DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MRP and ABCB5

DIOPT Version :9

Sequence 1:NP_723772.2 Gene:MRP / 34686 FlyBaseID:FBgn0032456 Length:1549 Species:Drosophila melanogaster
Sequence 2:NP_001157413.1 Gene:ABCB5 / 340273 HGNCID:46 Length:1257 Species:Homo sapiens


Alignment Length:1423 Identity:311/1423 - (21%)
Similarity:560/1423 - (39%) Gaps:354/1423 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   279 QNVRKNYKNKARVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFGG----VFLFGALM 339
            :.:::||:.....|.:.:.                ||:.:.||  .|::...|    :.:.|.|.
Human     8 EEMQENYQRNGTAEEQPKL----------------RKEAVGSI--EIFRFADGLDITLMILGILA 54

  Fly   340 KLFTDTLTFAQPQVL-----SLII------------SFVEAQDAEPE--------WKGILYAVLL 379
            .|.........|.||     :||.            :..::|:...|        :.||..|.|:
Human    55 SLVNGACLPLMPLVLGEMSDNLISGCLVQTNTTNYQNCTQSQEKLNEDMTLLTLYYVGIGVAALI 119

  Fly   380 F---------VLAAAQT-FILGQYFHRMFIVGL---------RIRTALINAIYRKALRISNSTKK 425
            |         :.||.|| .|..|:||.:....:         .:.|.:.:.|          .|.
Human   120 FGYIQISLWIITAARQTKRIRKQFFHSVLAQDIGWFDSCDIGELNTRMTDDI----------DKI 174

  Fly   426 ESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLA----LYFLWQQLGPSVLAGLAV---MI 483
            ...:|:.:.|:      |..::|:     |..|.:||.    |..:.....|.::|..|.   |:
Human   175 SDGIGDKIALL------FQNMSTF-----SIGLAVGLVKGWKLTLVTLSTSPLIMASAAACSRMV 228

  Fly   484 ILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIK-VLKLYAWEPSFEKQVLDIRD-KEIA 546
            |     .:.:..:..|        .:...:..||||.|: |:...|.|...::...:::| |:..
Human   229 I-----SLTSKELSAY--------SKAGAVAEEVLSSIRTVIAFRAQEKELQRYTQNLKDAKDFG 280

  Fly   547 TLRSTA----------YLNA--GTSFLWSCAPFLVSLVTFATYVLTSEANQLSVEKVLVSIALFD 599
            ..|:.|          ::|.  |.:| |           :.|.::.:.....::..||.  ..|.
Human   281 IKRTIASKVSLGAVYFFMNGTYGLAF-W-----------YGTSLILNGEPGYTIGTVLA--VFFS 331

  Fly   600 LMKLPLTILPMLSVDIAETQVSVNRINKFLNSEELDPNSVLHDSSKP--HPMSIE------NGEF 656
            ::.....|  ..:|...|| .::.|...|...:.:|....:.:.|..  .|.|||      |..|
Human   332 VIHSSYCI--GAAVPHFET-FAIARGAAFHIFQVIDKKPSIDNFSTAGYKPESIEGTVEFKNVSF 393

  Fly   657 SWGDEIT---LRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVV----NTVGKL--- 711
            ::....:   |:.:|:.:|.|..|||||..|||||:|||......:...|.:    |.:..|   
Human   394 NYPSRPSIKILKGLNLRIKSGETVALVGLNGSGKSTVVQLLQRLYDPDDGFIMVDENDIRALNVR 458

  Fly   712 ------AYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDL--------- 761
                  ..|.|:..:...|:.:||.:|:       :.|.|....||..: .:|.|.         
Human   459 HYRDHIGVVSQEPVLFGTTISNNIKYGR-------DDVTDEEMERAARE-ANAYDFIMEFPNKFN 515

  Fly   762 TEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVI--GPKGILARKS 824
            |.:||||..:||||||||::|||:..:..:.:||:..||:|:. .|...:..:  ..||    ::
Human   516 TLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSE-SKSAVQAALEKASKG----RT 575

  Fly   825 RVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFADFII-QHLQEGNEEEEELNQIKR 888
            .::|.|.::.:...|.|..:|.|.::|.|...:|:..:|.:...:: |.:::.:|:.|.:..   
Human   576 TIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQDIKKADEQMESMTY--- 637

