DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MRP and abcc8

DIOPT Version :9

Sequence 1:	NP_723772.2	Gene:	MRP / 34686	FlyBaseID:	FBgn0032456	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	XP_005170744.1	Gene:	abcc8 / 553281	ZFINID:	ZDB-GENE-050517-22	Length:	1594	Species:	Danio rerio

Alignment Length:	1719	Identity:	517/1719 - (30%)
Similarity:	816/1719 - (47%)	Gaps:	316/1719 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DTSSPMDRFCG----STFWNATETWYTNDPDFTPCFEQTALVWTPCAFYWAFVIFDFYYL----- 59
            ||:..: .|||    |..:|.......|.     || ..||...|..|. .|:.|...::
Zfish    11 DTTMSL-AFCGNDNNSAAYNVDAGVLNNG-----CF-LDALTVVPHVFL-LFITFPILFIGWGSQ 67

  Fly    60 --KASL---------DRNIPWNKLNVSKALVNLGLLVITALDLIMALVKKGGDSELPLYDLDVWG 113
              |..:         ..|:.|        ::...||.:|..::...:|..|.:..:.|:   ::.
Zfish    68 SSKVHIHHSTWLHFPGHNLRW--------ILTFILLFVTVCEIAEGIVSDGFNQSVHLH---LYM 121

  Fly   114 P-IIKFATFLLLFIFIPLNRKYGVQTTG------CQFIFWFLLTVLSIPRCRTEVRLDAERQKIL 171
            | .:.|...:...|:.     :.::|:.      ...|:|.|..|                .|.:
Zfish   122 PSCLAFMAAITSIIYY-----HNIETSNFPKLLITLLIYWVLAFV----------------SKTI 165

  Fly   172 NSQQPSEQDFSWEEYQFVSFFIFFTFTSIMLILN----------CFADGMPRQTKYQRGENEIPE 226
            ...:.:|......:.:|....:......::|.:.          |||    ..|:.:..| ::.:
Zfish   166 KFAKYTEHGIGLRQLRFGITGLLTLLYGLLLAVEINVIFSRRYMCFA----HATEVKPPE-DLQD 225

  Fly   227 LSASF-------LSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHHWNQNVRKN 284
            |...|       ||:.||.|.:......:|.|::.|.:..|          ||     ......|
Zfish   226 LGVRFLQPFVNLLSKSTYWWMNTFITSAHRRPIDLKVIGRL----------PI-----AMRALTN 275

  Fly   285 YKNKARVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGALMKLFTDTLTFA 349
            |....:            .||...|.::...:|...|...:.::||...:.....:...|.|.||
Zfish   276 YIKLRQ------------AFEAQKGPQDTPPQGSKWIWAALRQAFGKPLILSITYRFMADLLGFA 328

  Fly   350 QPQVLSLIIS-------------------FVEAQDAEPEWKGILYAVLL-FVLAAAQTFILGQYF 394
            .|..:|.|:.                   |:.:|:...  .|.:.|||| |.|...:||:...|:
Zfish   329 GPLCISGIVHHLSKENHTILPPVKHLGMYFISSQEFLA--NGYVLAVLLFFALLLQRTFLQASYY 391

  Fly   395 HRMFIVGLRIRTALINAIYRKALRI--SNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAP 457
            ..: ..|:.:|.|:...|:.|.:|:  ||.:....|||:|.||:|:|..:.|........:::.|
Zfish   392 VAI-ETGINLRGAIQTKIFNKIMRLCTSNLSMGGMTVGQICNLVAIDTNQLMWFFFLCPNLFAMP 455

  Fly   458 LQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIK 522
            :||.:.:..|:..||.|.|.|..::.:|.||...:|:::...|...::|..||:|..||:|.|||
Zfish   456 VQIIVGIILLYYLLGISALIGATIITLLAPVQYFVATKLSDAQKSTLEYSSERLKKTNELLRGIK 520

  Fly   523 VLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVLTSEANQLS 587
            :|||||||..|...|.:.|.||:.:|::.|...:.:.|:.:..|....||||..:|..|:...||
Zfish   521 LLKLYAWEHIFCSNVEETRCKELTSLQAFALYTSISIFMNTAIPIAAVLVTFVAHVHLSDDADLS 585

  Fly   588 VEKVLVSIALFDLMKLPLTILPMLSVDIAETQVSVNRINKFLNSEELD----------PNSVLHD 642
            ......|::||.::..||.:|..:.....:..|||.::::|.:.:|:.          |||..|:
Zfish   586 PAVAFASLSLFHILVTPLFLLSSVVRSTVKALVSVQKLSEFFSCDEIGGEQEPRATVVPNSTNHN 650

  Fly   643 SSKPHPM------------------------------------SIENGEFSWGD-EITLRNINIE 670
            ..:..|:                                    .|.||.|||.: ..||.|:||:
Zfish   651 KYQALPLKVVNRKRPVREDWNSFALQSEQEDEVLAVGDEDICIKITNGYFSWTEGTSTLSNVNIK 715

  Fly   671 VKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVV--NTV-----------------------GK 710
            :..|.|..:||.||.||||::.|.||||:|::|.|  |.:                       |.
Zfish   716 IPFGQLTMIVGQVGCGKSSLLLAALGEMQKISGTVIWNRMPTLDAEGNESLPDAAAEGDIRKRGA 780

  Fly   711 LAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQ 775
            :||..|:.|:.|.|:.:||.|.....::||..||:||:|:.|||||..||.|.|||:||.|||||
Zfish   781 VAYASQKPWLLNTTLAENITFEMPLIKQRYRAVIEACSLQPDIDILPQGDQTIIGERGIILSGGQ 845

