DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MRP and abcc2

DIOPT Version :9

Sequence 1:	NP_723772.2	Gene:	MRP / 34686	FlyBaseID:	FBgn0032456	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	NP_956883.2	Gene:	abcc2 / 393561	ZFINID:	ZDB-GENE-040426-1523	Length:	1567	Species:	Danio rerio

Alignment Length:	1595	Identity:	761/1595 - (47%)
Similarity:	1057/1595 - (66%)	Gaps:	93/1595 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SSPMDRFCGSTFWNATETWYTNDPDFTPCFEQTALVWTPCAFYWAFVIFDF--YYLKASLDRNIP 68
            ::.:|::|||.|||:: .....|||...|.|:|.|||.|.||.|....|.|  :..|::   ..|
Zfish     2 TAALDKYCGSVFWNSS-FLQREDPDLPVCVERTVLVWLPLAFLWICSPFHFRSFCQKSA---KAP 62

  Fly    69 WNKLNVSKALVNLGLLVITAL-DLIMALVKKGGDSELPLYDLDVW-GPIIKFAT---FLLLFIFI 128
            .:.|...|.:| .|||::||: :|.:.|    |:...|..|.|.. .|.:.:..   |.:.:|.:
Zfish    63 ASALYYCKQVV-AGLLLLTAVAELAVTL----GEDFGPSSDEDAQKNPAVLYTNPVLFAVSWIVV 122

  Fly   129 PL-----NRKYGVQTTGCQFIFWFLLTVLSIPRCRTEVRLDAERQKILNSQQPSEQDFSWEEYQF 188
            .|     ..:.....:|..|:||.|..|.::.:.:|.:| :|..|.|  |..|          :|
Zfish   123 MLCQESMRHRLMCVDSGSLFMFWLLQVVCAVFQFQTLLR-EALSQGI--SDVP----------RF 174

  Fly   189 VSFFIFFTFTSIMLILNCFADGMPRQTKYQRGENEIPELSASFLSRITYQWFDKMALKGYRNPLE 253
            ..|:|.:....|.|:|:..||..|...|.....   ||..|:||||||:.||:.|..||::.||.
Zfish   175 CLFYISYGLQIIALVLSAIADVSPEAKKVAETN---PEAKATFLSRITFNWFNSMVWKGFKRPLV 236

  Fly   254 EKDLWDLRPQDS----CSEVMPIFAHHWNQ---NVRKNYKNKARVEPKAQFSNG-------NVTF 304
            ::|:|||...||    |.....:.|....:   |::|. |:|.|....|:..||       :|..
Zfish   237 QEDMWDLNKNDSTHFICQTFEDVMAKELKKARNNLQKK-KSKKRKTVDAEGQNGLAKGVSQDVLV 300

  Fly   305 ENPHGEKNGRKK------------GMASIMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQVLSLI 357
            .....||..:||            ..:.::..|.|||.||.|..||.||..|.|:||.||:|.|:
Zfish   301 METETEKESKKKKKKKQKDSDSDYPQSWLVTTIVKSFKGVLLESALFKLLQDLLSFASPQLLKLM 365

  Fly   358 ISFVEAQDAEPEWKGILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKALRISNS 422
            |:|.:.:|:. .|.|.||||||.::|..|:.:|.|||.|.||:|:::|||::.|:|:|||.:||.
Zfish   366 IAFTQNKDSY-AWTGYLYAVLLVLVAFVQSVVLQQYFQRCFILGMKVRTAIMAAVYKKALVVSND 429

  Fly   423 TKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIP 487
            ::||||.|||||||:.|||||.::|.:::::||.||||.|::.|||.:||||||:||.||::::|
Zfish   430 SRKESTAGEIVNLMSADAQRFNDVTNFIHLLWSCPLQIALSIAFLWIELGPSVLSGLLVMVLMVP 494

  Fly   488 VNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTA 552
            :||.:|::.:.:|::.||:||.|:|::|::|:|||:||.||||.|||.||.:||:||:..:|..|
Zfish   495 INGWLATKSRQFQMQNMKFKDSRMKIVNDLLNGIKILKYYAWETSFEAQVQEIREKELKVMRKFA 559

  Fly   553 YLNAGTSFLWSCAPFLVSLVTFATYVLTSEANQLSVEKVLVSIALFDLMKLPLTILPMLSVDIAE 617
            ||::.::|::||||.||||.|||.:|..|..|.|..||...||:||::::.||.:||.|...:.:
Zfish   560 YLSSVSTFIFSCAPALVSLATFAVFVSVSPDNILDAEKAFTSISLFNILRFPLAMLPQLISIMVQ 624

  Fly   618 TQVSVNRINKFLNSEELDPNSVLHDSSKPHPMSIENGEFSW--GDEITLRNINIEVKKGSLVALV 680
            |.||..|:.|||:.::||..:|.||||....:|:.||.::|  ..|..|:.:::::|.|.|||:|
Zfish   625 TSVSKKRLEKFLSGDDLDTTTVTHDSSITAAVSMTNGTYAWERDTEPVLKRVSLDIKPGRLVAVV 689

  Fly   681 GTVGSGKSSVVQAFLGEMEKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVID 745
            |.|||||:|:|.|.|||:..:.|.:|..|.:|||||||||||||::||||||.:.|.:||..||.
Zfish   690 GAVGSGKTSLVSALLGELHSIKGNININGSVAYVPQQAWIQNATLKDNILFGSSVDEERYQSVIK 754

  Fly   746 ACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIF 810
            ||||..|:|:|...|.|||||||||||||||||:||||||||.||:|||||||||||:|||||:|
Zfish   755 ACALGPDLDLLPGRDQTEIGEKGINLSGGQKQRVSLARAVYSSADVYLLDDPLSAVDSHVGKHLF 819

  Fly   811 EEVIGPKGILARKSRVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFADFIIQHLQE 875
            |:||||.|:|..|:|:|:|||::|||.||.|.|:..|.:||.|:::.|..:||||::|:..:
Zfish   820 EKVIGPNGLLRDKTRILITHGISFLPYVDEIVVLVHGVVSEIGSYESLRASKGAFSEFLETY--- 881

  Fly   876 GNEEEEELNQIKRQISSTADVPELLGTVEKAIKLARTESLSDSISVTSADSLMGGGGSLR---RR 937
            |.:|..:.|. |:..::...|.|.:.|:.:.::.....|..|.:|     |.:....|||   |.
Zfish   882 GKDESNKDND-KKAAAAQTPVYEEIETLPEGLETQADGSPEDIVS-----STLKRENSLRHSQRH 940

  Fly   938 TKRQDSHDSVASAASLKKKQEVEGK----LIETEKSQTGGVEFAVYKHYIKSVGIFLSVATLVLN 998
            :||..| ..|...:||:.:::.|.|    |||.|..:||.|:|:||..|:.::|.:....:.|..
Zfish   941 SKRNGS-VKVRKNSSLRAQKDPEDKKGQRLIEKEMMETGRVKFSVYLQYLSAMGWWYVGFSFVFY 1004

  Fly   999 FVFQAFQIGSNLWLTQWANDQ----NVANDTGLRDMYLGVYGAFGFGQGVLAYFAVVIVYLGGFQ 1059
            |:.....||.||||:.|.:|.    |......:||..:||:||.|..||.|.:|..:::..|...
Zfish  1005 FIQNVAVIGQNLWLSDWTDDSIEYFNQTYPNHIRDTRIGVFGALGLAQGFLVFFGTILLADGSIS 1069

  Fly  1060 AAKTIHNELLAVIIRGSVCRFFDITPIGRLLNSFSGDMDVVDEELPATMDSFMTFIFMVLATIVV 1124
            |::|:|..||..|::..: .|||.||.||::|.|:.|:..|||.:|.:..|::..:..||.|:.|
Zfish  1070 ASRTLHTSLLTNILKVPM-MFFDTTPSGRIVNRFAKDIFTVDEMIPMSFRSWILCLLGVLGTLFV 1133

  Fly  1125 ISLSTPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGD 1189
            |.|:||||.||:||:|.:|||.|||||||||||.||:|||||||||||.|||:|.|.||||...|
Zfish  1134 ICLATPIFTAVVVPMAVVYYFVQRFYVATSRQLRRLDSVSRSPIYSHFGETVSGLSVIRAYGHQD 1198

  Fly  1190 RFIEESDAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAVLGGQT-NPGLVGLSVSYA 1253
            ||::.::..:|:|....||.:::|||||:|||.:|||::.||:||||:...: |.||||||:|||
Zfish  1199 RFLKRNEHTIDQNLKSVYPWIVSNRWLAMRLESLGNLVVFFAALFAVISRDSLNSGLVGLSISYA 1263

  Fly  1254 LQVTQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKNKPKNWPQEGRVEFQNFQVR 1318
            |.|||||||||||:|::|||||:|||::||.|.:.||||  ......|.:||..|.:.|::::||
Zfish  1264 LNVTQTLNWLVRMTSELETNIVAVERVREYAEIQNEAPW--VTSVRPPDDWPSAGNIRFEDYKVR 1326

  Fly  1319 YREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHML 1383
            ||..|:|||.||:.:||..||:||||||||||||||..||||:|||.|||.||.:|||::|||.|
Zfish  1327 YRPELELVLHGVTCDIQSTEKIGIVGRTGAGKSSLTNCLFRIVEAADGRILIDDIDIATLGLHDL 1391

  Fly  1384 RSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLS 1448
            ||||||||||||||||:||:|||||:..:|.|||..|||:|||.:|:.|..||.||::|||||||
Zfish  1392 RSRLTIIPQDPVLFSGTLRMNLDPFQTFSDAEIWSVLELAHLKEYVRGLPTGLEHEVSEGGENLS 1456

  Fly  1449 VGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDK 1513
            :|||||:|||||||||:::|:|||||||||||||||||.|||.||..||||||||||||||||.:
Zfish  1457 LGQRQLLCLARALLRKSRILILDEATAAVDLETDDLIQSTIRREFSHCTVLTIAHRLNTILDSSR 1521

  Fly  1514 VIVLDKGQIIEFASPTELLDNPKSAFYSMAKDANL 1548
            |:|||.|:|:||.||.|||..| ..|.|||:||.:
Zfish  1522 VMVLDSGKIVEFDSPNELLSKP-GHFSSMAEDAGI 1555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	759/1585 (48%)
		ABC_membrane	338..601	CDD:279056	136/262 (52%)
		ABCC_MRP_domain1	649..848	CDD:213217	123/200 (62%)
		ABC_membrane	988..1260	CDD:279056	133/276 (48%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	156/219 (71%)
abcc2	NP_956883.2	MRP_assoc_pro	10..1555	CDD:188098	759/1585 (48%)
		ABC_membrane	346..612	CDD:294371	136/266 (51%)
		ABCC_MRP_domain1	656..856	CDD:213217	123/199 (62%)
		ABC_membrane	1001..1270	CDD:279056	133/269 (49%)
		ABCC_MRP_domain2	1316..1536	CDD:213211	156/219 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586113
Domainoid	1	1.000	260	1.000	Domainoid score	I1931
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0000087
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	O	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X177
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.760