Protein Alignment MRP and Abcc9

DIOPT Version :10

• Sequence 1: NP_723772.2
• Gene: MRP / 34686
• FlyBaseID: FBgn0032456
• Length: 1549
• Species: Drosophila melanogaster
• Sequence 2: NP_037172.2
• Gene: Abcc9 / 25560
• RGDID: 3787
• Length: 1545
• Species: Rattus norvegicus
• Alignment Length: 1676
• Identity: 533/1676 - (31%)
• Similarity: 831/1676 - (49%)
• Gaps: 281/1676 - (16%)

  Fly    12 FCGSTF--WNATETWYTNDPDFTPCFEQTALVWTPCAFYWAFVIFDFYYL-------KASLDRN- 66
            |||:..  :|.......|     |||.. ||...|..|. .|:.|...::       |..:..|
  Rat     5 FCGNNISSYNIYHGVLQN-----PCFVD-ALNLVPHVFL-LFITFPILFIGWGSQSSKVQIHHNT 62

  Fly    67 ---IPWNKLNVSKALVNLGLLVITALDLIMALVKKGGDSELPLYDLDVWGP-IIKFATFLLLFIF 127
               .|.:.|   :.::...||.:...::...:|   .||:.....|.::.| ::.|.......::
  Rat    63 WLHFPGHNL---RWILTFALLFVHVCEIAEGIV---SDSQRASRHLHLFMPAVMGFVATTTSIVY 121

  Fly   128 IPLNRKYGVQTTG------CQFIFWFLLTVLSIPRCRTEVRLDAERQKILNSQQPSEQDFSWEEY 186
            .     :.::|:.      ..|::|.:..:             .:..|::...|     ..|...
  Rat   122 Y-----HNIETSNFPKLLLALFLYWVMAFI-------------TKTIKLVKYWQ-----LGWGMS 163

  Fly   187 QFVSFFIFFTFTSIMLILNCFADGM-------------------PRQTKYQRGENEIPELSASF- 231
            .     :.|..|.:|:|||    |:                   |::.|   ...::.:|...|
  Rat   164 D-----LRFCITGVMVILN----GLLMAVEINVIRVRRYVFFMNPQKVK---PPEDLQDLGVRFL 216

  Fly   232 ------LSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHHWNQNVRKNY---KN 287
                  ||:.||.|.:.:.:..:|.|::.|.:..|          ||     ......||   |.
  Rat   217 QPFVNLLSKATYWWMNTLIISAHRKPIDLKAIGKL----------PI-----AMRAVTNYVCLKE 266

  Fly   288 KARVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQ 352
            ....:.|....:.|.|               .||...:|::||...|..:..:...|.|.||.|.
  Rat   267 AYEEQKKKAADHPNRT---------------PSIWLAMYRAFGRPILLSSTFRYLADLLGFAGPL 316

  Fly   353 VLSLIISFVEAQDAEPE----------------WKGILYAVLLFV-LAAAQTFILGQYFHRMFIV 400
            .:|.|:..|.    ||:                ....:.|||||: |...:||:...|:..: ..
  Rat   317 CISGIVQRVN----EPKNNTTRFSETLSSKEFLENAHVLAVLLFLALILQRTFLQASYYVTI-ET 376

  Fly   401 GLRIRTALINAIYRKALRI--SNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLA 463
            |:.:|.||:..||.|.||:  ||.:..|.|:|:|.||:|::..:.|........:|:.|:||.:.
  Rat   377 GINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMG 441

  Fly   464 LYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLYA 528
            :..|:..||.|.|.|.||:::|.|:...||:::...|...:.|..||:|..||:|.|||:|||||
  Rat   442 VILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYA 506

  Fly   529 WEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVLTSEANQLSVEKVLV 593
            ||..|.|.|.:.|.||:::|::.|...:.:.|:.:..|....|.||.|:...| .|.|...:...
  Rat   507 WEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYAS-GNNLKPAEAFA 570

  Fly   594 SIALFDLMKLPLTILPMLSVDIAETQVSVNRINKFLNSEELDPNS-------VLHDSSKPH---- 647
            |::||.::..||.:|..:.....:..:||.::|:||.|:|:..:|       :..:|.|.|
  Rat   571 SLSLFHILVTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGEDSWRTGEGTLPFESCKKHTGVQ 635

  Fly   648 -------------------------------PMSIENGEFSWGDEI-TLRNINIEVKKGSLVALV 680
                                           .:.:.||.||||..: ||.||:|.:..|.|..:|
  Rat   636 SKPINRKQPGRYHLDNYEQARRLRPAETEDVAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIV 700

