DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MRP and abc3

DIOPT Version :9

Sequence 1:	NP_723772.2	Gene:	MRP / 34686	FlyBaseID:	FBgn0032456	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	NP_595055.1	Gene:	abc3 / 2540937	PomBaseID:	SPBC359.05	Length:	1465	Species:	Schizosaccharomyces pombe

Alignment Length:	1578	Identity:	560/1578 - (35%)
Similarity:	845/1578 - (53%)	Gaps:	207/1578 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 FTPCFEQTALVWTPCAFYWAFVIFDFYYLKASLDRNIPWNKLNVSKALVNLGLLVITALDLIMAL 95
            |.|.|.|...:|.. .|..|.||....|: ....:||.||..:           |:|...::...
pombe    36 FRPHFSQFWTIWMK-FFSIALVIITQIYV-GYKTKNIGWNFFS-----------VVTYCFVLFLQ 87

  Fly    96 VKKGGDSELPLYDLDV-WGPIIKFATFLLLFIFIPLNRKYGVQTTGCQFIFWFLLTVLSIPRCRT 159
            ..:.....:|:..|.: |  ::|..|.||:.:|.|                  .:.:.|:.|..|
pombe    88 FAEQSTLRVPMASLLIFW--LLKVVTSLLILLFSP------------------YIAITSMARLLT 132

  Fly   160 EVRLDAERQKILNSQQPSEQDFSWEEYQFVSFFIFFTFTSIMLILNCFADGMPRQTKYQRGENEI 224
            .:.|                           |.....|.|.:.:..|      .:..|....||:
pombe   133 LITL---------------------------FCSLVCFISEVYVPPC------NRVWYSDDTNEV 164

  Fly   225 PELS--------ASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHHWNQNV 281
            .|..        |:..|::::.|.......||.|.|:|.|:|.|.|.:....::..|...|..
pombe   165 EEKGIRPSEVRYANIFSKLSFSWISSFIKFGYTNYLKESDVWLLPPDERSGNLIIGFEDWWIY-- 227

  Fly   282 RKNYKNKARVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGALM------- 339
              :.|||.|                                        .:||:..|.
pombe   228 --HSKNKRR----------------------------------------SLFLWKLLFFNHWKLV 250

  Fly   340 ------KLFTDTLTFAQPQVLS---LIISFVEAQDAEPEWKGILYAVLLFVLAAAQTFILGQYFH 395
                  ||..|.|.|.||.::.   |.||...:.:.|...:|.:.|:|:.|....||.:|.||..
pombe   251 ALITITKLIQDVLAFVQPTLIQKTILFISSYTSPNPESPSRGFIIAILVLVANFLQTLLLQQYNQ 315

  Fly   396 RMFIVGLRIRTALINAIYRKALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQI 460
            .:.::|:|.:|.|:.:||||:|.:|:|.::..::|:|:|.||||.|:..:|..||.:|.|.|.||
pombe   316 LIMLLGMRWKTELLASIYRKSLLLSSSARQNRSIGDIINYMAVDTQKISDLPIYLFIIVSGPFQI 380

  Fly   461 GLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLK 525
            .|||..|:..:|.|...|:|..:||.|.|.::|:..|.:|...||.||.|.|||.|:::.|:.:|
pombe   381 ALALSNLYHLMGYSAFTGVAASVILFPCNIIVANVYKKFQSILMKNKDSRSKLMTEIINNIRSIK 445

  Fly   526 LYAWEPSFEKQVLDIRD-KEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVLTSEANQ-LSV 588
            |||||..|.:::|.||: ||::.|:...::.|...|.|.....:|:.|.|..:::.....| |:.
pombe   446 LYAWETPFLQKLLHIRNTKELSMLKKIGFITAIGDFAWIFTTIIVTTVAFGAFIIFHGKTQALTA 510

  Fly   589 EKVLVSIALFDLMKLPLTILPMLSVDIAETQVSVNRINKFLNSEELDPNSV--LHDSSKPHP--M 649
            :.|..:::||:|::.||.:||.:...:.|..|||:||.:||.::|||.|.|  ...:..||.  :
pombe   511 DIVFPAVSLFNLLQFPLAMLPTVISSLLEASVSVSRIYEFLIAQELDYNGVQRFPATEIPHEICL 575

  Fly   650 SIENGEFSWGDEI-------TLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVVNT 707
            .|::|.|||..:.       |||.||...|.|.|..:.|.||:||||:::|.:|.|.|.:|.|..
pombe   576 EIKSGTFSWSKKTLKQQVTPTLRQINFVAKNGELTCIFGKVGAGKSSLLEACMGNMYKNSGSVFQ 640

  Fly   708 VGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLS 772
            .|.|||..||.||.:||:|:|||||..:|.:.|.|.|.||.|:.|.:|.:.||.||:|:||.:||
pombe   641 CGSLAYAAQQPWIFDATIRENILFGSEFDPELYEKTIHACCLKRDFEIFTEGDQTEVGQKGASLS 705

  Fly   773 GGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQ 837
            ||||.|||||||:||.||:|||||.||:||.||.:.:.:.:.||:|.|.....||.|:.:..|.:
pombe   706 GGQKSRISLARAIYSQADIYLLDDVLSSVDQHVSRDLIKNLFGPEGFLRTHCVVLTTNSLNVLKE 770

