DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MRP and Abcc6

DIOPT Version :9

Sequence 1:	NP_723772.2	Gene:	MRP / 34686	FlyBaseID:	FBgn0032456	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	NP_112275.1	Gene:	Abcc6 / 81642	RGDID:	620268	Length:	1502	Species:	Rattus norvegicus

Alignment Length:	1586	Identity:	590/1586 - (37%)
Similarity:	877/1586 - (55%)	Gaps:	135/1586 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SSPMDRFCGSTFWNATETWYTNDPD----FTPCFEQTALVWTPCAFYWAF-VIFDFY-------Y 58
            ::|.:...|...||.||    .:|.    ...||.:.|..|.|..:.|.. .|:..|       |
  Rat     8 ATPGESCAGLRVWNQTE----QEPVAYHLLNLCFLRAAGSWVPPMYLWVLGPIYLLYIHRHGCCY 68

  Fly    59 LKASLDRNIPWNKLNVSKALVNLGLLVITALDLIMALVK-KGGDSELP--LYDLDVWGPIIKFAT 120
            |:.|        :|...|.::...|:::...:..:.|.: ..|..:.|  |....||...:.|||
  Rat    69 LRMS--------RLFKIKMVLGFALILLYTFNAAVPLWRIHRGMPQAPELLIHPTVWLTTMSFAT 125

  Fly   121 FLLLFIFIPLNRKYGVQTTGCQFIFWFLLTVLSIPRCRTEVRLDAERQKILNSQQPSEQDFSWEE 185
            ||     |.:.||.||:.:|..|.:|.|..:  :|...|             .||.|...|..|.
  Rat   126 FL-----IHMERKKGVRASGLLFGYWLLCCL--VPAIDT-------------VQQASAGSFRQEP 170

  Fly   186 YQFVSFFIFFTFTSIMLILNCFADGMPRQTKYQRGENEIPELSASFLSRITYQWFDKMALKGYRN 250
            ...::.::..:.....|:|:|..|..|..::..:..|..||..|||.|:..:.|...:..||||.
  Rat   171 LHHLATYLCLSLVVAELVLSCLVDQPPFFSEDSKPLNPCPEAEASFPSKAMFWWASGLLWKGYRK 235

  Fly   251 PLEEKDLWDLRPQDSCSEVMPIFAHHWNQNV-----RKNYKNKARVEPKAQFSNGNVTFENPHGE 310
            .|..||||.|..::|..|::......|.:|.     .|.:......|.:|        |..|...
  Rat   236 LLGPKDLWSLERENSSEELVSQLEREWRRNFSELPGHKGHSGMGTPETEA--------FLQPERS 292

  Fly   311 KNGRKKGMASIMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQVLSLIISFVEAQDAEPE-WKGIL 374
            :.|      .::..|::.|...||.|.|..:.:|...||.|::|||.:.|:  .|.|.. |.|.|
  Rat   293 QRG------PLLRAIWRVFRSTFLLGTLSLVISDAFRFAVPKLLSLFLEFM--GDLESSAWTGWL 349

  Fly   375 YAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKALRISNSTKKESTVGEIVNLMAVD 439
            .|||:|:.|..||....||.:|:.::.:|:|||:...:|||.|.:|:.::|.|..|::|||::||
  Rat   350 LAVLMFLSACLQTLFEQQYMYRVKVLQMRLRTAITGLVYRKVLVLSSGSRKSSAAGDVVNLVSVD 414

  Fly   440 AQRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQM 504
            .||.:|...:||.:|...|.|.:...:|||.||||.|..:||.:.|:|:|..|..:...:|..||
  Rat   415 VQRLVESILHLNGLWLLFLWIIVCFVYLWQLLGPSALTAVAVFLSLLPLNFFITKKRSFHQEEQM 479

  Fly   505 KYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLV 569
            :.|..|.:|.:.:|..::.:|.:.||.:|.:::|.||.:|:..|:::|:|.:.:...:..:.|||
  Rat   480 RQKASRARLTSSMLRTVRTIKSHGWECAFLERLLHIRGQELGALKTSAFLFSVSLVSFQVSTFLV 544

  Fly   570 SLVTFATYVLTSEANQLSVEKVLVSIALFDLMKLPLTILPMLSVDIAETQVSVNRINKFLNSEEL 634
            :||.||.:.|.:|.|.:..||..|::.:..::......||.....:.:.:||.:|:..||..||:
  Rat   545 ALVVFAVHTLVAEDNAMDAEKAFVTLTVLSILNKAQAFLPFSVHCLVQARVSFDRLAAFLCLEEV 609

  Fly   635 DPNS-VLHDS--SKPHPMSIENGEFSWGDEI--TLRNINIEVKKGSLVALVGTVGSGKSSVVQAF 694
            |||. ||..|  |....:||.||.|:|..|.  .|..||:.|.:|.|:|:||.||:||||::.|.
  Rat   610 DPNGMVLSPSRCSSKDRISIHNGTFAWSQESPPCLHGINLTVPQGCLLAVVGPVGAGKSSLLSAL 674

  Fly   695 LGEMEKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAG 759
            |||:.|:.|.|:..|.:|||||:||:||.:|.:|:.|.|..|.....:|::||||.:|:....||
  Rat   675 LGELLKVEGSVSIEGSVAYVPQEAWVQNTSVVENVCFRQELDLPWLQEVLEACALGSDVASFPAG 739

