DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MRP and Abcc9

DIOPT Version :9

Sequence 1:	NP_723772.2	Gene:	MRP / 34686	FlyBaseID:	FBgn0032456	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	NP_035641.1	Gene:	Abcc9 / 20928	MGIID:	1352630	Length:	1546	Species:	Mus musculus

Alignment Length:	1677	Identity:	533/1677 - (31%)
Similarity:	832/1677 - (49%)	Gaps:	282/1677 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 FCGSTFWNATETWY---TNDPDFTPCFEQTALVWTPCAFYWAFVIFDFYYL-------KASLDRN 66
            |||:.. ::...:|   .|     |||.. ||...|..|. .|:.|...::       |..:..|
Mouse     5 FCGNNI-SSYNIYYGVLQN-----PCFVD-ALNLVPHVFL-LFITFPILFIGWGSQSSKVQIHHN 61

  Fly    67 ----IPWNKLNVSKALVNLGLLVITALDLIMALVKKGGDSELPLYDLDVWGP-IIKFATFLLLFI 126
                .|.:.|   :.::...||.:...::...:|   .||......|.::.| ::.|.......:
Mouse    62 TWLHFPGHNL---RWILTFALLFVHVCEIAEGIV---SDSHRASRHLHLFMPAVMGFVATTTSIV 120

  Fly   127 FIPLNRKYGVQTTG------CQFIFW---FLLTVLSIPRCRTEVRLDAERQKILNSQQPSEQDFS 182
            :.     :.::|:.      ..|::|   |:...:.:.:                         .
Mouse   121 YY-----HNIETSNFPKLLLALFLYWVMAFITKTIKLVK-------------------------Y 155

  Fly   183 WEEYQFVSFFIFFTFTSIMLILNCFADGM-------------------PRQTKYQRGENEIPELS 228
            |:....|| .:.|..|.:|:|||    |:                   |::.|   ...::.:|.
Mouse   156 WQLGWGVS-DLRFCITGVMVILN----GLLMAVEINVIRVRRYVFFMNPQKVK---PPEDLQDLG 212

  Fly   229 ASF-------LSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHHWNQNVRKNY- 285
            ..|       ||:.||.|.:.:.:..:|.|::.|.:..|          ||     ......||
Mouse   213 VRFLQPFVNLLSKATYWWMNTLIISAHRKPIDLKAIGKL----------PI-----AMRAVTNYV 262

  Fly   286 --KNKARVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGALMKLFTDTLTF 348
              |.....:.|....:.|.|               .||...:|::||...|..:..:...|.|.|
Mouse   263 CLKEAYEEQKKKAADHPNRT---------------PSIWLAMYRAFGRPILLSSTFRYLADLLGF 312

  Fly   349 AQPQVLSLIISFVE-----AQDAEPEW--------KGILYAVLLFV-LAAAQTFILGQYFHRMFI 399
            |.|..:|.|:..|.     .::..||.        ...:.|||||: |...:||:...|:..: .
Mouse   313 AGPLCISGIVQRVNEKTNTTREMFPETLSSKEFLENAHVLAVLLFLALILQRTFLQASYYVTI-E 376

  Fly   400 VGLRIRTALINAIYRKALRI--SNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGL 462
            .|:.:|.||:..||.|.||:  ||.:..|.|:|:|.||:|::..:.|........:|:.|:||.:
Mouse   377 TGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIM 441

  Fly   463 ALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLY 527
            .:..|:..||.|.|.|.||:::|.|:...||:::...|...:.|..||:|..||:|.|||:||||
Mouse   442 GVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLY 506

  Fly   528 AWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVLTSEANQLSVEKVL 592
            |||..|.|.|.:.|.||:::|::.|...:.:.|:.:..|....|.||.|:...| .|.|...:..
Mouse   507 AWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYAS-GNNLKPAEAF 570

  Fly   593 VSIALFDLMKLPLTILPMLSVDIAETQVSVNRINKFLNSEELDPNS-------VLHDSSKPH--- 647
            .|::||.::..||.:|..:.....:..:||.::|:||.|:|:..:|       :..:|.|.|
Mouse   571 ASLSLFHILVTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGEDSWRAGEGTLPFESCKKHTGV 635

  Fly   648 --------------------------------PMSIENGEFSWGDEI-TLRNINIEVKKGSLVAL 679
                                            .:.:.||.||||..: ||.||:|.:..|.|..:
Mouse   636 QSKPINRKQPGRYHLDSYEQARRLRPAETEDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMI 700

  Fly   680 VGTVGSGKSSVVQAFLGEMEKLAGVV--NTVGK---------------LAYVPQQAWIQNATVRD 727
            ||.||.||||::.|.||||:.|.|.|  |.|.:               :||..|:.|:.||||.:
Mouse   701 VGQVGCGKSSLLLAILGEMQTLEGKVYWNNVNESEPSFEATRSRSRYSVAYAAQKPWLLNATVEE 765

