Protein Alignment MRP and Abcc8

DIOPT Version :9

• Sequence 1: NP_723772.2
• Gene: MRP / 34686
• FlyBaseID: FBgn0032456
• Length: 1549
• Species: Drosophila melanogaster
• Sequence 2: XP_036008753.1
• Gene: Abcc8 / 20927
• MGIID: 1352629
• Length: 1597
• Species: Mus musculus
• Alignment Length: 1534
• Identity: 486/1534 - (31%)
• Similarity: 760/1534 - (49%)
• Gaps: 256/1534 - (16%)

  Fly   181 FSWEEYQFVSFF--------IFFTFTSIMLILNCFADGM-------------------PRQTKYQ 218
            |..:..:||.|:        :.|..|.:::||.    ||                   ||:.|
Mouse   147 FITKTIKFVKFYDHAIGFSQLRFCLTGLLVILY----GMLLLVEINVIRVRRYIFFKTPREVK-- 205

  Fly   219 RGENEIPELSASF-------LSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHH 276
             ...::.:|...|       ||:.||.|.:......:|.|:      |||........|....::
Mouse   206 -PPEDLQDLGVRFLQPFVNLLSKGTYWWMNAFIKTAHRKPI------DLRAIGKLPIAMRALTNY 263

  Fly   277 WNQNVRKNYKNKARVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGALMKL 341
              |.:...:..:||.:.::|                   :|..:|...:..:||...:..:..::
Mouse   264 --QRLCAAFDAQARKDTQSQ-------------------QGARAIWRALCHAFGRRLVLSSTFRI 307

  Fly   342 FTDTLTFA-------------------QPQVLSLIISFVEAQDAEPEWKGILY--AVLLFV-LAA 384
            ..|.|.||                   ||:...|.:.||.:|    |:.|..|  |||||: |..
Mouse   308 LADLLGFAGPLCIFGIVDHLGKENHVFQPKTQFLGVYFVSSQ----EFLGNAYVLAVLLFLALLL 368

  Fly   385 AQTFILGQYFHRMFIVGLRIRTALINAIYRKALRI--SNSTKKESTVGEIVNLMAVDAQRFMELT 447
            .:||:...|:..: ..|:.:|.|:...||.|.:.:  ||.:..|.|.|:|.||:|:|..:.|...
Mouse   369 QRTFLQASYYVAI-ETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNLVAIDTNQLMWFF 432

  Fly   448 TYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVK 512
            .....:|:.|:||.:.:..|:..||.|.|.|.||:|:|.||...:|:::...|...::|.:||:|
Mouse   433 FLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRSTLEYSNERLK 497

  Fly   513 LMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATY 577
            ..||:|.|||:|||||||..|..:|...|.||:.:||:.|...:.:.|:.:..|....|:||..:
Mouse   498 QTNEMLRGIKLLKLYAWENIFCSRVEMTRRKEMTSLRAFAVYTSISIFMNTAIPIAAVLITFVGH 562

  Fly   578 VLTSEANQLSVEKVLVSIALFDLMKLPLTILPMLSVDIAETQVSVNRINKFLNSEELDPNSVLHD 642
            |...:.:..|......|::||.::..||.:|..:.....:..|||.::::||:|.|:........
Mouse   563 VSFFKESDFSPSVAFASLSLFHILVTPLFLLSSVVRSTVKALVSVQKLSEFLSSAEIREEQCAPR 627

  Fly   643 SSKPH---------PMSIEN------------------------------------GEFSW-GDE 661
            ...|.         |:.:.|                                    |.|:| .|.
Mouse   628 EPAPQGQAGKYQAVPLKVVNRKRPAREEVRDLLGPLQRLTPSMDGDADNFCVQIIGGFFTWTPDG 692

  Fly   662 I-TLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVV-------------------- 705
            | ||.||.|.:.:|.|..:||.||.||||::.|.||||::::|.|
Mouse   693 IPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLATLGEMQRVSGAVFWNSSLPDSEGEDPRYCLRT 757

  Fly   706 -------------NTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILS 757
                         .:.|.:||..|:.|:.||||.:||.|...::::||..||:||:|:.|||||.
Mouse   758 SNPERETAADSDARSRGPVAYASQKPWLLNATVEENITFESPFNKQRYKMVIEACSLQPDIDILP 822

  Fly   758 AGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILA- 821
            .||.|:|||:||||||||:||||:|||:|...::..||||.||:|.|:..|:.:     .|||.
Mouse   823 HGDQTQIGERGINLSGGQRQRISVARALYQHTNVVFLDDPFSALDVHLSDHLMQ-----AGILEL 882

