Protein Alignment MRP and Tap2

DIOPT Version :9

• Sequence 1: NP_723772.2
• Gene: MRP / 34686
• FlyBaseID: FBgn0032456
• Length: 1549
• Species: Drosophila melanogaster
• Sequence 2: NP_035660.3
• Gene: Tap2 / 21355
• MGIID: 98484
• Length: 702
• Species: Mus musculus
• Alignment Length: 489
• Identity: 132/489 - (26%)
• Similarity: 247/489 - (50%)
• Gaps: 59/489 - (12%)

  Fly  1064 IHNELLAVIIRGSVCRFFDITPIGRLLNSFSGDMDVVDEELPATMDSFMTFIFMVLATIVVISLS 1128
            |..:|.:.::|..: .||..|..|.|.:..|.|..::...||...:..:..:..|:.....:...
Mouse   224 IREQLFSSLLRQDL-GFFQETKTGELNSRLSSDTSLMSRWLPFNANILLRSLVKVVGLYFFMLQV 287

  Fly  1129 TP--IFLAVI-VPIAFLYYFAQRFY--------------VATSRQLMRLESVSRSPIYSHFSETV 1176
            :|  .||::: :|:...   |::.|              ||.:.|::|              |.|
Mouse   288 SPRLTFLSLLDLPLTIA---AEKVYNPRHQAVLKEIQDAVAKAGQVVR--------------EAV 335

  Fly  1177 TGASTIRAYNVGDRFIEESDAKVD-------KNQVCKYPSVIANRWLAIRLEMVGNLIILFASLF 1234
            .|..|:|::...::.:......::       :..:.|...::..|.:|:.::    ::||...:.
Mouse   336 GGLQTVRSFGAEEQEVSHYKEALERCRQLWWRRDLEKDVYLVIRRVMALGMQ----VLILNCGVQ 396

  Fly  1235 AVLGGQ-TNPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDK 1298
            .:|.|: |..||:.. :.|..:|.|.:..||.|..|:.:|:.:.|::..|.:.|...|    |..
Mouse   397 QILAGEVTRGGLLSF-LLYQEEVGQYVRNLVYMYGDMLSNVGAAEKVFSYLDRKPNLP----QPG 456

  Fly  1299 NKPKNWPQEGRVEFQNFQVRY-REGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIE 1362
            .....| .|||||||:....| |.....||:|::|.:..|....:||..|:|||::...|..:.:
Mouse   457 ILAPPW-LEGRVEFQDVSFSYPRRPEKPVLQGLTFTLHPGTVTALVGPNGSGKSTVAALLQNLYQ 520

  Fly  1363 AAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIK--TDDEIWKALELSHL 1425
            ..||::.:||..:.....|.|..::.::.|:|||||||::.|: .:.::  .|.::..|.:.:..
Mouse   521 PTGGQLLLDGEPLTEYDHHYLHRQVVLVGQEPVLFSGSVKDNI-AYGLRDCEDAQVMAAAQAACA 584

  Fly  1426 KSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIR 1490
            ..|:..:..|:|.||.|.|..|:|||:|.:.:||||:|..:||:|||||:|:|.:.:..:|.. |
Mouse   585 DDFIGEMTNGINTEIGEKGGQLAVGQKQRLAIARALVRNPRVLILDEATSALDAQCEQALQNW-R 648

  Fly  1491 TEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIE 1524
            :: .:.|:|.|||||:|:.::|:|:||.:|:::|
Mouse   649 SQ-GDRTMLVIAHRLHTVQNADQVLVLKQGRLVE 681

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	132/489 (27%)
		ABC_membrane	338..601	CDD:279056
		ABCC_MRP_domain1	649..848	CDD:213217
		ABC_membrane	988..1260	CDD:279056	41/220 (19%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	79/220 (36%)
Tap2	NP_035660.3	3a01208	1..696	CDD:273363	132/489 (27%)
		ABC_membrane	155..415	CDD:279056	38/213 (18%)
		Part of the peptide-binding site. /evidence=ECO:0000250|UniProtKB:Q03519	300..388		15/108 (14%)
		Part of the peptide-binding site. /evidence=ECO:0000250|UniProtKB:Q03519	413..432		6/18 (33%)
		P-loop_NTPase	456..679	CDD:304359	80/226 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000