DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MRP and ABCC8

DIOPT Version :9

Sequence 1:	NP_723772.2	Gene:	MRP / 34686	FlyBaseID:	FBgn0032456	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	NP_001326629.1	Gene:	ABCC8 / 821679	AraportID:	AT3G21250	Length:	1470	Species:	Arabidopsis thaliana

Alignment Length:	1582	Identity:	506/1582 - (31%)
Similarity:	793/1582 - (50%)	Gaps:	232/1582 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 CFEQTALVWTP----CAFY--------------------WAFV-------IFDFYYLKASLD--- 64
            ||::||:.:..    |.||                    |.||       |..|.:|...|:
plant    27 CFQRTAIAFVNLLFLCIFYLFLIASCVSTHFIVRGRKKGWIFVAVAICCAITSFIFLGVGLNSLI 91

  Fly    65 ------RNIPWNKLNVSKALVNLGLLVITALDLIMALVKKGGDSELPLYDLDVWGPIIKFATFLL 123
                  ..|.|....|.      |::.::   |.::|:..|..          |..|: .:.:.:
plant    92 HGGNDVTEISWVACFVE------GIIWVS---LAVSLLVNGSK----------WVNIL-VSVWWV 136

  Fly   124 LFIFIPLNRKYGV--QTTGCQFIFWFLLTVLSIPR------CRTEVRLDAERQKILNSQQPSEQD 180
            .|..:.|..|.|:  |..|.:     :|.:|::|.      |
plant   137 SFALLDLVAKSGILLQGNGIR-----ILDILTLPMSLLLLLC----------------------- 173

  Fly   181 FSWEEYQFVSFFIFFTFTSIMLILNCFADGM--PRQTKYQRGENEIPELSASFLSRITYQWFDKM 243
             ||...:          :|.....:|...|:  |..||..|.|: ....:|.|.|.:::.|.:.:
plant   174 -SWMNLR----------SSSAAAQDCSVTGLSDPLLTKNPRKES-ARLATAGFFSILSFSWMNPL 226

  Fly   244 ALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHHWNQNVRKNYKNKARVEPKAQFSNGNVTFENPH 308
            ...|::.||..:|:..:.|:|........|:..|:..:......|.|          |:.|.
plant   227 LSLGFKKPLSPEDIPSVVPEDEAQLAYKKFSQAWDTLLGDESSTKER----------NLVFR--- 278

  Fly   309 GEKNGRKKGMASIMPPIYKS--FGGVFLFGALMKLFTDTLTFAQPQVLSLIISFVEAQDAEPE-- 369
                       :::...:|.  |..||.|         ..|||...:..::..||:..:::..
plant   279 -----------AVVKVYFKENIFIAVFAF---------LRTFAVVSLPLMLYVFVDYANSDHRDL 323

  Fly   370 WKGILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKALRISNSTKKESTVGEIVN 434
            ..|......|.:|...::..:..::......|:|||:||:.|.|:|.|::|:..:|..:.|||||
plant   324 RNGFFNLACLVMLKLVESLTMRHWYFASRRSGMRIRSALMVAAYKKQLKLSSLGRKRHSSGEIVN 388

  Fly   435 LMAVDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTY 499
            .:||||.|..|...:.:..||..||:.|:...|:..:|.....||.::::...:|...|..::..
plant   389 YIAVDAYRMGEFLWWFHSGWSLSLQLLLSTAVLFGVVGAGAFPGLILLLLCGLLNLPFAKMLQNC 453

  Fly   500 QIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSC 564
            |.:.|..:|:|::..:|:|:.:||:||.:||..|:|::...||.|...|.......|..|||:..
plant   454 QTQFMIAQDKRLRSTSEILNSMKVIKLQSWEDEFKKKIESCRDDEFTWLAKAQLTKAFGSFLYWM 518

  Fly   565 APFLVSLVTFATYVLTSEANQLSVEKVLVSIALFDLMKLPLTILPMLSVDIAETQVSVNRINKFL 629
            :|.:||.|.|....|...| .|:...:...:|...:|..|:.|:|.....|.:..||..|:|.||
plant   519 SPTIVSSVVFLGCALLKSA-PLNASTIFTVLATLRVMSEPVKIIPDAISAIIQGNVSFQRLNNFL 582

  Fly   630 NSEELDPNSVLH---DSSKPHPMSIENGEFSWGDEI---TLRNINIEVKKGSLVALVGTVGSGKS 688
            ..:||..:.:..   |:|.. .:.|:.|.|.|..|.   |||||::|:|.|..||:.|.||:|||
plant   583 LDDELKMDEIERSGLDASGT-AVDIQVGNFGWEPETKIPTLRNIHLEIKHGQKVAVCGPVGAGKS 646

  Fly   689 SVVQAFLGEMEKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADI 753
            |::.|.|||:.|::|.|...|.:|||.|.:|||:.|:|||||:|:..:.:|||..|.||||..|:
plant   647 SLLHAVLGEIPKVSGTVKVFGSIAYVSQTSWIQSGTIRDNILYGKPMESRRYNAAIKACALDKDM 711

