DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MRP and Abcc3

DIOPT Version :9

Sequence 1:NP_723772.2 Gene:MRP / 34686 FlyBaseID:FBgn0032456 Length:1549 Species:Drosophila melanogaster
Sequence 2:NP_001350116.1 Gene:Abcc3 / 76408 MGIID:1923658 Length:1523 Species:Mus musculus


Alignment Length:1565 Identity:766/1565 - (48%)
Similarity:1054/1565 - (67%) Gaps:68/1565 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 MDRFC-----GSTFWNATETWYTNDPDFTPCFEQTALVWTPCAFYWAFVIFDFYYLKASLDRNIP 68
            |||.|     ||.||::..:.|||.||.||||:.:.|.|.||.:.||.:....:||:......|.
Mouse     1 MDRLCGSGELGSKFWDSNLSIYTNTPDLTPCFQNSLLAWVPCIYLWAALPCYLFYLRHHQLGYIV 65

  Fly    69 WNKLNVSKALVNLGLLVITALDLIMA---LVKKGGDSELPLYDLDVWGPIIKFATFLLLFIFIPL 130
            .:.|:..|..:.:.|..::.:||..:   |:.  |.|..|::.:.   |::...|.||..:.|..
Mouse    66 LSWLSRLKTALGVLLWCVSWVDLFYSFHGLIH--GSSPAPVFFVT---PLVVGITMLLATLLIQY 125

  Fly   131 NRKYGVQTTGCQFIFWFLLTVLSIPRCRTEVRLDAERQKILNSQQPSEQDFSWEEYQFVSFFIFF 195
            .|..|||::|...|||.|..:.:|...|:::.......|||            :.::|.:|:|:|
Mouse   126 ERLRGVQSSGVLIIFWLLCVICAIIPFRSKILSALAEGKIL------------DPFRFTTFYIYF 178

  Fly   196 TFTSIMLILNCFADGMPRQTKYQRGENEIPELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDL 260
            ......|||:||.:..|..:......|..||.||.|.||:::.||.::|:.|||.|||::|||.|
Mouse   179 ALVFCALILSCFKEKPPLFSPENLDTNPCPEASAGFFSRLSFWWFTRLAILGYRRPLEDRDLWSL 243

  Fly   261 RPQDSCSEVMPIFAHHW-NQNVRKNYKNKARVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPP 324
            ..:|...:|:......| .|..:.:....|..|||....:..:....|       |....|.:..
Mouse   244 SEEDCSHKVVQRLLEAWQKQQNQASRSQTATAEPKIPGEDAVLLKPRP-------KSKQPSFLRA 301

  Fly   325 IYKSFGGVFLFGALMKLFTDTLTFAQPQVLSLIISFVEAQDAEPEWKGILYAVLLFVLAAAQTFI 389
            :.::|....|..|...|..:.|.|..||:||::|.|:....| |.|.|.|.|.|:|:.:..||.|
Mouse   302 LVRTFTSSLLMSACFNLIQNLLGFVNPQLLSILIRFISDPTA-PTWWGFLLAGLMFLSSTMQTLI 365

  Fly   390 LGQYFHRMFIVGLRIRTALINAIYRKALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIW 454
            |.||:|.:|::.||:|||:|..||||||.|:||.|:||||||:||||:|||||||:::.::|::|
Mouse   366 LHQYYHCIFVMALRLRTAIIGVIYRKALVITNSVKRESTVGEMVNLMSVDAQRFMDVSPFINLLW 430

  Fly   455 SAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLS 519
            |||||:.||:|||||.||||.|||:||:::|||:||.::.::||||::|||:||.|:|||:|:|:
Mouse   431 SAPLQVILAIYFLWQILGPSALAGVAVIVLLIPLNGAVSMKMKTYQVKQMKFKDSRIKLMSEILN 495

  Fly   520 GIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVLTSEAN 584
            ||||||||||||||.:||..||..|:..||..|||.|.::|:|.|.||||:|:|...||...|:|
Mouse   496 GIKVLKLYAWEPSFLEQVKGIRQSELQLLRKGAYLQAISTFIWICTPFLVTLITLGVYVYVDESN 560

  Fly   585 QLSVEKVLVSIALFDLMKLPLTILPMLSVDIAETQVSVNRINKFLNSEELDPNSVLHDSSKP-HP 648
            .|..||..||::||:::|:||.:||.|...:.:..||:.||..|||..||||..|...:..| :.
Mouse   561 VLDAEKAFVSLSLFNILKIPLNMLPQLISGLTQASVSLKRIQDFLNQNELDPQCVERKTISPGYA 625

  Fly   649 MSIENGEFSWGDEI--TLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVVNTVGKL 711
            ::|.||.|:|..::  ||.::||::.||:|||:||.||.||||:|.|.|||||||.|||:..|.:
Mouse   626 ITIHNGTFTWAQDLPPTLHSLNIQIPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGVVSVKGSV 690

  Fly   712 AYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQK 776
            |||||||||||.|:::|:||||..:.|||.:.::.|||.||:|:|..||.||||||||||||||:
Mouse   691 AYVPQQAWIQNCTLQENVLFGQPMNPKRYQQALETCALLADLDVLPGGDQTEIGEKGINLSGGQR 755

  Fly   777 QRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDSI 841
            ||:||||||||||:::||||||||||:||.||||::||||:|:||.|:|||||||::||||.|.|
Mouse   756 QRVSLARAVYSDANIFLLDDPLSAVDSHVAKHIFDQVIGPEGVLAGKTRVLVTHGISFLPQTDFI 820