  Fly   760 DLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKS 824
            ..|.:||:|:|||||||||:|||||||..|.:||:||||:|:||||.:.:|::||||.|:|...:
  Rat   740 VHTPVGEQGMNLSGGQKQRLSLARAVYRRAAVYLMDDPLAALDAHVSQEVFKQVIGPSGLLQGTT 804

  Fly   825 RVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKRQ 889
            |:||||.:..|||.|.|.|:..|.|:|.|::..|:...||....:....|...|.|.|.:
  Rat   805 RILVTHTLHVLPQADQILVLANGTIAEMGSYQDLLHRNGALVGLLDGARQPAGEGEGEAH----- 864

  Fly   890 ISSTADVPELLGTVEKAIKLARTESLSDSISVTSADSLMG--GGGSLRRRTKRQDSHDSVASAAS 952
                                          :..::|.|.|  |||:..||.:|....|:.....|
  Rat   865 ------------------------------AAATSDDLGGFSGGGTPTRRPERPRPSDAAPVKGS 899

  Fly   953 LKKKQ--------EVEGKLIETEKSQTGGVEFAVYKHYIKSVGIFLSVATLVLNFVFQAFQIGS- 1008
            ..:.|        ||.|.....:..|.|.|:.|.|..|:::||..|...||   |:|...|:.|
  Rat   900 TSEAQMEPSLDDVEVTGLTAGEDSVQYGRVKSATYLSYLRAVGTPLCTYTL---FLFLCQQVASF 961

  Fly  1009 --NLWLTQWANDQNVAN---DTGLRDMYLGVYGAFGFGQGVLAYFAVVIVYLGGFQAAKTIHNEL 1068
              ..||:.||:|..|..   .:.||.   .::|..|..|.:..:.::..|:|||.:|:..:...|
  Rat   962 CQGYWLSLWADDPVVDGKQMHSALRG---SIFGLLGCLQAIGLFASMAAVFLGGARASCLLFRSL 1023

  Fly  1069 LAVIIRGSVCRFFDITPIGRLLNSFSGDMDVVDEELPATMDSFMTFIFMVLATIVVISLSTPIFL 1133
            |..:.|..: .||:.||:|.|||.||.:.|:||.::|..|.:.:|:.|.:|...:.:|::||:.:
  Rat  1024 LWDVARSPI-GFFERTPVGNLLNRFSKETDIVDVDIPDKMRTLLTYAFGLLEVGLAVSMATPLAI 1087

  Fly  1134 AVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAK 1198
            ..|:|:..||...|..||||..||.||||.|.|.:.||.:||..|:..:||:.....|..:.||.
  Rat  1088 VAILPLMLLYAGFQSLYVATCCQLRRLESASYSSVCSHLAETFQGSQVVRAFQAQGPFTAQHDAL 1152

  Fly  1199 VDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAVLG-GQTNPGLVGLSVSYALQVTQTLNW 1262
            :|:||...:|.::|:||||..||::||.::..|:..|||. ...:.||.|.|||.||||||||.|
  Rat  1153 MDENQRISFPRLVADRWLAANLELLGNGLVFVAATCAVLSKAHLSAGLAGFSVSAALQVTQTLQW 1217

  Fly  1263 LVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYREGLDLVL 1327
            :||..:|:|.::|:|||:::|..|.:||||.|.....:|. ||..|::||::|.:|:|..|.:.:
  Rat  1218 VVRSWTDLENSMVAVERVQDYVHTPKEAPWRLPSSAAQPL-WPCGGQIEFRDFGLRHRPELPMAV 1281

  Fly  1328 RGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQ 1392
            :|||..|..||||||||||||||||||..|.|:.||..|.|.||||.|..||||.||||:|||||
  Rat  1282 QGVSLKIHAGEKVGIVGRTGAGKSSLTWGLLRLQEATEGGIWIDGVPITDMGLHTLRSRITIIPQ 1346

  Fly  1393 DPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCL 1457
            |||||.||||:|||..:..||:.||.|||...||:||.||...|.:|.:..|::|||||:||:||
  Rat  1347 DPVLFPGSLRMNLDLLQENTDEGIWAALETVQLKAFVTSLPGQLQYECSGQGDDLSVGQKQLLCL 1411

  Fly  1458 ARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQI 1522
            ||||||||::|:||||||:||..|:..:|..:...|.:||||.|||||.::::..:|:|:|:||:
  Rat  1412 ARALLRKTQILILDEATASVDPGTEIQMQAALERWFAQCTVLLIAHRLRSVMNCARVLVMDEGQV 1476

  Fly  1523 IEFASPTELLDNPKSAFYSMAKDANL 1548
            .|..||.:||.. |..||.:|:::.|
  Rat  1477 AESGSPAQLLAQ-KGLFYRLAQESGL 1501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	588/1576 (37%)
		ABC_membrane	338..601	CDD:279056	94/263 (36%)
		ABCC_MRP_domain1	649..848	CDD:213217	102/200 (51%)
		ABC_membrane	988..1260	CDD:279056	103/278 (37%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	125/219 (57%)
Abcc6	NP_112275.1	MRP_assoc_pro	36..1501	CDD:188098	582/1552 (38%)
		ABC_membrane	313..577	CDD:294371	94/265 (35%)
		ABCC_MRP_domain1	627..828	CDD:213217	102/200 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	854..909		16/89 (18%)
		ABC_membrane	950..1215	CDD:294371	101/271 (37%)
		ABCC_MRP_domain2	1262..1482	CDD:213211	125/219 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345092
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0000087
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	O	PTHR24223
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X177
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.710