  Fly   838 VDSIYVIKMGEISESGTFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKRQISSTADVPELLGT 902
            .||||::..|:|.|.|.::.|..:..:   .:.|.|.|.|:|::           |..:||
pombe   771 ADSIYILSNGKIVEKGNYEHLFVSTNS---ELKQQLSEFNDEKD-----------TQPLPE---- 817

  Fly   903 VEKAIKLARTESLSDSISVTSADSLMGGGGSLRRRTKRQDSHDSVASAASLKKKQEVEGKLIETE 967
                    .|.|. .|..::.|.|:...|......::|:||.:...|    :|:..:..|:.|.:
pombe   818 --------HTTSY-PSTQISLAPSIHVEGLETYSSSERKDSSNKYKS----RKRNPIRQKVTEDD 869

  Fly   968 KS----------QTGGVEFAVYKHYIKSVGIFLSVATLVLNFVF----QAFQIGSNLWLTQWAND 1018
            |.          |.|.|::.||..|.||    .|:..::|.|.|    ....:.:|:||..| ::
pombe   870 KGKCVAQTDELVQRGKVKWHVYWMYFKS----CSIGLILLYFFFIISGIMMNVATNVWLKHW-SE 929

  Fly  1019 QNVANDTGLRD---MYLGVYGAFGF-GQGVLAYFAVVIVYLGGFQAAKTIHNELLAVIIRGSVCR 1079
            :|..:.:.|..   .|||:|..||| ....::..::.:..|.|.::.:.:|:.:|..|:|..: .
pombe   930 ENGKSSSELNPSPYFYLGIYLFFGFLSCAFISSSSLTMTVLCGIRSGRYLHDSMLKTILRAPM-G 993

  Fly  1080 FFDITPIGRLLNSFSGDMDVVDEELPATMDSFMTFIFMVLATIVVISLSTPIFLAVIVPIAFLYY 1144
            ||:.|..||:||.||.|:..|||.:..|...|......||..:.||..|.|:.|.:|||:.|||.
pombe   994 FFETTSSGRILNRFSNDVYKVDEVVSLTFMFFFRNSIQVLFILGVICYSAPLSLLLIVPLFFLYL 1058

  Fly  1145 FAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPS 1209
            :.:.:||.|||:|.||::|:|||:|:|..|:::|.||||||.:.:.|:||:|.::|.|....:..
pombe  1059 YNRAYYVRTSRELKRLDNVTRSPLYAHVQESLSGLSTIRAYGMQETFVEENDLRIDTNHRVWFMF 1123

  Fly  1210 VIANRWLAIRLEMVGNLIILFASLFAVLG---GQTNPGLVGLSVSYALQVTQTLNWLVRMSSDIE 1271
            ..::||.|||:|.:|:|||...:.:.:|.   |..||||||.|:|||:|:||.|:::|:.|.|.|
pombe  1124 FSSSRWQAIRVECIGDLIIFCTAFYGILSAIKGSPNPGLVGFSLSYAIQITQGLSFIVQQSVDAE 1188

  Fly  1272 TNIVSVERIKEYGETKQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQG 1336
            .|.||||||.||...|.||| |:..:...|..||.:|.|.|.::..:|||.|...|..::..|..
pombe  1189 NNTVSVERILEYINVKSEAP-EIIPENRPPCEWPTDGAVSFNHYSAKYREDLSFALNNINIEISP 1252

  Fly  1337 GEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSL 1401
            .||:|||||||||||:|.:|||||||...|:|.||..||...||:.|||||:||||:..:|.|::
pombe  1253 REKIGIVGRTGAGKSTLAMALFRIIEPTEGKIEIDNEDITKFGLYDLRSRLSIIPQESQIFEGNI 1317

  Fly  1402 RINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTK 1466
            |.||||....||.:||:.||::.||:.:..|..||...:||||.|.|.|||||:||||.||..|:
pombe  1318 RENLDPNHRLTDKKIWEVLEIASLKNCISQLEDGLYSRVAEGGANFSSGQRQLICLARVLLTSTR 1382

  Fly  1467 VLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTEL 1531
            :|:||||||:|..|||.::|:|||..||:.|:||:|||:||::|||:::|||.|:::||.:..:|
pombe  1383 ILLLDEATASVHAETDAIVQQTIRKRFKDRTILTVAHRINTVMDSDRILVLDHGKVVEFDATKKL 1447

  Fly  1532 LDNPKSAFYSMAKDANLV 1549
            |:|..|.|||:||::.|:
pombe  1448 LENKDSMFYSLAKESGLI 1465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	559/1575 (35%)
		ABC_membrane	338..601	CDD:279056	97/280 (35%)
		ABCC_MRP_domain1	649..848	CDD:213217	98/205 (48%)
		ABC_membrane	988..1260	CDD:279056	104/282 (37%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	117/219 (53%)
abc3	NP_595055.1	MRP_assoc_pro	101..1464	CDD:188098	542/1497 (36%)
		ABC_membrane	254..527	CDD:294371	97/272 (36%)
		ABCC_MRP_domain1	575..781	CDD:213217	98/205 (48%)
		ABC_membrane	907..1177	CDD:279056	102/271 (38%)
		ABCC_MRP_domain2	1224..1443	CDD:213211	117/218 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	200	1.000	Domainoid score	I657
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68364
Inparanoid	1	1.050	957	1.000	Inparanoid score	I44
OMA	1	1.010	-	-		QHG51855
OrthoFinder	1	1.000	-	-		FOG0000087
OrthoInspector	1	1.000	-	-		otm47308
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	O	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X177
TreeFam	1	0.960	-	-
	13	12.830