Protein Alignment MRP and NFT1

DIOPT Version :10

• Sequence 1: NP_723772.2
• Gene: MRP / 34686
• FlyBaseID: FBgn0032456
• Length: 1549
• Species: Drosophila melanogaster
• Sequence 2: NP_013029.3
• Gene: NFT1 / 853978
• SGDID: S000001811
• Length: 1218
• Species: Saccharomyces cerevisiae
• Alignment Length: 1352
• Identity: 333/1352 - (24%)
• Similarity: 590/1352 - (43%)
• Gaps: 273/1352 - (20%)

  Fly    19 NATETWYTNDPDFTPCFEQ-------------TALVWTPCAFYWAFVI----------------- 53
            |.|..::..| |.:.|..:             |.:::..|..:.||.:
Yeast     4 NGTCPYWERD-DLSECARREYIEFKFPLFILLTGMIYAFCKVFRAFYLRGKNHTNEAPEFEEQGN 67

  Fly    54 -------FDFYYLKASLDRNIPWNKLNVS-----KALVNLGLLVITALDLIMALVKKGGDSELPL 106
                   |....||::.:.....|..|.|     |..:. |..::..|.:.:.::     |.:|:
Yeast    68 GNHEYARFSVLRLKSAWESRSFCNVNNRSTFDKFKKFIE-GAFIVLQLTIHLYIL-----SSMPM 126

  Fly   107 YDLDVW--GPIIKFATFLLLFIFIPLNRKYGVQT----TGCQFIFW----------FLLTVLSIP 155
            .:...:  |.:::...::||.:.|.|......|:    ..|:...|          |.|::|.:
Yeast   127 DNKKFFHQGFLVQMFLWILLLVVITLRLISASQSFRWVLACKRDLWAVSFYSYASLFTLSILPL- 190

  Fly   156 RCRTEVRLDAERQKILNSQQPSEQDFSWEEYQFVSFFIFFTFTSIMLILNCFADGMPRQTKYQ-R 219
               ..|.:...:.||:                 |.:.|..||..:.|:| ..:......|:|. .
Yeast   191 ---RSVFIGKIKDKIM-----------------VKYIISETFIDLALLL-LLSTSSIEGTRYSFL 234

  Fly   220 GENEIPEL--SASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHHWNQNVR 282
            .|||..:|  :.:....:|:...|::..|.|::.|...|:|||   |..::.:.|.|:
Yeast   235 VENENKKLPPAPTVFGLLTFSRIDRLIWKAYKHCLGNADIWDL---DINNKSIAILAN------- 289

  Fly   283 KNYKNKARVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGALMKLFTDTLT 347
                                 ||  ...|.||      ::|.|...|..||:....:...:..|.
Yeast   290 ---------------------FE--MSSKKGR------LLPNIICYFKAVFISQLFLAFVSSFLN 325

  Fly   348 FAQPQVLSLIISFVEAQDAEPEWKGI-LYAVLLFVLAAAQTFILGQYFHRMFIVG----LRIRTA 407
            |....::..|:|:|....:: .|..: ||...:.|.....|...||   .:|: |    :::||.
Yeast   326 FVPSLLMPRILSYVNDPKSK-SWNLVSLYVSSMLVSKIIATTCRGQ---GLFL-GEKGTMQLRTV 385

  Fly   408 LINAIYRKALR---ISNST----KKESTVGE--------------------IVNLMAVDAQRFME 445
            ||:.||.|.||   :.:||    |..||..|                    :.|:|::||.:..|
Yeast   386 LISNIYSKTLRRTILKDSTTSLQKNASTSFEENPDSSEAEPRKKSSRKDNSVNNVMSIDAFKVSE 450

  Fly   446 LTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDER 510
            ......:...|......||..|:..||.|..||...::.:||:|...|:....||..|:...|:|
Yeast   451 AMNTFYLACEAVFMTVTALMILYSLLGWSAFAGTFALLAMIPLNFWCATFYGNYQADQLILTDKR 515

  Fly   511 VKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFA 575
            ...::|.|:.|:|:||.|||..|.::::::||.||..|:..|.:......:|...|.|||.:||:
Yeast   516 TSGISEALNSIRVIKLLAWENLFYQKIINVRDGEIRLLKKKATIFFLNHLIWFFGPTLVSAITFS 580

