Protein Alignment MRP and abcc3

DIOPT Version :9

• Sequence 1: NP_723772.2
• Gene: MRP / 34686
• FlyBaseID: FBgn0032456
• Length: 1549
• Species: Drosophila melanogaster
• Sequence 2: XP_009304645.1
• Gene: abcc3 / 323301
• ZFINID: ZDB-GENE-050517-16
• Length: 1540
• Species: Danio rerio
• Alignment Length: 1579
• Identity: 783/1579 - (49%)
• Similarity: 1046/1579 - (66%)
• Gaps: 79/1579 - (5%)

  Fly     9 MDRFCG--STFWNATETWYTNDPDFTPCFEQTALVWTPCAFYWAFVIFDFYYLKASLDRNIPWNK 71
            |:..||  ..||....|.|...||...||:.:.|.|.||.:.||.......:|:.:....|..:.
Zfish     1 MEHLCGPDKPFWELNLTLYGQQPDLPECFQMSVLSWAPCIYLWAAAPLYILHLRRNNRGYIMMSI 65

  Fly    72 LNVSKALVNLGLLVITALDLIMALVKKGGDSEL-PLYDLDVWGPIIKFATFLLLFIFIPLNRKYG 135
            ||..|.::.|.|.::...||..|..:....|:: |:|.:.   |:|...|.||....|...|..|
Zfish    66 LNRIKTVLGLILWIVCWTDLFSAFHQMNQGSKISPIYFVT---PLIVGMTMLLATFLIQFERLKG 127

  Fly   136 VQTTGCQFIFWFLLTVLSIPRCRTEVRLDAERQKILNSQQPSEQDFSWEEYQFVSFFIFFTFTSI 200
            ||::|..||||.|..|.:|...|:         ||:::.....:|    :.:|.:|:|:|:||.:
Zfish   128 VQSSGVLFIFWTLSVVFAIVPFRS---------KIMHANTEQVKD----KLRFTTFYIYFSFTLL 179

  Fly   201 MLILNCFADGMPRQTKYQRGENEIPELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDS 265
            .|||:||.:..|..:......|..||.:|.||||:|:.||.:||:|||::|||.||||.|...||
Zfish   180 ELILSCFNEKPPLFSSAVMDPNVCPETTAGFLSRMTFWWFTRMAIKGYKSPLENKDLWSLNKNDS 244

  Fly   266 CSEVMPIFAHHWNQNVRK-------NYKNKARVEPKAQFSNGNVTFENPHG-----EKNGRKKGM 318
            ...|:|...:.|.....|       |.|.:.........:..|...|:|..     .|..:|...
Zfish   245 SELVVPGLLNQWEVEKSKAHSSDDQNVKEQVTFTKPGSGAESNHVNESPEEAEVLLSKQQQKSRQ 309

  Fly   319 ASIMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQVLSLIISFVEAQDAEPEWKGILYAVLLFVLA 383
            .|.:..:.::||..||.|:..||..|.:||..||:|.::|:|.:..|. |.|.|...|.|:|..:
Zfish   310 PSFLWALLRAFGPYFLIGSAFKLLQDLITFINPQLLRMLIAFTKQSDV-PSWWGYALAFLMFGTS 373

  Fly   384 AAQTFILGQYFHRMFIVGLRIRTALINAIYRKALRISNSTKKESTVGEIVNLMAVDAQRFMELTT 448
            ..||.||.|:|...|:.|:|:||.:|.|||||||.|:|..|:.|||||:||||:|||||||:|||
Zfish   374 LLQTLILHQHFQYCFVTGMRLRTGIIGAIYRKALVITNEAKRSSTVGEVVNLMSVDAQRFMDLTT 438

  Fly   449 YLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKL 513
            :|||:|||||||.|||:||||.||||||||:|||::|||.|..||.:.:|||:.||||||:|:||
Zfish   439 FLNMLWSAPLQIFLALFFLWQNLGPSVLAGVAVMVLLIPFNAFIAMKTRTYQVEQMKYKDDRIKL 503

  Fly   514 MNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYV 578
            |||:|:||||||||||||||..::|.||.||:..||.||||:|.::..|:.|||||:|.:||.:|
Zfish   504 MNEILNGIKVLKLYAWEPSFRDKILQIRQKELHVLRKTAYLSALSTMAWTSAPFLVALTSFAVFV 568

  Fly   579 LTSEANQLSVEKVLVSIALFDLMKLPLTILPMLSVDIAETQVSVNRINKFLNSEELDPNSVLHDS 643
            ...|.|.|..||..||::||::::.||.:||.:...|.:..||:.|:..|||.:||||.||...|
Zfish   569 NVDEKNVLDAEKAFVSLSLFNILRFPLNMLPQVISSIVQASVSLKRLQDFLNHDELDPESVDRKS 633

  Fly   644 -SKPHPMSIENGEFSWG--DEITLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVV 705
             :..:.:|:.||:|||.  |::.|.|||:.|.:|||:|:||.||.||:|::.|.|||||||.|.:
Zfish   634 NTTEYAVSVVNGKFSWAKRDQVILDNINVLVPQGSLLAVVGHVGCGKTSLISALLGEMEKLDGQI 698

  Fly   706 NTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGIN 770
            :..|.:|||||||||||||:|||||||:.|..::|..|::||||..|:::|..||||||||||||
Zfish   699 SIRGSVAYVPQQAWIQNATLRDNILFGRPYVEQKYRCVLEACALTPDLEVLPGGDLTEIGEKGIN 763

  Fly   771 LSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFL 835
            |||||:||:|||||:||:||:||||||||||||||.||||:.||||:|.|..|:|:|||||::||
Zfish   764 LSGGQRQRVSLARALYSEADVYLLDDPLSAVDAHVAKHIFDHVIGPEGALKGKTRILVTHGISFL 828