  Fly   728 NILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLY 792
            ||.||..::|:||..|.|||:|:.|||:|..||.|||||:||||||||:|||.:|||:|.:.::.
Mouse   766 NITFGSPFNRQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIV 830

  Fly   793 LLDDPLSAVDAHVGKHIFEEVIGPKGILA-----RKSRVLVTHGVTFLPQVDSIYVIKMGEISES 852
            .||||.||:|.|:..|:.:|     |||.     :::.|||||.:.:|...|.|..:|.|.:...
Mouse   831 FLDDPFSALDIHLSDHLMQE-----GILKFLQDDKRTVVLVTHKLQYLTHADWIIAMKDGSVLRE 890

  Fly   853 GTFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKRQISSTADVPELLGTVEKAIKLARTESLSD 917
            ||                  |::...::.||.:..:.:.:..| .||    ||.::..:|
Mouse   891 GT------------------LKDIQTKDVELYEHWKTLMNRQD-QEL----EKDMEADQT----- 927

  Fly   918 SISVTSADSLMGGGGSLRRRTKRQDSHDSVASAASLKKKQEVEGKLIETEKSQT-----GGVEFA 977
                           :|.|:|.|:..:...|.|....:.:|.|.:..|.:...|     ..:.:.
Mouse   928 ---------------TLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEEDNMSTVMRLRTKMPWK 977

  Fly   978 VYKHYIKSVGIFLSVATLVLNFVFQAFQIGSNLWLTQWANDQNVANDTGLRDMYLGVYGAFGF-- 1040
            ....|:.|.|.||....:....:..:..:..:.||..|.::.:: |..|..|....|.| |..
Mouse   978 TCWWYLTSGGFFLLFLMIFSKLLKHSVIVAIDYWLATWTSEYSI-NHPGKADQTFYVAG-FSILC 1040

  Fly  1041 GQGV-LAYFAVVIVYLGGFQAAKTIHNELLAVIIRGSVCRFFDITPIGRLLNSFSGDMDVVDEEL 1104
            |.|: |.....:.|...|..|||.:|:.||..||.|.: ||||.||:|.:||.||.|.:::|:.:
Mouse  1041 GAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPI-RFFDTTPLGLILNRFSADTNIIDQHI 1104

  Fly  1105 PATMDSFMTFIFMVLATIVVISLSTPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIY 1169
            |.|::|......:.|:.|.:||.:||:||..:.|:...:||.|:::...|:.|..|:..::.|:.
Mouse  1105 PPTLESLTRSTLLCLSAIGMISYATPVFLVALAPLGVAFYFIQKYFRVASKDLQELDDSTQLPLL 1169

  Fly  1170 SHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLF 1234
            .|||||..|.:||||:....||.:......|.|.:.......|||||.:|.:.:|..|:|.||:
Mouse  1170 CHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASI- 1233

  Fly  1235 AVLGGQTNPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKN 1299
            |.:.|.:|.|||||.:.|||.:|..|||:||..:|:|..:.:|:::..: .|.:...:|...|.:
Mouse  1234 ASISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSF-LTMESENYEGTMDPS 1297

  Fly  1300 K-PKNWPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEA 1363
            : |::|||||.::..:..|||...|..||:.|...|:.|:||||.||||:|||||:||.||:::.
Mouse  1298 QVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDI 1362

  Fly  1364 AGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIK-TDDEIWKALELSHLKS 1427
            ..|:|.|||:||:.:.||.|||||:||.|||:|||||:|.|||| |.| |||.:|:|||::.||:
Mouse  1363 FDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDP-ECKCTDDRLWEALEIAQLKN 1426

  Fly  1428 FVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTE 1492
            .||||..||:..:.|||||.|||||||.|||||.:||:.:|::|||||::|:.|::::||.:.|.
Mouse  1427 MVKSLPGGLDATVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTA 1491

  Fly  1493 FKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAFYSMAK 1544
            |.:.||:|||||::|||.:|.|||:.:|.|:|:.:|..||......|.|..:
Mouse  1492 FADRTVVTIAHRVHTILTADLVIVMKRGNILEYDTPESLLAQEDGVFASFVR 1543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	531/1675 (32%)
		ABC_membrane	338..601	CDD:279056	92/278 (33%)
		ABCC_MRP_domain1	649..848	CDD:213217	99/221 (45%)
		ABC_membrane	988..1260	CDD:279056	94/274 (34%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	121/220 (55%)
Abcc9	NP_035641.1	MRP_assoc_pro	23..1543	CDD:188098	528/1651 (32%)
Abcc9	NP_035641.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	941..964		5/22 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841666
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.640