DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MRP and abcc9

DIOPT Version :9

Sequence 1:NP_723772.2 Gene:MRP / 34686 FlyBaseID:FBgn0032456 Length:1549 Species:Drosophila melanogaster
Sequence 2:XP_005164758.1 Gene:abcc9 / 561160 ZFINID:ZDB-GENE-050517-23 Length:1583 Species:Danio rerio


Alignment Length:1665 Identity:510/1665 - (30%)
Similarity:819/1665 - (49%) Gaps:308/1665 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    93 MALVKKGGDSELPLYDLD---------------VWGPIIKFATFLLLFIFIPLNRKYGVQTTGCQ 142
            |||...|.|.:...|.:|               |....:.|.||.:|||      .:|.|::..|
Zfish     1 MALSFCGNDRDSNAYSVDNGVLDNGCFVDALNLVPHVFLLFITFPILFI------GWGSQSSKVQ 59

  Fly   143 F------------IFWFL-LTVLSIPRCRTEVRLDAERQ---KILNSQQPSEQDF---------- 181
            .            :.|.| .|:|.:..|.....:.:..|   ..|:...|:...|          
Zfish    60 IHHNTWLHFPGHNMRWILTFTLLFVHVCEIAEGIVSNTQMESNHLHLFMPAFMGFIAATTSVVYY 124

  Fly   182 -SWEEYQF----VSFFIFF--TFTSIMLILNCFAD----------------------------GM 211
             :.|...|    ::.||::  .|.:.|:.|..||:                            .:
Zfish   125 HNIETANFPKLLLALFIYWILAFITKMIKLWKFAEASLGVQHLRFCITALLVVLYGLLMAVEINV 189

  Fly   212 PRQTKY------QRGE--NEIPELSASF-------LSRITYQWFDKMALKGYRNPLEEKDLWDLR 261
            .|..||      ||.:  .::.:|...|       ||:.||.|.:.:.:..::.|:|.|.:..| 
Zfish   190 IRVRKYVFFANPQRVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNPLIIGAHKRPIELKKIGKL- 253

  Fly   262 PQDSCSEVMPIFAHHWNQNVRKNYKNKARVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIY 326
                     ||        ..:...|..|::...:....|.  |:|  ||:      .||...:|
Zfish   254 ---------PI--------AMRALTNYLRLKDSYEEQRQNT--EDP--EKS------PSIWKSMY 291

  Fly   327 KSFGGVFLFGALMKLFTDTLTFAQPQVLSLIISFV-EAQDAEPEWK------GILY--------- 375
            ::|||..|..:..:...|.|.||.|..:|.|:..: .:.:.:...|      |:.:         
Zfish   292 RAFGGSILLSSTFRYMADLLGFAGPLCISGIVEHLHNSTEIDRTNKTGNMTFGVYFMSSTELLQN 356

  Fly   376 ----AVLLFV-LAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKALRI--SNSTKKESTVGEIV 433
                |||||: |...:||:...|:..: ..|:.:|.||:..||.|.||:  ||.:..|.|:|:|.
Zfish   357 TSVLAVLLFLALVLQRTFLQASYYVTI-ETGINLRGALLAMIYNKILRLSTSNMSMGEMTLGQIN 420

  Fly   434 NLMAVDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKT 498
            ||:|::..:.|........:|:.|:||.:.:..|:..||.|.|.|..|:::|.||..:||:::..
Zfish   421 NLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYYLLGNSALIGAGVILLLAPVQYLIATKLAD 485

  Fly   499 YQIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWS 563
            .|...:.|..:|:|...|:|.|||:|||||||..|..:|.:.|.||:.:|::.|...:.:.|:.:
Zfish   486 IQKSTLDYSTDRLKKTTEILKGIKLLKLYAWENIFCDRVEETRGKELTSLKTFALHTSMSIFMNA 550

  Fly   564 CAPFLVSLVTFATYVLTSEANQLSVEKVLVSIALFDLMKLPLTILPMLSVDIAETQVSVNRINKF 628
            ..|....|.||.|:....| ::||..|...|:|||.::..||.:|..:.....:..|||.::::|
Zfish   551 AIPIAAVLATFVTHAYIEE-DRLSPAKAFASLALFHILVTPLFLLSTVVRFAVKALVSVQKLSEF 614

  Fly   629 LNSEELDPNS-------------------------------------------VLHDSSKPHPMS 650
            |.|:|:..:|                                           :....::...:.
Zfish   615 LQSDEIGDDSWRNGDMCMSLEVGKKYKYQGDTKAINRKGRYRMDNYEQPVRRQLRPSETEDVAVQ 679

  Fly   651 IENGEFSWGDEI-TLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVV--------- 705
            :.:|.|:||..: ||.:|||.:..|.|..:||.||.||||::.|.||||:.::|.|         
Zfish   680 VNDGFFTWGSNLSTLSDINIRIPTGQLTMIVGQVGCGKSSLLLAMLGEMQTISGKVYWSKLPDCE 744

  Fly   706 -----NTVG---------------KLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALR 750
                 |..|               .:||..|::|:.||||.:||.||..::::||..|||||:|:
Zfish   745 ILFDGNISGHDMELSHEERSKNRYSVAYATQKSWLLNATVEENITFGSPFNKQRYKAVIDACSLQ 809

