DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MRP and ybt1

DIOPT Version :9

Sequence 1:	NP_723772.2	Gene:	MRP / 34686	FlyBaseID:	FBgn0032456	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	NP_594585.1	Gene:	ybt1 / 2542640	PomBaseID:	SPAC9E9.12c	Length:	1427	Species:	Schizosaccharomyces pombe

Alignment Length:	1598	Identity:	457/1598 - (28%)
Similarity:	737/1598 - (46%)	Gaps:	273/1598 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 AFYWAFVIFDFYYLKASLDRNIPWNKLNVSKALVNLGLLVITALDLIMALVKKGGDSELPLYDLD 110
            :|:..::..:| :..|:||:.:         .|..|.|..:|.|.||..|........
pombe     6 SFFSNYIDINF-FRNATLDQCL---------LLFYLSLFSLTNLFLIQKLFHANHTQH------- 53

  Fly   111 VWGPIIKF--ATFLLLFIFIPLNRKYGVQTTGCQF------IFWFLLTVLSIPRCRTEVRLDAER 167
               |:.|:  .|.||.:|.|.|:    :.:....|      ::|.:         ||...|:...
pombe    54 ---PLKKYFGETCLLEYIQIILS----IVSAALSFYLDTNAVWWAI---------RTITHLEIVG 102

  Fly   168 QKILNSQQPSEQDFSWEE---------YQFVSFFIFFTFTS-----------------------I 200
            ..||:|.:.....|||..         .:.:|.:.|.|::|                       :
pombe   103 LNILSSLKYGSTLFSWISVANAFGLLLLRLISIYDFLTYSSWSFSVKGGSFLLLLPLAYNITLFL 167

  Fly   201 MLILNCFADGMPR----QTKYQRGENEIPELSASFLSRI-TYQWFDKMALKGYRNPLEEKDLWDL 260
            ::|:..|   .||    ..|:.:.....||.:.|..|.| ||.|.:.:..|.::.|:...|:..|
pombe   168 LVIIPLF---FPRAWSPTVKFSKVARPSPEQTCSIFSLIFTYGWLNGIIWKSWKKPITLTDVPAL 229

  Fly   261 RPQDSCSEVMPIFAHHWNQNVRKNYKNKARVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPI 325
             |...|:::       |       |...|                     ||.||    |:|..|
pombe   230 -PDTECTQI-------W-------YSRFA---------------------KNDRK----SLMHTI 254

  Fly   326 YKSFGGVFLFGALMKLFTDTLTFAQPQVLSLIISFVEAQDAEPEWKGILYAVLLFVLAAAQTFIL 390
            ..|.....|....:.:...:..|..|..:..::.:::...::......|:..:|.:.....:.:.
pombe   255 LLSLKSTILLMVFLSVLVSSTLFVTPLAIKKLLQYLQNPKSDEGNSPFLWVFVLLIGPYLASVVK 319

  Fly   391 GQYFH--RMFIVGLRIRTALINAIYRKALRISNSTKK---------ESTVGEIVNLMAVDAQRFM 444
            ..|.|  |.|:  |||:.|:...||:|.|     |.|         :..:..:.||:|.|.....
pombe   320 ELYVHVSRRFM--LRIKAAITQMIYKKVL-----TSKTLFVAVDGSKINLDYVYNLLAKDVDNIG 377

  Fly   445 ELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDE 509
            |:..::.:|..|||::|:::|||:|.||.|...||.:.|:......::||:|...........||
pombe   378 EMREFIGIIARAPLEMGVSMYFLYQLLGWSAYVGLLLAILSSSFPLLVASKISRLTSIANTSSDE 442

  Fly   510 RVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTF 574
            |::|..|:|..||:.||:.||.....::.:.|..|:..:.|....:.........|||:...:||
pombe   443 RIRLTTELLKSIKITKLFGWERPMLSRIQEKRSFEVNNMYSLTLFDIIFKSGMKIAPFISMFITF 507

  Fly   575 ATYVLTSEANQLSVEKVLVSIALFDLMKLPLTILPMLSVDIAETQVSVNRINKFLNSEELDPNSV 639
            |.|.... .:||:......||::|.|::.....|..:|....:.:||:.|::.|:....::.:|:
pombe   508 AIYTKIM-GHQLTPATAFTSISMFGLLRYQFIWLASVSRQFIQFKVSLKRVDNFVYGNMVNDSSI 571

  Fly   640 LHDSSKPHPMSIENGEFSWGDE-----ITLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEME 699
            ....|    ...||...||...     ..|:|:|..:.:.....:||:.|||||::..|.|||:.
pombe   572 ESSDS----FVFENTSLSWSPTPSTALFQLKNLNFTIPRNQFTLVVGSTGSGKSTLAMALLGELH 632

  Fly   700 KLAGVVNTVG---KLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDL 761
            .::|.:.|..   ::|||||.||::|.|:|.|||||:.||.:||.::|.||.|.:|::.::.|||
pombe   633 VISGKMTTPSISQRIAYVPQAAWLRNGTIRSNILFGEPYDEERYFQIIKACCLDSDLNSMNDGDL 697

  Fly   762 TEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRV 826
            |.|...|.:||||||||:|||||:||:|::|:.||..||:|....:.|:|... ...:|..|:.:
pombe   698 TYIHSNGSSLSGGQKQRVSLARALYSNAEVYIFDDIFSALDVSTSRKIYESCF-LSTLLQHKTII 761

