DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MRP and ABCC12

DIOPT Version :9

Sequence 1:	NP_723772.2	Gene:	MRP / 34686	FlyBaseID:	FBgn0032456	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	NP_001319111.1	Gene:	ABCC12 / 839921	AraportID:	AT1G30410	Length:	1498	Species:	Arabidopsis thaliana

Alignment Length:	1576	Identity:	552/1576 - (35%)
Similarity:	841/1576 - (53%)	Gaps:	209/1576 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 WTPCA-----------------FYWAFVIF-----DFYYLKASLDRNIPWNKLNVSKALVN--LG 82
            :||||                 ||..::||     ..|.|:               |...|  ||
plant    29 YTPCAIDSLVMLVSHFVLLGLCFYRIWIIFHNTKAQIYVLR---------------KKYYNCVLG 78

  Fly    83 LL-----VITALDLIMALVKKGGDSELPLYDLDVWGPIIK-FATFLLLFIFIPLNRKYGVQTTGC 141
            ||     |...|.|:|.:.....|.|......:|...::: ||.|.:| :.|.|..|..|:
plant    79 LLACYCVVEPVLRLVMGISLFDMDEETDFPPFEVASLMVEAFAWFSML-VLIGLETKQYVK---- 138

  Fly   142 QFIFWFLLTVLSIPRCRTEVRLDAERQKILNSQQPSEQDFSWEE-YQFVSFFIFFTFTSIMLILN 205
            :|.::....||.:      :..||   .:|:...|.:...:... |.|:|.........|:|::.
plant   139 EFRWYVRFGVLYV------LVADA---VLLDLVLPLKNSINRTALYLFISSRCSQALFGILLLIY 194

  Fly   206 CFADGMPRQTKY-------------------QRGENEIPELSASFLSRITYQWFDKMALKGYRNP 251
                 :|....|                   :.||:..||..||..|||.:.|...:...|||.|
plant   195 -----IPELDPYPGYHIVNNEPLDNVEYDALRGGEHICPERHASIFSRIYFGWITPLMQLGYRKP 254

  Fly   252 LEEKDLWDLRPQDSCSEVMPIFAHHWNQNVRKNYKNKARVEPKAQFSNGNVTFENPHGEKNGRKK 316
            :.|||:|.|...|....::..|...|.:..|:         ||..
plant   255 ITEKDVWQLDKWDQTETLIKRFQRCWTEESRR---------PKPW-------------------- 290

  Fly   317 GMASIMPPIYKSFGGVFLFGALMK---LFTDTLTFAQPQVLSLIISFVEAQDAEPEWKGILYAVL 378
                ::..:..|.||.|....:.|   :..|...|..|.:||.::.  ..|:.:|.|.|.:||.:
plant   291 ----LLRALNNSLGGRFWLAGIFKVTRIGNDLSQFVGPVILSHLLR--SMQEGDPAWVGYVYAFI 349

  Fly   379 LFVLAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKALRISNSTKKESTVGEIVNLMAVDAQRF 443
            :||..........|||..::.||.|:|:.|:.||:.|:||:::..:|....|::.|::..||...
plant   350 IFVGVTLGVLCEAQYFQNVWRVGFRLRSTLVAAIFHKSLRLTHEARKNFASGKVTNMITTDANAL 414

  Fly   444 MELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKD 508
            .:::..|:.:||||.:|.:::..|:||||.:.|.|..::.:|||:..:|.|:::......:::.|
plant   415 QQISQQLHGLWSAPFRIIVSMILLYQQLGVASLFGSLILFLLIPLQTLIISKMRKLTKEGLQWTD 479

  Fly   509 ERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVT 573
            :||.:.||:||.:..:|.||||.|||.::..||::|::..|....|:|..||:.:..|.:|::|:
plant   480 KRVGITNEILSSMDTVKCYAWEKSFESRIQGIRNEELSWFRKAQLLSAFNSFILNSIPVVVTVVS 544

  Fly   574 FATYVLTSEANQLSVEKVLVSIALFDLMKLPLTILPMLSVDIAETQVSVNRINKFLNSEE--LDP 636
            |..:||.  ...|:..:...|::||.:::.||.:||.|...:....||:.||.:.|.|||  |..
plant   545 FGVFVLL--GGDLTPARAFTSLSLFAVLRFPLNMLPNLLSQVVNANVSLQRIEELLLSEERILAQ 607

  Fly   637 NSVLHDSSKPHPMSIENGEFSWGDEI---TLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEM 698
            |..|...:.  .:||:||.|||..:.   ||.:||:|:..|:|||:||..|.||:|::.|.|||:
plant   608 NPPLQPGTP--AISIKNGYFSWDSKTTKPTLSDINLEIPVGTLVAIVGGTGEGKTSLISAMLGEL 670

  Fly   699 ---EKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGD 760
               |..:.|:.  |.:|||||.:||.|||||:|||||..::.:||.:.|||.||:.|:|:|...|
plant   671 SHAETTSVVIR--GSVAYVPQVSWIFNATVRENILFGSDFESERYWRAIDATALQHDLDLLPGRD 733

