWLGLWL- 820

  Fly  1018 DQNVANDTGLRDMYLGVYG----------AFGFGQGVLAY-------FAVVIVYLGGF------- 1058
                  |.|.| |..|..|          ....||.|..:       |.:|.....||       
Human   821 ------DKGSR-MTCGPQGNRTMCEVGAVLADIGQHVYQWVYTASMVFMLVFGVTKGFVFTKTTL 878

  Fly  1059 QAAKTIHNELLAVIIRGSVCRFFDITPIGRLLNSFSGDMDVVDEELPATMDSFMTFIFMVLATIV 1123
            .|:.::|:.:...|:: |...|||.||.|||:|.||.|||.:|..||...::|:...|||:..:|
Human   879 MASSSLHDTVFDKILK-SPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQFFMVVFILV 942

  Fly  1124 VISLSTPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVG 1188
            :::...|..|.|:..:|..::...|.:....::|.::|:|||||.::|.:.::.|...|.||.  
Human   943 ILAAVFPAVLLVVASLAVGFFILLRIFHRGVQELKKVENVSRSPWFTHITSSMQGLGIIHAYG-- 1005

  Fly  1189 DRFIEESDAKVDKNQVC-KYPSVIAN---RWLAIRLEMVGNLIILFASLFAVLG-GQTNPGLVGL 1248
                        |.:.| .|..:..|   ||.|:|::::.|::....:|...|. ...:....||
Human  1006 ------------KKESCITYHLLYFNCALRWFALRMDVLMNILTFTVALLVTLSFSSISTSSKGL 1058

  Fly  1249 SVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGET-KQEAPWELEQDKNKPKNWPQEGRVEF 1312
            |:||.:|::..|...||..::.:....|||.::||..| ..|....|:.. ..||:||..|.:.|
Human  1059 SLSYIIQLSGLLQVCVRTGTETQAKFTSVELLREYISTCVPECTHPLKVG-TCPKDWPSRGEITF 1122

  Fly  1313 QNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIAS 1377
            :::|:|||:...|||..::.|||.|:.||||||||:|||||.:||||::|.|.|.|.||.|||..
Human  1123 RDYQMRYRDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPASGTIFIDEVDICI 1187

  Fly  1378 MGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAE 1442
            :.|..||::||:||||||||.|::|.||||||..||:.:|:.||.:.::..:..|...|..|:.|
Human  1188 LSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESHTDEMLWQVLERTFMRDTIMKLPEKLQAEVTE 1252

  Fly  1443 GGENLSVGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNT 1507
            .|||.|||:|||:|:||||||.:|:::||||||::|.:||.|:|.||:..||.||||||||||||
Human  1253 NGENFSVGERQLLCVARALLRNSKIILLDEATASMDSKTDTLVQNTIKDAFKGCTVLTIAHRLNT 1317

  Fly  1508 ILDSDKVIVLDKGQIIEFASPTELLDNPKSAF 1539
            :|:.|.|:|::.|::|||..|..|.:.|.|||
Human  1318 VLNCDHVLVMENGKVIEFDKPEVLAEKPDSAF 1349

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MRPNP_723772.2 MRP_assoc_pro 14..1548 CDD:188098 478/1397 (34%)
ABC_membrane 338..601 CDD:279056 63/266 (24%)
ABCC_MRP_domain1 649..848 CDD:213217 108/225 (48%)
ABC_membrane 988..1260 CDD:279056 82/300 (27%)
ABCC_MRP_domain2 1308..1528 CDD:213211 121/219 (55%)
ABCC12NP_001380726.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 446..491 5/44 (11%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165151580
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG51855
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 1 1.000 - - FOG0000087
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.660

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