DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MRP and wu:fb13g09

DIOPT Version :9

Sequence 1:	NP_723772.2	Gene:	MRP / 34686	FlyBaseID:	FBgn0032456	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	XP_009289330.1	Gene:	wu:fb13g09 / 336563	ZFINID:	ZDB-GENE-030131-8507	Length:	1393	Species:	Danio rerio

Alignment Length:	1436	Identity:	486/1436 - (33%)
Similarity:	738/1436 - (51%)	Gaps:	216/1436 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 ENEIPELSASFLSRITYQWFDKMALKGYRNP-LEEKDLWDLRPQDSCSEVMPIFAHHWNQNVRKN 284
            :::.|..:|.|.|.:|.||...:|.:.:::. |:.:|:|.|    ||.|.              :
Zfish    57 KHQHPVDNAGFFSFMTLQWLSPLAWRAHKDSCLKMEDVWGL----SCHEA--------------S 103

  Fly   285 YKNKARVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGALMKLFTDTLTFA 349
            ..|..|:|...            |.|...|.|..||:....::......|......|.|....|.
Zfish   104 ETNCQRLEWLW------------HEELKRRGKDGASLSRVFWRFCQTRMLVAIFSLLITMVAGFV 156

  Fly   350 QPQVL-SLIISFVEAQDAEPEWKGILYAVLL----FVLAAAQTFILGQYFHRMFIVGLRIRTALI 409
            .|.:| ..::.|.:..:.:     :||.:.|    |::...:::.|...:...:....|:|.|.:
Zfish   157 GPALLIRALLEFSQCSEVK-----LLYGLALVAGIFLMELTRSWSLAFMWAINYRTAARLRGAAL 216

  Fly   410 NAIYRKALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPS 474
            ...::|.||: .|||..|: ||:||:.|.|.||..|..:...::...||...|.|.:....|||:
Zfish   217 TFAFQKILRL-RSTKDVSS-GELVNICASDGQRLYEAVSVGCLLAGGPLVGMLGLTYTTYFLGPT 279

  Fly   475 VLAGLAVMIILIPVNGVIASRIKTY-QIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVL 538
            .|.|.|:.||..|.. ::|||:..| :.:.:...|.||:||||:|..:|.:|:|.||..|...:.
Zfish   280 ALVGSAIFIIFYPTM-MLASRMTAYFRKKCVAVTDRRVRLMNEILGCMKFIKMYCWETPFANNIQ 343

  Fly   539 DIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVL-TSEANQLSVEKVLVSIALFDLMK 602
            .:|.:|   .|:..:.....|.....||.:|.:.:..|:.| .:....|:..:....:|:|:.|.
Zfish   344 KVRSEE---RRNLEWAGCVQSLTLGVAPVVVVIASVCTFTLHMALGYDLTAAQAFTVVAVFNSMT 405

  Fly   603 LPLTILPMLSVDIAETQVSVNRINKF--------------------------------------- 628
            ..|.:.|:....::|..|:|.|..|.
Zfish   406 FALKVTPLAVRALSEGSVAVKRFQKLFMMEDRELISVKTEDPYNVVEFKDATLAWEKTCGSQTKK 470

  Fly   629 -------------LNSEEL--------------DPNS--VLHDSSKPHPMSIENGEFSWGDEI-- 662
                         |..|:|              :||:  :|....:..|.|..:...|....:
Zfish   471 SRTQLKRGGMKRVLRREKLSLYIITEENKGKIEEPNAEHLLTHMEQESPQSTISSTQSIRPPLHK 535

  Fly   663 TLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVVNTVGKLAYVPQQAWIQNATVRD 727
            ||..|::.::|||||.:.|.|||||||::.|.||:|..|.|.|:..|..|||.|||||.|.::|:
Zfish   536 TLHRIDLCIQKGSLVGVCGGVGSGKSSLLSALLGQMTLLGGSVSVNGGFAYVAQQAWILNDSLRE 600

  Fly   728 NILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLY 792
            |||||:.|:.::||.|::||.|..||..|..||:|||||:|.||||||:||:|||||:||:..:.
Zfish   601 NILFGKKYNEEKYNAVLEACCLFPDIIELPYGDMTEIGERGANLSGGQRQRVSLARALYSERPIL 665

  Fly   793 LLDDPLSAVDAHVGKHIFEEVIGP--KGILARKSRVLVTHGVTFLPQVDSIYVIKMGEISESGTF 855
            |||||||||||.||..:|...|.|  ||    |:.:.|||.:.:||:.|.:.::|.|:|:|.||.
Zfish   666 LLDDPLSAVDARVGSRLFHSAIRPAAKG----KTVIFVTHQLQYLPECDDVVLMKDGQIAEHGTH 726