  Fly   842 YVIKMGEISESGTFDQLVKNKGAFADFIIQHLQEGNEEE---------EELNQIKRQISSTADVP 897
            .|:..|::||.|.:..|:::.|:||:|:..:..:.::|:         ||:..::..:|:..|:.
Mouse   821 IVLAGGQVSEMGHYSALLQHDGSFANFLRNYAPDEDQEDHEAALQNANEEVLLLEDTLSTHTDLT 885

  Fly   898 ELLGTVEKAIKLARTESLSDSISVTSADSLMGGGGSLRRRTKRQDSHDSVASAASLKKKQEVEGK 962
            :    .|.||...|.:.:.:..|::|.       |.::.||..:...:|:...|.:.|.:|. |.
Mouse   886 D----NEPAIYEVRKQFMREMSSLSSE-------GEVQNRTMPKKHTNSLEKEALVTKTKET-GA 938

  Fly   963 LIETEKSQTGGVEFAVYKHYIKSVGIFLSVATLVLNFVFQAFQIGSNLWLTQWAND---QNVAND 1024
            ||:.|.::||.|:.:||..|.||:|:..:::..:|.....|..||:|:||:.|:||   ....|.
Mouse   939 LIKEEIAETGNVKLSVYWDYAKSMGLCTTLSICLLYGGQSAAAIGANVWLSAWSNDAEEHGQQNK 1003

  Fly  1025 TGLRDMYLGVYGAFGFGQGVLAYFAVVIVYLGGFQAAKTIHNELLAVIIRGSVCRFFDITPIGRL 1089
            |.:|   ||||.|.|..||:|...:...:.:|..|||:.:|..||...|| |...|||.||.||:
Mouse  1004 TSVR---LGVYAALGILQGLLVMLSAFTMVVGAIQAARLLHEALLHNKIR-SPQSFFDTTPSGRI 1064

  Fly  1090 LNSFSGDMDVVDEELPATMDSFMTFIFMVLATIVVISLSTPIFLAVIVPIAFLYYFAQRFYVATS 1154
            ||.||.|:.|:||.|..|:...:...|..::||:||..|||:|:.|::|:|.||.|.||||||||
Mouse  1065 LNRFSKDIYVIDEVLAPTILMLLNSFFTSISTIMVIVASTPLFMVVVLPLAVLYGFVQRFYVATS 1129

  Fly  1155 RQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLAIR 1219
            |||.||||:|||||:|||||||||.|.||||.....|...||.|||.||...||.:.:||||.:.
Mouse  1130 RQLKRLESISRSPIFSHFSETVTGTSVIRAYGRIQDFKVLSDTKVDNNQKSSYPYIASNRWLGVH 1194

  Fly  1220 LEMVGNLIILFASLFAVLG-GQTNPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEY 1283
            :|.|||.::|||:||||:| ...||||||||||||||||..|||::||.||:|:||::|||:|||
Mouse  1195 VEFVGNCVVLFAALFAVIGRNSLNPGLVGLSVSYALQVTMALNWMIRMISDLESNIIAVERVKEY 1259

  Fly  1284 GETKQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGA 1348
            .:||.||||.:|.:: .|:.||..|.|||:|:.||||.||:|||:.|:.::||||||||||||||
Mouse  1260 SKTKTEAPWVVESNR-APEGWPTRGMVEFRNYSVRYRPGLELVLKNVTVHVQGGEKVGIVGRTGA 1323

  Fly  1349 GKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKTD 1413
            ||||:||.||||:|||.|.|.|||:::|.:|||.|||:||||||||:||||:||:|||||...::
Mouse  1324 GKSSMTLCLFRILEAAEGEIVIDGLNVAHIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGRYSE 1388

  Fly  1414 DEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAAVD 1478
            ::||:|||||||.:||.|..|||:.:.||||:|||||||||||||||||||::||||||||||:|
Mouse  1389 EDIWRALELSHLNTFVSSQPAGLDFQCAEGGDNLSVGQRQLVCLARALLRKSRVLVLDEATAAID 1453

  Fly  1479 LETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAFYSMA 1543
            ||||||||.||||:|::|||||||||||||:|.::|:|||||.:.||.||..|: .....||.||
Mouse  1454 LETDDLIQGTIRTQFEDCTVLTIAHRLNTIMDYNRVLVLDKGVVAEFDSPVNLI-AAGGIFYGMA 1517

  Fly  1544 KDANL 1548
            |||.|
Mouse  1518 KDAGL 1522

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MRPNP_723772.2 MRP_assoc_pro 14..1548 CDD:188098 761/1553 (49%)
ABC_membrane 338..601 CDD:279056 146/262 (56%)
ABCC_MRP_domain1 649..848 CDD:213217 128/200 (64%)
ABC_membrane 988..1260 CDD:279056 140/275 (51%)
ABCC_MRP_domain2 1308..1528 CDD:213211 157/219 (72%)
Abcc3NP_001350116.1 MRP_assoc_pro 7..1522 CDD:188098 761/1557 (49%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 903..923 5/26 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167841636
Domainoid 1 1.000 253 1.000 Domainoid score I2064
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H68364
Inparanoid 1 1.050 1450 1.000 Inparanoid score I114
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG51855
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 1 1.000 - - FOG0000087
OrthoInspector 1 1.000 - - otm43692
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R8
SonicParanoid 1 1.000 - - X177
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1514.700

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