  Fly   822 ----RKSRVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFADFIIQHLQE-GNEEEE 881
                :::.|||||.:.:||..|.|..:|.|.|...||.....:::..    :.:|.:. .|.:::
Mouse   883 LRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQ----LFEHWKTLMNRQDQ 943

  Fly   882 ELNQIKRQISSTADVPELLGTVEKAIKLARTESLSDSISVTSADSLMGGGGSLRRRTKRQDSHDS 946
            ||   :::.......||....:.:|              ::|.|.|:            .|..:.
Mouse   944 EL---EKETVMERKAPEPSQGLPRA--------------MSSRDGLL------------LDEDEE 979

  Fly   947 VASAASLKKKQEVEGKLIETEKSQTGGVEFAVYKHYIKSVGIFLSVATLVLNFVFQAFQIGSNLW 1011
            ...||..::...:...|.:..|     :.:.....|:.|.|:.|....:....:.....:..:.|
Mouse   980 EEEAAESEEDDNLSSVLHQRAK-----IPWRACTKYLSSAGVLLLSLLVFSQLLKHMVLVAIDYW 1039

  Fly  1012 LTQWAN--------------DQNVANDTGLRDMYLGVYGAFGFGQGVLAYFAVVIVYLGGFQAAK 1062
            |.:|.:              .|..|.|..:..|...|..:.|.   .|.....|.|...|.:.||
Mouse  1040 LAKWTDSALVLSPAARNCSLSQECALDQSVYAMVFTVLCSLGI---ALCLVTSVTVEWTGLKVAK 1101

  Fly  1063 TIHNELLAVIIRGSVCRFFDITPIGRLLNSFSGDMDVVDEELPATMDSFMTFIFMVLATIVVISL 1127
            .:|..||..||...: |||:.||:|.:||.||.|.:.:|:.:|:|::.......:.::.:.|||.
Mouse  1102 RLHRSLLNRIILAPM-RFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALTVISY 1165

  Fly  1128 STPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFI 1192
            .||:||..::|:|.:.||.|:::...||.|.:|:..::.|:.|||:|||.|.:||||:....||.
Mouse  1166 VTPVFLVALLPLAVVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQ 1230

  Fly  1193 EESDAKVDKNQVCKYPSVIANRWLAIRL---------EMVGNLIILFASLFAV---LGGQTNPGL 1245
            ::.....|.|.:.......|||||.:|:         |.:|..::|.|:..::   |..:.:.||
Mouse  1231 QKLLEYTDSNNIASLFLTAANRWLEVRMPGPAAVLPQEYIGACVVLIAAATSISNSLHRELSAGL 1295

  Fly  1246 VGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKNKPKNWPQEGRV 1310
            |||.::|||.|:..|||:||..:|:|..:.:|:||....:|:.|:...|......|||||.:|::
Mouse  1296 VGLGLTYALMVSNYLNWMVRNLADMEIQLGAVKRIHTLLKTEAESYEGLLAPSLIPKNWPDQGKI 1360

  Fly  1311 EFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDI 1375
            :.||..|||...|..||:.|:..|..|:|:||.||||:||||.:||.||:::...|||.|||:||
Mouse  1361 QIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDMFEGRIIIDGIDI 1425

  Fly  1376 ASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEI 1440
            |.:.||.|||||:||.||||||||::|.||||.:..:|..:|:|||::.||..||:|..||:..|
Mouse  1426 AKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPEKKCSDSTLWEALEIAQLKLVVKALPGGLDAII 1490

  Fly  1441 AEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRL 1505
            .|||||.|.|||||.|||||.:|||.:.::|||||::|:.|::::||.:.|.|.:.||:|||||:
Mouse  1491 TEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRV 1555

  Fly  1506 NTILDSDKVIVLDKGQIIEFASPTELLDNPKSAFYSMAK 1544
            :|||.:|.|:||.:|.|:||..|.:||....|.|.|..:
Mouse  1556 HTILSADLVMVLKRGAILEFDKPEKLLSQKDSVFASFVR 1594

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	486/1534 (32%)
		ABC_membrane	338..601	CDD:279056	92/286 (32%)
		ABCC_MRP_domain1	649..848	CDD:213217	96/274 (35%)
		ABC_membrane	988..1260	CDD:279056	87/297 (29%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	119/219 (54%)
Abcc8	XP_036008753.1	MRP_assoc_pro	224..1594	CDD:188098	471/1448 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841686
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.650