DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MRP and abcc12

DIOPT Version :9

Sequence 1:	NP_723772.2	Gene:	MRP / 34686	FlyBaseID:	FBgn0032456	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	XP_009301629.1	Gene:	abcc12 / 568482	ZFINID:	ZDB-GENE-050517-25	Length:	1368	Species:	Danio rerio

Alignment Length:	1462	Identity:	515/1462 - (35%)
Similarity:	769/1462 - (52%)	Gaps:	188/1462 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 PSEQDFSWEEYQFVSFFIFFTFTSIMLILNCFADG-----------MPRQTKYQR---------- 219
            |||:    ::.:.|||......:|.|   :.|.:|           .|::.|||:
Zfish     5 PSEK----QKVEGVSFKQRRDSSSAM---SAFPEGPPVLDYREPEPPPKKHKYQQSLKTLIPFRF 62

  Fly   220 GENEIPELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHHWNQNVRKN 284
            ..|..|...|.|.|..::.|...|..:.:||.|:|..|: |.|.|........|...|::.|.:.
Zfish    63 ASNSHPVDDAGFFSFTSFSWMTPMMWRLFRNRLDEDSLF-LSPHDGAHINGERFQRLWDEEVARV 126

  Fly   285 YKNKARVE------PKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGALMKLFT 343
            ...||.:.      .|.:|.   |:|             :||:|          |.|.
Zfish   127 GLEKASLSAVIMRFQKTRFI---VSF-------------LASVM----------FAFA------- 158

  Fly   344 DTLTFAQPQVLSL-IISFVEAQDAEPEWKGILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTA 407
               .|..|.:|.. |:::||..:......|:...|.||:...::.|.....:.......:|::.|
Zfish   159 ---VFVGPSILVYEILNYVEQSEPSTVVHGVGVCVALFLTEFSKAFFASVLWAVNLRTAVRVKGA 220

  Fly   408 LINAIYRKALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQLG 472
            .....::|.:.:.:.|  ..||||.:|::..|..|..:...:...:...|:.:.:.:.:....||
Zfish   221 FSMLAFKKIISLRSLT--TITVGETINVLTSDGYRLFDAVIFGTFLLCVPVLLIICIIYACFILG 283

  Fly   473 PSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQV 537
            .:.|.|:.|.:|.:|:...||..|..::.|.:...|:||:.|||||:.||::|:||||.||||.:
Zfish   284 YTALIGILVYLIFLPIQFSIARLIGVFRRRAVSVTDKRVRTMNEVLTCIKLIKMYAWEESFEKSI 348

  Fly   538 LDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVLTSEANQLSVEKVLVSIALFDLMK 602
            .|||..|...|:...|:.:..|.|.:..|.|.::|||..:  ||....|........||:|:.|:
Zfish   349 TDIRKNEKLLLQKAGYVQSLNSSLTTIVPTLATIVTFIVH--TSLKLPLLPSTAYTIIAVFNCMR 411

  Fly   603 LPLTILPMLSVDIAETQVSVNRINKFLNSEELDPNSVL-HDSSKPHPMSIENGEFSWG------- 659
            :.:.:||.....:||.:|::.|:.:.:..:  :|...| .|.:....:.:|...|||.
Zfish   412 MSMGLLPFSVKAVAEAKVALTRLKRIMLVQ--NPKGYLTQDKNMDLALVMEKATFSWSPTDDKNT 474

  Fly   660 ----------------DEITLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVVNTV 708
                            .:.:||||::.:.||||:.:.|.|||||:|::.:.|.:|..|:|.|:..
Zfish   475 SQMPENPSQNGKHKAESQPSLRNISLTLSKGSLLGVCGNVGSGKTSLISSILEQMHLLSGSVSAN 539

  Fly   709 GKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSG 773
            |.||||.|||||.:.|||||||.|:.:|..||..||:||.|:.|:.||..||.|||||:||||||
Zfish   540 GTLAYVSQQAWIFHGTVRDNILMGEPFDEARYASVINACCLKPDLAILPYGDQTEIGERGINLSG 604

  Fly   774 GQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQV 838
            |||||:||||||||:.|::||||||||||||||||||||.|  |..|..||.:||||.:.:|...
Zfish   605 GQKQRVSLARAVYSNRDIFLLDDPLSAVDAHVGKHIFEECI--KKELKGKSVILVTHQLQYLEFC 667

  Fly   839 DSIYVIKMGEISESGTFDQLVKNKGAFADFIIQ-HLQEGNEEEEELNQIKRQIS--STADVPELL 900
            |.:.::..|||.|:||...|:|.||.::..|.. ||::.||..:...|.:...|  :..|.|:..
Zfish   668 DEVMLLDNGEIKEAGTHSDLMKTKGRYSQLITNVHLEQNNERADSKPQTEHNDSEQTNPDEPKAN 732