  Fly   761 LTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSR 825
            ||||||:|:|:|||||||:|:||||||::|:|:.||||||:||||...:|:..:  |..|..|:|
plant   734 LTEIGERGVNISGGQKQRVSMARAVYSNSDVYIFDDPLSALDAHVAHQVFDSCM--KDELRGKTR 796

  Fly   826 VLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFADFI-----IQHLQEGNEEEEELNQ 885
            ||||:.:.|||.:|.|.::..|.|.|.|||.:|.|:...|...:     :...||.|..:|  |.
plant   797 VLVTNQLHFLPLMDKIILVSEGMIKEEGTFVELSKSGILFKKLMENAGKMDATQEVNTNDE--NI 859

  Fly   886 IKRQISSTADVPEL-LGTVEKAIKLARTESLSDSISVTSADSLMGGGGSLRRRTKRQDSHDSVAS 949
            :|...:.|.||.|. ||:.::.
plant   860 LKLGPTVTVDVSERNLGSTKQG------------------------------------------- 881

  Fly   950 AASLKKKQEVEGKLIETEKSQTGGVEFAVYKHYIKSV-GIFLSVATLVLNFVFQAFQIGSNLWLT 1013
                |:::.|   ||:.|:.:||.:.:.|...|.::| |:::.:..|......:..::.|:.||:
plant   882 ----KRRRSV---LIKQEERETGIISWNVLMRYKEAVGGLWVVMILLACYLATEVLRVSSSTWLS 939

  Fly  1014 QWANDQNVANDTGLRDMYLGVYGAFGFGQGVLAYFAVVIVYLGGFQAAKTIHNELLAVIIRGSVC 1078
            .| .||:.:.:.. ...|:.||...||||..:.:.....:......||:.:|:.:|:.|:|..:.
plant   940 IW-TDQSTSKNYS-PGFYIVVYALLGFGQVAVTFTNSFWLITSSLHAARRLHDAMLSSILRAPML 1002

  Fly  1079 RFFDITPIGRLLNSFSGDMDVVDEELPATMDSFMTFIFMVLATIVVISLSTPIFLAVIVPIAFLY 1143
             ||...|.||::|.||.|:..:|..:...|:.||..::.:|:|..:|...:.|.|..|:|:..|:
plant  1003 -FFHTNPTGRVINRFSKDIGDIDRNVANLMNMFMNQLWQLLSTFALIGTVSTISLWAIMPLLILF 1066

  Fly  1144 YFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYP 1208
            |.|..:|.:|||::.||:||:|||||:.|.|.:.|.|:||||...||..:.:...:|.|......
plant  1067 YAAYLYYQSTSREVRRLDSVTRSPIYAQFGEALNGLSSIRAYKAYDRMAKINGKSMDNNIRFTLA 1131

  Fly  1209 SVIANRWLAIRLEMVGNLIILFASLFAVL-GGQTN-----PGLVGLSVSYALQVTQTLNWLVRMS 1267
            :..:||||.||||.:|.::|...:.|||| .|.||     ...:||.:||.|.:|..|:.::|.:
plant  1132 NTSSNRWLTIRLETLGGVMIWLTATFAVLQNGNTNNQAGFASTMGLLLSYTLNITSLLSGVLRQA 1196

  Fly  1268 SDIETNIVSVERIKEYGETKQEAPWELEQDKNKPK-NWPQEGRVEFQNFQVRYREGLDLVLRGVS 1331
            |..|.::.||||:..|.:...||...:|  .|:|. .||..|.::|::..:|||.||..||.|::
plant  1197 SRAENSLNSVERVGNYIDLPSEATDIIE--NNRPVCGWPSGGSIKFEDVHLRYRPGLPPVLHGLT 1259

  Fly  1332 FNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVL 1396
            |.:...||||:||||||||||:..|||||:|...|||.||..|:|..||..:|..|:||||.|||
plant  1260 FFVSPSEKVGVVGRTGAGKSSMLNALFRIVEVEKGRIMIDDCDVAKFGLTDVRRVLSIIPQSPVL 1324

  Fly  1397 FSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARAL 1461
            |||::|.|:|||....|..:|:||..:|:|..:.....||:.|:.|||||.|||||||:.|||||
plant  1325 FSGTVRFNIDPFSEHNDAGLWEALHRAHIKDVISRNPFGLDAEVCEGGENFSVGQRQLLSLARAL 1389

  Fly  1462 LRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFA 1526
            ||::|:||||||||:||:.||.|||:|||.|||.||:|.||||||||:|.||::||..||::|:.
plant  1390 LRRSKILVLDEATASVDVRTDSLIQRTIREEFKSCTMLVIAHRLNTIIDCDKILVLSSGQVLEYD 1454

  Fly  1527 SPTELLDNPKSAFYSM 1542
            ||.|||....|||:.|
plant  1455 SPQELLSRDTSAFFRM 1470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	552/1576 (35%)
		ABC_membrane	338..601	CDD:279056	83/265 (31%)
		ABCC_MRP_domain1	649..848	CDD:213217	105/204 (51%)
		ABC_membrane	988..1260	CDD:279056	91/277 (33%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	126/219 (58%)
ABCC12	NP_001319111.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	183	1.000	Domainoid score	I1011
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	895	1.000	Inparanoid score	I55
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0000087
OrthoInspector	1	1.000	-	-		otm2810
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	O	PTHR24223
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X177
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.870