DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MRP and Abcc12

DIOPT Version :9

Sequence 1:NP_723772.2 Gene:MRP / 34686 FlyBaseID:FBgn0032456 Length:1549 Species:Drosophila melanogaster
Sequence 2:NP_766500.3 Gene:Abcc12 / 244562 MGIID:2441679 Length:1366 Species:Mus musculus


Alignment Length:1411 Identity:472/1411 - (33%)
Similarity:727/1411 - (51%) Gaps:169/1411 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly   211 MPRQTKYQRGENEIPELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAH 275
            :|.:.:.:...|.:.:  |..||..|:.|...:.::.|::.|....|..|.|.||.......|..
Mouse    33 IPVRPRARLAPNPVDD--AGLLSFATFSWLTPVMIRSYKHTLTVDTLPPLSPYDSSDINAKRFQI 95

  Fly   276 HWNQNVRKNYKNKARVEPKAQFSNGNVTFENPHGEKNGRKKGM----ASIMPPIYKSFGGVFLFG 336
            .|.:.::       ||.|: :.|.|.|.:      |..|.:.:    |:|:..:..:.|...|. 
Mouse    96 LWEEEIK-------RVGPE-KASLGRVVW------KFQRTRVLMDVVANILCIVMAALGPTVLI- 145

  Fly   337 ALMKLFTDTLTFAQPQVLSLIISFVEAQDAEPEWKGILYAVLLFVLAAAQTFILGQYFHRMFIVG 401
                          .|:|..|.|.......    .||...:.||.....:.......:...:...
Mouse   146 --------------HQILQHITSISSGHIG----IGICLCLALFTTEFTKVLFWALAWAINYRTA 192

  Fly   402 LRIRTALINAIYRKALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLALYF 466
            :|::.||...|:...|  |..|....:.||::|:::.|:....|...:..:..:.|:.:.:...:
Mouse   193 IRLKVALSTLIFENLL--SFKTLTHISAGEVLNILSSDSYSLFEAALFCPLPATIPILMVVCAVY 255

  Fly   467 LWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLYAWEP 531
            .:..||.:.|.|::|.:|.||:...:|....|::...:...|:||:.|||.|:.||::|:||||.
Mouse   256 AFFILGSTALVGISVYLIFIPIQMFMAKLNSTFRRSAISVTDKRVQTMNEFLTCIKLIKMYAWEE 320

  Fly   532 SFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVLTSEANQLSVEKVLVSIA 596
            ||...:.|||.:|...|....|:.:|.|.|......:..:.||..::...  .:|:.......||
Mouse   321 SFINTIHDIRKREKKLLEKAGYVQSGNSALAPIVSTIAIVSTFTCHIFLK--RKLTAPVAFSVIA 383

  Fly   597 LFDLMKLPLTILPMLSVDIAETQVSVNRINKFLNSEELDPNSVLHDSSKPHP-MSIENGEFSWGD 660
            :|::||..:.|||.....:||..||:.|:.|.|.::  .|.|.:.....|.. :.:.|...:|..
Mouse   384 MFNVMKFSIAILPFSVKAVAEASVSLRRMKKILIAK--SPPSYITQPEDPDTILLLANATLTWEQ 446

  Fly   661 EI-----------------------------------------------TLRNINIEVKKGSLVA 678
            ||                                               .|.||:..|:||.::.
Mouse   447 EINRKSDPPKAQIQKRHVFKKQRPELYSEQSRSDQGVASPEWQSGSPKSVLHNISFVVRKGKVLG 511

  Fly   679 LVGTVGSGKSSVVQAFLGEMEKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKV 743
            :.|.|||||||::.|.||:|:...|||...|.||||.|||||.:..||:|||||:.|:.:||...
Mouse   512 ICGNVGSGKSSLISALLGQMQLQKGVVAVNGPLAYVSQQAWIFHGNVRENILFGEKYNHQRYQHT 576

  Fly   744 IDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKH 808
            :..|.|:.|::.|..||||||||:|:||||||:||||||||||::..||||||||||||||||||
Mouse   577 VHVCGLQKDLNSLPYGDLTEIGERGVNLSGGQRQRISLARAVYANRQLYLLDDPLSAVDAHVGKH 641

  Fly   809 IFEEVIGPKGILARKSRVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFADFIIQHL 873
            :|||.|  |..|..|:.|||||.:.||...|.:.:::.|||.|.||..:|::.:|.:|..|  |.
Mouse   642 VFEECI--KKTLKGKTVVLVTHQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLI--HN 702

