Protein Alignment MRP and abc4

DIOPT Version :9

• Sequence 1: NP_723772.2
• Gene: MRP / 34686
• FlyBaseID: FBgn0032456
• Length: 1549
• Species: Drosophila melanogaster
• Sequence 2: NP_594558.1
• Gene: abc4 / 2543059
• PomBaseID: SPAC30.04c
• Length: 1469
• Species: Schizosaccharomyces pombe
• Alignment Length: 1579
• Identity: 465/1579 - (29%)
• Similarity: 728/1579 - (46%)
• Gaps: 242/1579 - (15%)

  Fly    44 PCAFYW--------AFVIFDFYYLKASLDRNIPWNKLNVSKALVNLGLLVITALDLIMALVKKGG 100
            |.:.|:        |..||..:|.:..|:....|.|.::...||.|.|.:|.........||:..
pombe    19 PTSLYYSLSDFSLSAISIFPTHYDQPYLNEAPSWYKYSLESGLVCLYLYLIYRWITRSFTVKQTV 83

  Fly   101 DSEL----PLYDLDVWGPIIKFATFLLLFIFIPLNRKYGVQTTG-----CQF---IFWFLLTVLS 153
            .||.    ..:.:.:|   :....||.:..|:.:|..:....:.     |..   :..|||..|.
pombe    84 GSEFSGLRKAHGILLW---LLSILFLGMTAFMFVNDAFPTAFSDPPVKICLLAYSVHLFLLHSLR 145

  Fly   154 I--PRCRTEVRLDAERQKILNSQQPSEQDFSWEEYQF----------VSFFIFFTFTSIMLILNC 206
            :  ||.|..:...|    :|.:.......|.:..|.|          .|.|::|.| .|.::.|.
pombe   146 MIYPRARPTLYHAA----VLLNLLLLPPIFHFYSYPFFFVDHPPLSSYSPFLWFYF-FITIVGNF 205

  Fly   207 FADGMPR-------QTKYQRGENEIPELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQD 264
            .....||       :..||....::   .:.|....:|.:.:.:.|...|..:|..|
pombe   206 IPLFTPRVWYPLFPEDNYQPSAEQV---CSMFNFACSYGYLNPLVLTAKRRVVEVDD-------- 259

  Fly   265 SCSEVMPIFAHHWNQNVRKNYKNKARVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSF 329
              :.|:|.:.           ||||          ....||        |.| ..|:...|:|.|
pombe   260 --TPVIPDYD-----------KNKA----------WTYRFE--------RMK-TPSLFITIHKIF 292

  Fly   330 GGVFLFGALMKLFTDTLTFAQPQVLSLIISFVEAQDAEPEWKGILYAVLLFV---LAAAQT---- 387
            ....|...:.........|..|..|:.::..:|:..:. ....:::.|||..   |.:..|
pombe   293 WRQILGMGVSSFMVSVCQFLSPIALNRLLKHLESPSSS-SVNPLVWIVLLLTGPFLTSLFTQFYL 356

  Fly   388 FILGQYFHRMFIVGLRIRTALINAIYRKALR---ISNSTKKESTVGEIVNLMAVDAQRFMELTTY 449
            |:..:|..|.:       |.|:..||.|.:|   :.|.: .:|.||...||::.|.....|:..:
pombe   357 FMSTRYLARSY-------TTLVQQIYNKVIRSRFVQNKS-GDSKVGRSNNLISTDVDDIGEIREF 413

  Fly   450 LNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLM 514
            :::|..||::|..::|.|.:.||.|...|||:.::...|..|:...:....:|..:..|.|::||
pombe   414 IHIIVRAPVEIAGSIYLLQKLLGWSAYVGLALTVLTCSVPIVLGPLVAKLTLRANRATDSRIELM 478

  Fly   515 NEVLSGIKVLKLYAWE-PSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWS------CAPFLVSLV 572
            :|:|..|::.|.:.|| |..::    ::.:....|..|          |.      |...||..:
pombe   479 SELLQSIRITKFFGWELPMLDR----VKQRRQVELNRT----------WKLLLMEICIQVLVESL 529

  Fly   573 ----TFATYVL--TSEANQLSVEKVLVSIALFDLMKLPLTILPMLSVDIAETQVSVNRINKFLNS 631
                .|||:|:  |.....::......||:||..::...:.:..|...|.:..||:.|::.|||.
pombe   530 PVFSMFATFVVFTTIMGQTITPSIAFTSISLFSFIRTQFSWIAYLMRQIVQIFVSIGRVSDFLND 594

  Fly   632 -EELDPNSVLHDSSKPHPMSIENGEFSW------GDEITLRNINIEVKKGSLVALVGTVGSGKSS 689
             :|:||.:.:.|:|:  .:...|...:|      || ..||::||...:..|..::|..||||||
pombe   595 PDEVDPVNTIEDTSQ--EIGFFNASLTWVSNPSPGD-FCLRDLNIVFPRNKLSIVIGPTGSGKSS 656

  Fly   690 VVQAFLGEMEKLAGVVNTVGK--LAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRAD 752
            ::.|.|||:....|..|....  ::||.|..|::|||:||||||...|..:||.|||.||.|..|
pombe   657 LISALLGELSLNKGSYNLPRSKGVSYVSQVPWLRNATIRDNILFDYPYIEERYKKVIQACGLLTD 721

