DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MRP and Tap1

DIOPT Version :9

Sequence 1:	NP_723772.2	Gene:	MRP / 34686	FlyBaseID:	FBgn0032456	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	NP_114444.2	Gene:	Tap1 / 24811	RGDID:	3817	Length:	725	Species:	Rattus norvegicus

Alignment Length:	495	Identity:	125/495 - (25%)
Similarity:	223/495 - (45%)	Gaps:	48/495 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly  1064 IHNELLAVIIRGSVCRFFDITPIGRLLNSFSGDMDVVDEELPATMDSFMTFI--------FMVLA 1120
            :|.|:...::.... .||...|.|.:.:..:.|...|.|.:...::.|:.::        ||:..
  Rat   237 VHGEVFRAVLHQET-GFFLKNPTGSITSRVTEDTSNVCESISDKLNLFLWYLGRGLCLLAFMIWG 300

  Fly  1121 TI---VVISLSTPIFLAVIVPIAFLYYFAQRFYVATSRQLMR-----LESVSRSPIYSHFSETVT 1177
            :.   ||..||.|:...:...:..:|   |...|.....|.:     ||::|..|....|:....
  Rat   301 SFYLTVVTLLSLPLLFLLPRRLGKVY---QSLAVKVQESLAKSTQVALEALSAMPTVRSFANEEG 362

  Fly  1178 GASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAVLGGQTN 1242
            .|...|      :.:||. ..::|.:...|.:.:....::..|..||  |:.......|.|..::
  Rat   363 EAQKFR------QKLEEM-KPLNKKEALAYVTEVWTMSVSGMLLKVG--ILYLGGQLVVRGAVSS 418

  Fly  1243 PGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKNKPKNWPQE 1307
            ..||.. |.|.||.|:.:..|:.:...::.::.:.|:|.||   ....|.........|.|  .:
  Rat   419 GNLVSF-VLYQLQFTRAVEVLLSIYPSMQKSVGASEKIFEY---LDRTPCSPLSGSLAPLN--MK 477

  Fly  1308 GRVEFQNFQVRYREGLDL-VLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISID 1371
            |.|:||:....|....:: ||:|::|.:..|:...:||..|:|||::...|..:.:..||::.:|
  Rat   478 GLVKFQDVSFAYPNHPNVQVLQGLTFTLYPGKVTALVGPNGSGKSTVAALLQNLYQPTGGKVLLD 542

  Fly  1372 GVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINL------DPFEIKTDDEIWKALELSHLKSFVK 1430
            |..:.....|.|.:::..:.|:|:||..|.|.|:      .|    |.:||......|....|:.
  Rat   543 GELLVQYDHHYLHTQVAAVGQEPLLFGRSFRENIAYGLTRTP----TMEEITAVAMESGAHDFIS 603

  Fly  1431 SLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTI--RTEF 1493
            ....|.:.|:.|.|..||.||||.|.|||||:||.::|:||:||:|:|......:|:.:  ..|:
  Rat   604 GFPQGYDTEVGETGNQLSGGQRQAVALARALIRKPRLLILDDATSALDAGNQLRVQRLLYESPEW 668

  Fly  1494 KECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLD 1533
            ...|||.|..:|:....:..::.|.:|.:.|..:..:|::
  Rat   669 ASRTVLLITQQLSLAERAHHILFLKEGSVCEQGTHLQLME 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	125/495 (25%)
		ABC_membrane	338..601	CDD:279056
		ABCC_MRP_domain1	649..848	CDD:213217
		ABC_membrane	988..1260	CDD:279056	45/211 (21%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	71/228 (31%)
Tap1	NP_114444.2	3a01208	2..717	CDD:273363	125/495 (25%)
		ABC_membrane	177..435	CDD:279056	45/211 (21%)
		Part of the peptide-binding site. /evidence=ECO:0000250\|UniProtKB:Q03518	352..397		8/51 (16%)
		Part of the peptide-binding site. /evidence=ECO:0000250\|UniProtKB:Q03518	430..464		7/36 (19%)
		P-loop_NTPase	469..697	CDD:304359	72/233 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000