DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MRP and YCF1

DIOPT Version :9

Sequence 1:	NP_723772.2	Gene:	MRP / 34686	FlyBaseID:	FBgn0032456	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	NP_010419.3	Gene:	YCF1 / 851713	SGDID:	S000002542	Length:	1515	Species:	Saccharomyces cerevisiae

Alignment Length:	1590	Identity:	614/1590 - (38%)
Similarity:	893/1590 - (56%)	Gaps:	174/1590 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 DFTPCFEQTALVWTPCAFYWAFVIFDFYYLKASLDRNIPWNKLNVSKALVNLGLLVITALDLIMA 94
            |||.||....::.....|...|.|.|...|.......|.:.:..:..:.:.|.||.|..:.|...
Yeast    27 DFTQCFIDGVILNLSAIFMITFGIRDLVNLCKKKHSGIKYRRNWIIVSRMALVLLEIAFVSLASL 91

  Fly    95 LVKKGGDSELPLYDLDVWGPIIKFA-TFLLLFI-----FIPLNRKYGVQTTGCQFIFWFLLTVLS 153
            .:.|.......:        :.::| |.|.||:     :|..:|.....|.   .:|::|....
Yeast    92 NISKEEAENFTI--------VSQYASTMLSLFVALALHWIEYDRSVVANTV---LLFYWLFETF- 144

  Fly   154 IPRCRTEVRLDAERQKILNSQQPSEQDFSWEEYQ---FVSFFIFFTFTSIMLILNCFADGMPR-- 213
                       ....|::|.......:..|...|   .::.|...|..||:|:     :.:|:
Yeast   145 -----------GNFAKLINILIRHTYEGIWYSGQTGFILTLFQVITCASILLL-----EALPKKP 193

  Fly   214 --------QTKYQRGENEIPELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVM 270
                    ||..:|..|  |..||:..||||:.|...:...||...|.|.||:.| |::..||.:
Yeast   194 LMPHQHIHQTLTRRKPN--PYDSANIFSRITFSWMSGLMKTGYEKYLVEADLYKL-PRNFSSEEL 255

  Fly   271 PIFAHHWNQNVRKNYKNKARVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFGGVFLF 335
                   :|.:.||::|:.:     |.||.::::                   .|.::||...|.
Yeast   256 -------SQKLEKNWENELK-----QKSNPSLSW-------------------AICRTFGSKMLL 289

  Fly   336 GALMKLFTDTLTFAQPQVLSLIISFV-----EAQDAE--------------PEWKGILYAVLLFV 381
            .|..|...|.|.|.|||:|.::|.||     |.||..              |..:|.|.|..:|:
Yeast   290 AAFFKAIHDVLAFTQPQLLRILIKFVTDYNSERQDDHSSLQGFENNHPQKLPIVRGFLIAFAMFL 354

  Fly   382 LAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKALRISNSTKKESTVGEIVNLMAVDAQRFMEL 446
            :...||.:|.|||..:|..|:.|::||...||:|:|.:||.....|:.|:|||||:||.|:..:|
Yeast   355 VGFTQTSVLHQYFLNVFNTGMYIKSALTALIYQKSLVLSNEASGLSSTGDIVNLMSVDVQKLQDL 419

  Fly   447 TTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERV 511
            |.:||:|||.|.||.:.||.|::.||.|:..|:.:::|::|:|..:....|..|..||||||||.
Yeast   420 TQWLNLIWSGPFQIIICLYSLYKLLGNSMWVGVIILVIMMPLNSFLMRIQKKLQKSQMKYKDERT 484

  Fly   512 KLMNEVLSGIKVLKLYAWEPSFEKQVLDIR-DKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFA 575
            ::::|:|:.||.|||||||..:.:::.::| :||:..|.......|.|||.::..|||||..|||
Yeast   485 RVISEILNNIKSLKLYAWEKPYREKLEEVRNNKELKNLTKLGCYMAVTSFQFNIVPFLVSCCTFA 549

  Fly   576 TYVLTSEANQLSVEKVLVSIALFDLMKLPLTILPMLSVDIAETQVSVNRINKFLNSEELDPNSVL 640
            .:|.| |...|:.:.|..::.||:|:..||.|:||:.....|..||:.|:..|..:|||.|:||
Yeast   550 VFVYT-EDRALTTDLVFPALTLFNLLSFPLMIIPMVLNSFIEASVSIGRLFTFFTNEELQPDSV- 612

  Fly   641 HDSSKPHPMSIENGEFSWGDEIT------------LRNINIEVKKGSLVALVGTVGSGKSSVVQA 693
              ...|...:|.:...:.||:.|            |:|||.:.|||:|..:||.|||||::::..
Yeast   613 --QRLPKVKNIGDVAINIGDDATFLWQRKPEYKVALKNINFQAKKGNLTCIVGKVGSGKTALLSC 675

  Fly   694 FLGEMEKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSA 758
            .||::.::.|.....|.:|||.|..||.|.||::|||||..||.:.|.|.|.||||..|:.||..
Yeast   676 MLGDLFRVKGFATVHGSVAYVSQVPWIMNGTVKENILFGHRYDAEFYEKTIKACALTIDLAILMD 740

  Fly   759 GDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARK 823
            ||.|.:|||||:||||||.|:|||||||:.||.|||||||:|||.||.:|:.|.|:||.|:|..|
Yeast   741 GDKTLVGEKGISLSGGQKARLSLARAVYARADTYLLDDPLAAVDEHVARHLIEHVLGPNGLLHTK 805