  Fly   751 ADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIG 815
            .|||:|..||.|||||:||||||||:|||.:|||:|.:.::..||||.||:|.|:..|:.:|   
Zfish   810 PDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQE--- 871

  Fly   816 PKGILA-----RKSRVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFADFIIQHLQE 875
              |||.     :::.|||||.:.:|...|.|..:|.|.:...||               ::.:|.
Zfish   872 --GILKFLQDDKRTVVLVTHKLQYLIHADWIIAMKDGSVLREGT---------------LKDIQT 919

  Fly   876 GNEEEEE-----LNQIKRQISSTADVPELLGTVEKAIKLARTESLSDSISVTSADSLMGGGGSLR 935
            .:.|..|     :|:..:::....|: |...|:|:.                          :||
Zfish   920 HDVELYEHWKTLMNRQDQELEKDTDL-ESQTTLERK--------------------------TLR 957

  Fly   936 RRTKRQDSHDSVASAASLKKKQEVEGKLIETEKSQTGGVEFAVYKHYIKSVG---IFLSVATLVL 997
            |....:::.:.|......::.:|.:...:.|..|:...:.:.:...|:.|.|   :||.|::.:.
Zfish   958 RAFYSREAKNHVDDEDEEEEVEEEDDDNMSTTTSRRSKIPWKMCCCYLSSGGFLMVFLMVSSKLA 1022

  Fly   998 NFVFQAFQIGSNLWLTQWA----NDQNVANDT---GLRD---------MYLGVYGAFGFGQGVLA 1046
            .   .:..:..:.||..|.    ::|:..|.:   .|.|         .|:.|:.........|.
Zfish  1023 K---HSVMVAIDYWLAAWTSSNPHNQSFVNSSFNHTLNDDATQIAEHRSYVPVFIILCAAAIALC 1084

  Fly  1047 YFAVVIVYLGGFQAAKTIHNELLAVIIRGSVCRFFDITPIGRLLNSFSGDMDVVDEELPATMDSF 1111
            ....:.|...|..||..:|:.||..||...: ||||:||:|::||.||.|.:::|:.:|.|::|.
Zfish  1085 LITSLTVEFLGVAAATNLHHNLLNKIIHAPI-RFFDVTPLGQILNRFSADTNIIDQHIPPTLESL 1148

  Fly  1112 MTFIFMVLATIVVISLSTPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETV 1176
            .....:.|:.|.||:..||.||..:||:|..:||.|:::...|:.|..|:..::.|:..|||||.
Zfish  1149 TRSTLLCLSAIGVIAFVTPAFLIALVPLAVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETA 1213

  Fly  1177 TGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAVLGGQT 1241
            .|.:||||:....||.:......|.|.........|||||.:|.:.:|.:|:|.|::.|:  ..|
Zfish  1214 EGLTTIRAFRHEARFKQRMLELTDTNNTAYLFLSAANRWLEVRTDYLGAVIVLTAAVAAI--WST 1276

  Fly  1242 NP-GLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKNK-PKNW 1304
            :| |||||.::|||.:|..|||:||..:|:|..:.:|:::..:..|:.| .:|...|.:: |::|
Zfish  1277 SPSGLVGLGLTYALTLTNYLNWVVRNLADLEVQMAAVKKVNSFLSTESE-NYEGSMDVSQVPEDW 1340

  Fly  1305 PQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRIS 1369
            ||.|.:...:..|||...|..||:.|:.:|..|:||||.||||:|||||:||.|.:::...|:|.
Zfish  1341 PQHGEITIHDLCVRYDSMLKPVLKHVNAHINPGQKVGICGRTGSGKSSLSLAFFNMVDVFEGKIV 1405

  Fly  1370 IDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAA 1434
            |||:||..:.|..|||||:||.|||||||||:|:||||....|||.:|:|||::.||:.||:|..
Zfish  1406 IDGIDICKLPLQTLRSRLSIILQDPVLFSGSIRLNLDPERTCTDDRLWEALEIAQLKNMVKALPG 1470

  Fly  1435 GLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVL 1499
            ||:..:.|||||.|||||||.|||||.:||:.:|::|||||::|:.|::::||.:.|.|.:.||:
Zfish  1471 GLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVV 1535

  Fly  1500 TIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAF 1539
            ||||.:::||::::|:|...|.::|..|...||....|.|
Zfish  1536 TIAHLVSSILEAEQVLVFSSGILVENDSAINLLAQEDSLF 1575

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MRPNP_723772.2 MRP_assoc_pro 14..1548 CDD:188098 510/1665 (31%)
ABC_membrane 338..601 CDD:279056 90/285 (32%)
ABCC_MRP_domain1 649..848 CDD:213217 96/233 (41%)
ABC_membrane 988..1260 CDD:279056 92/288 (32%)
ABCC_MRP_domain2 1308..1528 CDD:213211 112/219 (51%)
abcc9XP_005164758.1 CFTR_protein 223..1575 CDD:273530 467/1435 (33%)
ABC_membrane 304..591 CDD:294371 90/288 (31%)
ABCC_SUR1_N 678..907 CDD:213257 96/233 (41%)
ABC_membrane 1045..1300 CDD:294371 89/257 (35%)
ABCC_SUR2 1269..1583 CDD:213255 145/310 (47%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170585998
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
54.650

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