  Fly   776 KQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGIL-----ARKSRVLVTHGVTFL 835
            :||||:|||:|...::..||||.||:|.|:..|:.:|     |||     .:::.|:|||.:.:|
Zfish   846 RQRISVARALYQTTNVVFLDDPFSALDIHLSDHLMQE-----GILKLLREEKRTVVIVTHKLQYL 905

  Fly   836 PQVDSIYVIKMGEISESGTFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKRQISSTADVPELL 900
            |..|.|..:|.|.|...||...:.|::                                  |||.
Zfish   906 PHADWIIAMKDGSIQTEGTLKDIQKSQ----------------------------------PELF 936

  Fly   901 ----GTVEKAIKLARTESLSDSISVTSADSLMGGGGSLRRRTKRQDSHDSVASAASLKKKQEVEG 961
                ..:.:..|....|::.::::|            |.|:..|:    ::.|..:||.:::.|.
Zfish   937 EQWKTLMHRQDKEFEKETVDENMTV------------LERKNLRR----AMYSREALKTEEDEEE 985

  Fly   962 KLIETEK----SQTGGVEFAVYKH-----------YIKSVGIFLSVATLVLNFVFQAFQIGSNLW 1011
            :.:|::.    ||       |.:|           |:.|.|:.|.:..|:...:..:..:..:.|
Zfish   986 ESLESDDDDNLSQ-------VMRHRATIPWRSCGTYLSSAGLLLLLLLLLSQLLKHSLLVAIDYW 1043

  Fly  1012 LTQW------------ANDQNVANDTGL-RDMYLGVYGAFGFGQGVLAYFAVVIVYLGGFQAAKT 1063
            |..|            |::.::..|.|. ...||.|:........||.....|.|...|.:.||.
Zfish  1044 LAHWTSKVITAKIDAAAHNCSLVQDIGFTHSSYLLVFSLLCCLGIVLCLATSVAVEWTGLRVAKE 1108

  Fly  1064 IHNELLAVIIRGSVCRFFDITPIGRLLNSFSGDMDVVDEELPATMDSFMTFIFMVLATIVVISLS 1128
            :|:.||:.||...: |.|:.||:|.:||.||.|.:.:|:.:|||::.......:.::.:.|||..
Zfish  1109 LHHNLLSNIILAPM-RLFETTPLGSILNRFSSDTNTIDQHIPATLECLSRSTLLCVSALGVISYV 1172

  Fly  1129 TPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIE 1193
            ||:||.|:.|:....||.|:::...|:.|.:||..::.|:.|||||||.|.:||||:....||.:
Zfish  1173 TPVFLIVLAPLTIACYFIQKYFRVASKDLQQLEDSTQLPLLSHFSETVEGLTTIRAFRYEPRFRQ 1237

  Fly  1194 ESDAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAV---LGGQTNPGLVGLSVSYALQ 1255
            ......|.|.:.......|||||.:|:|.:|..|:|.|::.::   |....:.|||||.::|||.
Zfish  1238 RLLQFTDANNMASLFLTAANRWLEVRMEYIGACIVLIAAVASITNSLYSHLSTGLVGLGLTYALM 1302

  Fly  1256 VTQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYR 1320
            |:..|||:||..:|:|..:.:|:|||....|:.|....|......|:.|||:|.::.||..|||.
Zfish  1303 VSNYLNWMVRNLADMEVQLGAVKRIKALLRTEPENYEGLLSASQVPEGWPQQGEIQIQNLSVRYD 1367

  Fly  1321 EGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRS 1385
            ..|..||:.|:.:|:.|:|:||.||||:||||.:||.||:::...|||.||.:|||.:.|..|||
Zfish  1368 STLKPVLKHVNAHIKPGQKLGICGRTGSGKSSFSLAFFRMVDTFEGRIIIDDIDIAKLPLQTLRS 1432

  Fly  1386 RLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVG 1450
            |.:||.|||.||||::|.||||....||..:|:|||::.||..||:|..||:..|.|||||.|.|
Zfish  1433 RFSIIQQDPFLFSGTIRFNLDPEMKATDSMLWEALEIAQLKPVVKTLPGGLDAIITEGGENFSQG 1497

  Fly  1451 QRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVI 1515
            ||||.|||||.:||:.:|::|||||::|:.|:.::||.:.|.|.:.||:|||||::|||::|.||
Zfish  1498 QRQLFCLARAFVRKSSILIMDEATASIDMATESILQKVVMTAFADRTVVTIAHRVHTILNADLVI 1562

  Fly  1516 VLDKGQIIEFASPTELLDNPKSAFYSMAK 1544
            |:.:|.|:||..|..|||...|.|.|..:
Zfish  1563 VMKRGVILEFDKPEVLLDQEDSVFASFVR 1591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	513/1709 (30%)
		ABC_membrane	338..601	CDD:279056	87/284 (31%)
		ABCC_MRP_domain1	649..848	CDD:213217	95/265 (36%)
		ABC_membrane	988..1260	CDD:279056	91/287 (32%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	116/219 (53%)
abcc8	XP_005170744.1	MRP_assoc_pro	39..1591	CDD:188098	509/1683 (30%)
		ABC_membrane	<388..603	CDD:294371	69/215 (32%)
		P-loop_NTPase	693..918	CDD:304359	95/229 (41%)
		ABC_membrane	1038..1307	CDD:279056	89/269 (33%)
		P-loop_NTPase	1355..1594	CDD:304359	123/237 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586048
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.650