  Fly   856 DQLVKNKGAFADFIIQHLQEGNEEEEELNQIKRQISSTADVPELLGTVEKAIKLARTESLSDSIS 920
            .||::....:|...       |..::| |.:::.:.:.          |||.|    ||...::.
Zfish   727 TQLMEKGRDYAALF-------NSVQQE-NLVRKNLKNK----------EKAEK----ESSPQTLH 769

  Fly   921 VTSADSLMGGGGSLRRRTKRQDSHDSVASAASLKKKQEVEGK----LIETEKSQTGGVEFAVYKH 981
            |::                              ..|.:.|.|    |::.|:..:|.|.:.||..
Zfish   770 VSN------------------------------PPKPDTESKKTDQLMQAEEKGSGAVAWPVYAA 804

  Fly   982 YIKSVGIFLSVATLVLNFVFQAFQIG-SNLWLTQWANDQN------VANDTGLRD-MYLGVYGAF 1038
            |||:.|..|:....:|.|:|....|. ||.||:.|....:      :.|:|...| |.|..:
Zfish   805 YIKAAGGPLAFIVTILLFLFTTGSIAFSNWWLSYWIRQGSGNSSLLLGNETAESDSMRLNPH--- 866

  Fly  1039 GFGQGVLAYFAVVIVYLGG----------------FQAAKTIHNELLAVIIRGSVCRFFDITPIG 1087
                 :..|..|.::.:|.                .:||..:|::|...::. |..||||.||:|
Zfish   867 -----IQYYSRVYVLSMGAALFLKTIRGLVFVKCTVRAASVLHDKLFKTLLL-SPMRFFDTTPLG 925

  Fly  1088 RLLNSFSGDMDVVDEELPATMDSFMTFIFMVLATIVVISLSTPIFLAVIVPIAFLYYFAQRFYVA 1152
            |:||.||.|||.||..|....:..:..:.:||..:.|:....|.||..|:|:....:...|....
Zfish   926 RILNRFSKDMDEVDVRLAMQAEMLLQNVTLVLFCLGVVGAVFPWFLFSIIPLGAFLFIVNRISRV 990

  Fly  1153 TSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLA 1217
            ..|:|.|||::|:||..||.:.::.|.|||.||..|..||....|.:|.||.|::....|.||||
Zfish   991 LIRELKRLENISQSPFTSHITSSLQGLSTIYAYGRGADFIHRYQALLDTNQACQFLFSCAMRWLA 1055

  Fly  1218 IRLEMVG-NLIILFASLFAVLGGQTNPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIK 1281
            :||:::. :||...|.|..::.|..:|...||::|||:|:|....:.||:.|:.|....|||||.
Zfish  1056 VRLDLISISLITTVALLIVLMHGHISPAYAGLALSYAVQLTGLFQFTVRLLSETEARFTSVERIN 1120

  Fly  1282 EY-GETKQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGR 1345
            .| ...:.|.|.::........:||.||::.||:.::|||:||.|||:.:.|:|...|.:|||||
Zfish  1121 HYIKNLESEGPRQITGCPTSSSSWPAEGQITFQDVEMRYRDGLPLVLKNLCFSILPEETIGIVGR 1185

  Fly  1346 TGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEI 1410
            ||:|||||.:||||:.|.:.|.|.||||:||.:||..|||:|::|||:||||.|::|.||||::.
Zfish  1186 TGSGKSSLGVALFRLAELSRGSIIIDGVNIAHIGLEDLRSKLSVIPQEPVLFIGTVRSNLDPWDQ 1250

  Fly  1411 KTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATA 1475
            .||.:||:|||.:|:|..|..|...|:.|:.:.|||.|||:|||:|:||||||.:|:|:||||||
Zfish  1251 YTDAQIWEALEKTHIKDMVSQLPNSLHSEVTDNGENFSVGERQLLCVARALLRHSKILLLDEATA 1315

  Fly  1476 AVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAFY 1540
            |:|.|||.|||.|||:.|..||.|.|||||||:|..::::|||:|||:||.:|:.||.:..|.|:
Zfish  1316 AIDTETDRLIQDTIRSSFSGCTTLVIAHRLNTVLGCNRIMVLDQGQILEFDTPSNLLTDENSRFH 1380

  Fly  1541 SMAKDA 1546
            :|.:.|
Zfish  1381 AMMEAA 1386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	486/1436 (34%)
		ABC_membrane	338..601	CDD:279056	73/269 (27%)
		ABCC_MRP_domain1	649..848	CDD:213217	100/202 (50%)
		ABC_membrane	988..1260	CDD:279056	94/296 (32%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	126/219 (58%)
wu:fb13g09	XP_009289330.1	SunT	61..1386	CDD:331423	485/1430 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585988
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0000087
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.760