Protein Alignment MRP and ABCC12

DIOPT Version :10

• Sequence 1: NP_723772.2
• Gene: MRP / 34686
• FlyBaseID: FBgn0032456
• Length: 1549
• Species: Drosophila melanogaster
• Sequence 2: NP_150229.2
• Gene: ABCC12 / 94160
• HGNCID: 14640
• Length: 1359
• Species: Homo sapiens
• Alignment Length: 1397
• Identity: 481/1397 - (34%)
• Similarity: 719/1397 - (51%)
• Gaps: 174/1397 - (12%)

  Fly   225 PELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHHWNQNVRKNYKNKA 289
            |...|..||..|:.|...:.:||||..|....|..|...||.......|...|::.|       |
Human    45 PVDDAGLLSFATFSWLTPVMVKGYRQRLTVDTLPPLSTYDSSDTNAKRFRVLWDEEV-------A 102

  Fly   290 RVEP-KAQFSNGNVTFENPHGEKNGRKKGM----ASIMPPIYKSFGGVFLFGALMKLFTDTLTFA 349
            ||.| ||..|:....|:        |.:.:    |:|:..|..:.|.|.|...:::....|
Human   103 RVGPEKASLSHVVWKFQ--------RTRVLMDIVANILCIIMAAIGPVILIHQILQQTERT---- 155

  Fly   350 QPQVLSLIISFVEAQDAEPEWKGILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAIYR 414
                            :...|.||...:.||.....:.|.....:...:...:|::.||...::.
Human   156 ----------------SGKVWVGIGLCIALFATEFTKVFFWALAWAINYRTAIRLKVALSTLVFE 204

  Fly   415 KALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGL 479
            ..  :|..|....:|||::|:::.|:....|...:..:..:.|:.:.....:.:..|||:.|.|:
Human   205 NL--VSFKTLTHISVGEVLNILSSDSYSLFEAALFCPLPATIPILMVFCAAYAFFILGPTALIGI 267

  Fly   480 AVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKE 544
            :|.:|.|||...:|.....::...:...|:||:.|||.|:.|:::|:||||.||...:.|||.:|
Human   268 SVYVIFIPVQMFMAKLNSAFRRSAILVTDKRVQTMNEFLTCIRLIKMYAWEKSFTNTIQDIRRRE 332

  Fly   545 IATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVLTSEANQLSVEKVLVSIALFDLMKLPLTILP 609
            ...|....::.:|.|.|......:..::|.:.::|.  ..:|:.......||:|::||..:.|||
Human   333 RKLLEKAGFVQSGNSALAPIVSTIAIVLTLSCHILL--RRKLTAPVAFSVIAMFNVMKFSIAILP 395

  Fly   610 MLSVDIAETQVSVNRINKFL--------NSEELDPNSVL----------HDSS-KPHPMSIEN-- 653
            .....:||..||:.|:.|.|        .::..||::||          |::| |..|..::|
Human   396 FSIKAMAEANVSLRRMKKILIDKSPPSYITQPEDPDTVLLLANATLTWEHEASRKSTPKKLQNQK 460

  Fly   654 -----------------------GEFSWGDEI--TLRNINIEVKKGSLVALVGTVGSGKSSVVQA 693
                                   |.....|.:  .|.:|:..|:||.::.:.|.|||||||::.|
Human   461 RHLCKKQRSEAYSERSPPAKGATGPEEQSDSLKSVLHSISFVVRKGKILGICGNVGSGKSSLLAA 525

  Fly   694 FLGEMEKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSA 758
            .||:|:...|||...|.||||.|||||.:..||:|||||:.||.:||...:..|.|:.|:..|..
Human   526 LLGQMQLQKGVVAVNGTLAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPY 590

  Fly   759 GDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARK 823
            ||||||||:|:||||||:||||||||||||..||||||||||||||||||:|||.|  |..|..|
Human   591 GDLTEIGERGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECI--KKTLRGK 653

  Fly   824 SRVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKR 888
            :.|||||.:.||...|.:.:::.|||.|.||..:|::.:|.:|..|  |...|.:.::
Human   654 TVVLVTHQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLI--HNLRGLQFKD------- 709

