Protein Alignment MRP and abcc4

DIOPT Version :10

• Sequence 1: NP_723772.2
• Gene: MRP / 34686
• FlyBaseID: FBgn0032456
• Length: 1549
• Species: Drosophila melanogaster
• Sequence 2: NP_001007039.2
• Gene: abcc4 / 368620
• ZFINID: ZDB-GENE-030616-511
• Length: 1331
• Species: Danio rerio
• Alignment Length: 1367
• Identity: 511/1367 - (37%)
• Similarity: 755/1367 - (55%)
• Gaps: 143/1367 - (10%)

  Fly   225 PELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHHWNQNVRKNYKNKA 289
            |..||:..|:|.:.|.:.:...|.:..|||.|::::.|:|...::......:|:|.     |.||
Zfish    16 PSASANLFSQIFFCWLNPLFSIGSKRRLEEDDMFNVLPEDRSKKLGEELQSYWDQE-----KEKA 75

  Fly   290 RVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFG--GVFLFGALMKLFTDTLTFAQPQ 352
            ..|.|.                   .|...:|:...:||:.  |||      .|..:::...||.
Zfish    76 AKELKT-------------------PKLTKAIIRCYWKSYAVLGVF------TLIEESIKVIQPV 115

  Fly   353 VLSLIISFVE-----AQDAEPEWKGILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAI 412
            .|..:|.:.|     ...|..|..|....|.|..|..|....|  ||:.:...|::||.|:.:.|
Zfish   116 FLGKLIKYFENYRHDDMAALSEAYGYATGVCLSTLGLALLHHL--YFYHVQRAGMKIRIAMCHMI 178

  Fly   413 YRKALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLA 477
            |||||.:|.:...::|.|:||||::.|..:|.|||.:|:.:|..|||....:..|||::|||.||
Zfish   179 YRKALCLSAAAMGQTTTGQIVNLLSNDVNKFDELTIFLHFLWVGPLQAAAVIGLLWQEIGPSCLA 243

  Fly   478 GLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRD 542
            |:||::.|:|:..:.......|:.:.....|.|::.||||:|||:::|:||||..|...|.|:|.
Zfish   244 GMAVLVFLMPLQTMFGKLFSKYRSKTAALTDSRIRTMNEVVSGIRIIKMYAWEKPFAMLVNDVRR 308

  Fly   543 KEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVLTSEANQLSVEKVLVSIALFDLMKLPLTI 607
            |||:.:.|::||.......:..|..::..|||..|||.  .|.:|..:|.|:::|:..::|.:|:
Zfish   309 KEISKIMSSSYLRGLNMASFFTANKIILFVTFTVYVLV--GNTMSASRVFVAVSLYSAVRLTVTL 371

  Fly   608 -LPMLSVDIAETQVSVNRINKFLNSEELDPNSV-LHDSSKPHPMSIENGEF--SWG---DEITLR 665
             .|.....::|:.:|:.||.|||..:||..|.: |....|..| |:|..:.  .|.   |..||:
Zfish   372 FFPAAIEKVSESAISIRRIKKFLLLDELVKNHLPLSQEEKKEP-SVEMQDLICYWDKTLDAPTLQ 435

  Fly   666 NINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVVNTVGKLAYVPQQAWIQNATVRDNIL 730
            |:...||.|.|:|::|.||:||||::...|||:....||:...|:|.|..||.|:...|:|.|||
Zfish   436 NVCFTVKPGQLLAVIGPVGAGKSSLLSTVLGELPAEKGVIKVKGELTYASQQPWVFPGTIRSNIL 500

  Fly   731 FGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLD 795
            ||:....:||.:|:.||||:.|:::|..||||.||::|..||||||.|::||||||.|||:||||
Zfish   501 FGKELQPQRYERVLRACALKRDMELLPDGDLTVIGDRGATLSGGQKARVNLARAVYQDADIYLLD 565

  Fly   796 DPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVK 860
            ||||||||.|.:|:||:.:  .|||..|.|:||||.:.:|...:.|.|:|.|.:...|::.:|.:
Zfish   566 DPLSAVDAEVSRHLFEQCV--CGILKDKPRILVTHQLQYLKAANQILVLKEGHMVARGSYSELQQ 628

