Protein Alignment MRP and YOR1

DIOPT Version :10

• Sequence 1: NP_723772.2
• Gene: MRP / 34686
• FlyBaseID: FBgn0032456
• Length: 1549
• Species: Drosophila melanogaster
• Sequence 2: NP_011797.3
• Gene: YOR1 / 853198
• SGDID: S000003513
• Length: 1477
• Species: Saccharomyces cerevisiae
• Alignment Length: 1444
• Identity: 432/1444 - (29%)
• Similarity: 709/1444 - (49%)
• Gaps: 202/1444 - (13%)

  Fly   225 PELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAH---HWNQNVRKNYK 286
            |....:.:|.:.:.|...:...||:..::..||:.:.|:.|...:...|..   ::.:..||.|:
Yeast   109 PLFHTNIISNMFFWWVLPILRVGYKRTIQPNDLFKMDPRMSIETLYDDFEKNMIYYFEKTRKKYR 173

  Fly   287 NKARVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGALMKLFTDTLTFAQP 351
            .:   .|:|   ......||....|:       :::..:..:|...:....:..:..:..:...|
Yeast   174 KR---HPEA---TEEEVMENAKLPKH-------TVLRALLFTFKKQYFMSIVFAILANCTSGFNP 225

  Fly   352 QVLSLIISFVEAQDAEPEW---KGILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAIY 413
            .:...:|.|||.:......   |||.||:...::..........:||...:.|::.::.|..|..
Yeast   226 MITKRLIEFVEEKAIFHSMHVNKGIGYAIGACLMMFVNGLTFNHFFHTSQLTGVQAKSILTKAAM 290

  Fly   414 RKALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAG 478
            :|....||..:.....|::.:.:..|..|.....::...:...|..:.:.:..|...|||..|.|
Yeast   291 KKMFNASNYARHCFPNGKVTSFVTTDLARIEFALSFQPFLAGFPAILAICIVLLIVNLGPIALVG 355

  Fly   479 LAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDK 543
            :.:......::......|..::|....:.|.||.:|.|||:.||::|.|.||.::||.:.|||.|
Yeast   356 IGIFFGGFFISLFAFKLILGFRIAANIFTDARVTMMREVLNNIKMIKYYTWEDAYEKNIQDIRTK 420

  Fly   544 EIATLRSTAYLNAGTSFLWSCA---PFLVSLVTF-ATYVLTSEANQLSVEKVLVSIALFDLMKLP 604
            ||:.:|.   :....:||.:.|   |.:.||||| |.|.:.....|..  .:..|::||.::.|.
Yeast   421 EISKVRK---MQLSRNFLIAMAMSLPSIASLVTFLAMYKVNKGGRQPG--NIFASLSLFQVLSLQ 480

  Fly   605 LTILPMLSVDIAETQVSVNRINKFLNSEELDPNSVLHDSSKPHP-------MSIENGEFSWGD-- 660
            :..||:......:..:.:.|:...|.:.|.|||.::  ..||.|       :.:.:..|.|.|
Yeast   481 MFFLPIAIGTGIDMIIGLGRLQSLLEAPEDDPNQMI--EMKPSPGFDPKLALKMTHCSFEWEDYE 543

  Fly   661 -----------------------------------------------------EIT----LRNIN 668
                                                                 |.|    .:::|
Yeast   544 LNDAIEEAKGEAKDEGKKNKKKRKDTWGKPSASTNKAKRLDNMLKDRDGPEDLEKTSFRGFKDLN 608

  Fly   669 IEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVVNTVGKL---AYVPQQAWIQNATVRDNIL 730
            .::|||..:.:.|.:|:||||::.|..|.|.|..|.|...|.|   .|    .|||||:|||||:
Yeast   609 FDIKKGEFIMITGPIGTGKSSLLNAMAGSMRKTDGKVEVNGDLLMCGY----PWIQNASVRDNII 669

  Fly   731 FGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLD 795
            ||..:::::|::|:..|:|:||:|||.|||:|||||:||.||||||.||:|||:||...|:||.|
Yeast   670 FGSPFNKEKYDEVVRVCSLKADLDILPAGDMTEIGERGITLSGGQKARINLARSVYKKKDIYLFD 734

  Fly   796 DPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQL-V 859
            |.|||||:.|||||.:|.:  .|:||.|:|:|.||.::.:.:...:.|:......:.||.|:| .
Yeast   735 DVLSAVDSRVGKHIMDECL--TGMLANKTRILATHQLSLIERASRVIVLGTDGQVDIGTVDELKA 797

