DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MRP and abc2

DIOPT Version :9

Sequence 1:	NP_723772.2	Gene:	MRP / 34686	FlyBaseID:	FBgn0032456	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	NP_593943.3	Gene:	abc2 / 2543193	PomBaseID:	SPAC3F10.11c	Length:	1478	Species:	Schizosaccharomyces pombe

Alignment Length:	1508	Identity:	582/1508 - (38%)
Similarity:	856/1508 - (56%)	Gaps:	172/1508 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 LYDL-----DVWGPIIKFATFLLLFIF--------IPLNRKYGVQTTGCQFIFW---FLLTVLSI 154
            :||.     .||..:.....||.||:.        ||:         ....:||   ||.:.|.:
pombe    79 IYDCYKTNESVWNVLSIITYFLALFLHVVEQPTLRIPM---------ASLLMFWLFKFLASALVL 134

  Fly   155 PRCRTEVRLDAERQKILNSQQPSEQDFSWEEYQFVSFFIFFTFTSIMLILNCFADGMPRQTKYQR 219
                 .:|.:.....:|| ..||           ::||.    :.:.|:...:.....| ..|..
pombe   135 -----LLRPNYTMFPMLN-VVPS-----------ITFFC----SLVCLLAEIYVPPANR-VWYPD 177

  Fly   220 GENEIPELS--------ASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHH 276
            ...|:.|..        |:..|||::.|...:...||||.|.|.|.|.|.|.:..|.:..:|..:
pombe   178 DAAELEETGLRPSRFTYANIFSRISFGWLSPLMKFGYRNYLTESDAWSLPPAERSSNLTIVFEKN 242

  Fly   277 WNQNVRKNYKNKARVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGALMKL 341
            |..:.:|                               ||....:...::.:...:.:...::||
pombe   243 WISHAKK-------------------------------KKSSLYMWGVLFLNHWKLTVVIIVLKL 276

  Fly   342 FTDTLTFAQPQVLSLIISFVEAQDAE---PEWKGILYAVLLFVLAAAQTFILGQYFHRMFIVGLR 403
            ..|.:.|.||.::..|:.||.:..:|   |...|...|:.:|:....||.:|.|||....::|:|
pombe   277 VQDVVAFIQPNLIRKIVIFVSSYSSEHPQPPQVGFSLAIAMFLTNVVQTALLQQYFQLGMVLGMR 341

  Fly   404 IRTALINAIYRKALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLALYFLW 468
            .|:.||.|||||:||:|::.::..:||:|||.|:||.|:..:||.:|.:|.|.|.||.|||..|:
pombe   342 WRSELITAIYRKSLRLSSAARQSRSVGDIVNYMSVDTQKVCDLTMFLFVIVSGPFQIVLALTNLY 406

  Fly   469 QQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSF 533
            ..:|...|:|..|..:|.|.|.||||..|.:|.||||.||.|.:.|.|:::.|:.:||||||..|
pombe   407 HLVGYGALSGAFVTFLLFPCNVVIASIFKRFQNRQMKNKDARSQFMTEIINNIRSIKLYAWENIF 471

  Fly   534 EKQVLDIRD-KEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATY-VLTSEANQLSVEKVLVSIA 596
            .:::|.:|: :|:..|:....:|...:|.|..||.|||..||.|: ||..:...|||:.|...::
pombe   472 LQKLLQLRNTRELRMLKKIGIVNTIGNFTWLFAPILVSAATFGTFIVLYGKTRVLSVDIVFACLS 536

  Fly   597 LFDLMKLPLTILPMLSVDIAETQVSVNRINKFLNSEELDPNSVLHDSSKPHP----MSIENGEFS 657
            ||:|::.|||:||::...:.|..|:::||..||.:.|||.|:|....:...|    :.|:.|.||
pombe   537 LFNLLQFPLTMLPIVVSSVLEASVAISRIYGFLTAGELDSNAVQRYPANKEPSGVCLEIKKGTFS 601

  Fly   658 WGD------EITLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVVNTVGKLAYVPQ 716
            |..      |.|||:|:...::|.|..:||.||.||||:::|.||.|:|.:|.|...|.:||..|
pombe   602 WSGPGQNAAEPTLRDIDFVARRGELCCIVGKVGMGKSSLLEACLGNMQKHSGSVFRCGSIAYAAQ 666

  Fly   717 QAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISL 781
            |.||.|||:::|||||...|.:.|.|.|.||.|..|.:||:.||.||:|||||:||||||.||||
pombe   667 QPWILNATIQENILFGLELDPEFYEKTIRACCLLRDFEILADGDQTEVGEKGISLSGGQKARISL 731

  Fly   782 ARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDSIYVIKM 846
            ||||||.:|:|||||.|||||.||.:.:...::|.||:|..:..:|.|:.:|.|.:...||:::.
pombe   732 ARAVYSRSDIYLLDDILSAVDQHVNRDLVRNLLGSKGLLRSRCVILSTNSLTVLKEASMIYMLRN 796

  Fly   847 GEISESGTFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKRQISST-ADVPELLGTVEKAIKLA 910
            |:|.|||:|.||..:..:   .:.|.|.|.::        |...||| ||.|           |:
pombe   797 GKIIESGSFTQLSSSPDS---QLFQLLSEFSK--------KDTASSTGADTP-----------LS 839