  Fly   576 TYVLTSEANQ-LSVEKVLVSIALFDLMKLPLTILPMLSVDIAETQVSVNRINKFLNSEELDPNSV 639
            .::  ...|| |:......:::||.:::.|:..:......:.::.:|:.||..:||..|.....:
Yeast   581 VFI--KFQNQTLTPTIAFTALSLFAILRTPMDQIASTVSLLIQSFISLERIQDYLNESETRKYEI 643

  Fly   640 LHDSSKPHPMSIENGEFSWGDEIT---LRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKL 701
            |..|:.  ....|:....|....|   |:||:|:.|..||.|::|..||||||::...|||:..|
Yeast   644 LEQSNT--KFGFEDASMEWEAAETSFKLKNISIDFKLNSLNAIIGPTGSGKSSLLLGLLGELNLL 706

  Fly   702 AGVVNT----------VGK------LAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALR 750
            :|.:..          :||      :||..|..|:.:.|::||::||:.:::::::.|:.:|.|.
Yeast   707 SGKIYVPTVESRDDLEIGKDGMTNSMAYCSQTPWLISGTIKDNVVFGEIFNKQKFDDVMKSCCLD 771

  Fly   751 ADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVI- 814
            .||..::||..|::|:.|.:|||||:|||:||||:||.:...:|||.|||||.....:|:||.:
Yeast   772 KDIKAMTAGIRTDVGDGGFSLSGGQQQRIALARAIYSSSRYLILDDCLSAVDPETALYIYEECLC 836

  Fly   815 GPKGILARKSRVLVTHGVTFL-PQVDSIYVIKMGEISESGTFDQLVKNKGAFADFIIQHLQEGNE 878
            ||  ::..::.::.:|.::.: .:.|.:.::..||:...|....|:|:.    :|:
Yeast   837 GP--MMKGRTCIITSHNISLVTKRADWLVILDRGEVKSQGKPSDLIKSN----EFL--------- 886

  Fly   879 EEEELNQIKRQISSTADVPELLGTVEKAIKLARTESLSDSISVTSADSLMGGGGSLRRRTKRQD- 942
             .|.:|...:            .|....|.|.|        |.||            ::||..|
Yeast   887 -RESINNDSK------------NTTHNQIDLKR--------STTS------------KKTKNGDP 918

  Fly   943 ----SHDSVASAASLKKKQEVEGKLIETEKSQTGGVEFAVYK---HYIKSVG-IFLSVATLVLNF 999
                |.|.|.:        |||.  .|..|.: |.|:|:.||   .|...:| :|:..::.:|
Yeast   919 EGGNSQDEVCA--------EVEN--FEETKME-GSVKFSAYKWLADYFGGLGVVFVFTSSSIL-- 970

  Fly  1000 VFQAFQIGSNLWLTQWANDQNVANDT--------GLRDMY-LGVYGAFGFGQGVLAYFAVVIVYL 1055
             .....:....||..|.:..:..:.:        |..::| |..|...|.....|....|.|..:
Yeast   971 -IHGITLSQGFWLRYWLDTGSSGSKSTWLYRIVEGHSNIYFLLTYIIIGLVSSFLTSGKVWIAII 1034

  Fly  1056 GGFQAAKTIHNELLAVIIRGSVCRFFDITPIGRLLNSFSGDMDVVDEELPATMDSFMTFIFMVLA 1120
            .|....|.|..:||:.|:...: ||.::||.||::|.||.|||::|::|....:.....:.:.|.
Yeast  1035 SGTNVTKKIFAKLLSSILYAKL-RFHNVTPTGRIMNRFSKDMDIIDQQLIPNFEGLSYSVVVCLW 1098

  Fly  1121 TIVVISLSTPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAY 1185
            .|::|...||.||...:|:..|||.....|:..||:|.|:::::.|||:..|:|.:.|.:||||.
Yeast  1099 IILLIGYVTPQFLLFAIPLCALYYTVCTLYLRASRELKRIDNINISPIHQLFAEAIKGVTTIRAL 1163

  Fly  1186 NVGDRFIEESDAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAVL 1237
            ....|||.:|...:|::....:...:|..|:..|::::|.|::..:|:..::
Yeast  1164 ADERRFITQSLVAIDRSNAPFFYLNMATEWITYRVDIIGTLVLFSSSVMIIM 1215

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	333/1352 (25%)
NFT1	NP_013029.3	MRP_assoc_pro	252..>1218	CDD:188098	287/1075 (27%)