DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MRP and Cftr

DIOPT Version :9

Sequence 1:NP_723772.2 Gene:MRP / 34686 FlyBaseID:FBgn0032456 Length:1549 Species:Drosophila melanogaster
Sequence 2:XP_006236159.1 Gene:Cftr / 24255 RGDID:2332 Length:1530 Species:Rattus norvegicus


Alignment Length:1507 Identity:391/1507 - (25%)
Similarity:691/1507 - (45%) Gaps:246/1507 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   214 QTKYQRGE--NEIPELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHH 276
            ||....|:  .:.|...|||:|::.:.|...:..||||:.||..|::.....||...:.......
  Rat    46 QTLVHHGDIMQKSPLEKASFISKLFFSWTTPILRKGYRHHLELSDIYQAPSSDSADHLSEKLERE 110

  Fly   277 WNQNVRKNYKNKARVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGALMKL 341
            |::                              |:..:||  ..::..:.:.|...|:|..::..
  Rat   111 WDR------------------------------EQASKKK--PQLIHALRRCFVWRFVFYGVLLY 143

  Fly   342 FTDTLTFAQPQVLSLIISFVEAQDAEPEWKGILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIRT 406
            ..:.....||.:|..||:..:..:.|.....|...:.|.:|...:|.:|......:..:|:::|.
  Rat   144 LGEVTKAVQPVLLGRIIASYDPDNTEERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRI 208

  Fly   407 ALINAIYRKALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQL 471
            |:.:.||:|.|::|:....:.::|::::|::.:..:|.|.....:.||.||||:.|.:..||..|
  Rat   209 AMFSLIYKKTLKLSSRVLDKISIGQLISLLSNNLNKFDEGLALAHFIWIAPLQVVLLMGLLWDLL 273

  Fly   472 GPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQ 536
            ..|...||.::|:|:....::...:..|:.::....:||:.:.:||:..|..:|.|.||.:.||.
  Rat   274 QFSAFCGLGLLIVLVIFQAILGKMMVKYRDKRAAKINERLVITSEVIDNIYSVKAYCWESAMEKI 338

  Fly   537 VLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVLTSEANQLSVEKVLVSIALFDLM 601
            :..:|::|:...|.:||:...||..:..:.|.|..::...|.:   .|.:.:.|:..:|:...::
  Rat   339 IESLREEELKMTRRSAYMRFFTSSAFFFSGFFVVFLSVLPYTV---INGIVLRKIFTTISFCIVL 400

  Fly   602 KLPLTILPMLSVDI-AETQVSVNRINKFLNSEE-----------------------------LDP 636
            ::.:|.....:|.| .::...:.:|..||.::|                             |:.
  Rat   401 RMSVTRQFPTAVQIWYDSLGMIRKIQDFLQTQEYKVLEYNLMFTGLVMENVTAFWEEGFQELLEK 465

  Fly   637 NSVLHDSSKPHPMSIENGE----FSW----GDEITLRNINIEVKKGSLVALVGTVGSGKSSVVQA 693
            ..:.:|..|     ..|||    ||.    |:.: |:|||:.:|||.::|:.|:.|:||:|::..
  Rat   466 VQLNNDDRK-----TSNGENHLSFSHLCLVGNPV-LKNINLNIKKGEMLAITGSTGAGKTSLLML 524

  Fly   694 FLGEMEKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSA 758
            .|||:|...|::...|::::..|.:||...|:::||:||.:||..||..|:.||.|:.||...:.
  Rat   525 ILGELEASEGIIKHSGRVSFSSQISWIMPGTIKENIIFGVSYDEYRYKSVVKACQLQEDITKFAE 589

  Fly   759 GDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARK 823
            .|.|.:||.|:.|||||:.|||||||||.||||||||.|...:|....:.|||..:..  ::|.|
  Rat   590 QDNTVLGEGGVTLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEEQIFESCVCK--LMASK 652

  Fly   824 SRVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFADFIIQH---------------- 872
            :|:|||..:..|.:.|.|.::..|.....|||.:|...:..|:..::.:                
  Rat   653 TRILVTSKMEQLKKADKILILHEGSSYFYGTFSELQSLRPDFSSKLMGYDTFDQFTEERRSSILT 717

  Fly   873 ----------------------LQEGNEEEEELNQIKRQISSTADVPELLGT-----------VE 904
                                  .|.|...|:..|.|....||...:..:..|           .|
  Rat   718 ETLRRFSVDDASTTWNKAKQSFRQTGEFGEKRKNSILSSFSSVKKISIVQKTPLSIEGESDDLQE 782

  Fly   905 KAIKLA-------------------------RTESLSDSISVTSADSLMGGGGSLRRRTKRQDSH 944
            :.:.|.                         |.:|:.|.::.|.:..     .|..:||:.....
  Rat   783 RRLSLVPDSEHGEAALPRSNMITAGPTFPGRRRQSVLDLMTFTPSSV-----SSSLQRTRASIRK 842