  Fly   901 GTVEKAIKLARTESLSDSISVTSADSLMGGGGSLRRRTKRQDSHDSVASAASLKKKQEVEGK--- 962
            |....|..:                                 |.:..|:..:.|...|.:||
Zfish   733 GIENPAFDM---------------------------------SDEKPATNETPKDSSETKGKKDQ 764

  Fly   963 LIETEKSQTGGVEFAVYKHYIKSVGIFLSVATLVLNFVF----QAFQIGSNLWLTQW-------- 1015
            |:..|.:|.|.|.:..|..|.::.|.::.:..:||.|..    .||   ||.||:.|
Zfish   765 LVTREVAQEGSVTWRTYHQYCQAAGGYILLFLVVLLFTLLVGSTAF---SNWWLSYWLDQGSGNN 826

  Fly  1016 ------ANDQNVANDTGLRDMYLGVYGAFGFGQGVLAYFAVVIVYLGGF-------QAAKTIHNE 1067
                  :|..|::.:..| ..|..||       ||:....:|:..|.|:       :::..:|:.
Zfish   827 SSSNATSNSGNISENPDL-SFYQMVY-------GVIIIAMIVLSILKGYTFTKVTLRSSSKLHDT 883

  Fly  1068 LLAVIIRGSVCRFFDITPIGRLLNSFSGDMDVVDEELPATMDSFMTFIFMVLATIVVISLSTPIF 1132
            :...|: ||...|||.||.|||:|.||.|.|.||..||..|::|:.|..:|..|::.|.:..|..
Zfish   884 MFKRIL-GSPMSFFDTTPTGRLVNRFSKDQDEVDAVLPFNMENFLQFCLIVTFTLLTICIVFPFL 947

  Fly  1133 LAVIVPIAFLYYFAQRFYV--ATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEES 1195
            |..:|.:..:  ||...||  .:.|.:.|:|:|||||..|..:.|:.|.|||.||:...::||..
Zfish   948 LIAVVILGLI--FATILYVFQRSIRHMKRMENVSRSPWISLTTSTIQGLSTIHAYDKRQQYIERF 1010

  Fly  1196 DAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAVLG-GQT-NPGLVGLSVSYALQVTQ 1258
            ....|.|...........|||:..|:::...:.|..|||.||. .:| ||.|.||::||.:|:|.
Zfish  1011 KMLSDNNSNHFMLFNAGTRWLSFWLDVLSATVTLIVSLFVVLSPNETINPSLKGLALSYTIQLTG 1075

  Fly  1259 TLNWLVRMSSDIETNIVSVERIKEY-GETKQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYREG 1322
            .|.::||:|:::|....||||:.|| .....|.|..: :|.|.|..|||||.:.|:|:.:|||:.
Zfish  1076 ILQFVVRLSTEVEAKFTSVERLLEYITSCVSEGPRRV-KDANIPAGWPQEGTITFKNYSMRYRDN 1139

  Fly  1323 LDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRL 1387
            ..:||..::..|:.|||:|||||||:|||||.:||||:.|.|.|.|.||.:||..:||..|||:|
Zfish  1140 TPIVLDNLNITIRPGEKLGIVGRTGSGKSSLGVALFRLAEPAEGTILIDDMDICKLGLKDLRSQL 1204

  Fly  1388 TIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQR 1452
            ::||||||||.|::|.|||||....|:|:|.|||.:::|..:..|...|...:.|.|||.|||:|
Zfish  1205 SVIPQDPVLFIGTVRYNLDPFNNYKDEELWLALEKTYMKDTISKLPEKLQSPVVENGENFSVGER 1269

  Fly  1453 QLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVL 1517
            ||:|:||||||.:|:::||||||::|.|||.|||.|||..|:.||:||||||:||:|:||:::|:
Zfish  1270 QLMCMARALLRNSKIILLDEATASIDSETDSLIQHTIRDGFQHCTMLTIAHRINTVLESDRILVM 1334

  Fly  1518 DKGQIIEFASPTELLDNPKSAFYSMAKDANLV 1549
            |:|::|||..|.:|:..|.|.|.|:...||.|
Zfish  1335 DQGKVIEFDPPQDLIQRPNSLFASLLAAANQV 1366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	513/1459 (35%)
		ABC_membrane	338..601	CDD:279056	72/263 (27%)
		ABCC_MRP_domain1	649..848	CDD:213217	111/221 (50%)
		ABC_membrane	988..1260	CDD:279056	95/300 (32%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	120/219 (55%)
abcc12	XP_009301629.1	CFTR_protein	68..1366	CDD:273530	499/1390 (36%)
		ABC_membrane	149..414	CDD:294371	79/301 (26%)
		ABCC_MRP_domain1	457..677	CDD:213217	111/221 (50%)
		ABC_membrane	809..1077	CDD:294371	92/281 (33%)
		ABCC_MRP_domain2	1125..1345	CDD:213211	120/219 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586091
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0000087
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.660