DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MRP and Abcc5

DIOPT Version :9

Sequence 1:NP_723772.2 Gene:MRP / 34686 FlyBaseID:FBgn0032456 Length:1549 Species:Drosophila melanogaster
Sequence 2:NP_038818.2 Gene:Abcc5 / 27416 MGIID:1351644 Length:1436 Species:Mus musculus


Alignment Length:1438 Identity:496/1438 - (34%)
Similarity:745/1438 - (51%) Gaps:218/1438 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   215 TKYQRGENEIPELSASFLSRITYQWFDKMA-LKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHHWN 278
            ||:|.     |..:|...|.:|:.|...:| :...:..|..:|:|.|...:| |:|         
Mouse    95 TKHQH-----PVDNAGLFSYMTFSWLSPLARVVHKKGELLMEDVWPLSKYES-SDV--------- 144

  Fly   279 QNVRKNYKNKARVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGALMKLFT 343
                    |..|:|...|            .|.|......||:...::.......:...:..:.|
Mouse   145 --------NSRRLERLWQ------------EELNEVGPDAASLRRVVWIFCRTRLILSIVCLMIT 189

  Fly   344 DTLTFAQPQ-VLSLIISFVEAQDAEPEWKGILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTA 407
            ....|:.|. |:..::.:.:|.::..:: .:|..:.|.:....:::.|...:...:..|:|:|.|
Mouse   190 QLAGFSGPAFVVKHLLEYTQATESNLQY-SLLLVLGLLLTEVVRSWSLALTWALNYRTGVRLRGA 253

  Fly   408 LINAIYRKALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQLG 472
            ::...::|.|::.|.  ||.::||::|:.:.|.||..|.....:::...|:...|.:.:....||
Mouse   254 ILTMAFKKILKLKNI--KEKSLGELINICSNDGQRMFEAAAVGSLLAGGPVVAILGMIYNVIILG 316

  Fly   473 PSVLAGLAVMIILIPVNGVIASRIKTYQIRQ-MKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQ 536
            |:...|.||.|:..|.. :..||:..|..|: :...|:||:.|||||:.||.:|:|||..:|.:.
Mouse   317 PTGFLGSAVFILFYPAM-MFVSRLTAYFRRKCVAATDDRVQKMNEVLTYIKFIKMYAWVKAFSQC 380

  Fly   537 VLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLV---SLVTFATYVLTSEANQLSVEKVLVSIALF 598
            |..||::|...|....|..   |.....||.:|   |:|||:.::  :....|:..:....:.:|
Mouse   381 VQKIREEERRILEKAGYFQ---SITVGVAPIVVVIASVVTFSVHM--TLGFHLTAAQAFTVVTVF 440

  Fly   599 DLMKLPLTILPMLSVDIAETQVSVNRINKFLNSEELDPNSVLHDSSKPH-PMSIENGEFSW---- 658
            :.|...|.:.|.....::|..|:|:|.......||:  :.:.:..:.|| .:.::|...:|    
Mouse   441 NSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEV--HMIKNKPASPHIKIEMKNATLAWDSSH 503

  Fly   659 ------------------------------------------------------------GDEI- 662
                                                                        |.:| 
Mouse   504 SSIQNSPKLTPKMKKDKRATRGKKEKSRQLQHTEHQAVLAEQKGHLLLDSDERPSPEEEEGKQIH 568

  Fly   663 --------TLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVVNTVGKLAYVPQQAW 719
                    ||.||::|:::|.||.:.|:|||||:|:|.|.||:|..|.|.:...|..|||.||||
Mouse   569 TGSLRLQRTLYNIDLEIEEGKLVGICGSVGSGKTSLVSAILGQMTLLEGSIAVSGTFAYVAQQAW 633

  Fly   720 IQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARA 784
            |.|||:|||||||:.:|.:|||.|:::|.||.|:.||...|||||||:|.||||||:||||||||
Mouse   634 ILNATLRDNILFGKEFDEERYNSVLNSCCLRPDLAILPNSDLTEIGERGANLSGGQRQRISLARA 698

  Fly   785 VYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDSIYVIKMGEI 849
            :|||..:|:|||||||:|||||.|||...|..:  |..|:.:.|||.:.:|...|.:..:|.|.|
Mouse   699 LYSDRSIYILDDPLSALDAHVGNHIFNSAIRKR--LKSKTVLFVTHQLQYLVDCDEVIFMKEGCI 761