  Fly   824 SRVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKR 888
            ::||.|:.|:.|...|||.::..|||::.||:|::.|:
Yeast   806 TKVLATNKVSALSIADSIALLDNGEITQQGTYDEITKD--------------------------- 843

  Fly   889 QISSTADVP--ELLGTVEKAIKLARTESLSDSISVTSADSLMGGGGSLRRRTKRQDSHDSVASAA 951
                 ||.|  :||....|. ...::....||...:..:|.:...|.|.:..|..|.....:.|.
Yeast   844 -----ADSPLWKLLNNYGKK-NNGKSNEFGDSSESSVRESSIPVEGELEQLQKLNDLDFGNSDAI 902

  Fly   952 SLKKKQEV---------EGKLIETEKSQTGGVEFAVYKHYIKSVGIFLSVATLVLNFVFQAF-QI 1006
            ||::..:.         :..:.:.|..:.|.|::.:|..|.|:... .||...:|..|...| .:
Yeast   903 SLRRASDATLGSIDFGDDENIAKREHREQGKVKWNIYLEYAKACNP-KSVCVFILFIVISMFLSV 966

  Fly  1007 GSNLWLTQWA--NDQNVANDTGLRDMYLGVYGAFGFGQGVLAYFAVVIVYL-GGFQAAKTIHNEL 1068
            ..|:||..|:  |.:..:|....|  ||.:|.|.|.|..:......::::: ....|:|.:||.:
Yeast   967 MGNVWLKHWSEVNSRYGSNPNAAR--YLAIYFALGIGSALATLIQTIVLWVFCTIHASKYLHNLM 1029

  Fly  1069 LAVIIRGSVCRFFDITPIGRLLNSFSGDMDVVDEELPATMDSFMTFIFMVLATIVVISLSTPIFL 1133
            ...::|..: .||:.|||||:||.||.|:..||..|..|...|......|..||.||..:|..|:
Yeast  1030 TNSVLRAPM-TFFETTPIGRILNRFSNDIYKVDALLGRTFSQFFVNAVKVTFTITVICATTWQFI 1093

  Fly  1134 AVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAK 1198
            .:|:|::..|.:.|::|:.|||:|.||:|::||||||||.||:.|.:|:|.|:...||...:..:
Yeast  1094 FIIIPLSVFYIYYQQYYLRTSRELRRLDSITRSPIYSHFQETLGGLATVRGYSQQKRFSHINQCR 1158

  Fly  1199 VDKNQVCKYPSVIANRWLAIRLEMVGNLIILFA---SLFAVLGGQTNPGLVGLSVSYALQVTQTL 1260
            :|.|....|||:.||||||.|||::|::|||.|   |:|.:..|....|:||||:|||||:||||
Yeast  1159 IDNNMSAFYPSINANRWLAYRLELIGSIIILGAATLSVFRLKQGTLTAGMVGLSLSYALQITQTL 1223

  Fly  1261 NWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYREGLDL 1325
            ||:|||:.::|||||||||||||.:.|.|||..:|..: .||.||.:|.::|.|:..|||..|||
Yeast  1224 NWIVRMTVEVETNIVSVERIKEYADLKSEAPLIVEGHR-PPKEWPSQGDIKFNNYSTRYRPELDL 1287

  Fly  1326 VLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTII 1390
            ||:.::.:|:..||||||||||||||||||||||:|||:.|.|.||.:.|..:||:.||.:|:||
Yeast  1288 VLKHINIHIKPNEKVGIVGRTGAGKSSLTLALFRMIEASEGNIVIDNIAINEIGLYDLRHKLSII 1352

  Fly  1391 PQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLA-AGLNHEIAEGGENLSVGQRQL 1454
            |||..:|.|::|.|:||....||:.||:||||||||..|.|:: .||:.::.|||.|||||||||
Yeast  1353 PQDSQVFEGTVRENIDPINQYTDEAIWRALELSHLKEHVLSMSNDGLDAQLTEGGGNLSVGQRQL 1417

  Fly  1455 VCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDK 1519
            :|||||:|..:|:|||||||||||:|||.::|:||||.||:.|:||||||||||:|||::||||.
Yeast  1418 LCLARAMLVPSKILVLDEATAAVDVETDKVVQETIRTAFKDRTILTIAHRLNTIMDSDRIIVLDN 1482

  Fly  1520 GQIIEFASPTELLDNPKSAFYSMAKDANLV 1549
            |::.||.||.:||.:.||.|||:..:|.||
Yeast  1483 GKVAEFDSPGQLLSDNKSLFYSLCMEAGLV 1512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	612/1587 (39%)
		ABC_membrane	338..601	CDD:279056	110/282 (39%)
		ABCC_MRP_domain1	649..848	CDD:213217	101/210 (48%)
		ABC_membrane	988..1260	CDD:279056	109/278 (39%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	135/220 (61%)
YCF1	NP_010419.3	MRP_assoc_pro	27..1511	CDD:188098	612/1587 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	205	1.000	Domainoid score	I533
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68364
Inparanoid	1	1.050	982	1.000	Inparanoid score	I30
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoFinder	1	1.000	-	-		FOG0000087
OrthoInspector	1	1.000	-	-		otm46855
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	LDO	PTHR24223
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8
SonicParanoid	1	1.000	-	-		X177
TreeFam	1	0.960	-	-
	14	13.860