DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MRP and ABCC6

DIOPT Version :9

Sequence 1:	NP_723772.2	Gene:	MRP / 34686	FlyBaseID:	FBgn0032456	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	XP_024306029.1	Gene:	ABCC6 / 368	HGNCID:	57	Length:	1515	Species:	Homo sapiens

Alignment Length:	1589	Identity:	603/1589 - (37%)
Similarity:	898/1589 - (56%)	Gaps:	120/1589 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SSPMDRFCGSTFWNATETWYTNDPDFTP----CFEQTALVWTPCAFYWA----FVIFDFYYLKAS 62
            ::|.:...|...||.||.    :|..|.    ||.:||.||.|..:.|.    :::|..::.:..
Human     2 AAPAEPCAGQGVWNQTEP----EPAATSLLSLCFLRTAGVWVPPMYLWVLGPIYLLFIHHHGRGY 62

  Fly    63 LDRNIPWNKLNVSKAL---------VNLGLLVITALDLIMALVK-KGGDSELP--LYDLDVWGPI 115
            | |..|..|..:..|:         :...|:|:....:.:||.| :.|..|.|  |....||...
Human    63 L-RMSPLFKAKMVAAIPGSLEPGNVLGFALIVLCTSSVAVALWKIQQGTPEAPEFLIHPTVWLTT 126

  Fly   116 IKFATFLLLFIFIPLNRKYGVQTTGCQFIFWFLLTVLSIPRCRTEVRLDAERQKILNSQQPSEQD 180
            :.||.||     |...||.|||::|..|.:|.|..||.....               :||.|...
Human   127 MSFAVFL-----IHTERKKGVQSSGVLFGYWLLCFVLPATNA---------------AQQASGAG 171

  Fly   181 FSWEEYQFVSFFIFFTFTSIMLILNCFADGMPRQTKYQRGENEIPELSASFLSRITYQWFDKMAL 245
            |..:..:.:|.::..:......:|:|.||..|...:..:..|..||..|:|.|:.|:.|...:..
Human   172 FQSDPVRHLSTYLCLSLVVAQFVLSCLADQPPFFPEDPQQSNPCPETGAAFPSKATFWWVSGLVW 236

  Fly   246 KGYRNPLEEKDLWDLRPQDSCSEVMPIFAHHWNQNVRKNYKNKARVEPKA-QFS-NGNVTFENPH 308
            :|||.||..||||.|..::|..|::......|.:|     ::.||...|| .|. .|....:.|.
Human   237 RGYRRPLRPKDLWSLGRENSSEELVSRLEKEWMRN-----RSAARRHNKAIAFKRKGGSGMKAPE 296

  Fly   309 GEKNGRKKG--MASIMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQVLSLIISFVEAQDAEPEWK 371
            .|...|::|  ...::..|::.|...||.|.|..:.:|...|..|::|||.:.|: .....|.||
Human   297 TEPFLRQEGSQWRPLLKAIWQVFHSTFLLGTLSLIISDVFRFTVPKLLSLFLEFI-GDPKPPAWK 360

  Fly   372 GILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKALRISNSTKKESTVGEIVNLM 436
            |.|.|||:|:.|..||....|..:|:.::.:|:|:|:...:|||.|.:|:.::|.|.||::|||:
Human   361 GYLLAVLMFLSACLQTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLV 425

  Fly   437 AVDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQI 501
            :||.||..|...|||.:|...:.|.:...:|||.||||.|..:||.:.|:|:|..|:.:...:|.
Human   426 SVDVQRLTESVLYLNGLWLPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQE 490

  Fly   502 RQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAP 566
            .||:.||.|.:|.:.:|...|.:|.:.||.:|..:||.||.:|:..||::..|.:.:...:..:.
Human   491 EQMRQKDSRARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVST 555

  Fly   567 FLVSLVTFATYVLTSEANQLSVEKVLVSIALFDLMKLPLTILPMLSVDIAETQVSVNRINKFLNS 631
            |||:||.||.:.|.:| |.::.||..|::.:.:::......||.....:.:.:||.:|:..||..
Human   556 FLVALVVFAVHTLVAE-NAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCL 619

  Fly   632 EELDPNSVLHDSSKPHP------MSIENGEFSWGDEI--TLRNINIEVKKGSLVALVGTVGSGKS 688
            ||:||..|  |||....      ::|.:..|:|..|.  .|..||:.|.:|.|:|:||.||:|||
Human   620 EEVDPGVV--DSSSSGSAAGKDCITIHSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKS 682