  Fly   860 KNKGA--FADFIIQHLQEGNEEEE-----ELNQIKRQISSTADVPELLGTVEKAIKLARTESLSD 917
            :|:..  ...|..|:.::.:||:|     ||.|:|.:    ::|.||....:||.::::|.:...
Yeast   798 RNQTLINLLQFSSQNSEKEDEEQEAVVAGELGQLKYE----SEVKELTELKKKATEMSQTANSGK 858

  Fly   918 SISVTSADSLMGGGGSLRRRTKRQDSHDSVASAASLKKKQEVEGKLIETEKSQTGGVEFAVYKHY 982
            .::                     |.|.|                  ..|:.....:...:|:.|
Yeast   859 IVA---------------------DGHTS------------------SKEERAVNSISLKIYREY 884

  Fly   983 IK-SVGI--FLSV---ATLVLNFVFQAFQIGSNLWLTQWANDQNVANDTGLRDMYLGVYGAFGFG 1041
            || :||.  |:::   |.||:...|  ..:.|::||:.|..::......   ..|:|:|..|.|.
Yeast   885 IKAAVGKWGFIALPLYAILVVGTTF--CSLFSSVWLSYWTENKFKNRPP---SFYMGLYSFFVFA 944

  Fly  1042 QGVLAYFAVVIVYLGGFQAAKTIHNELLAVIIRGSVCRFFDITPIGRLLNSFSGDMDVVDEELPA 1106
            ..:.......|:...|..|:|.::...:..|:. :...:.|.||:||:||.|:.|.|.:|.||..
Yeast   945 AFIFMNGQFTILCAMGIMASKWLNLRAVKRILH-TPMSYIDTTPLGRILNRFTKDTDSLDNELTE 1008

  Fly  1107 TM----DSFMTFIFMVLATIVVI---SLSTPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVS 1164
            ::    ..|...:.:.:..||.:   :::.|..|.:.|.||       ..|.::.|::.|||:|.
Yeast  1009 SLRLMTSQFANIVGVCVMCIVYLPWFAIAIPFLLVIFVLIA-------DHYQSSGREIKRLEAVQ 1066

  Fly  1165 RSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIIL 1229
            ||.:|::.:|.:.|..||:||...:||:.:||..::|.....|..|:..||:.|.|:||.....|
Yeast  1067 RSFVYNNLNEVLGGMDTIKAYRSQERFLAKSDFLINKMNEAGYLVVVLQRWVGIFLDMVAIAFAL 1131

  Fly  1230 FASLFAVLGG-QTNPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYG-ETKQEAPW 1292
            ..:|..|... ..:...||:.::|.||:...||.::|..:..|.::.|.||:..|. |...||.:
Yeast  1132 IITLLCVTRAFPISAASVGVLLTYVLQLPGLLNTILRAMTQTENDMNSAERLVTYATELPLEASY 1196

  Fly  1293 ELEQDKNKPKNWPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLAL 1357
            . :.:...|::||..|.:.|:|....||.||.:||:.::.||:.|||:||.||||||||::..||
Yeast  1197 R-KPEMTPPESWPSMGEIIFENVDFAYRPGLPIVLKNLNLNIKSGEKIGICGRTGAGKSTIMSAL 1260

  Fly  1358 FRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKAL-- 1420
            :|:.|...|:|.||.|||:.:||..||.:|.|||||||||.|::|.|||||..:||||:|.||
Yeast  1261 YRLNELTAGKILIDNVDISQLGLFDLRRKLAIIPQDPVLFRGTIRKNLDPFNERTDDELWDALVR 1325

  Fly  1421 -------ELSHLK--------SFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVL 1470
                   :|..:|        :..|.....|:..:.|.|.|.|:|:|||:.|.|||:|::|:|:|
Yeast  1326 GGAIAKDDLPEVKLQKPDENGTHGKMHKFHLDQAVEEEGSNFSLGERQLLALTRALVRQSKILIL 1390

  Fly  1471 DEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNP 1535
            ||||::||.|||..||..|..||.:||:|.|||||.||::.|:::||:||::.||.:|..|....
Yeast  1391 DEATSSVDYETDGKIQTRIVEEFGDCTILCIAHRLKTIVNYDRILVLEKGEVAEFDTPWTLFSQE 1455

  Fly  1536 KSAFYSMAKDANLV 1549
            .|.|.||...:.:|
Yeast  1456 DSIFRSMCSRSGIV 1469

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	431/1441 (30%)
YOR1	NP_011797.3	MRP_assoc_pro	92..1468	CDD:188098	431/1441 (30%)