DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MRP and Abcb5

DIOPT Version :9

Sequence 1:	NP_723772.2	Gene:	MRP / 34686	FlyBaseID:	FBgn0032456	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	XP_006240775.1	Gene:	Abcb5 / 314537	RGDID:	1566342	Length:	1255	Species:	Rattus norvegicus

Alignment Length:	1400	Identity:	299/1400 - (21%)
Similarity:	539/1400 - (38%)	Gaps:	404/1400 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   357 IISFVEAQDAEPEWKGILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKALRISN 421
            |..|.:..|......|||.:::........:.:||:.... ||.|..::|        ...:..|
  Rat    37 IFRFADNLDIVLMTLGILASMINGATVPLMSLVLGEISDH-FINGCLVQT--------NKTKYQN 92

  Fly   422 STKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLALYFLW------------QQLGPS 474
            .::.:..:.|.:          :.||.|...|.:|.|.:|......|            :|...|
  Rat    93 CSQSQEKLNEDI----------IMLTLYYVGIGAAALVLGYVQISFWVITAARQTTRIRKQFFHS 147

  Fly   475 VLA---------------------------GLAVMIILIPVN------GVIASRIKTYQI----- 501
            :||                           |:...|.|:..|      |::.|.||::::
  Rat   148 ILAQDISWFDGTDICELNTRMNGDISKLCDGIGDKIPLMFQNISGFSIGLVISLIKSWKLSLAIL 212

  Fly   502 ----------------------RQMKYKDERVKLMNEVLSGIKVLKLY-AWEPSFEKQVLDIRD- 542
                                  :::....:...:..|.||.|:.:..: |.|...::...:::|
  Rat   213 STSPLIMAASALCSRMVISLTSKELDAYSKAGAVAEEALSSIRTVTAFGAQEKEIQRYTQNLKDA 277

  Fly   543 KEIATLRSTA----------YLNA--------GTSFLWSCAP-FLVSL-------VTFATYVLTS 581
            |:....|:.|          ::|.        |||.::...| :.|..       |..::|.:.|
  Rat   278 KDAGIKRAIASKLSLGAVYFFMNGAYGLAFWYGTSLIFGGEPGYTVGTILAVFFSVIHSSYCIGS 342

  Fly   582 EANQLSVEKVLVSIALFDLMKLPLTILPMLSVDIAETQVSVNRINKFLNSEELDPNSVLHDSSKP 646
            .|..|....:... |.|::..:                     |:|       .||.....::..
  Rat   343 VAPHLETFTIARG-AAFNIFHV---------------------IDK-------KPNIDNFSTAGY 378

  Fly   647 HPMSIE------NGEFSWGDEIT---LRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLA 702
            .|.|||      |..||:....:   |:..|:::|.|..|||||..||||::.||......:...
  Rat   379 KPESIEGNIEFKNVSFSYPSRPSAKILKGFNLKIKSGETVALVGPSGSGKTTTVQLLQRLYDPEE 443

  Fly   703 GVVNTVG--------------KLAYVPQQAWIQNATVRDNILFGQ----------------TYD- 736
            |.: ||.              ::..|.|:..:...|:.:||.||:                .||
  Rat   444 GCI-TVDENDIRTQNVRHYREQIGVVSQEPVLFGTTIGNNIKFGREGVSEEEMEQAAREANAYDF 507

  Fly   737 ----RKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDP 797
                .|::|                    |.:||||..:||||||||::|||:..:..:.:||:.
  Rat   508 IMAFPKKFN--------------------TLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEA 552

  Fly   798 LSAVDAHVGKHIFEEVIGPKGILARKSR--VLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVK 860
            .||:|..     .|.::......|.|.|  ::|.|.::.:...|.|..:|.||:.|.|...:|:.
  Rat   553 TSALDTE-----SESLVQAALEKASKGRTTLVVAHRLSTIRGADLIVTMKDGEVVEKGIHAELMA 612

  Fly   861 NKGAFADFIIQHLQEGNEEEEELNQIKRQISSTADVPELLGTVEKAIKLARTESLSDSISVTSAD 925
            .:|.:....:         .:::.::..|:.|                  ||.|.:.:.|
  Rat   613 KQGLYYSLAV---------AQDIKKVDEQMES------------------RTCSAAGNAS----- 645

  Fly   926 SLMGGGGSL-RRRTKRQDSHDSVASAASLKKKQEVEGKLIETEKSQTGGVEFAVYKHYIKSVGIF 989
                 .||| ...:.:....|....|...:|....|..|::..|..             ||...|
  Rat   646 -----NGSLCNVNSAKSPCTDQFEEAVPHQKTTLPEVSLLKIFKLS-------------KSEWPF 692

