Protein Alignment MRP and Abcc6

DIOPT Version :9

• Sequence 1: NP_723772.2
• Gene: MRP / 34686
• FlyBaseID: FBgn0032456
• Length: 1549
• Species: Drosophila melanogaster
• Sequence 2: XP_006541009.1
• Gene: Abcc6 / 27421
• MGIID: 1351634
• Length: 1500
• Species: Mus musculus
• Alignment Length: 1487
• Identity: 536/1487 - (36%)
• Similarity: 803/1487 - (54%)
• Gaps: 142/1487 - (9%)

  Fly     6 SSPMDRFCGSTFWNATETWYTNDPD----FTPCFEQTALVWTPCAFYWAF-VIFDFY-------Y 58
            ::|.::..|...||.||    .:|.    .:.||.:.|..|.|..:.|.. .|:..|       |
Mouse    76 ATPGEQCAGLRVWNQTE----QEPAAYHLLSLCFVRAASSWVPPMYLWVLGPIYLLYIHRHGRCY 136

  Fly    59 LKASLDRNIPWNKLNVSKALVNLGLLVITALDLIMALVK-KGGDSELP--LYDLDVWGPIIKFAT 120
            |:.|        .|..:|.::.|.|:::...::.:.|.: ..|..:.|  |....||...:.|||
Mouse   137 LRMS--------HLFKTKMVLGLALILLYTFNVAVPLWRIHQGVPQAPELLIHPTVWLTTMSFAT 193

  Fly   121 FLLLFIFIPLNRKYGVQTTGCQFIFWFLLTVLSIPRCRTEVRLDAERQKILNSQQPSEQDFSWEE 185
            ||     |.:.|:.||:::|..|.:|.|..:|  |...|             .||.|..:|..|.
Mouse   194 FL-----IHMERRKGVRSSGVLFGYWLLCCIL--PGINT-------------VQQASAGNFRQEP 238

  Fly   186 YQFVSFFIFFTFTSIMLILNCFADGMPRQTKYQRGENEIPELSASFLSRITYQWFDKMALKGYRN 250
            ...::.::..:.....|:|:|..|..|..::..:..|..||..|||.|:..:.|...:..:||:.
Mouse   239 LHHLATYLCLSLVVAELVLSCLVDQPPFFSEDSQPLNPCPEAEASFPSKAMFWWASGLLWRGYKK 303

  Fly   251 PLEEKDLWDLRPQDSCSEVMPIFAHHWNQNV-----RKNYKNKARVEPKAQFSNGNVTFENPHGE 310
            .|..||||.|..::|..|::......|.::.     .|.:.:....|.:|        |..|...
Mouse   304 LLGPKDLWSLGRENSSEELVSQLEREWRRSCNGLPGHKGHSSVGAPETEA--------FLQPERS 360

  Fly   311 KNGRKKGMASIMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQVLSLIISFVEAQDAEPEWKGILY 375
            :.|      .::..|::.|...||.|.|..:.:|...||.|::|||.:.|:..:::. .|.|.|.
Mouse   361 QRG------PLLRAIWRVFRSTFLLGTLSLVISDAFRFAVPKLLSLFLEFMGDRNSS-AWTGWLL 418

  Fly   376 AVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKALRISNSTKKESTVGEIVNLMAVDA 440
            |||:|..|..||....|:.:|..::.:|:|||:...:|||.|.:|:.::|.|..|::|||::||.
Mouse   419 AVLMFAAACLQTLFEQQHMYRAKVLQMRLRTAITGLVYRKVLVLSSGSRKSSAAGDVVNLVSVDI 483

  Fly   441 QRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMK 505
            ||..|...|||.:|...|.|.:...:|||.||||.|..:||.:.|:|:|..|..:...:|..||:
Mouse   484 QRLAESIIYLNGLWLLFLWIFVCFVYLWQLLGPSALTAVAVFLSLLPLNFFITKKRGFHQEEQMR 548

  Fly   506 YKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVS 570
            .|..|.:|.:.:|..::.:|.:.||.:|.:::|.||.:|::.|:::..|.:.:...:..:.|||:
Mouse   549 QKASRARLTSSMLRTVRTIKSHGWEHAFLERLLHIRGQELSALKTSTLLFSVSLVSFQVSTFLVA 613

  Fly   571 LVTFATYVLTSEANQLSVEKVLVSIALFDLMKLPLTILPMLSVDIAETQVSVNRINKFLNSEELD 635
            ||.||.:.|.:|.|.:..||..|::.:..::......||.....|.:.:||.:|:..||..||:|
Mouse   614 LVVFAVHTLVAEDNAMDAEKAFVTLTVLSILNKAQAFLPFSVHCIVQARVSFDRLAAFLCLEEVD 678

  Fly   636 PNSVLHDSSK---PHPMSIENGEFSWGDEI--TLRNINIEVKKGSLVALVGTVGSGKSSVVQAFL 695
            ||.::..:|:   ...:|:.||.|:|..|.  .|..||:.|.:|.|:|:||.||:||||::.|.|
Mouse   679 PNGMIASNSRRSSKDRISVHNGTFAWSQESPPCLHGINLTVPQGCLLAVVGPVGAGKSSLLSALL 743