  Fly   753 IDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAH----VGKHIFEEV 813
            :....|.|||||||||:.|||||||||:|||||||...:.|:||..||:|.|    :.||.|:
pombe   722 LQSFVASDLTEIGEKGVTLSGGQKQRIALARAVYSPTSIVLMDDVFSALDIHTSNWIYKHCFQ-- 784

  Fly   814 IGPKGILARKSRVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFADFIIQHLQEGNE 878
               ..::..::.:||||.|..              ..:|..|...|||..||         ...:
pombe   785 ---SSLMENRTVILVTHNVHL--------------FMDSAAFIVTVKNGSAF---------PVTD 823

  Fly   879 EEEELNQIKRQISSTAD--VPELLGTVEKAIKLARTESLSDSISVTSADSLMGGGGSLRRRTKRQ 941
            :...|..:..|.:|.::  .|:|     .||.:  ...:.|
pombe   824 KSSPLLFLAEQAASASEAAAPDL-----AAIPI--PNEVDD------------------------ 857

  Fly   942 DSHDSVASAASLKKKQEVEGKLIETEKSQTGGVEFAVYKHYIKSVGIFLSVATLVLNFV-FQAFQ 1005
                  |.||     .|.:|||:|.|:..||.|.|:....|:|..|....||.::|.|| .||..
pombe   858 ------AEAA-----DEKDGKLVEEEQRVTGDVVFSEIFSYMKHFGSGFYVAAVLLFFVTTQATS 911

  Fly  1006 IGSNLWLTQWANDQNVANDTGLRDMYLGVYGAFGFGQGVLAYFAVVIVYLGGFQAAKTIHNELLA 1070
            |..:||:..|.|....:.|.. .:.:|.|||.......:|.:...|....|.:.|::.:|:.:|.
pombe   912 ILIDLWVAFWTNSSVNSPDVN-NNKFLFVYGTMLLAYSLLDFLRTVSYDRGAWWASRKLHDSMLE 975

  Fly  1071 VIIRGSVCRFFDITPIGRLLNSFSGDMDVVDEELPATMDSFMTFIFMVLATIVVISLSTPIFL-- 1133
            .:. |:...:||.||.||::|.|:.|:..:|..|...:...:.....|...|:.:|.:.|||:
pombe   976 SVF-GTFASWFDKTPTGRIVNRFAKDIRSIDMNLSGWLFFSINCFLSVAGGILSVSSAMPIFMIP 1039

  Fly  1134 AVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAK 1198
            ||||.:|. |||. ..|......:.||.|:..|||:|...|::.|.|.|||:|....|.:....:
pombe  1040 AVIVCLAG-YYFG-LLYTRAQVGVKRLISIYTSPIFSLLGESIVGVSVIRAFNRQTIFKQMFSER 1102

  Fly  1199 VDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAVLGGQTNPGLVGLSVSYALQVTQTLNWL 1263
            :|.....:..|...|||:|:|.:.:..|:...|.|.|:|....:||:||.|::.|:..:.::...
pombe  1103 LDNLVRLQSTSYNLNRWVAVRTDGISGLVGAIAGLIALLQKDLSPGVVGFSLNQAVIFSSSVLLF 1167

  Fly  1264 VRMSSDIETNIVSVERIKEYGETKQE-APWELEQDKNKPKNWPQEGRVEFQNFQVRYREGLDLVL 1327
            ||..:.::..:.|.||:.||.:..|| ||....|   .|..||:||.:.|.:..|.|......:|
pombe  1168 VRSCNSLQAEMNSYERVLEYSKLPQEPAPTIAGQ---VPATWPKEGDIVFNHVSVSYSAAGPTIL 1229

  Fly  1328 RGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQ 1392
            :.|:.:|...|||.:|||||:|||:|.|.|.|......|.|.|:|.:..|:.|:.||.|::.|||
pombe  1230 KDVNLHINPSEKVAVVGRTGSGKSTLGLTLLRFTHRISGEIYINGRETQSVNLNALRQRISFIPQ 1294

  Fly  1393 DPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFV-------KSLAAGLNHEIAEGGENLSVG 1450
            ||:||||::|.|||||:...|:.:.:||:.|...|.:       |.:...|:..:|..|.|.|.|
pombe  1295 DPILFSGTVRSNLDPFDELEDNFLNEALKTSGASSMIMAHTDDQKPIHITLDTHVASEGSNFSQG 1359

  Fly  1451 QRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVI 1515
            |:|::.||||::|::|:::|||.||:||...|..||||:|..|.:.|:|.|||||.||:|.|||:
pombe  1360 QKQVLALARAIVRRSKIIILDECTASVDDAMDQKIQKTLREAFGDATMLCIAHRLKTIVDYDKVM 1424

  Fly  1516 VLDKGQIIEFASPTELLDN 1534
            |||||.::|:..|..|..|
pombe  1425 VLDKGVLVEYGPPAVLYHN 1443

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	465/1579 (29%)
		ABC_membrane	338..601	CDD:279056	67/285 (24%)
		ABCC_MRP_domain1	649..848	CDD:213217	86/210 (41%)
		ABC_membrane	988..1260	CDD:279056	83/274 (30%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	99/226 (44%)
abc4	NP_594558.1	CFTR_protein	240..1449	CDD:273530	418/1347 (31%)
		ABC_membrane	300..568	CDD:294371	67/290 (23%)
		ABCC_MRP_domain1	611..817	CDD:213217	91/225 (40%)
		ABC_membrane	901..1164	CDD:294371	81/266 (30%)
		ABCC_MRP_domain2	1210..1437	CDD:213211	99/226 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000087
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.710