DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MRP and abcc6a

DIOPT Version :9

Sequence 1:	NP_723772.2	Gene:	MRP / 34686	FlyBaseID:	FBgn0032456	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	XP_009300481.1	Gene:	abcc6a / 566555	ZFINID:	ZDB-GENE-050517-18	Length:	1507	Species:	Danio rerio

Alignment Length:	1557	Identity:	696/1557 - (44%)
Similarity:	986/1557 - (63%)	Gaps:	66/1557 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 MDRFCG----STFWNATETWYTNDPDFTPCFEQTALVWTPCAFYWAFVIFDFYYLKASLDRNIPW 69
            ||.||.    ...|:..:||||:.|:.:.||:.|.|||.||.:.|....|...:|.......:|.
Zfish     1 MDTFCSLSGLDPLWDWNQTWYTHRPELSNCFQNTVLVWAPCIYLWVLSPFYCLHLYCHGRGRLPL 65

  Fly    70 NKLNVSKALVNLGLLVITALDLIMALVKKGGDSELPLYDLDVWGPIIKFATFLLLFIFIPLNRKY 134
            :.|..:|.|:...|.....::....|:::  ..|:..:.:.:..||::..|.:|....|...|..
Zfish    66 SSLCNAKLLLGFFLASFGFVEFFYILLER--RLEIHQHLVFLLSPIMRSLTVVLAVCVIHWERVR 128

  Fly   135 GVQTTGCQFIFWFLLTVLSIPRCRTEVRLDAERQKILNSQQPSEQDFSWEEYQFVSFFIFFTFTS 199
            |.:::...|.||.|..:.||.....:|:|..            ||..|.:..::::||.:|....
Zfish   129 GCRSSVFLFFFWLLGVLCSIIPLHAKVQLAV------------EQGLSPDIVRYLAFFSYFALQL 181

  Fly   200 IMLILNCFADGMPRQTKYQRGENEIPELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQD 264
            ..|.|:||||..|......:  |..|...|||||:|.:.||..:..||||:||:.:|||.||.:|
Zfish   182 AQLFLSCFADQAPLGKAVHK--NACPVQDASFLSKILFWWFSGLIFKGYRSPLQAEDLWSLREED 244

  Fly   265 SCSEVMPIFAHHWNQNVRKNYKNKARVEPKAQFSNGNVTFENPHGEKNGRK--KGMAS---IMPP 324
            :...::......|.....|..:.:..:...|...:     ..|...:..||  |..:|   ::..
Zfish   245 TSERIISDLEEEWTAKRTKLQQQENHMSTSAALGS-----RLPDQAQLLRKIQKEQSSGFCLLRT 304

  Fly   325 IYKSFGGVFLFGALMKLFTDTLTFAQPQVLSLIISFVEAQDAEPEWKGILYAVLLFVLAAAQTFI 389
            :.:|||..||.|.|..:..|...|:.||||||::.|::.:|. |.|||..||.|:|:|:..|:..
Zfish   305 LARSFGPYFLTGTLCLIVHDVFMFSVPQVLSLLLGFMKDEDT-PLWKGYFYATLMFLLSCLQSVF 368

  Fly   390 LGQYFHRMFIVGLRIRTALINAIYRKALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIW 454
            ..||.:..|.||:|::||::..:|||:|.:::|.::..||||||||::.|.|:.|:...|.|.:|
Zfish   369 NHQYTYTCFTVGMRVKTAVMGLVYRKSLVMNSSARRTCTVGEIVNLVSADTQKLMDFVVYFNAVW 433

  Fly   455 SAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLS 519
            .||:::.|.|:||||.||||.|||:|.:|.:.|:||.||.:....|..||||.|.|||||||:|:
Zfish   434 LAPIEVTLCLFFLWQHLGPSALAGIATVIFIFPLNGFIARKRSKLQEIQMKYMDGRVKLMNEILN 498

  Fly   520 GIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVLTSEAN 584
            |||:||.||||.:|.:|||..|:||:.||:.:..|.:.:...::.:.||::...|..|||..:.|
Zfish   499 GIKILKFYAWEKAFLEQVLGYREKELKTLKKSQILYSVSLASFNSSSFLIAFAMFGVYVLIDDKN 563

  Fly   585 QLSVEKVLVSIALFDLMKLPLTILPMLSVDIAETQVSVNRINKFLNSEELDPNSVLHDSSKPHPM 649
            .|..:|:.||:||.:::|.||:.||.......:..||:.|:.|||..:||.|::|..:|.|....
Zfish   564 VLDAQKIFVSMALINILKTPLSQLPFAMSTTMQALVSLKRLGKFLCQDELKPDNVARESFKSDVD 628

  Fly   650 SI--ENGEFSWGDE--ITLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVVNTVGK 710
            .:  :||.|||..:  ..|:.|:::|..|||||:||.|||||||::.|.|||.||.:|.|:..|.
Zfish   629 GVVFDNGTFSWSKDGPPCLKRISVKVPCGSLVAVVGHVGSGKSSLLSAMLGETEKRSGTVSVKGS 693

  Fly   711 LAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQ 775
            :||||||||||||:::||||||:......|.:|::||||..|:|.|.|||.|||||||:||||||
Zfish   694 IAYVPQQAWIQNASLQDNILFGREKKESWYQRVLEACALLPDLDNLPAGDATEIGEKGLNLSGGQ 758

