DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MRP and ABCC2

DIOPT Version :9

Sequence 1:	NP_723772.2	Gene:	MRP / 34686	FlyBaseID:	FBgn0032456	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	NP_001189675.1	Gene:	ABCC2 / 818031	AraportID:	AT2G34660	Length:	1623	Species:	Arabidopsis thaliana

Alignment Length:	1572	Identity:	563/1572 - (35%)
Similarity:	851/1572 - (54%)	Gaps:	194/1572 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 MDRFC-GSTFWN----ATETWYTNDP-----------DF----TPCFEQTALVWTPCAFYWAFVI 53
            ::||| .|..:|    ....:.|.:|           ||    .|.||...|  ...||.|..|:
plant    63 VERFCLRSRLYNYFLALLAAYATAEPLFRLIMGISVLDFDGPGLPPFEAFGL--GVKAFAWGAVM 125

  Fly    54 FDFYYLKASLDRNIPWN-KLNVSKALVNLGLLVITALDLIMALVKKGGDSELPLYDLDVWGPIIK 117
            ...........|.:.|. :..|..|||  |.:|:  |:|::::.:......|.||..:|
plant   126 VMILMETKIYIRELRWYVRFAVIYALV--GDMVL--LNLVLSVKEYYSSYVLYLYTSEV------ 180

  Fly   118 FATFLLLFIFIPLNRKYGVQTTGCQFIFWFLLTVLSIPRCRTEVRLDAERQKILNSQQPSEQDFS 182
                                  |.|.:|..|| .:.:|...|.......|.:.::       |:.
plant   181 ----------------------GAQVLFGILL-FMHLPNLDTYPGYMPVRSETVD-------DYE 215

  Fly   183 WEEYQFVSFFIFFTFTSIMLILNCFADGMPRQTKYQRGENEIPELSASFLSRITYQWFDKMALKG 247
            :||                     .:|          |:...||..|:...:|.:.|.:.:...|
plant   216 YEE---------------------ISD----------GQQICPEKHANIFDKIFFSWMNPLMTLG 249

  Fly   248 YRNPLEEKDLWDLRPQDSCSEVMPIFAHHWNQNVRKNYKNKARVEPKAQFSNGNVTFENPHGEKN 312
            .:.||.|||:|.|...|....:...|.|.|::.::|         |:..
plant   250 SKRPLTEKDVWYLDTWDQTETLFTSFQHSWDKELQK---------PQPW---------------- 289

  Fly   313 GRKKGMASIMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQVLSLIISFVEAQDAEPEWKGILYAV 377
                    ::..:..|.||.|.:|...|:..|...|..|.:|:.::..:: :|| |.|.|.:||.
plant   290 --------LLRALNNSLGGRFWWGGFWKIGNDCSQFVGPLLLNQLLKSMQ-EDA-PAWMGYIYAF 344

  Fly   378 LLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKALRISNSTKKESTVGEIVNLMAVDAQR 442
            .:||..........|||..:..||.|:|:|||.|::||:||::|..:::...|:|.|||..||:.
plant   345 SIFVGVVFGVLCEAQYFQNVMRVGYRLRSALIAAVFRKSLRLTNEGRRKFQTGKITNLMTTDAES 409

  Fly   443 FMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYK 507
            ..::...|:.:||||.:|.:||..|:||||.:.|.|..:::::.|:..||.|:::......::..
plant   410 LQQICQSLHTMWSAPFRIIIALILLYQQLGVASLIGALLLVLMFPLQTVIISKMQKLTKEGLQRT 474

  Fly   508 DERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLV 572
            |:|:.||||||:.:..:|.||||.||:.:|..:||.|::..|.:..|.|...|:.:..|.||::|
plant   475 DKRIGLMNEVLAAMDTVKCYAWENSFQSKVQTVRDDELSWFRKSQLLGALNMFILNSIPVLVTIV 539

  Fly   573 TFATYVLTSEANQLSVEKVLVSIALFDLMKLPLTILPMLSVDIAETQVSVNRINKFLNSEE--LD 635
            :|..:.|.  ...|:..:...|::||.:::.||.:||.:...:....||:.|:.:.|.:||  |.
plant   540 SFGVFTLL--GGDLTPARAFTSLSLFAVLRFPLFMLPNIITQVVNANVSLKRLEEVLATEERILL 602

  Fly   636 PNSVLHDSSKPHPMSIENGEFSW---GDEITLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGE 697
            ||..: :..:| .:||.||.|||   ||..||.|||::|..|||||:||:.|.||:|::.|.|||
plant   603 PNPPI-EPGEP-AISIRNGYFSWDSKGDRPTLSNINLDVPLGSLVAVVGSTGEGKTSLISAILGE 665

  Fly   698 MEKLAGVVNTV-GKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDL 761
            :...:..:.|: |.:|||||.:||.|||||||||||..:||::|.:.||..:|:.|:::|..|||
plant   666 LPATSDAIVTLRGSVAYVPQVSWIFNATVRDNILFGSPFDREKYERAIDVTSLKHDLELLPGGDL 730

  Fly   762 TEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRV 826
            |||||:|:|:|||||||:|:||||||::|:|:.||||||:|||||:.:||:.|  |..|.:|:||
plant   731 TEIGERGVNISGGQKQRVSMARAVYSNSDVYIFDDPLSALDAHVGQQVFEKCI--KRELGQKTRV 793