  Fly   990 LSVATL--VLN-FVFQAFQI--GSNLWLTQWANDQNVANDTGLRDMYLGVYGAFGFGQGVLAYFA 1049
            :.:.||  .|| .|..||.|  |..:.:.:..|...:..|..|..|.|.|.|           ..
  Rat   693 VVLGTLASALNGSVHPAFSIIFGKLVTMFEDKNKTTLKQDAELYSMMLVVLG-----------IV 746

  Fly  1050 VVIVYL--GGFQAAKTIHNELLAVIIRGSVCR--------FFD-------------ITPIGRLLN 1091
            .::.||  |.|....   .|:||:.:|.|..:        ::|             ...:.::..
  Rat   747 ALVTYLMQGLFYGRA---EEILAMRLRHSAFKAMLYQDMAWYDEKDNSTGALTTTLAVDVAQIRG 808

  Fly  1092 SFSGDMDVVDEELP-ATMDSFMTFIFMVLATIVVISLSTPIFLAVIVPIAFLYYFAQR------- 1148
            :.:..:.::.:::. .::...::|::....|::::|.:..:.:..::..|.:..||.:
  Rat   809 AATSRLGIITQDVTNMSLSILISFVYGWEMTLLILSFAPILAVTGMIQTAAMAGFANKDKQELKR 873

  Fly  1149 -FYVATS--RQLMRLESVSRSPIYSH-FSET-------------VTGASTIRAYNVGDRFIEESD 1196
             ..:||.  ..:..:.|::|...:.| :.||             :||:    .|.|...|:..:.
  Rat   874 AGKIATEAVENIRTVVSLTREKAFEHMYEETLRTQHRNALKRAHITGS----CYAVSHAFVHFAH 934

  Fly  1197 AKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAVLGGQTNPG--LVGLSVSY-ALQVTQ 1258
            |...:                            |.:.....|..|..|  :|..:::| |:.:.:
  Rat   935 AAGFR----------------------------FGAYLIQAGRMTPEGMFIVFTAIAYGAMAIGE 971

  Fly  1259 TLNWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKNKP------KNWPQ----EGRVEFQ 1313
            ||.|                 ..||.:.|..|.......||||      :|..:    ||.:||:
  Rat   972 TLVW-----------------APEYSKAKAGAAHLFALLKNKPSIDSCSQNGEKPDACEGNLEFR 1019

  Fly  1314 NFQVRYREGLDL-VLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIAS 1377
            .....|....:: ||:.:|.:|:.|:.|..||.:|.|||:....|.|..:...|::.:||||:..
  Rat  1020 EVSFFYPCRPEVPVLQDMSLSIEKGKTVAFVGSSGCGKSTCVQLLQRFYDPMKGQVLLDGVDVKE 1084

  Fly  1378 MGLHMLRSRLTIIPQDPVLFSGSLRINL---DPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHE 1439
            :.:..|||:..|:.|:||||:.|:..|:   |...:...:||.:..:.:::.||::.|....:.:
  Rat  1085 LNVQWLRSQTAIVSQEPVLFNCSIAENIAYGDNSRMVPLEEIKEVADAANIHSFIEGLPGKYSTQ 1149

  Fly  1440 IAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHR 1504
            :...|.:||.||:|.:.:|||||||.|:|:|||||:|:|.|::.::|:.:....:..|.|.:|||
  Rat  1150 VGLRGMHLSGGQKQRLAIARALLRKPKILLLDEATSALDNESEKMVQQALDKARRGRTCLVVAHR 1214

  Fly  1505 LNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAF 1539
            |:||.::|.::||..|:|.|..:..|||.|.::.|
  Rat  1215 LSTIQNADMIVVLQNGRIKEQGTHQELLRNGETYF 1249

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	298/1399 (21%)
		ABC_membrane	338..601	CDD:279056	57/343 (17%)
		ABCC_MRP_domain1	649..848	CDD:213217	65/244 (27%)
		ABC_membrane	988..1260	CDD:279056	53/327 (16%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	78/223 (35%)
Abcb5	XP_006240775.1	PTZ00265	48..1252	CDD:240339	295/1388 (21%)
		ABC_membrane	53..334	CDD:279056	46/299 (15%)
		ABC_MTABC3_MDL1_MDL2	387..624	CDD:213216	68/271 (25%)
		ABC_membrane	697..963	CDD:279056	50/311 (16%)
		ABC_MTABC3_MDL1_MDL2	1017..1254	CDD:213216	81/232 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000