DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MRP and ABCC11

DIOPT Version :9

Sequence 1:	NP_723772.2	Gene:	MRP / 34686	FlyBaseID:	FBgn0032456	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	NP_001357425.1	Gene:	ABCC11 / 85320	HGNCID:	14639	Length:	1384	Species:	Homo sapiens

Alignment Length:	1408	Identity:	455/1408 - (32%)
Similarity:	716/1408 - (50%)	Gaps:	205/1408 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 SASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHHWNQNVRKNYKNKARV- 291
            :|...|.:|..|...:.::..|:.|:|..:..|...|:..:.:......|.:.|.:....||.|
Human    88 NAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEEVSRRGIEKASVL 152

  Fly   292 EPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQVLSL 356
            ....:|....:.|:    ...|....:||::.||.              :....|.:::.|:.::
Human   153 LVMLRFQRTRLIFD----ALLGICFCIASVLGPIL--------------IIPKILEYSEEQLGNV 199

  Fly   357 IISFVEAQDAEPEWKGILYAVLLF----VLAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKAL 417
            :           ...|:.:|:.|.    .|:.:.::|:.|.      ..:|.|.|:.:..:.|.:
Human   200 V-----------HGVGLCFALFLSECVKSLSFSSSWIINQR------TAIRFRAAVSSFAFEKLI 247

  Fly   418 RISNSTKKESTVGEIVNLMAVDAQRFMELTTY--LNMIWSAPLQI-GLALYFLWQQLGPSVLAGL 479
            :..:..  ..|.||.::....|.....|...|  |.:|..|.|.| .::.||:   :|.:....:
Human   248 QFKSVI--HITSGEAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFI---IGYTAFIAI 307

  Fly   480 AVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKE 544
            ...:::.|:...:.......|....:..|:|:::.:|||:.||::|:|.||..|.|.:.|:|.||
Human   308 LCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKE 372

  Fly   545 IATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVL--TSEANQLSVEKVLVSIALFDLMKLPLTI 607
            ...|.....:.:    |.|...|::..|..|.:||  ||...:|:.......:|..:|::|.:..
Human   373 RKLLEKCGLVQS----LTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSMLASLNLLRLSVFF 433

  Fly   608 LPMLSVDIAETQVSVNRINK-FLNSEELDPNSVLHDSSKPHPMSIENGEFSW------------- 658
            :|:....:..::.:|.|..| ||....:.....|.|.||  .:..|....||
Human   434 VPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSK--ALVFEEATLSWQQTCPGIVNGALE 496

  Fly   659 -----------------------GDEI--TLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEM 698
                                   |:.:  .|..||:.|.||.::.:.|..||||||::.|.|.||
Human   497 LERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEM 561

  Fly   699 EKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTE 763
            ..|.|.|...|.||||||||||.:..:|:|||.|..||:.||.:|:..|:|..|:::|..||:||
Human   562 HLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTE 626

  Fly   764 IGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLV 828
            |||:|:|||||||||||||||||||..:|||||||||||||||||||||.|  |..|..|:.|||
Human   627 IGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECI--KKTLRGKTVVLV 689

  Fly   829 THGVTFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKRQISST 893
            ||.:.:|.....|.:::.|:|.|:||..:|::.||.:|..|.:..:|...:         .:..|
Human   690 THQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSD---------MLQDT 745

  Fly   894 ADVPELLGTVEKAIKLARTESLSDSISVTSADSLMGGGGSLRRRTKRQDSHDSVASAASLKKKQE 958
            |.:.|            :.:..|.:::.:..:||.|..|::
Human   746 AKIAE------------KPKVESQALATSLEESLNGNAGNV------------------------ 774

  Fly   959 VEGKLIETEKSQTGGVEFAVYKHYIKSVG-------IFLSVATLVLNFVFQAFQIGSNLWLTQW- 1015
            .|.:|.:.|:.:.|.:.:.||.|||::.|       ||..|..:|...:|      |..||:.|
Human   775 PEHQLTQEEEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIF------SFWWLSYWL 833

  Fly  1016 ----------------ANDQNVANDTGLRDMYLGVYGAFGFGQGVLAYFAVVIVYLGGF-----Q 1059
                            |:..|:|::..| ..|..|||.     ..|....|.:...|.|     :
Human   834 EQGSGTNSSRESNGTMADLGNIADNPQL-SFYQLVYGL-----NALLLICVGVCSSGIFTKVTRK 892

  Fly  1060 AAKTIHNELLAVIIRGSVC--RFFDITPIGRLLNSFSGDMDVVDEELPATMDSFMTFIFMVLATI 1122
            |:..:||:|...:.|   |  .|||..|||||||.|:||::.:|:.||...:.|:....||:|.:
Human   893 ASTALHNKLFNKVFR---CPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVL 954

  Fly  1123 VVISLSTPIFL---AVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRA 1184
            :::|:.:|..|   |:|:.|.|:||...:..:...:   |||:.||||::||...::.|.|:|..
Human   955 LIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFK---RLENYSRSPLFSHILNSLQGLSSIHV 1016

  Fly  1185 YNVGDRFIEE----SDAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAVLGGQTNP-G 1244
            |...:.||.:    :||:  .|.:..:.|  :.||:|:|||::.||:.|..:||...|..:.| .
Human  1017 YGKTEDFISQFKRLTDAQ--NNYLLLFLS--STRWMALRLEIMTNLVTLAVALFVAFGISSTPYS 1077

  Fly  1245 LVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGE-TKQEAPWELEQDKNKPKNWPQEG 1308
            ...::|:..||:..:.....|:..:.|....:||||.:|.: ...|||..:| ..:.|:.|||.|
Human  1078 FKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHME-GTSCPQGWPQHG 1141

  Fly  1309 RVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGV 1373
            .:.||::.::||:....||.|::..|:|.|.||||||||:|||||.:||||::|...|||.||||
Human  1142 EIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGV 1206

  Fly  1374 DIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNH 1438
            ||.|:||..|||:|::|||||||.||::|.|||||:..||.:||.|||.:.|...:......|:.
Human  1207 DICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKAISKFPKKLHT 1271

  Fly  1439 EIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAH 1503
            ::.|.|.|.|||:|||:|:|||:||.:|::::|||||::|:|||.|||:|||..|:.||||.|||
Human  1272 DVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAH 1336

  Fly  1504 RLNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAFYSMAKDA 1546
            |:.|:|:.|.::|:..|:::||..|..|...|.|.|.::...|
Human  1337 RVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALMATA 1379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	455/1408 (32%)
		ABC_membrane	338..601	CDD:279056	57/271 (21%)
		ABCC_MRP_domain1	649..848	CDD:213217	108/236 (46%)
		ABC_membrane	988..1260	CDD:279056	91/303 (30%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	116/219 (53%)
ABCC11	NP_001357425.1	PLN03130	85..1373	CDD:215595	453/1400 (32%)
ABCC11	NP_001357425.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	504..523		1/18 (6%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151558
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0000087
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.650