  Fly   689 SVVQAFLGEMEKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADI 753
            |::.|.|||:.|:.|.|:..|.:|||||:||:||.:|.:|:.|||..|.....:|::||||:.|:
Human   683 SLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDV 747

  Fly   754 DILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKG 818
            |....|..|.|||:|:|||||||||:|||||||..|.:|||||||:|:|||||:|:|.:||||.|
Human   748 DSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGG 812

  Fly   819 ILARKSRVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFADFIIQHLQEGNEEEEEL 883
            :|...:|:||||.:..|||.|.|.|:..|.|:|.|::.:|::.|||....:.|..|.|:..|.|
Human   813 LLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALMCLLDQARQPGDRGEGE- 876

  Fly   884 NQIKRQISSTADVPELLGTVEKAIKLARTESLSDSISVTSADSLMGGGGSLRRRTKRQDSHDSVA 948
                                        ||      ..||.....|.....|...:|:.|..||.
Human   877 ----------------------------TE------PGTSTKDPRGTSAGRRPELRRERSIKSVP 907

  Fly   949 SAASLKKKQEVEGKLIETEKS---------QTGGVEFAVYKHYIKSVGIFLSVATLVLNFVFQAF 1004
            .......:.:.|..|.:.:::         |.|.|:..|:..|:::||..|.:..|   |:|...
Human   908 EKDRTTSEAQTEVPLDDPDRAGWPAGKDSIQYGRVKATVHLAYLRAVGTPLCLYAL---FLFLCQ 969

  Fly  1005 QIGS---NLWLTQWANDQNVANDTGLRDMYLGVYGAFGFGQGVLAYFAVVIVYLGGFQAAKTIHN 1066
            |:.|   ..||:.||:|..|........:..|::|..|..|.:..:.::..|.|||.:|::.:..
Human   970 QVASFCRGYWLSLWADDPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGARASRLLFQ 1034

  Fly  1067 ELLAVIIRGSVCRFFDITPIGRLLNSFSGDMDVVDEELPATMDSFMTFIFMVLATIVVISLSTPI 1131
            .||..::|..: .||:.||||.|||.||.:.|.||.::|..:.|.:.:.|.:|...:|::::||:
Human  1035 RLLWDVVRSPI-SFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPL 1098

  Fly  1132 FLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESD 1196
            ....|:|:..||...|..||.:|.||.||||.|.|.:.||.:||..|::.:||:.....|:.:::
Human  1099 ATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNN 1163

  Fly  1197 AKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAVLG-GQTNPGLVGLSVSYALQVTQTL 1260
            |:||::|...:|.::|:||||..:|::||.::..|:..|||. ...:.||||.|||.||||||||
Human  1164 ARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAALQVTQTL 1228

  Fly  1261 NWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYREGLDL 1325
            .|:||..:|:|.:||||||:::|..|.:||||.|.....:|. |||.|::||::|.:|||..|.|
Human  1229 QWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPP-WPQGGQIEFRDFGLRYRPELPL 1292

  Fly  1326 VLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTII 1390
            .::||||.|..|||||||||||||||||...|.|:.|||.|.|.||||.||.:|||.||||::||
Human  1293 AVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISII 1357

  Fly  1391 PQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLV 1455
            ||||:||.||||:|||..:..:|:.||.|||...||:.|.||...|.::.|:.||:|||||:||:
Human  1358 PQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLL 1422

  Fly  1456 CLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKG 1520
            ||||||||||::|:|||||||||..|:..:|..:.:.|.:||||.|||||.:::|..:|:|:|||
Human  1423 CLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKG 1487

  Fly  1521 QIIEFASPTELLDNPKSAFYSMAKDANLV 1549
            |:.|..||.:||.. |..||.:|:::.||
Human  1488 QVAESGSPAQLLAQ-KGLFYRLAQESGLV 1515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	600/1578 (38%)
		ABC_membrane	338..601	CDD:279056	95/262 (36%)
		ABCC_MRP_domain1	649..848	CDD:213217	104/200 (52%)
		ABC_membrane	988..1260	CDD:279056	99/275 (36%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	128/219 (58%)
ABCC6	XP_024306029.1	SunT	14..1514	CDD:331423	599/1574 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151600
Domainoid	1	1.000	166	1.000	Domainoid score	I3886
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0000087
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	O	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X177
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.710