  Fly   850 SESGTFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKRQISSTADVPELLGTVEKAIKLARTES 914
            :|.||.::|:...|.:|. |..:|..|.....|:|                              
Mouse   762 TERGTHEELMNLNGDYAT-IFNNLLLGETPPVEIN------------------------------ 795

  Fly   915 LSDSISVTSADSLMGGGGSLRRRTKRQDSHDSVASAASLKKKQEV---EGKLIETEKSQTGGVEF 976
                              |.:..|..|.|.|......|:||::.|   ||:|::.|:...|.|.:
Mouse   796 ------------------SKKEATGSQKSQDKGPKPGSVKKEKAVKSEEGQLVQVEEKGQGSVPW 842

  Fly   977 AVYKHYIKSVG---IFLSVATL-VLNFVFQAFQIGSNLWLTQWANDQNVANDT-----------G 1026
            :||..||::.|   .||.:..| :||....||   |..||:.|.. |...|.|           .
Mouse   843 SVYWVYIQAAGGPLAFLVIMVLFMLNVGSTAF---STWWLSYWIK-QGSGNSTVYQGNRSFVSDS 903

  Fly  1027 LRD-----MYLGVYGAFGFGQGVLAYFAVVIVYLGGFQAAKTIHNELLAVIIRGSVCRFFDITPI 1086
            ::|     .|..:|........:|.....|:...|..:|:..:|:||...|:| |..:|||.||.
Mouse   904 MKDNPFMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILR-SPMKFFDTTPT 967

  Fly  1087 GRLLNSFSGDMDVVDEELPATMDSFMTFIFMVLATIVVISLSTPIFLAVIVPIAFLY---YFAQR 1148
            ||:||.||.|||.||..||...:.|:..:.:|...:.:|:...|.||..:.|:..|:   :...|
Mouse   968 GRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLLILFSLLHIVSR 1032

  Fly  1149 FYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIAN 1213
            ..:   |:|.||:::::||..||.:.::.|.:||.|||....|:......:|.||...:....|.
Mouse  1033 VLI---RELKRLDNITQSPFLSHITSSIQGLATIHAYNKRQEFLHRYQELLDDNQAPFFLFTCAM 1094

  Fly  1214 RWLAIRLEMVGNLIILFASLFAVL-GGQTNPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSV 1277
            ||||:||:::...:|....|..|| .||......||::|||:|:|....:.||::|:.|....||
Mouse  1095 RWLAVRLDLISIALITTTGLMIVLMHGQIPSAYAGLAISYAVQLTGLFQFTVRLASETEARFTSV 1159

  Fly  1278 ERIKEYGET-KQEAPWELEQDKNK--PKNWPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEK 1339
            |||..|.:| ..|||..:   |||  |.:|||||.|.|:|.::||||.|.|||:.|||.|:..||
Mouse  1160 ERINHYIKTLSLEAPARI---KNKAPPHDWPQEGEVTFENAEMRYRENLPLVLKKVSFTIKPKEK 1221

  Fly  1340 VGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRIN 1404
            :|||||||:|||||.:||||::|.:||.|.|||:.|:.:||..|||:|.||||:||||||::|.|
Mouse  1222 IGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGIRISDIGLADLRSKLAIIPQEPVLFSGTVRSN 1286

  Fly  1405 LDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLV 1469
            ||||...|:|:||.|||.:|:|..:..|...|..|:.|.|:|.|||:|||:|:||||||..|:|:
Mouse  1287 LDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILI 1351

  Fly  1470 LDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDN 1534
            |||||||:|.|||.|||:|||..|.:||:|||||||:|:|.||:::||.:||::||.:|:.||.|
Mouse  1352 LDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSN 1416

  Fly  1535 PKSAFYSM 1542
            ..|.||:|
Mouse  1417 DSSRFYAM 1424

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MRPNP_723772.2 MRP_assoc_pro 14..1548 CDD:188098 496/1438 (34%)
ABC_membrane 338..601 CDD:279056 69/267 (26%)
ABCC_MRP_domain1 649..848 CDD:213217 106/271 (39%)
ABC_membrane 988..1260 CDD:279056 92/292 (32%)
ABCC_MRP_domain2 1308..1528 CDD:213211 131/219 (60%)
Abcc5NP_038818.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..41
PLN03130 100..1424 CDD:215595 492/1426 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 501..569 2/67 (3%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 798..822 7/23 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167841656
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG51855
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
65.660

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