DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MRP and ABCC11

DIOPT Version :9

Sequence 1:	NP_723772.2	Gene:	MRP / 34686	FlyBaseID:	FBgn0032456	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	NP_001319112.1	Gene:	ABCC11 / 839922	AraportID:	AT1G30420	Length:	1495	Species:	Arabidopsis thaliana

Alignment Length:	1604	Identity:	543/1604 - (33%)
Similarity:	832/1604 - (51%)	Gaps:	231/1604 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 FWNATETWYTNDPD-----FTPCFEQTAL------VWTPCAFYWAFVIF-----DFYYLKASLDR 65
            ||..|       ||     :|||...:.:      |.....||..::..     ..|.|:.....
plant    17 FWEKT-------PDGAFGAYTPCAIDSLVMIVSNSVLLGLCFYRIWITLYNAKAQIYVLRKMYYH 74

  Fly    66 NIPWNKLNVSKALVNLGLLVITALDLIM--ALVKKGGDSELPLYDLD-------VWGPI------ 115
            .:.|        ::....:|...|.|:|  :|...|.:::||.:::.       .|..:
plant    75 CVLW--------ILACCCVVEPVLRLVMGISLFDMGDETDLPPFEVASLMVEAFAWFAMLVLIGL 131

  Fly   116 ------------IKF-------ATFLLLFIFIPLNRKYG-------VQTTGCQFIFWFLLTVLSI 154
                        ::|       |..:||.:.:||.....       :.:..||.:|..||.|. |
plant   132 ETKQYVKEFRWYVRFGVVYVLVADAVLLDLVLPLKNSINRTALYLCISSRCCQALFGILLLVY-I 195

  Fly   155 PRCRTEVRLDAERQKILNSQQPSEQDFSWEEYQFVSFFIFFTFTSIMLILNCFADGMPRQTKYQR 219
            |    |:.|..: ..|||::.....::                           |.:|      .
plant   196 P----ELDLYPD-YHILNNESLDNVEY---------------------------DALP------G 222

  Fly   220 GENEIPELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHHWNQNVRKN 284
            |.|..||..||..|.|.:.|...:...|||.|:.|:|:|.|...|....::..|...|.:..|:
plant   223 GVNICPERYASIFSGIYFSWMTPLMQLGYRKPITERDVWQLDQWDQTETLIKRFQRCWTEESRR- 286

  Fly   285 YKNKARVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGALMKLFTDTLTFA 349
                    ||..                        ::..:..|.|..|..|.:.|:..|...|.
plant   287 --------PKPW------------------------LLRALNNSLGRRFWLGGIFKVGHDLSQFV 319

  Fly   350 QPQVLSLII-SFVEAQDAEPEWKGILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAIY 413
            .|.:||.|: |.:|   .:|.|.|.:||.|:|...........|||..:..||.|:|:.|:.||:
plant   320 GPVILSHILQSMIE---GDPAWVGYVYAFLIFFGVTFGVLCQSQYFQHVGRVGFRLRSTLVAAIF 381

  Fly   414 RKALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAG 478
            .|:||::|..:|....|::.|::..||.....:...|:.:||||.:|.:::..|:||||.:.:.|
plant   382 HKSLRLTNKARKNFASGKVTNMITTDANALQLIAEQLHGLWSAPFRIIVSMVLLYQQLGVASIFG 446

  Fly   479 LAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDK 543
            ..::.:|||...:|..:::......:::.|:||.::.|:|:.:.::|.||||.|||.::..||::
plant   447 SLILFLLIPFQTLIVRKMRKLTKEGLQWTDKRVGIIYEILASMDIVKCYAWEKSFESRIQGIRNE 511

  Fly   544 EIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVLTSEANQLSVEKVLVSIALFDLMKLPLTIL 608
            |::..|....|:|..||:.:..|.:|:||:|..|||.  ...|:..:...|::||.:::.||:.|
plant   512 ELSWFRKAQLLSAFNSFILNSTPVVVTLVSFGVYVLL--GGDLTPARAFTSLSLFAVLRSPLSTL 574

  Fly   609 PMLSVDIAETQVSVNRINKFLNSEE--LDPNSVLHDSSKPHPMSIENGEFSWGDEI---TLRNIN 668
            |.|........||:.||.:.|.|||  |..|..|...:.  .:||:||.|||..:.   ||.:||
plant   575 PNLISQAVNANVSLQRIEELLLSEERILAQNPPLQPGAP--AISIKNGYFSWDSKTSKPTLSDIN 637

  Fly   669 IEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKL-AGVVNTVGKLAYVPQQAWIQNATVRDNILFG 732
            :|:..|||||:||..|.||:|::.|.|||:... ...|:..|.:|||||.:||.|||:|:|||||
plant   638 LEIPVGSLVAIVGGTGEGKTSLISAMLGELSHAETSSVDIRGSVAYVPQVSWIFNATLRENILFG 702