  Fly   861 NKGAFADFIIQHLQEGNEEEEELNQIKRQISSTADVPELLGTVEKAIKLARTESLSDSISVTSAD 925
            :...|...:      ..:||||..      |...:.|.
Zfish   629 SGLDFTSLL------KKDEEEESG------SEKGEAPR--------------------------- 654

  Fly   926 SLMGGGGSLRRRTKRQD---SHDSVASAASLK-KKQEVEGKLIET---EKSQTGGVEFAVY-KHY 982
                   |.|.||..|:   ||.|  |..|:| ...::..:.:.|   |....|.:...:| |::
Zfish   655 -------SPRSRTVSQNSVRSHSS--SVLSVKDDSDQLPAEPVHTMAEELRSEGNIGIRMYWKYF 710

  Fly   983 IKSVGIFLSVATLVLNFVFQAFQIGSNLWLTQWANDQ---------------NVANDTGLRDM-- 1030
            .....:.:.|..|:||.:.|.|.|..:.||:.||.:|               :..|.|...|:
Zfish   711 RAGANVVMLVLLLLLNLLAQTFYILQDWWLSYWATEQEKLDHNTNNTNTNNTSAGNTTQQLDLNF 775

  Fly  1031 YLGVY----GA---FGFGQGVLAYFAVVIVYLGGFQAAKTIHNELLAVIIRGSVCRFFDITPIGR 1088
            |||:|    ||   |||.:.::.:.|:|       .:|:.:||.:...|:|..| |||||.||||
Zfish   776 YLGIYAGLTGATIVFGFMRCLIMFNALV-------SSAEMLHNRMFNSILRTPV-RFFDINPIGR 832

  Fly  1089 LLNSFSGDMDVVDEELPATMDSFMTFIFMVLATIVVISLSTPIFLAVIVPIAFLYYFAQRFYVAT 1153
            :||.||.|:..:|..||.|...|:.....::..|.|.|...|..|..::|:...:.|.:|:::.|
Zfish   833 ILNRFSKDIGHLDSLLPWTFVDFIQVFLQIVGVIAVASSVIPWILIPVLPLLICFLFLRRYFLRT 897

  Fly  1154 SRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLAI 1218
            ||.:.|:||.:|||::||.|.::.|..||||:...:||.:..||..|.:....:..:..:||.|:
Zfish   898 SRDVKRIESTTRSPVFSHLSSSLQGLWTIRAFKAEERFQQTFDAHQDLHSEAWFLFLTTSRWFAV 962

  Fly  1219 RLEMVGNLIILFASLFAVLGGQT-NPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKE 1282
            ||:.:.::.:...:...:|...| |.|.|||::|||:.:.....|.||.|:::|..:.||||:.|
Zfish   963 RLDGMCSVFVTITAFGCLLLKDTMNAGDVGLALSYAVTLMGMFQWGVRQSAEVENMMTSVERVVE 1027

  Fly  1283 YGETKQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTG 1347
            |.|.:.|||||.:  |....:||..|.:.|......|.....:||:.:|...:..||||||||||
Zfish  1028 YTELESEAPWETQ--KRPSPDWPNRGLITFDRVNFSYSSDGPVVLKNISAMFRPREKVGIVGRTG 1090

  Fly  1348 AGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKT 1412
            ||||||..||||:.|.. |:|.:|||..:.:|||.||.:::|||||||||:|::|.|||||...:
Zfish  1091 AGKSSLISALFRLSEPE-GKILVDGVLTSEIGLHDLRQKMSIIPQDPVLFTGTMRKNLDPFNQHS 1154

  Fly  1413 DDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAAV 1477
            |.::|||||...||:.|:.|...|..|:||.|.|.|||||||||||||:|||.:||::|||||.|
Zfish  1155 DHDLWKALEEVQLKAAVEELPGKLETELAESGSNFSVGQRQLVCLARAILRKNRVLIIDEATANV 1219

  Fly  1478 DLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAFYSM 1542
            |..||:|||||||.:||||||||||||||||:|||:::|||.|:|.|:.:|..||.|....||.|
Zfish  1220 DPRTDELIQKTIRDKFKECTVLTIAHRLNTIIDSDRILVLDAGRIHEYDAPHVLLQNQSGIFYKM 1284

  Fly  1543 AK 1544
            .:
Zfish  1285 VQ 1286

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	511/1367 (37%)
abcc4	NP_001007039.2	MRP_assoc_pro	11..1289	CDD:188098	511/1367 (37%)