  Fly   827 LVTHGVTF-LPQVDSIYVIK--MGEISESGTFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKR 888
            |.||.|:. ||..:::.|:|  ..::....:..:||.     :.|...:.::.|.|||.|
pombe   762 LFTHNVSLCLPIAENVIVLKNSTAQLVSPDSIQELVP-----STFFSSNTKKDNIEEENL----- 816

  Fly   889 QISSTADVPELLGTVEKAIKLARTESLS-DSISVTSADSLMGGGGSLRRRTKRQDSHDSVASAAS 952
                                  ...|.| ||...:|:|:               |.....||.:|
pombe   817 ----------------------EPHSFSFDSTLASSSDN---------------DEQRDFASNSS 844

  Fly   953 LKKKQEVEGKLIETEKSQTGGVEFAVYKHYIKSVGIFLSVATLVLNFVFQAFQIGS-NLWLTQWA 1016
            :                      ..:..||:|..|....:...:|..:.....:.| :.|:..|:
pombe   845 I----------------------VLLGLHYLKYFGSNKYILGSILLVMMSQVSLASIHFWIALWS 887

  Fly  1017 NDQNVANDTGLRDMYLGVYGAFGFGQGVL--AYFAV-----VIVYLGGFQAAKTIHNELLAVIIR 1074
            .:       .|..:.|....:|.:|..:|  .||.:     :....||..|::.|| ::|:..:.
pombe   888 GN-------SLFSLKLPSSFSFLWGYAILLFIYFLMDLSRAITFAKGGRTASENIH-DILSERVL 944

  Fly  1075 GSVCRFFDITPIGRLLNSFSGDMDVVDEELPATMDSFMTFIFMVLATIVVISLSTPIFLAVIVPI 1139
            .|...:|:.|..||:||.||.||...|..|.|:::..:..:..:|.|::.::|..|||:   ||.
pombe   945 YSPLHWFEKTAAGRILNRFSKDMYATDNLLWASLEGMLLCVMAILITMLNVTLVMPIFM---VPA 1006

  Fly  1140 AF---LYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDK 1201
            ||   |.|.....|....:||..|:|...||:::...||:.|.:.|||:.....|..|:.|.:|.
pombe  1007 AFVSLLVYLHGYAYSKAQKQLTSLQSSRTSPVFTMLGETLGGITVIRAFKKEKIFEHENMAFIDD 1071

  Fly  1202 NQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAVLGGQTNPGLVGLSVSYALQVTQTLNWLVRM 1266
            .....|.|...|||||||.:.:..|:.....|.|:|.....|||||.|::.|:....::...||.
pombe  1072 MIQPLYISFAINRWLAIRTDGISGLVGFSTGLIALLRQNIPPGLVGFSLNSAIGFNISVLVFVRA 1136

  Fly  1267 SSDIETNIVSVERIKEYGETKQEAPWELEQDKN------KP--KNWPQEGRVEFQNFQVRYREGL 1323
            :::|.|.|.:..|:.||        ..|..:||      ||  |.||..|.|..:|..|.|..|.
pombe  1137 NNEILTYINNFRRLYEY--------MLLPSEKNESSCLTKPMNKEWPTLGHVSIKNLTVSYSIGQ 1193

  Fly  1324 DLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLT 1388
            ..||..::..|...||:.||||||:|||::.|.|.|......|.:.:||:||.|:.|.:||.|::
pombe  1194 AAVLEDINLEILPKEKIAIVGRTGSGKSTMGLTLLRFTMIMSGAVEVDGIDINSLDLEVLRQRIS 1258

  Fly  1389 IIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVK--------SLAAGLNHEIAEGGE 1445
            :|||||||.||::|.||||||...|.|:.:.|:.:..:|.|:        :.|..|:..:..||.
pombe  1259 LIPQDPVLISGTVRSNLDPFEEYGDGELNEILKTASCESLVQASNKNSLDAFAIHLDTPVDSGGV 1323

  Fly  1446 NLSVGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILD 1510
            |.|.||||::.|||||:||:::::|||:||:||..||..||:.:|..||..|||.||||:.||:|
pombe  1324 NFSSGQRQILALARALVRKSRIVILDESTASVDDTTDRRIQQMLRAAFKHATVLCIAHRIKTIVD 1388

  Fly  1511 SDKVIVLDKGQIIEFASPTELLDNPKSAFYSMAKDANL 1548
            .|||:|||.|:.:||.||..|. ..:.||:.|.|::::
pombe  1389 YDKVLVLDSGKTVEFGSPKSLY-TQRRAFWKMCKESHI 1425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	457/1596 (29%)
		ABC_membrane	338..601	CDD:279056	68/273 (25%)
		ABCC_MRP_domain1	649..848	CDD:213217	84/209 (40%)
		ABC_membrane	988..1260	CDD:279056	80/282 (28%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	104/227 (46%)
ybt1	NP_594585.1	CFTR_protein	192..1416	CDD:273530	412/1365 (30%)
		ABC_membrane	266..537	CDD:294371	69/278 (25%)
		ABCC_MRP_domain1	577..782	CDD:213217	83/205 (40%)
		ABC_membrane	866..1094	CDD:294371	69/238 (29%)
		ABCC_MRP_domain2	1178..1406	CDD:213211	104/227 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000087
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.710