  Fly   681 GTVGSGKSSVVQAFLGEMEKLAGVV--NTVGK---------------LAYVPQQAWIQNATVRDN 728
            |.||.||||::.|.||||:.|.|.|  |.|.:               :||..|:.|:.||||.:|
  Rat   701 GQVGCGKSSLLLAILGEMQTLEGKVYWNNVNESEPSFEATRSRSRYSVAYAAQKPWLLNATVEEN 765

  Fly   729 ILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYL 793
            |.||.:::|:||..|.|||:|:.|||:|..||.|||||:||||||||:|||.:|||:|.:.::..
  Rat   766 ITFGSSFNRQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVF 830

  Fly   794 LDDPLSAVDAHVGKHIFEEVIGPKGILA-----RKSRVLVTHGVTFLPQVDSIYVIKMGEISESG 853
            ||||.||:|.|:..|:.:|     |||.     :::.|||||.:.:|...|.|..:|.|.:...|
  Rat   831 LDDPFSALDIHLSDHLMQE-----GILKFLQDDKRTVVLVTHKLQYLTHADWIIAMKDGSVLREG 890

  Fly   854 TFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKRQISSTADVPELLGTVEKAIKLARTESLSDS 918
            |                  |::...::.||.:..:.:.:..| .||    ||.::..:|
  Rat   891 T------------------LKDIQTKDVELYEHWKTLMNRQD-QEL----EKDMEADQT------ 926

  Fly   919 ISVTSADSLMGGGGSLRRRTKRQDSHDSVASAASLKKKQEVEGKLIETEKSQT-----GGVEFAV 978
                          :|.|:|.|:..:...|.|....:.:|.|.:..|.:...|     ..:.:..
  Rat   927 --------------TLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKT 977

  Fly   979 YKHYIKSVGIFLSVATLVLNFVFQAFQIGSNLWLTQWANDQNVANDTGLRDMYLGVYGAFGF--G 1041
            ...|:.|.|.||....:....:..:..:..:.||..|.::.:: ||.|..|....|.| |..  |
  Rat   978 CWWYLTSGGFFLLFLMIFSKLLKHSVIVAIDYWLATWTSEYSI-NDPGKADQTFYVAG-FSILCG 1040

  Fly  1042 QGV-LAYFAVVIVYLGGFQAAKTIHNELLAVIIRGSVCRFFDITPIGRLLNSFSGDMDVVDEELP 1105
            .|: |.....:.|...|..|||.:|:.||..||.|.: ||||.||:|.:||.||.|.:::|:.:|
  Rat  1041 AGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPI-RFFDTTPLGLILNRFSADTNIIDQHIP 1104

  Fly  1106 ATMDSFMTFIFMVLATIVVISLSTPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYS 1170
            .|::|......:.|:.|.:||.:||:||..:.|:...:||.|:::...|:.|..|:..::.|:..
  Rat  1105 PTLESLTRSTLLCLSAIGMISYATPVFLIALAPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLC 1169

  Fly  1171 HFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFA 1235
            |||||..|.:||||:....||.:......|.|.:.......|||||.:|.:.:|..|:|.||: |
  Rat  1170 HFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASI-A 1233

  Fly  1236 VLGGQTNPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKNK 1300
            .:.|.:|.|||||.:.|||.:|..|||:||..:|:|..:.:|:::..: .|.:...:|...|.::
  Rat  1234 SISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSF-LTMESENYEGTMDPSQ 1297

  Fly  1301 -PKNWPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAA 1364
             |::|||||.::..:..|||...|..||:.|...|:.|:||||.||||:|||||:||.||:::..
  Rat  1298 VPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIF 1362

  Fly  1365 GGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIK-TDDEIWKALELSHLKSF 1428
            .|:|.|||:||:.:.||.|||||:||.|||:|||||:|.|||| |.| |||.:|:|||::.||:.
  Rat  1363 DGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDP-ECKCTDDRLWEALEIAQLKNM 1426

  Fly  1429 VKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEF 1493
            ||||..||:..:.|||||.|||||||.|||||.:||:.:|::|||||::|:.|::::||.:.|.|
  Rat  1427 VKSLPGGLDATVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAF 1491

  Fly  1494 KECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAFYSMAK 1544
            .:.||:|||||::|||.:|.|||:.:|.|:|:.:|..||......|.|..:
  Rat  1492 ADRTVVTIAHRVHTILTADLVIVMKRGNILEYDTPESLLAQEDGVFASFVR 1542

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	531/1674 (32%)
Abcc9	NP_037172.2	MRP_assoc_pro	222..1542	CDD:188098	490/1409 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	940..963		5/22 (23%)