  Fly   696 GEMEKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGD 760
            ||:.|:.|.|:..|.:|||||:||:||.:|.:|:.|.|..|.....||:|||||.:|:....||.
Mouse   744 GELLKVEGSVSIEGSVAYVPQEAWVQNTSVVENVCFRQELDLPWLQKVLDACALGSDVASFPAGV 808

  Fly   761 LTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSR 825
            .|.|||:|:|||||||||:|||||||..|.:|||||||:|:||||.:.:|::||||.|:|...:|
Mouse   809 HTPIGEQGMNLSGGQKQRLSLARAVYKKAAIYLLDDPLAALDAHVSQQVFKQVIGPSGLLQGTTR 873

  Fly   826 VLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKRQI 890
            :||||.:..|||.|.|.|:..|.|:|.|::..|::..||
Mouse   874 ILVTHTLHVLPQADRILVLANGTIAEMGSYQDLLQRNGA-------------------------- 912

  Fly   891 SSTADVPELLGTVEKAIKLARTESLSDSISVTSADSLMG--GGGSLRRRTKRQD----------- 942
                    |:|.::.|.:.|.|...:.|      |.|.|  |||   |.|.|.|
Mouse   913 --------LVGLLDGARQPAGTHDAATS------DDLGGFPGGG---RPTCRPDRPRPTEAAPVK 960

  Fly   943 --SHDSVASAASLKKKQEVEGKLIETEKSQTGGVEFAVYKHYIKSVGIFLSVATLVLNFVFQAFQ 1005
              |...|...||| ...|..|...|.:..:.|.|:..:|..|:::||..|...||.|....|...
Mouse   961 GRSTSEVQMEASL-DDPEATGLTAEEDSVRYGRVKTTIYLSYLRAVGTPLCTYTLFLFLCQQVAS 1024

  Fly  1006 IGSNLWLTQWANDQNVANDTGLRDMYLG----VYGAFGFGQGVLAYFAVVIVYLGGFQAAKTIHN 1066
            .....||:.||:|..|..    |.|:..    |:|..|..|.:..:.::..|:|||.:|:..:..
Mouse  1025 FSQGYWLSLWADDPVVDG----RQMHAALRGWVFGLLGCLQAIGLFASMAAVFLGGARASGLLFR 1085

  Fly  1067 ELLAVIIRGSVCRFFDITPIGRLLNSFSGDMDVVDEELPATMDSFMTFIFMVLATIVVISLSTPI 1131
            .||..:.|..: .||:.||:|.|||.||.:.|.||.::|..:.|.:|:.|.:|...:.::::||:
Mouse  1086 SLLWDVARSPI-GFFERTPVGNLLNRFSKETDTVDVDIPDKLRSLLTYAFGLLEVGLAVTMATPL 1149

  Fly  1132 FLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESD 1196
            .:..|:|:..||...|..|||||.||.||||...|.:.||.:||..|:..:||:.....|..:.|
Mouse  1150 AIVAILPLMVLYAGFQSLYVATSCQLRRLESARYSSVCSHMAETFQGSLVVRAFRAQASFTAQHD 1214

  Fly  1197 AKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAVLG-GQTNPGLVGLSVSYALQVTQTL 1260
            |.:|:||...:|.::|:||||..||::||.::..|:..|||. ...:.||||.|||.||||||||
Mouse  1215 ALMDENQRVSFPKLVADRWLATNLELLGNGLVFVAATCAVLSKAHLSAGLVGFSVSAALQVTQTL 1279

  Fly  1261 NWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYREGLDL 1325
            .|:||..:|:|.::|:|||:::|....:||||.|.....:|. ||..|::||::|.:|:|..|.|
Mouse  1280 QWVVRSWTDLENSMVAVERVQDYARIPKEAPWRLPTCAAQPL-WPCGGQIEFRDFGLRHRPELPL 1343

  Fly  1326 VLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTII 1390
            .::|||..|..|||||||||||||||||...|.|:.|||.|.|.||||.|..:|||.||||:|||
Mouse  1344 AVQGVSLKIHAGEKVGIVGRTGAGKSSLAWGLLRLQEAAEGNIWIDGVPITHVGLHTLRSRITII 1408

  Fly  1391 PQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENL 1447
            |||||||.||||:|||..:..||:.||.|||...||:||.||...|.:|.|..|::|
Mouse  1409 PQDPVLFPGSLRMNLDLLQEHTDEGIWAALETVQLKAFVTSLPGQLQYECAGQGDDL 1465

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	535/1479 (36%)
		ABC_membrane	338..601	CDD:279056	91/262 (35%)
		ABCC_MRP_domain1	649..848	CDD:213217	105/200 (53%)
		ABC_membrane	988..1260	CDD:279056	102/276 (37%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	83/140 (59%)
Abcc6	XP_006541009.1	MRP_assoc_pro	101..1465	CDD:188098	528/1456 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841718
Domainoid	1	1.000	161	1.000	Domainoid score	I3987
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0000087
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	O	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X177
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.710