  Fly   836 PQVDSIYVIKMGEISESGTFDQLVKNKGAFADFIIQHLQEG-----------NEEEEELNQIKRQ 889
            |||::|.|:..|.:||.|::..|::..||||:|:..:..|.           :|||||..:  ..
Zfish   829 PQVNNILVLVDGRVSEMGSYQDLLRQNGAFAEFLRNYSLEDIIEDDELTVSFDEEEEEFPE--DA 891

  Fly   890 ISSTADVPELLGTVEKAIKLARTESLSDSISVTSADSLMGGGGSLRRRTKRQDSHDSVASAASLK 954
            :|:..|:.:    .|..:..||.:.:. .:|:.|.|.......|.|||...:...::...    |
Zfish   892 LSNHTDMVD----NEPVVNEARRQFMR-QMSIMSNDVENPKKMSRRRRCSERKHPETPTE----K 947

  Fly   955 KKQEVEGKLIETEKSQTGGVEFAVYKHYIKSVGIFLSVATLVLNFVFQAFQIGSNLWLTQWANDQ 1019
            |:.:|| |||:.|.::||.|:..||..|:|::|..|::....|.....|..||:|.||::|.||.
Zfish   948 KEPKVE-KLIQAETTETGRVKLQVYWEYVKAIGPLLALFICFLYGCQSAAAIGANFWLSEWTNDA 1011

  Fly  1020 NVANDTGLRDMYLGVYGAFGFGQGVL---------AYFAVVIVYLGGFQAAKTIHNELLAVIIRG 1075
            .......:....:|||.|.|..||||         ||..:        :||:..|..:|..::|.
Zfish  1012 LHNRTQEMLQTRVGVYAALGISQGVLILSICLLCRAYSTL--------RAARHTHQHMLNSVLRA 1068

  Fly  1076 SVCRFFDITPIGRLLNSFSGDMDVVDEELPATMDSFMTFIFMVLATIVVISLSTPIFLAVIVPIA 1140
            ... ||:.||.||:||.||.|:|.:|..:|..:|.:|...:..:..::|.|:.|||||.||||:.
Zfish  1069 PQA-FFEATPSGRVLNRFSKDVDTIDSLIPDNIDIWMRTFWYTVNVLMVCSVLTPIFLIVIVPLM 1132

  Fly  1141 FLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVC 1205
            ..|::.|||||||||||.||||||||||||||||::||.|.||||.....|:..||.|||:||..
Zfish  1133 LFYWWVQRFYVATSRQLKRLESVSRSPIYSHFSESITGTSVIRAYGRNAAFVLMSDNKVDENQKS 1197

  Fly  1206 KYPSVIANRWLAIRLEMVGNLIILFASLFAVLG-GQTNPGLVGLSVSYALQVTQTLNWLVRMSSD 1269
            .||.:::||||.:|:|.:||.|:|||:||||.| .:.:|||||||||||||||.:|||:|||:||
Zfish  1198 YYPGIVSNRWLGVRIEFIGNCIVLFAALFAVTGKDKLSPGLVGLSVSYALQVTMSLNWMVRMTSD 1262

  Fly  1270 IETNIVSVERIKEYGETKQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYREGLDLVLRGVSFNI 1334
            :|:|||:|||:|||.||:.|||||: .:|..|.:||..|.|||.::.|||||||||||:.:|..:
Zfish  1263 LESNIVAVERVKEYSETQTEAPWEV-LEKKPPPDWPPLGNVEFVDYSVRYREGLDLVLKNISLKV 1326

  Fly  1335 QGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSG 1399
            :||||:||||||||||||:||.|||::|||.|.|.||.|.|:.:|||.|||:||||||:||||||
Zfish  1327 RGGEKIGIVGRTGAGKSSMTLCLFRLLEAAAGEIVIDDVKISEIGLHDLRSKLTIIPQEPVLFSG 1391

  Fly  1400 SLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRK 1464
            :||:||||||..:|:|:|||||||||:.||.:.||.|..|.:|||||||||||||||||||||||
Zfish  1392 TLRMNLDPFERYSDEEVWKALELSHLQKFVTNQAAKLELECSEGGENLSVGQRQLVCLARALLRK 1456

  Fly  1465 TKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPT 1529
            |::|||||||||||||||||||.||||||::|||.|||||||||:|..:|:|||||||.||.:||
Zfish  1457 TRILVLDEATAAVDLETDDLIQSTIRTEFQDCTVFTIAHRLNTIMDYTRVLVLDKGQIAEFDTPT 1521

  Fly  1530 ELLDNPKSAFYSMAKDANL 1548
            .|: |.|..|:.|||||.|
Zfish  1522 NLM-NQKGLFFGMAKDAGL 1539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	780/1572 (50%)
		ABC_membrane	338..601	CDD:279056	153/262 (58%)
		ABCC_MRP_domain1	649..848	CDD:213217	128/200 (64%)
		ABC_membrane	988..1260	CDD:279056	131/281 (47%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	161/219 (74%)
abcc3	XP_009304645.1	MRP_assoc_pro	10..1539	CDD:188098	779/1568 (50%)
		ABC_membrane	330..595	CDD:279056	153/265 (58%)
		ABCC_MRP_domain1	640..841	CDD:213217	128/200 (64%)
		ABC_membrane	985..1253	CDD:279056	130/276 (47%)
		ABCC_MRP_domain2	1300..1520	CDD:213211	161/219 (74%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586008
Domainoid	1	1.000	343	1.000	Domainoid score	I1039
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1486	1.000	Inparanoid score	I105
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0000087
OrthoInspector	1	1.000	-	-		otm24337
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X177
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.810