  Fly   874 QEGNEEEEELNQIKRQISSTADVPELLGTVEKAIKLARTESLSDSISVTSADSLMGGGGSLRRRT 938
            ..|.:.::               ||.:..|      |..|:|.:|.:....|:::..|.. :...
Mouse   703 LRGLQFKD---------------PEHIYNV------AMVETLKESPAQRDEDAVLASGDE-KDEG 745

  Fly   939 KRQDSHDSVASAASLKKKQEVEGKLIETEKSQTGGVEFAVYKHYIKSVGIFL-SVATLVLNFVFQ 1002
            |..::.:.|.:.|...       :||:||..|.|.|.:..|..|||:.|.:| |...|.|.|:..
Mouse   746 KEPETEEFVDTNAPAH-------QLIQTESPQEGIVTWKTYHTYIKASGGYLVSFLVLCLFFLMM 803

  Fly  1003 AFQIGSNLWLTQW-----------ANDQNVAN-DTGLRD----MYLGVYGAFGFGQGVLAYFAVV 1051
            .....|..||..|           .|::...| |..|:|    ||..||         :|....|
Mouse   804 GSSAFSTWWLGIWLDRGSQVVCASQNNKTACNVDQTLQDTKHHMYQLVY---------IASMVSV 859

  Fly  1052 IVY--LGGF-------QAAKTIHNELLAVIIRGSVCRFFDITPIGRLLNSFSGDMDVVDEELPAT 1107
            :::  :.||       .|:.::||.:...|:| |...|||.||.|||:|.||.|||.:|..||..
Mouse   860 LMFGIIKGFTFTNTTLMASSSLHNRVFNKIVR-SPMSFFDTTPTGRLMNRFSKDMDELDVRLPFH 923

  Fly  1108 MDSFMTFIFMVLATIVVISLSTPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHF 1172
            .::|:...|||:..:|:::...|:.|.|:..:|.::....|.:....::|.::|::||||.:||.
Mouse   924 AENFLQQFFMVVFILVIMAAVFPVVLVVLAGLAVIFLILLRIFHRGVQELKQVENISRSPWFSHI 988

  Fly  1173 SETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAVL 1237
            :.::.|...|.||:..|..|.:.....|:|.........|.||.|:|::::.|::....:|...|
Mouse   989 TSSIQGLGVIHAYDKKDDCISKFKTLNDENSSHLLYFNCALRWFALRMDILMNIVTFVVALLVTL 1053

  Fly  1238 G-GQTNPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGET---KQEAPWELEQDK 1298
            . ...:....|||:||.:|::..|...||..::.:....|.|.::||..|   :...|:::   .
Mouse  1054 SFSSISASSKGLSLSYIIQLSGLLQVCVRTGTETQAKFTSAELLREYILTCVPEHTHPFKV---G 1115

  Fly  1299 NKPKNWPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEA 1363
            ..||:||..|.:.|:::::|||:...|||.|::.|||.|:.||||||||:|||||.:||||::|.
Mouse  1116 TCPKDWPSRGEITFKDYRMRYRDNTPLVLDGLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEP 1180

  Fly  1364 AGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSF 1428
            |.|.|.||.|||.::||..||::||:||||||||.|::|.||||....||:.:|..||.:.::..
Mouse  1181 ASGTIIIDEVDICTVGLEDLRTKLTMIPQDPVLFVGTVRYNLDPLGSHTDEMLWHVLERTFMRDT 1245

  Fly  1429 VKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEF 1493
            :..|...|..|:.|.|||.|||:|||:|:||||||.:|:::||||||::|.:||.|:|.||:..|
Mouse  1246 IMKLPEKLQAEVTENGENFSVGERQLLCMARALLRNSKIILLDEATASMDSKTDTLVQSTIKEAF 1310

  Fly  1494 KECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAF 1539
            |.||||||||||||:|:.|.|:|::.|::|||..|..|.:.|.|||
Mouse  1311 KSCTVLTIAHRLNTVLNCDLVLVMENGKVIEFDKPEVLAEKPDSAF 1356

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MRPNP_723772.2 MRP_assoc_pro 14..1548 CDD:188098 472/1411 (33%)
ABC_membrane 338..601 CDD:279056 62/262 (24%)
ABCC_MRP_domain1 649..848 CDD:213217 107/245 (44%)
ABC_membrane 988..1260 CDD:279056 85/298 (29%)
ABCC_MRP_domain2 1308..1528 CDD:213211 120/219 (55%)
Abcc12NP_766500.3 MRP_assoc_pro 43..1366 CDD:188098 471/1401 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 470..492 0/21 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 726..749 4/23 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167841698
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG51855
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 1 1.000 - - FOG0000087
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
76.660

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