  Fly   889 QISSTADVPELLGTVEKAIKLARTESLSDSISVTSADSLMGGGGSLRRRTKRQDSHDSVASAASL 953
                                  .||..::|:.:.|..|:            :.|..|....:...
Human   638 ----------------------STERKTNSLPLHSVKSI------------KSDFIDKAEESTQS 668

  Fly   954 KKKQEVEGKLIETEKSQTGGVEFAVYKHYIKSVGIFLSVATLVLN-FVFQAFQIGSNLWLTQWAN 1017
            |:....|..|::..|.......|.|           |.....||| .|...|.|.....:|.:.|
Human   669 KEISLPEVSLLKILKLNKPEWPFVV-----------LGTLASVLNGTVHPVFSIIFAKIITMFGN 722

  Fly  1018 DQ--NVANDTGLRDMYLGVYGAFGFGQGVLAYFAVVIVY--LGGFQAAKTIHNELLAVIIRGSVC 1078
            :.  .:.:|..:..|...:.|...|    ::||...:.|  .|.....:..|....|::      
Human   723 NDKTTLKHDAEIYSMIFVILGVICF----VSYFMQGLFYGRAGEILTMRLRHLAFKAML------ 777

  Fly  1079 RFFDITPIGRLLNSFSGDMDVVDEELPATMDSFMTFIFMVLATI---------VVISLSTPIFLA 1134
             :.||.......||..|               ..|.:.:.:|.|         |:...:|.:.|:
Human   778 -YQDIAWFDEKENSTGG---------------LTTILAIDIAQIQGATGSRIGVLTQNATNMGLS 826

  Fly  1135 VIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFS---------------------ETVTG 1178
            ||  |:|:|.:...|.:.:...::.:..:..:...:.|:                     .|:..
Human   827 VI--ISFIYGWEMTFLILSIAPVLAVTGMIETAAMTGFANKDKQELKHAGKIATEALENIRTIVS 889

  Fly  1179 ASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFA-------SLFAV 1236
            .:..:|:   ::..||. .:.......|...:|.:.:      ...:..|.||       ..:.:
Human   890 LTREKAF---EQMYEEM-LQTQHRNTSKKAQIIGSCY------AFSHAFIYFAYAAGFRFGAYLI 944

  Fly  1237 LGGQTNPG---LVGLSVSY-ALQVTQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPW----- 1292
            ..|:..|.   :|..:::| |:.:.:||             :::    .||.:.|..|..     
Human   945 QAGRMTPEGMFIVFTAIAYGAMAIGETL-------------VLA----PEYSKAKSGAAHLFALL 992

  Fly  1293 -------ELEQDKNKPKNWPQEGRVEFQNFQVRYREGLDL-VLRGVSFNIQGGEKVGIVGRTGAG 1349
                   ...|:..||...  ||.:||:.....|....|: :|||:|.:|:.|:.|..||.:|.|
Human   993 EKKPNIDSRSQEGKKPDTC--EGNLEFREVSFFYPCRPDVFILRGLSLSIERGKTVAFVGSSGCG 1055

  Fly  1350 KSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINL---DPFEIK 1411
            ||:....|.|:.:...|::..||||...:.:..|||::.|:||:||||:.|:..|:   |...:.
Human  1056 KSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVV 1120

  Fly  1412 TDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAA 1476
            ..|||.:|...:::.||::.|....|.::...|..||.||:|.:.:|||||:|.|:|:|||||:|
Human  1121 PLDEIKEAANAANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSA 1185

  Fly  1477 VDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDN 1534
            :|.:::.::|..:.......|.|.:.|||:.|.::|.::||..|:|.|..:..|||.|
Human  1186 LDNDSEKVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRN 1243

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MRPNP_723772.2 MRP_assoc_pro 14..1548 CDD:188098 311/1423 (22%)
ABC_membrane 338..601 CDD:279056 60/327 (18%)
ABCC_MRP_domain1 649..848 CDD:213217 66/231 (29%)
ABC_membrane 988..1260 CDD:279056 51/317 (16%)
ABCC_MRP_domain2 1308..1528 CDD:213211 80/223 (36%)
ABCB5NP_001157413.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..24 3/15 (20%)
PTZ00265 8..1251 CDD:240339 311/1423 (22%)
ABC_membrane 52..333 CDD:279056 60/328 (18%)
ABC_MTABC3_MDL1_MDL2 386..623 CDD:213216 68/249 (27%)
ABC_membrane 696..962 CDD:279056 48/303 (16%)
ABC_MTABC3_MDL1_MDL2 1016..1254 CDD:213216 83/228 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.000

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