  Fly   889 QISSTADVPELLGTVEKAIKLARTESLSDSISVTSADSLMGGGGSLRRRTKRQDSHDSVASAASL 953
                    ||.|      ...|..|:..:|.:....|:   |...|....::.:..:|...:..:
Human   710 --------PEHL------YNAAMVEAFKESPAEREEDA---GIIVLAPGNEKDEGKESETGSEFV 757

  Fly   954 KKKQEVEGKLIETEKSQTGGVEFAVYKHYIK-SVGIFLSVATLVLNFVFQAFQIGSNLWLTQWAN 1017
            ..|.. |.:||:||..|.|.|.:..|..||| |.|..||:.|:.|..:.......||.||..|.
Human   758 DTKVP-EHQLIQTESPQEGTVTWKTYHTYIKASGGYLLSLFTVFLFLLMIGSAAFSNWWLGLWL- 820

  Fly  1018 DQNVANDTGLRDMYLGVYG----------AFGFGQGVLAY-------FAVVIVYLGGF------- 1058
                  |.|.| |..|..|          ....||.|..:       |.:|.....||
Human   821 ------DKGSR-MTCGPQGNRTMCEVGAVLADIGQHVYQWVYTASMVFMLVFGVTKGFVFTKTTL 878

  Fly  1059 QAAKTIHNELLAVIIRGSVCRFFDITPIGRLLNSFSGDMDVVDEELPATMDSFMTFIFMVLATIV 1123
            .|:.::|:.:...|:: |...|||.||.|||:|.||.|||.:|..||...::|:...|||:..:|
Human   879 MASSSLHDTVFDKILK-SPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQFFMVVFILV 942

  Fly  1124 VISLSTPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVG 1188
            :::...|..|.|:..:|..::...|.:....::|.::|:|||||.::|.:.::.|...|.||.
Human   943 ILAAVFPAVLLVVASLAVGFFILLRIFHRGVQELKKVENVSRSPWFTHITSSMQGLGIIHAYG-- 1005

  Fly  1189 DRFIEESDAKVDKNQVC-KYPSVIAN---RWLAIRLEMVGNLIILFASLFAVLG-GQTNPGLVGL 1248
                        |.:.| .|..:..|   ||.|:|::::.|::....:|...|. ...:....||
Human  1006 ------------KKESCITYHLLYFNCALRWFALRMDVLMNILTFTVALLVTLSFSSISTSSKGL 1058

  Fly  1249 SVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGET-KQEAPWELEQDKNKPKNWPQEGRVEF 1312
            |:||.:|::..|...||..::.:....|||.::||..| ..|....|:.. ..||:||..|.:.|
Human  1059 SLSYIIQLSGLLQVCVRTGTETQAKFTSVELLREYISTCVPECTHPLKVG-TCPKDWPSRGEITF 1122

  Fly  1313 QNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIAS 1377
            :::|:|||:...|||..::.|||.|:.||||||||:|||||.:||||::|.|.|.|.||.|||..
Human  1123 RDYQMRYRDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPASGTIFIDEVDICI 1187

  Fly  1378 MGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAE 1442
            :.|..||::||:||||||||.|::|.||||||..||:.:|:.||.:.::..:..|...|..|:.|
Human  1188 LSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESHTDEMLWQVLERTFMRDTIMKLPEKLQAEVTE 1252

  Fly  1443 GGENLSVGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNT 1507
            .|||.|||:|||:|:||||||.:|:::||||||::|.:||.|:|.||:..||.||||||||||||
Human  1253 NGENFSVGERQLLCVARALLRNSKIILLDEATASMDSKTDTLVQNTIKDAFKGCTVLTIAHRLNT 1317

  Fly  1508 ILDSDKVIVLDKGQIIEFASPTELLDNPKSAF 1539
            :|:.|.|:|::.|::|||..|..|.:.|.|||
Human  1318 VLNCDHVLVMENGKVIEFDKPEVLAEKPDSAF 1349

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	481/1397 (34%)
ABCC12	NP_150229.2	MRP_assoc_pro	43..1344	CDD:188098	477/1390 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	446..491		5/44 (11%)