  Fly   911 RTES-LSDSISVTSADS------------LMGGGGSLRRRTKRQDSHDSVASAASLKKKQEVEGK 962
            |::| ::.|..|||:.|            .:.|.|.:|:|...:|:..:...||
pombe   840 RSQSVITSSTDVTSSASRSSDTVSNYPKATIKGTGRIRKRLTDEDNVKATGQAA----------- 893

  Fly   963 LIETEKSQTGGVEFAVYKHYIKSVGIFLSVATLVLNFVF----QAFQIGSNLWLTQWANDQNVAN 1023
                ||.:.|.|::.||..|.|:..:||    :.|.|:|    ....:|:|:||..|:   .|..
pombe   894 ----EKMERGKVKWKVYWTYFKACSLFL----IFLYFLFIIGGIGMNVGTNVWLKHWS---EVNT 947

  Fly  1024 DTGLRD---MYLGVYGAFG-FGQGVLAYFAVVIVYLGGFQAAKTIHNELLAVIIRGSVCRFFDIT 1084
            ..|...   .|||:|..|| ....:::..::.|......::.:.:|:.::..::|..: .||:.|
pombe   948 QLGYNPKPYFYLGIYTLFGLLSCALISLSSLTITVFCAIKSCRYLHDSMVKAVLRAPM-SFFETT 1011

  Fly  1085 PIGRLLNSFSGDMDVVDEELPATMDSFMTFIFMVLATIVVISLSTPIFLAVIVPIAFLYYFAQRF 1149
            |.||:||.||.|:..|||.:......|...:|.::..:.||..|:|:|:.:|||:.|||.:.|.:
pombe  1012 PTGRILNRFSSDVYRVDEVISRVFMFFFRNLFQIVFVLAVICYSSPMFMILIVPLFFLYRYNQVY 1076

  Fly  1150 YVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANR 1214
            |..|||:|.||:||:|||:|:||.|::.|.||||||::.|.||.|:|.:||.|....:....:||
pombe  1077 YTQTSRELKRLDSVTRSPLYAHFQESLGGLSTIRAYDMEDTFISENDIRVDTNHRIWFLYFSSNR 1141

  Fly  1215 WLAIRLEMVGNLIILFASLFAVLG---GQTNPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVS 1276
            |.|||:|.:|.|::..::.|.||.   |..|.||||||:|||:|:||:|.::||.|.|:||||||
pombe  1142 WQAIRVEAIGALVVFSSAFFGVLSAVRGNPNSGLVGLSLSYAVQITQSLTFVVRQSVDVETNIVS 1206

  Fly  1277 VERIKEYGETKQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVG 1341
            |||:.||.....||| .:..|...|:.||..|.::|.::.|||||.|.|||..:|.||:..||:|
pombe  1207 VERMLEYIGLPSEAP-SIIPDHRPPEGWPSHGAIKFDHYSVRYRENLPLVLNDISVNIKPQEKIG 1270

  Fly  1342 IVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLD 1406
            ||||||||||:|||||||:||...|.|.:|.::|.|:|||.|||||.||||:...|.|::|.|||
pombe  1271 IVGRTGAGKSTLTLALFRLIEPTSGDIQLDDINITSIGLHDLRSRLAIIPQENQAFEGTIRENLD 1335

  Fly  1407 PFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLD 1471
            |....||:|||.|||.:.||.|:::|..||...:.|||.|||.|||||:||.||||..|:||:||
pombe  1336 PNANATDEEIWHALEAASLKQFIQTLDGGLYSRVTEGGANLSSGQRQLMCLTRALLTPTRVLLLD 1400

  Fly  1472 EATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNPK 1536
            |||||||:|||.::|:|||..|.:.|:||||||:||::||::::|||.|:::||.|..:||:|..
pombe  1401 EATAAVDVETDAIVQRTIRERFNDRTILTIAHRINTVMDSNRILVLDHGKVVEFDSTKKLLENKA 1465

  Fly  1537 SAFYSMAKDANLV 1549
            |.|||:||::.|:
pombe  1466 SLFYSLAKESGLI 1478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	581/1505 (39%)
		ABC_membrane	338..601	CDD:279056	107/267 (40%)
		ABCC_MRP_domain1	649..848	CDD:213217	100/204 (49%)
		ABC_membrane	988..1260	CDD:279056	106/282 (38%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	128/219 (58%)
abc2	NP_593943.3	MRP_assoc_pro	96..1477	CDD:188098	577/1488 (39%)
		ABC_membrane	272..545	CDD:279056	108/272 (40%)
		ABCC_MRP_domain1	593..798	CDD:213217	100/204 (49%)
		ABC_membrane	928..1190	CDD:279056	101/265 (38%)
		ABCC_MRP_domain2	1237..1456	CDD:213211	128/218 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	200	1.000	Domainoid score	I657
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68364
Inparanoid	1	1.050	957	1.000	Inparanoid score	I44
OMA	1	1.010	-	-		QHG51855
OrthoFinder	1	1.000	-	-		FOG0000087
OrthoInspector	1	1.000	-	-		otm47308
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	LDO	PTHR24223
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8
SonicParanoid	1	1.000	-	-		X177
TreeFam	1	0.960	-	-
	14	13.860