  Fly   754 DILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKG 818
            :....|||||||::||||||||||||.||||||:|||:||||||.||||||....:|.:.:  :.
plant   712 NGFGHGDLTEIGQRGINLSGGQKQRIQLARAVYADADVYLLDDPFSAVDAHTAGVLFHKCV--ED 774

  Fly   819 ILARKSRVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFADFIIQHLQEGNEEEEEL 883
            .|..|:.:||||.|.||.:||.|.|::.|.|::||.:::|:....||...:..|
plant   775 SLKEKTVILVTHQVEFLSEVDQILVMEEGTITQSGKYEELLMMGTAFQQLVNAH----------- 828

  Fly   884 NQIKRQISSTADVPELLGTVEKAIKLARTESLSDSISVTSADSLMGGGGSLRRRTKRQDSHDS-- 946
                             ......:.||..|||                |.||:..|.::..:.
plant   829 -----------------NDAVTVLPLASNESL----------------GDLRKEGKDREIRNMTV 860

  Fly   947 VASAASLKKKQEVEG-KLIETEKSQTGGVEFAVYKHYI-KSVGIFLSVATLVLNFVFQAFQIGSN 1009
            |.......:|.::.| :|.:.|:.::|.|....:..|| .|.|..|..::::....|..||..|.
plant   861 VEKIEEEIEKTDIPGVQLTQEEEKESGYVGMKPFLDYIGVSRGWCLLWSSVLGQVGFVVFQAAST 925

  Fly  1010 LWLTQWANDQNVANDTGLRDMYLGVYGAFG-FGQGVLAYFAVVIVYLGGFQAAKTIHNELLAVII 1073
            .||........:.|     .|.:|||.... ...|.:...|:...:| |.:|:|...:.....:.
plant   926 YWLAFAIGIPKITN-----TMLIGVYSIISTLSAGFVYARAITTAHL-GLKASKAFFSGFTNAVF 984

  Fly  1074 RGSVCRFFDITPIGRLLNSFSGDMDVVDEELPATMDSFMTFIFMVLATI---VVISLSTPIFLAV 1135
            :..:. |||.||:||:|...|.|::|:|.::|      ..|||:|...:   ..:.:.|.:...|
plant   985 KAPML-FFDSTPVGRILTRASSDLNVLDYDVP------FAFIFVVAPAVELTAALLIMTYVTWQV 1042

  Fly  1136 IVPIAFLYYFA----QRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESD 1196
            |: ||.|...|    |.:|:|::|:|:|:...:::|:.::.:||..|..||||:...:||.:...
plant  1043 II-IALLALAATKVVQDYYLASARELIRINGTTKAPVMNYAAETSLGVVTIRAFGTAERFFKNYL 1106

  Fly  1197 AKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAVL--GGQTNPGLVGLSVSYALQVTQT 1259
            ..||.:.|..:.|..|..|:.:|:|.:.|:.:...:|..:|  .|...|||||||:||||.:|||
plant  1107 NLVDADAVLFFLSNAAMEWVILRIETLQNVTLFTCALLLILIPKGYIAPGLVGLSLSYALTLTQT 1171

  Fly  1260 LNWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYREGLD 1324
            ..:|.|....:..:|:||||||:|....:|.| .:..||..|.:||..|.:..|..::|||....
plant  1172 QVFLTRWYCTLSNSIISVERIKQYMNIPEEPP-AIIDDKRPPSSWPSNGTIHLQELKIRYRPNAP 1235

  Fly  1325 LVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTI 1389
            |||:|:|...:.|.:||:|||||:|||:|..||||::|.|.|.|.|||:||:.:||..||.:|:|
plant  1236 LVLKGISCTFREGTRVGVVGRTGSGKSTLISALFRLVEPASGCILIDGIDISKIGLKDLRMKLSI 1300

  Fly  1390 IPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQL 1454
            |||:|.||.|.:|.||||..:.:|||||||||...||:.:.:|...|:..:::.|||.|||||||
plant  1301 IPQEPTLFRGCIRTNLDPLGVYSDDEIWKALEKCQLKTTISNLPNKLDSSVSDEGENWSVGQRQL 1365

  Fly  1455 VCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDK 1519
            .||.|.||::.|:||||||||::|..||.:||:.||.||.:|||:|:|||:.|::|||.|:||..
plant  1366 FCLGRVLLKRNKILVLDEATASIDSATDAIIQRIIREEFADCTVITVAHRVPTVIDSDMVMVLSF 1430

  Fly  1520 GQIIEFASPTELLDNPKSAFYS 1541
            |.::|:..|::|::.  .:::|
plant  1431 GDLVEYNEPSKLMET--DSYFS 1450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	506/1582 (32%)
		ABC_membrane	338..601	CDD:279056	73/264 (28%)
		ABCC_MRP_domain1	649..848	CDD:213217	107/201 (53%)
		ABC_membrane	988..1260	CDD:279056	83/281 (30%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	115/219 (53%)
ABCC8	NP_001326629.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	178	1.000	Domainoid score	I1063
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0000087
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.720