  Fly   827 LVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKRQIS 891
            |||:.:.||.|||.|.::..|.:.|.||:::|..|...|     |.|.|...:.||.::...:
plant   794 LVTNQLHFLSQVDRIVLVHEGTVKEEGTYEELSSNGPLF-----QRLMENAGKVEEYSEENGE-- 851

  Fly   892 STADVPELLGTVEKAIKLARTESLSDSISVTSADSLMGGGGSLRRRTKRQDSHDSVASAASLKKK 956
            :.||     .|.|:.:....|..|                        :.|..|...|....||
plant   852 AEAD-----QTAEQPVANGNTNGL------------------------QMDGSDDKKSKEGNKK- 886

  Fly   957 QEVEGK--LIETEKSQTGGVEFAVYKHYIKSVGIFLSVATLVLNFVF-QAFQIGSNLWLTQWAND 1018
               .||  ||:.|:.:||.|.:.|.|.|..::|....|..|:|.:|. :.|::.|:.||::|.:.
plant   887 ---GGKSVLIKQEERETGVVSWRVLKRYQDALGGAWVVMMLLLCYVLTEVFRVTSSTWLSEWTDA 948

  Fly  1019 QNVANDTGLRDMYLGVYGAFGFGQGVLAYFAVVIVYLGGFQAAKTIHNELLAVIIRGSVCRFFDI 1083
            ....:...|  .|..:|....|||.::.......:.:....|||.:|:.:|..|:|..: .||..
plant   949 GTPKSHGPL--FYNLIYALLSFGQVLVTLTNSYWLIMSSLYAAKKLHDNMLHSILRAPM-SFFHT 1010

  Fly  1084 TPIGRLLNSFSGDMDVVDEELPATMDSFMTFIFMVLATIVVISLSTPIFLAVIVPIAFLYYFAQR 1148
            .|:||::|.|:.|:..:|..:...::.||..:..:|:|:|:|.:.:.:.|..|:|:..|:|.|..
plant  1011 NPLGRIINRFAKDLGDIDRTVAVFVNMFMGQVSQLLSTVVLIGIVSTLSLWAIMPLLVLFYGAYL 1075

  Fly  1149 FYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIAN 1213
            :|..|:|::.|::|:||||:|:.|.|.:.|.||||||...||..:.:...:|.|......::.||
plant  1076 YYQNTAREVKRMDSISRSPVYAQFGEALNGLSTIRAYKAYDRMADINGRSMDNNIRFTLVNMGAN 1140

  Fly  1214 RWLAIRLEMVGNLIILFASLFAVL------GGQTNPGLVGLSVSYALQVTQTLNWLVRMSSDIET 1272
            |||.||||.:|.|:|...:.|||:      ..|.....:||.:||||.:|..|..::|::|..|.
plant  1141 RWLGIRLETLGGLMIWLTASFAVMQNGRAENQQAFASTMGLLLSYALNITSLLTGVLRLASLAEN 1205

  Fly  1273 NIVSVERIKEYGETKQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGG 1337
            ::.:|||:..|.|...|||..:|.:: .|..||..|.::|::..:|||..|..||.||||.|...
plant  1206 SLNAVERVGNYIEIPPEAPPVIENNR-PPPGWPSSGSIKFEDVVLRYRPQLPPVLHGVSFFIHPT 1269

  Fly  1338 EKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLR 1402
            :|||||||||||||||..|||||:|...|||.||..|:...||..||..|.||||.||||||::|
plant  1270 DKVGIVGRTGAGKSSLLNALFRIVEVEKGRILIDDCDVGKFGLMDLRKVLGIIPQSPVLFSGTVR 1334

  Fly  1403 INLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKV 1467
            .|||||....|.::|::||.:|||..::....||:.|::|.|||.|||||||:.|:|||||::|:
plant  1335 FNLDPFGEHNDADLWESLERAHLKDTIRRNPLGLDAEVSEAGENFSVGQRQLLSLSRALLRRSKI 1399

  Fly  1468 LVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELL 1532
            |||||||||||:.||.|||||||.|||.||:|.||||||||:|.||::|||.|::.||:||..||
plant  1400 LVLDEATAAVDVRTDALIQKTIREEFKSCTMLIIAHRLNTIIDCDKILVLDSGRVQEFSSPENLL 1464

  Fly  1533 DNPKSAFYSMAK 1544
            .|..|:|..|.:
plant  1465 SNEGSSFSKMVQ 1476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	560/1566 (36%)
		ABC_membrane	338..601	CDD:279056	89/262 (34%)
		ABCC_MRP_domain1	649..848	CDD:213217	112/202 (55%)
		ABC_membrane	988..1260	CDD:279056	89/278 (32%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	132/219 (60%)
ABCC2	NP_001189675.1	PLN03130	1..1623	CDD:215595	563/1572 (36%)
		ABC_membrane	309..570	CDD:279056	89/264 (34%)
		ABCC_MRP_domain1	614..815	CDD:213217	112/202 (55%)
		ABC_membrane	925..1179	CDD:294371	80/256 (31%)
		ABCC_MRP_domain2	1240..1460	CDD:213211	132/219 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	183	1.000	Domainoid score	I1011
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	895	1.000	Inparanoid score	I55
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0000087
OrthoInspector	1	1.000	-	-		otm2810
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	O	PTHR24223
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X177
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.870