DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MRP and ABCC15

DIOPT Version :9

Sequence 1:	NP_723772.2	Gene:	MRP / 34686	FlyBaseID:	FBgn0032456	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	NP_191656.2	Gene:	ABCC15 / 825269	AraportID:	AT3G60970	Length:	1053	Species:	Arabidopsis thaliana

Alignment Length:	1127	Identity:	435/1127 - (38%)
Similarity:	629/1127 - (55%)	Gaps:	101/1127 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   436 MAVDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQ 500
            |:||.||..:...|:|.||..|:||..|:|.|.:.||...||.|...::::..|..:....:.||
plant     1 MSVDVQRITDFIWYVNSIWMLPIQIFSAIYILQKHLGLGALAALVTTLMVMACNYPLTRLQRNYQ 65

  Fly   501 IRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSF-LWSC 564
            ...|..||:|:|..:|:|..:|:|||.||:..|..:|..:|.||...|..:..|...|:| ||.
plant    66 SDIMNAKDDRMKATSEILKNMKILKLQAWDNQFLNKVKTLRKKEYDCLWKSLRLQDFTTFILWG- 129

  Fly   565 APFLVSLVTFATYVLTSEANQLSVEKVLVSIALFDLMKLPLTILPMLSVDIAETQVSVNRINKFL 629
            ||.|:|:|||.|.:|...  :|:...||.::|.|.:::.|:..||.|...:.:::||.:||..:|
plant   130 APSLISVVTFVTCMLMGV--KLTAGAVLSALATFQMLQSPIFGLPDLLSALVQSKVSADRIASYL 192

  Fly   630 NSEELDPNSVLHDSSKPHPMS--IENGEFSWGDEI---TLRNINIEVKKGSLVALVGTVGSGKSS 689
            ...|...::|.:.|:.....|  ||||.|||..|.   ||.:|.::||.|..||:.|.|||||||
plant   193 QQSETQKDAVEYCSNDHTEFSVEIENGAFSWEPESSRPTLDDIELKVKSGMKVAICGAVGSGKSS 257

  Fly   690 VVQAFLGEMEKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADID 754
            :..:.|||::||.|.|...||.|||||..||.:.|:|||||||..|:.::|.:.:.||||..|.:
plant   258 LPSSILGEIQKLKGTVRVSGKQAYVPQSPWILSGTIRDNILFGSIYESEKYERTVKACALIKDFE 322

  Fly   755 ILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGI 819
            :.|.||||||||:|||:||||||||.:|||||.:||:||||||.||||||.|:.:||:.:  .||
plant   323 LFSNGDLTEIGERGINMSGGQKQRIQIARAVYQNADIYLLDDPFSAVDAHTGRELFEDCL--MGI 385

  Fly   820 LARKSRVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFADFIIQHLQEGNEEEEELN 884
            |..|:.:.|||.|.|||..|.|.|::.|.:.::|.|::|:|....|               |.|.
plant   386 LKDKTVLYVTHQVEFLPAADLILVMQNGRVMQAGKFEELLKQNIGF---------------EVLT 435

  Fly   885 QIKRQISSTADVPELLGTVEKAIKLARTESLSDSISVTSADSLMGGGGSLRRRTKRQDSHDSVAS 949
            |.                                                       ||..::::
plant   436 QC-------------------------------------------------------DSEHNIST 445

  Fly   950 AASLKKKQEVEGKLIETEKSQTGGVEFAVYKHYIKSVGIFLSVATLVL-NFVFQAFQIGSNLWLT 1013
              ..|||   |.||::.|:::.|.:...||..|:.:|...|.|..::| ...||..||.||.|:.
plant   446 --ENKKK---EAKLVQDEETEKGVIGKEVYLTYLTTVKGGLLVPFIILAQSCFQMLQIASNYWMA 505

