DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MRP and Abcc8

DIOPT Version :9

Sequence 1:	NP_723772.2	Gene:	MRP / 34686	FlyBaseID:	FBgn0032456	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	NP_037171.2	Gene:	Abcc8 / 25559	RGDID:	3786	Length:	1582	Species:	Rattus norvegicus

Alignment Length:	1519	Identity:	487/1519 - (32%)
Similarity:	760/1519 - (50%)	Gaps:	241/1519 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   181 FSWEEYQFVSFF--------IFFTFTSIMLILNCFADGM-------------------PRQTKYQ 218
            |..:..:||.|:        :.|..|.:::||.    ||                   ||:.|
  Rat   147 FITKTIKFVKFYDHAIGFSQLRFCLTGLLVILY----GMLLLVEVNVIRVRRYVFFKTPREVK-- 205

  Fly   219 RGENEIPELSASF-------LSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHH 276
             ...::.:|...|       ||:.||.|.:......::.|:      |||........|....::
  Rat   206 -PPEDLQDLGVRFLQPFVNLLSKGTYWWMNAFIKTAHKKPI------DLRAIGKLPIAMRALTNY 263

  Fly   277 WNQNVRKNYKNKARVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGALMKL 341
              |.:...:..:||.:.::|                   :|..:|...:..:||...:..:..::
  Rat   264 --QRLCLAFDAQARKDTQSQ-------------------QGARAIWRALCHAFGRRLVLSSTFRI 307

  Fly   342 FTDTLTFA-------------------QPQVLSLIISFVEAQDAEPEWKGILY--AVLLFV-LAA 384
            ..|.|.||                   ||:...|.:.||.:|    |:.|..|  |||||: |..
  Rat   308 LADLLGFAGPLCIFGIVDHLGKENHVFQPKTQFLGVYFVSSQ----EFLGNAYVLAVLLFLALLL 368

  Fly   385 AQTFILGQYFHRMFIVGLRIRTALINAIYRKALRI--SNSTKKESTVGEIVNLMAVDAQRFMELT 447
            .:||:...|:..: ..|:.:|.|:...||.|.:.:  ||.:..|.|.|:|.||:|:|..:.|...
  Rat   369 QRTFLQASYYVAI-ETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNLVAIDTNQLMWFF 432

  Fly   448 TYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVK 512
            .....:|:.|:||.:.:..|:..||.|.|.|.||:|:|.||...:|:::...|...::|.:||:|
  Rat   433 FLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRSTLEYSNERLK 497

  Fly   513 LMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATY 577
            ..||:|.|||:|||||||..|..:|...|.||:.:||:.|...:.:.|:.:..|....|:||..:
  Rat   498 QTNEMLRGIKLLKLYAWENIFCSRVEKTRRKEMTSLRAFAVYTSISIFMNTAIPIAAVLITFVGH 562

  Fly   578 VLTSEANQLSVEKVLVSIALFDLMKLPLTILPMLSVDIAETQVSVNRINKFLNSEELDPNSVLHD 642
            |...:.:..|......|::||.::..||.:|..:.....:..|||.::::||:|.|:........
  Rat   563 VSFFKESDFSPSVAFASLSLFHILVTPLFLLSSVVRSTVKALVSVQKLSEFLSSAEIREEQCAPR 627

  Fly   643 SSKPH---------PMSIEN------------------------------------GEFSW-GDE 661
            ...|.         |:.:.|                                    |.|:| .|.
  Rat   628 EPAPQGQAGKYQAVPLKVVNRKRPAREEVRDLLGPLQRLTPSTDGDADNFCVQIIGGFFTWTPDG 692

  Fly   662 I-TLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVV-------------------- 705
            | ||.||.|.:.:|.|..:||.||.||||::.|.||||:|::|.|
  Rat   693 IPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLATLGEMQKVSGAVFWNSSLPDSEGEDPSNPERE 757

  Fly   706 -------NTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTE 763
                   .:.|.:||..|:.|:.||||.:||.|...::::||..||:||:|:.|||||..||.|:
  Rat   758 TAADSDARSRGPVAYASQKPWLLNATVEENITFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQ 822

  Fly   764 IGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILA-----RK 823
            |||:||||||||:||||:|||:|...::..||||.||:|.|:..|:.:     .|||.     ::
  Rat   823 IGERGINLSGGQRQRISVARALYQHTNVVFLDDPFSALDVHLSDHLMQ-----AGILELLRDDKR 882

