Protein Alignment MRP and Abcc12

DIOPT Version :10

• Sequence 1: NP_723772.2
• Gene: MRP / 34686
• FlyBaseID: FBgn0032456
• Length: 1549
• Species: Drosophila melanogaster
• Sequence 2: XP_008770597.1
• Gene: Abcc12 / 291923
• RGDID: 735100
• Length: 1378
• Species: Rattus norvegicus
• Alignment Length: 1412
• Identity: 473/1412 - (33%)
• Similarity: 726/1412 - (51%)
• Gaps: 185/1412 - (13%)

  Fly   225 PELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEV----MPIFAHHWNQNVRKNY 285
            |...|..||..|:.|...:.::.|::.|....|..|.|.|| |:|    :.|.   |::.:.
  Rat    45 PVDDAGLLSFATFSWLTPVMIRSYKHTLTVDTLPPLSPYDS-SDVNAKRLQIL---WDEEIE--- 102

  Fly   286 KNKARVEPKAQFSNGNVTFENPHGEKNGRKKGM----ASIMPPIYKSFGGVFLFGALMKLFTDTL 346
                ||.|: :.|.|.|.:      |..|.:.:    |:|:..|..:.|...|...:::..|:..
  Rat   103 ----RVGPE-RASLGRVVW------KFQRTRVLMDVVANILCIIMAALGPTVLIHQILQHVTNIS 156

  Fly   347 TFAQPQVLSLIISFVEAQDAEPEWKGILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALINA 411
            :......:.|.::....:..:         ||.:.||.|..          :...:|::.||...
  Rat   157 SGHIGISICLCLALFATEFTK---------VLFWALAWAIN----------YRTAIRLKVALSTL 202

  Fly   412 IYRKALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVL 476
            |::..|  |..|....:.||::|:::.|:....|...:..:..:.|:.:.:...:.:..||.:.|
  Rat   203 IFKNLL--SFKTLTHISAGEVLNVLSSDSYSLFEAALFCPLPATIPILMVVCAVYAFFILGSTAL 265

  Fly   477 AGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIR 541
            .|:.|.:|.||:...:|.....::...:...|:||:.|||.|:.||::|:||||.||...:.|||
  Rat   266 VGICVYLIFIPIQMFMAKLNSAFRRSAISVTDKRVQTMNEFLTCIKLIKMYAWEKSFMNTIHDIR 330

  Fly   542 DKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVLTSEANQLSVEKVLVSIALFDLMKLPLT 606
            .:|...|....|:.:|.|.|......:..:.||..::.....  |:.......||:|::||..:.
  Rat   331 KREKKLLEKAGYVQSGNSALAPIVSTIAIVSTFTCHIFLKRT--LTAPVAFSVIAMFNVMKFSIA 393

  Fly   607 ILPMLSVDIAETQVSVNRINKFLNSEELDPNSVLHDSSKPHP-MSIENGEFSWGDEI-------- 662
            |||.....:||..||:.|:.|.|.::  .|.|.:.....|.. :.:.|...:|..||
  Rat   394 ILPFSVKAVAEASVSLRRMKKILVAK--SPPSYITQPEDPDTILLLANATLTWEQEINRKRGPLK 456

  Fly   663 ---------------------------------------TLRNINIEVKKGSLVALVGTVGSGKS 688
                                                   .|.||:..|:||.::.:.|.||||||
  Rat   457 TQDQRRHVFKKQRAELYSEQSLSDQGVASPERQSGSPKSVLHNISFVVRKGKVLGICGNVGSGKS 521

  Fly   689 SVVQAFLGEMEKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADI 753
            |::.|.||:|:...|||...|.||||.|||||.:..||:|||||:.|:.:||...:..|.|:.|:
  Rat   522 SLISALLGQMQLQKGVVAVSGPLAYVSQQAWIFHGNVRENILFGEKYNHQRYQHTVHVCGLQKDL 586

  Fly   754 DILSAGDLTE-------IGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFE 811
            :.|..|||||       |||:|:||||||:||||||||||::..||||||||||||||||||:||
  Rat   587 NSLPYGDLTECHYPHLQIGERGVNLSGGQRQRISLARAVYANRQLYLLDDPLSAVDAHVGKHVFE 651

  Fly   812 EVIGPKGILARKSRVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFADFIIQHLQEG 876
            |.|  |..|..|:.|||||.:.||...|.:.:::.|||.|.||..:|::.:|.:|..|  |...|
  Rat   652 ECI--KKTLKGKTVVLVTHQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLI--HNLRG 712

  Fly   877 NEEEEELNQIKRQISSTADVPELLGTVEKAIKLARTESLSDSISVTSADSLMGGGGSLRRRTKRQ 941
            .:.::               ||.:..|      |..|:|.:|.:....|:::..|.. |...|..
  Rat   713 LQFKD---------------PEHIYNV------AMVETLKESQAQRDEDAVLASGDE-RDEGKEP 755

  Fly   942 DSHDSVASAASLKKKQEVEGKLIETEKSQTGGVEFAVYKHYIKSVGIFL-SVATLVLNFVFQAFQ 1005
            ::.:.|...|.:.       :||:.|..|.|.|.:..|..|||:.|.:| |...|.|.|:.....
  Rat   756 ETEEFVDIKAPVH-------QLIQIESPQEGIVTWKTYHTYIKASGGYLVSFLVLCLFFLMMGSS 813

  Fly  1006 IGSNLWLTQWANDQN------VANDTG------LRD----MYLGVYGAFGFGQGVLAYFAVVIVY 1054
            ..|..||..|.:..:      .:|:|.      |:|    ||..||         :|....|:.:
  Rat   814 AFSTWWLGLWLDSGSQVICAPQSNETACNVNQTLQDTKHHMYQLVY---------IASMMSVLTF 869

  Fly  1055 --LGGF-------QAAKTIHNELLAVIIRGSVCRFFDITPIGRLLNSFSGDMDVVDEELPATMDS 1110
              :.||       .|:.::||.:...|: .|...|||.||.|||:|.||.|||.:|..||...::
  Rat   870 GIIKGFTFTNTTLMASSSLHNRVFNKIV-SSPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAEN 933

  Fly  1111 FMTFIFMVLATIVVISLSTPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSET 1175
            |:....||:..:|:::.|.|:.|.|:..:|.|::...|.:....::|.::|::||||.:||.:.:
  Rat   934 FLQQFSMVVFILVIMAASFPVVLVVLAGLAILFFILLRIFHRGVQELKQVENISRSPWFSHITSS 998

  Fly  1176 VTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAVLG-G 1239
            :.|...|.||:..|..|.:..|..|:|.........|.||.|:|::::.|::....:|...|. .
  Rat   999 MQGLGVIHAYDKKDDCISKFKALNDENSSHLLYFNCALRWFALRMDILMNIVTFVVALLVTLSFS 1063

  Fly  1240 QTNPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDK--NKPK 1302
            ..:....|||:||.:|::..|...||..::.:....|.|.::||..|.  .|...:..|  ..||
  Rat  1064 SISASSKGLSLSYIIQLSGLLQVCVRTGTETQAKFTSAELMREYISTC--VPEHTQSFKVGTCPK 1126

  Fly  1303 NWPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGR 1367
            :||..|.:.|:::::|||:...|||.|::.|||.|:.||||||||:|||||.:||||::|.|.|.
  Rat  1127 DWPSRGEITFKDYRMRYRDNTPLVLDGLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPASGT 1191

  Fly  1368 ISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSL 1432
            |.||.|||.::||..||::||:||||||||.|::|.||||....||:.:|..||.:.::..:..|
  Rat  1192 IFIDEVDICTVGLEELRTKLTMIPQDPVLFVGTVRYNLDPLGSHTDEMLWHVLERTFMRDTIMKL 1256

  Fly  1433 AAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECT 1497
            ...|..|:.|.|||.|||:|||:|:||||||.:|:::||||||::|.:||.|:|.||:..||.||
  Rat  1257 PEKLQAEVTENGENFSVGERQLLCMARALLRNSKIILLDEATASMDSKTDTLVQSTIKEAFKSCT 1321

  Fly  1498 VLTIAHRLNTILDSDKVIVLDKGQ-----IIEFASPTELLDNPKSAF 1539
            ||||||||||:|:.|.|:|::.|:     :|||..|..|.:.|.|||
  Rat  1322 VLTIAHRLNTVLNCDLVLVMENGKVQEVLVIEFDKPEVLAEKPDSAF 1368

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	473/1412 (33%)
Abcc12	XP_008770597.1	MRP_assoc_pro	43..1378	CDD:188098	473/1412 (33%)