  Fly   733 QTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDP 797
            ..::.:||.:.||..||:.|:|:....|.|||||:|:|:|||||||:|:||||||::|:|:.|||
plant   703 SDFESERYWRAIDVTALQHDLDLFPGRDRTEIGERGVNISGGQKQRVSMARAVYSNSDIYIFDDP 767

  Fly   798 LSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKNK 862
            .||:||||...:|:..:  |..|..|:|||||:.:.|||.:|.|.::..|.|.|.|.|.:|.|:.
plant   768 FSALDAHVAHQVFDSCV--KHELKGKTRVLVTNQLHFLPLMDRIILVSEGMIKEEGNFAELSKSG 830

  Fly   863 GAFADFI-----IQHLQEGNEEEEELNQIKRQISSTADVPE-LLGTVEKAIKLARTESLSDSISV 921
            ..|...:     :...||.|..:|.::::...:  |.||.| .||::::. |..|:
plant   831 TLFKKLMENAGKMDATQEVNTNDENISKLGPTV--TIDVSERSLGSIQQG-KWGRS--------- 883

  Fly   922 TSADSLMGGGGSLRRRTKRQDSHDSVASAASLKKKQEVEGKLIETEKSQTGGVEFAVYKHYIKSV 986
                                                    .|::.|:.:||.:.:.|...|.|:|
plant   884 ----------------------------------------MLVKQEERETGIISWDVVMRYNKAV 908

  Fly   987 -GIFLSVATLVLNFVFQAFQIGSNLWLTQWANDQNVANDTGLRDMYLGVYGAFGFGQGVLAYFAV 1050
             |:::.:..||.....:..::.|:.||:.| .||:...... ...|:.||...||||..:.:...
plant   909 GGLWVVMILLVCYLTTEVLRVLSSTWLSIW-TDQSTPKSYS-PGFYIVVYALLGFGQVAVTFTNS 971

  Fly  1051 VIVYLGGFQAAKTIHNELLAVIIRGSVCRFFDITPIGRLLNSFSGDMDVVDEELPATMDSFMTFI 1115
            ..:......|||.:|:.:|..|:|..:. ||:..|.||::|.||.|:..:|..:...|:.||..:
plant   972 FWLISSSLHAAKRLHDAMLNSILRAPML-FFETNPTGRVINRFSKDIGDIDRNVANLMNMFMNQL 1035

  Fly  1116 FMVLATIVVISLSTPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGAS 1180
            :.:|:|..:|.:.:.|.|..|:|:..|:|....:|.:|||::.||:||:|||||:.|.|.:.|.|
plant  1036 WQLLSTFALIGIVSTISLWAIMPLLILFYATYIYYQSTSREVRRLDSVTRSPIYALFGEALNGLS 1100

  Fly  1181 TIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAVL--GGQTNP 1243
            :||||...||..:.:...:|.|......|..:||||.||.|.:|.::|...:.||||  |...|.
plant  1101 SIRAYKAYDRMAKINGKSMDNNIRFTLASTSSNRWLTIRSESLGGVMIWLTATFAVLRYGNAENQ 1165

  Fly  1244 GL----VGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKNKP-KN 1303
            .:    :||.:||.|.:|..|:.::|.:|..|.::.||||:..|.:...||...:|  .|:| ..
plant  1166 AVFASTMGLLLSYTLNITTLLSGVLRQASKAENSLNSVERVGNYIDLPSEATAIIE--NNRPVSG 1228

  Fly  1304 WPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRI 1368
            ||..|.::|::..:|||.||..||.|:||.:...||||:||||||||||:..||:||:|...|||
plant  1229 WPSRGSIQFEDVHLRYRPGLPPVLHGLSFFVYPSEKVGVVGRTGAGKSSMLNALYRIVELEKGRI 1293

  Fly  1369 SIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLA 1433
            .||..|:|..||..||..|:||||.||||||::|.|:|||....|.::|:|||.:|:|..:....
plant  1294 LIDDYDVAKFGLTDLRRVLSIIPQSPVLFSGTVRFNIDPFSEHNDADLWEALERAHIKDVIDRNP 1358

  Fly  1434 AGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTV 1498
            .||:.|::|||||.|||||||:.|||||||::|:|.||||||:||:.||.|||:|||.|||.||:
plant  1359 FGLDAEVSEGGENFSVGQRQLLSLARALLRRSKILFLDEATASVDVRTDSLIQRTIREEFKSCTM 1423

  Fly  1499 LTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAFYSM 1542
            |.||||||||:|.||::||..||::|:.||.|||....|||:.|
plant  1424 LIIAHRLNTIIDCDKILVLSSGQVLEYDSPQELLSRDTSAFFKM 1467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	543/1604 (34%)
		ABC_membrane	338..601	CDD:279056	84/263 (32%)
		ABCC_MRP_domain1	649..848	CDD:213217	100/202 (50%)
		ABC_membrane	988..1260	CDD:279056	91/277 (33%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	127/219 (58%)
ABCC11	NP_001319112.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	183	1.000	Domainoid score	I1011
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	895	1.000	Inparanoid score	I55
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0000087
OrthoInspector	1	1.000	-	-		otm2810
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	O	PTHR24223
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X177
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.870