  Fly   776 KQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDS 840
            |||:|||||||...|:|||||||||||||||:|||.:||||||||..|:|||||||::||||.|.
Zfish   759 KQRVSLARAVYRKGDVYLLDDPLSAVDAHVGQHIFNKVIGPKGILRDKTRVLVTHGMSFLPQADL 823

  Fly   841 IYVIKMGEISESGTFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKRQISSTADVPELLGTVEK 905
            |.|:..|||||.|::.:|:...|||||||  |....:|.:|..::..::.|            .|
Zfish   824 ILVLVDGEISERGSYQELLNRNGAFADFI--HTFANSERKECFSEALQRGS------------RK 874

  Fly   906 AIKLARTESLSDSISVTSADSLMGGG-GSLRRRTKRQDSHDSVASAASLKKKQEVEGKLIETEKS 969
            :::|:.|:.:..|..: |.:.|:||. .|:..........|.:         .|..|||.:.:|:
Zfish   875 SVRLSVTDYMPFSRDL-SQEQLIGGDTNSIAIEPLPDSDEDHI---------PEDLGKLTKVDKA 929

  Fly   970 QTGGVEFAVYKHYIKSVGIFLSVATLVLNFVFQAFQIGSNLWLTQWANDQNVANDTGLR-DMYLG 1033
            :.|.|:..:|..|.:::|:.|.::.:.|....||..:.:|.||:.|| ||.|.|.|.|. |:.||
Zfish   930 RIGRVKLEMYIEYFRTIGLPLIISIVFLYAFQQAASLSNNYWLSLWA-DQPVINGTQLNTDLKLG 993

  Fly  1034 VYGAFGFGQGVLAYFAVVIVYLGGFQAAKTIHNELLAVIIRGSVCRFFDITPIGRLLNSFSGDMD 1098
            ||||.||.||:..:...|.:.||...|::.:|.:||..::. |...||:.||.|.|||.|:.::|
Zfish   994 VYGALGFAQGISIFGTTVAISLGCIIASRHLHLDLLNNVLH-SPMSFFESTPSGNLLNRFAKEID 1057

  Fly  1099 VVDEELPATMDSFMTFIFMVLATIVVISLSTPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESV 1163
            .:|..:|..:...:::.|.:....:::.::||....:|:|:.|||.|.|.||||||.||.|||||
Zfish  1058 AIDNMIPDGLKMMLSYFFKLTEVCIIVLMATPFAAVIILPMVFLYGFIQSFYVATSCQLRRLESV 1122

  Fly  1164 SRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLAIRLEMVGNLII 1228
            ||||||:|.:|||.|||.|||:|...|||..::.|||.||...:|..||.|||.:.||.:||.|:
Zfish  1123 SRSPIYTHLNETVQGASVIRAFNEQSRFIMGANHKVDHNQTAYFPRFIATRWLGVNLEFLGNGIV 1187

  Fly  1229 LFASLFAVLG-GQTNPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPW 1292
            |.||:.:|:. |..:||:|||:||::||||..|:|:||..:|:|.|||||||:|||.:|.:||.|
Zfish  1188 LAASILSVMAKGTLSPGMVGLAVSHSLQVTGFLSWIVRSWTDVENNIVSVERVKEYADTPKEAAW 1252

  Fly  1293 ELEQDKNKPKNWPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLAL 1357
            .:| ..:.|.:|||.|.:|||::.::||:||:|.|:|:|.:|...||:|||||||||||||.|.:
Zfish  1253 SIE-GSSLPPSWPQTGTIEFQDYGLQYRKGLELALKGISVHIHEREKIGIVGRTGAGKSSLALGI 1316

  Fly  1358 FRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALEL 1422
            |||:|||.|.|.|||::||.:|||.||||:|||||||||||||||:|||||...:|:|:|.||||
Zfish  1317 FRILEAAKGEIYIDGINIAEIGLHDLRSRITIIPQDPVLFSGSLRMNLDPFNAYSDEEVWNALEL 1381

  Fly  1423 SHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQK 1487
            :|||:||..|...||||.:|||||||:|||||||||||||||||||||||||||:|||||.|||.
Zfish  1382 AHLKNFVSELPDKLNHECSEGGENLSLGQRQLVCLARALLRKTKVLVLDEATAALDLETDTLIQS 1446

  Fly  1488 TIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAFYSMAKDANLV 1549
            |||::|::|.|||||||||||:|..||||:|||.::|..||:.|:.. :..||.|.::|.|:
Zfish  1447 TIRSQFEDCAVLTIAHRLNTIMDYTKVIVMDKGHVVEMDSPSNLIAK-RGQFYYMCREAGLL 1507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	691/1549 (45%)
		ABC_membrane	338..601	CDD:279056	116/262 (44%)
		ABCC_MRP_domain1	649..848	CDD:213217	126/202 (62%)
		ABC_membrane	988..1260	CDD:279056	121/273 (44%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	153/219 (70%)
abcc6a	XP_009300481.1	MRP_assoc_pro	5..1506	CDD:188098	692/1550 (45%)
		ABC_membrane	317..584	CDD:279056	117/267 (44%)
		ABCC_MRP_domain1	630..831	CDD:213217	126/200 (63%)
		ABC_membrane	955..1218	CDD:279056	119/264 (45%)
		ABCC_MRP_domain2	1267..1487	CDD:213211	153/219 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586071
Domainoid	1	1.000	229	1.000	Domainoid score	I2404
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0000087
OrthoInspector	1	1.000	-	-		otm24337
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	O	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X177
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.720