  Fly   824 SRVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFADFIIQHLQE-GNEEEEELNQIK 887
            :.|||||.:.:||..|.|..:|.|.|...||.....:::..    :.:|.:. .|.:::||   :
  Rat   883 TVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQ----LFEHWKTLMNRQDQEL---E 940

  Fly   888 RQISSTADVPELLGTVEKAIKLARTESLSDSISVTSADSLMGGGGSLRRRTKRQDSHDSVASAAS 952
            ::.......||....:.:|              ::|.|.|:            .|..:....||.
  Rat   941 KETVMERKAPEPSQGLPRA--------------MSSRDGLL------------LDEDEEEEEAAE 979

  Fly   953 LKKKQEVEGKLIETEKSQTGGVEFAVYKHYIKSVGIFLSVATLVLNFVFQAFQIGSNLWLTQWAN 1017
            .::...:...|.:..|     :.:.....|:.|.||.|....:....:.....:..:.||.:|.:
  Rat   980 SEEDDNLSSVLHQRAK-----IPWRACTKYLSSAGILLLSLLVFSQLLKHMVLVAIDYWLAKWTD 1039

  Fly  1018 --------------DQNVANDTGLRDMYLGVYGAFGFGQGVLAYFAVVIVYLGGFQAAKTIHNEL 1068
                          .|..|.|..:..|...|..:.|.   .|.....|.|...|.:.||.:|..|
  Rat  1040 SALVLSPAARNCSLSQECALDQSVYAMVFTVLCSLGI---ALCLVTSVTVEWTGLKVAKRLHRSL 1101

  Fly  1069 LAVIIRGSVCRFFDITPIGRLLNSFSGDMDVVDEELPATMDSFMTFIFMVLATIVVISLSTPIFL 1133
            |..||...: |||:.||:|.:||.||.|.:.:|:.:|:|::.......:.::.:.|||..||:||
  Rat  1102 LNRIILAPM-RFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALAVISYVTPVFL 1165

  Fly  1134 AVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAK 1198
            ..::|:|.:.||.|:::...||.|.:|:..::.|:.|||:|||.|.:||||:....||.::....
  Rat  1166 VALLPLAVVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEY 1230

  Fly  1199 VDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAV---LGGQTNPGLVGLSVSYALQVTQTL 1260
            .|.|.:.......|||||.:|:|.:|..::|.|:..::   |..:.:.|||||.::|||.|:..|
  Rat  1231 TDSNNIASLFLTAANRWLEVRMEYIGACVVLIAAATSISNSLHRELSAGLVGLGLTYALMVSNYL 1295

  Fly  1261 NWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYREGLDL 1325
            ||:||..:|:|..:.:|:||....:|:.|:...|......|||||.:|:::.||..|||...|..
  Rat  1296 NWMVRNLADMEIQLGAVKRIHTLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSLKP 1360

  Fly  1326 VLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTII 1390
            ||:.|:..|..|:|:||.||||:||||.:||.||:::...|||.|||:|||.:.||.|||||:||
  Rat  1361 VLKHVNALISPGQKIGICGRTGSGKSSFSLAFFRMVDMFEGRIIIDGIDIAKLPLHTLRSRLSII 1425

  Fly  1391 PQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLV 1455
            .||||||||::|.||||.:..:|..:|:|||::.||..||:|..||:..|.|||||.|.|||||.
  Rat  1426 LQDPVLFSGTIRFNLDPEKKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLF 1490

  Fly  1456 CLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKG 1520
            |||||.:|||.:.::|||||::|:.|::::||.:.|.|.:.||:|||||::|||.:|.|:||.:|
  Rat  1491 CLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVMVLKRG 1555

  Fly  1521 QIIEFASPTELLDNPKSAFYSMAK 1544
            .|:||..|.:||....|.|.|..:
  Rat  1556 AILEFDKPEKLLSQKDSVFASFVR 1579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	487/1519 (32%)
		ABC_membrane	338..601	CDD:279056	92/286 (32%)
		ABCC_MRP_domain1	649..848	CDD:213217	97/268 (36%)
		ABC_membrane	988..1260	CDD:279056	88/288 (31%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	119/219 (54%)
Abcc8	NP_037171.2	CFTR_protein	223..1582	CDD:273530	472/1436 (33%)
		ABC_membrane	<375..590	CDD:279056	71/215 (33%)
		P-loop_NTPase	679..907	CDD:304359	96/232 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	741..768		0/26 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	939..962		4/39 (10%)
		ABC_membrane	1017..1295	CDD:279056	86/281 (31%)
		ABCC_SUR2	1343..1582	CDD:213255	125/237 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345060
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.650