  Fly   945 DSVASAASLKKKQEVEGKLIE------TEKSQTGGVEFAVYKHYIK----------------SVG 987
            .|:|...|||::.....:|.:      ||:.....::...:...:|                ..|
  Rat   843 ISLAPRISLKEEDIYSRRLSQDSTLNITEEINEEDLKECFFDDMVKIPTVTTWNTYLRYFTLHRG 907

  Fly   988 IFLSVATLVLNFVFQAFQIGSNLWLTQ------WANDQNVANDTGLRDMYLGVYGAFGFGQGVLA 1046
            :|..:...||.|:.:.......|||.:      ..|...:||.:     |:.|..:..|      
  Rat   908 LFAVLIWCVLVFLVEVAASLFVLWLLKNNPVNGGNNGTKIANTS-----YVVVITSSSF------ 961

  Fly  1047 YFAVVIVYLGG-------------------FQAAKTIHNELLAVIIRGSVCRFFDITPIGRLLNS 1092
             :.:..:|:|.                   ..|:|.:|.::|..|:...:..|..: ..|.:||.
  Rat   962 -YYIFYIYVGVADTLLALSLFRGLPLVHTLITASKILHRKMLHSILHAPMSTFNKL-KAGGILNR 1024

  Fly  1093 FSGDMDVVDEELPATMDSFMTFIFMVLATIVVISLSTP-IFLAVIVPIAFLYYFAQRFYVATSRQ 1156
            ||.|:.::|:.||.|:..|:..:|:|:..|:|:|...| ||||.:..:| ::...:.:::.||:|
  Rat  1025 FSKDIAILDDFLPLTIFDFIQLLFIVVGAIIVVSALQPYIFLATVPGLA-VFILLRAYFLHTSQQ 1088

  Fly  1157 LMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIAN-RWLAIRL 1220
            |.:|||..||||::|...::.|..|:||:. ...:.|....|........:...:|. ||..:|:
  Rat  1089 LKQLESEGRSPIFTHLVTSLKGLWTLRAFR-RQTYFETLFHKALNLHTANWFMYLATLRWFQMRI 1152

  Fly  1221 EMVGNLIILFASLFAVLGGQTNPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGE 1285
            :|:..|..:..:..::|......|..|:.::.|:.:..||.|.|..|.|.::.:.||.|:.::.:
  Rat  1153 DMIFVLFFIVVTFISILTTGEGEGTTGIILTLAMNIMSTLQWAVNSSIDTDSLMRSVSRVFKFID 1217

  Fly  1286 TKQEAP------WELEQD--------KN----KPKNWPQEGRVEFQNFQVRYREGLDLVLRGVSF 1332
            .:.|..      .||..:        ||    |...||..|.:..::..|:|.:..:.:|..:||
  Rat  1218 IQTEESICTKIMKELHSEDSPNALVIKNEHVKKCDTWPSGGEMVVKDLTVKYVDDGNAILENISF 1282

  Fly  1333 NIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLF 1397
            :|..|::||::||||:|||:|..|..|::... |.|.||||...||.|...|....:|.|...:|
  Rat  1283 SISPGQRVGLLGRTGSGKSTLLSAFLRMLNIK-GEIQIDGVSWNSMTLQEWRKAFGVITQKVFIF 1346

  Fly  1398 SGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALL 1462
            ||:.|.||||.....|:||||..:...|||.::.....||..:.:||..||.|.:||:||||::|
  Rat  1347 SGTFRQNLDPNGKWRDEEIWKVADQVGLKSVIEQFPGQLNFTLVDGGYVLSHGHKQLMCLARSVL 1411

  Fly  1463 RKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFAS 1527
            .|.|:::|||.:|.:|..|..:|::.:|..|..|||:...||:..:||..:.:|:::|.:.::.|
  Rat  1412 SKAKIILLDEPSANLDPITYQVIRRVLRQAFAGCTVVLCEHRIEAMLDCQRFLVIEQGNVWQYES 1476

  Fly  1528 PTELLDNPKSAF 1539
            ...|| :.||.|
  Rat  1477 LQALL-SEKSVF 1487

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MRPNP_723772.2 MRP_assoc_pro 14..1548 CDD:188098 391/1507 (26%)
ABC_membrane 338..601 CDD:279056 63/262 (24%)
ABCC_MRP_domain1 649..848 CDD:213217 84/206 (41%)
ABC_membrane 988..1260 CDD:279056 71/298 (24%)
ABCC_MRP_domain2 1308..1528 CDD:213211 82/219 (37%)
CftrXP_006236159.1 CFTR_protein 55..1518 CDD:273530 388/1498 (26%)
ABC_membrane 139..357 CDD:294371 55/217 (25%)
ABCC_CFTR1 444..724 CDD:213258 93/287 (32%)
CFTR_R 693..898 CDD:291094 27/209 (13%)
ABC_membrane 915..1196 CDD:279056 73/295 (25%)
P-loop_NTPase 1258..1518 CDD:304359 88/232 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166345082
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.940

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