  Fly  1014 QWANDQNVAN--DTGLRDMYLGVYGAFGFGQGVLAYFAVVIVYLGGFQAAKTIHNELLAVIIRGS 1076
             |.......:  ..|:..:.| ||.....|..:......::|.:||...|:|..:.:|..|.|..
plant   506 -WTAPPTAESIPKLGMGRILL-VYALLAAGSSLCVLARTILVAIGGLSTAETFFSRMLCSIFRAP 568

  Fly  1077 VCRFFDITPIGRLLNSFSGDMDVVDEELPATMDSFMTFIFMVLATIVVISLSTPIFLAVIVPIAF 1141
            : .:||.||.||:||..|.|..|:|.|:...:......|..::.||.|:|........:.:|:|.
plant   569 M-SYFDSTPTGRILNRASTDQSVLDLEMAVKLGWCAFSIIQIVGTIFVMSQVAWQVCVIFIPVAV 632

  Fly  1142 LYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCK 1206
            ...|.||:|..|.|:|.|:..|.|:||..||:|::.||:||||::..||||..:...:|.:....
plant   633 ACVFYQRYYTPTERELSRMSGVERAPILHHFAESLAGATTIRAFDQRDRFISSNLVLIDSHSRPW 697

  Fly  1207 YPSVIANRWLAIRLEMVGNLIILFASLFAVL--GGQTNPGLVGLSVSYALQVT---QTLNWLVRM 1266
            :....|..||:.||.::.:.:..|:.:..|.  .|..||.:.||.|:|.|.:.   .|:.|.:
plant   698 FHVASAMEWLSFRLNLLSHFVFAFSLVLLVTLPEGVINPSIAGLGVTYGLSLNVLQATVIWNI-- 760

  Fly  1267 SSDIETNIVSVERIKEYGETKQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYREGLDLVLRGVS 1331
             .:.|..::|||||.::.:...|||..:: |:....|||..|.:.|::.||||.|....||:.::
plant   761 -CNAENKMISVERILQHSKIPSEAPLVID-DQRPLDNWPNVGSIVFRDLQVRYAEHFPAVLKNIT 823

  Fly  1332 FNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVL 1396
            ....||:|:|:|||||:|||:|..|||||:|.:.|.|.||.|||..:|||.|||||.|||||..|
plant   824 CAFPGGKKIGVVGRTGSGKSTLIQALFRIVEPSHGTIVIDNVDITKIGLHDLRSRLGIIPQDNAL 888

  Fly  1397 FSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARAL 1461
            |.|::|:||||....||.|||:||:...|...:::....|:..:.|.|||.||||||||||.|.|
plant   889 FDGTIRLNLDPLAQYTDREIWEALDKCQLGDVIRAKDEKLDATVVENGENWSVGQRQLVCLGRVL 953

  Fly  1462 LRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFA 1526
            |:|:.:||||||||:||..||.:|||.|..|||:.||:|||||::|:::||.|:||..|:|.||.
plant   954 LKKSNILVLDEATASVDSATDGVIQKIINQEFKDRTVVTIAHRIHTVIESDLVLVLSDGRIAEFD 1018

  Fly  1527 SPTELLDNPKSAFYSMAKDANL 1548
            ||.:||....|.|..:.|:.:|
plant  1019 SPAKLLQREDSFFSKLIKEYSL 1040

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	434/1125 (39%)
		ABC_membrane	338..601	CDD:279056	61/165 (37%)
		ABCC_MRP_domain1	649..848	CDD:213217	112/203 (55%)
		ABC_membrane	988..1260	CDD:279056	85/279 (30%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	119/219 (54%)
ABCC15	NP_191656.2	ABC_membrane	<1..170	CDD:294371	62/171 (36%)
		EcfA2	214..428	CDD:224047	116/215 (54%)
		ABCC_MRP_domain1	214..414	CDD:213217	111/201 (55%)
		MdlB	481..1037	CDD:224055	225/562 (40%)
		ABC_membrane	520..756	CDD:294371	73/237 (31%)
		ABCC_MRP_domain2	800..1020	CDD:213211	119/219 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	178	1.000	Domainoid score	I1063
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0000087
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.680