Protein Alignment MRP and mrp-8

DIOPT Version :9

• Sequence 1: NP_723772.2
• Gene: MRP / 34686
• FlyBaseID: FBgn0032456
• Length: 1549
• Species: Drosophila melanogaster
• Sequence 2: NP_499598.2
• Gene: mrp-8 / 190710
• WormBaseID: WBGene00003414
• Length: 1461
• Species: Caenorhabditis elegans
• Alignment Length: 1538
• Identity: 565/1538 - (36%)
• Similarity: 842/1538 - (54%)
• Gaps: 169/1538 - (10%)

  Fly    77 ALVNLGLLVITALDLIMALVKKGGDSEL--PLYDLDVWGPII-------KFATFLLLFI-----F 127
            |:..:.||....|..:...:.:..:.:|  |.|   .|..:|       ..|.|..|:.     |
 Worm    23 AIAAIPLLAFWLLIPVFVRIIRDNEPKLRAPKY---FWAHLILQVLLLVDNAVFGALYFNQTDHF 84

  Fly   128 IPLNRKYGVQTTGCQFIFWFLLTVLSIPRCRTEVRLDAERQKILNSQQPSEQDFSWEEYQFVSFF 192
            :||.|               .|.|||...|.....|.::|   |:|..||          |...|
 Worm    85 LPLLR---------------FLQVLSYANCCIWFSLLSKR---LHSIHPS----------FCLIF 121

  Fly   193 IFFTFTSIMLIL-----NCFADGMPRQ--------------TKYQRGENE-----IPELSASFLS 233
            :.......:.:|     :.|..|:..:              || :.||:|     .||..:||||
 Worm   122 LILLVLKAVQVLVLVFESTFDAGVTAEFVLLMAETALLASSTK-RLGEDEQKIEQTPEEKSSFLS 185

  Fly   234 RITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHHWNQNVRKNYKNKARVEPKAQFS 298
            :|.:.|.:.:...|.:.||..:.|                 |:.|:|....:          .::
 Worm   186 KIFFCWLNPLIRAGAKQPLTNESL-----------------HNLNENATSEW----------LYT 223

  Fly   299 NGNVTFENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQVLSLIISFVEA 363
            .....|:.   ||.|||.|..||:.|..:......:...|.:|..|.:.:..|.:|..:|.:|..
 Worm   224 RWRAEFDK---EKAGRKSGETSIVWPFIRIQRATIITLTLARLTADIVHYLNPILLKQLIDYVSL 285

  Fly   364 QDAEPEWKGILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKALRISNSTKKEST 428
            .| :|...||..|.::|..:..::.:.......|....:..:|.|.|||..|.||:|.|.:...|
 Worm   286 HD-QPLSFGIAIACIMFSCSTTRSLLQNYQIAGMCRQAVYYQTVLSNAILHKILRLSPSARSNRT 349

  Fly   429 VGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIA 493
            .|||:|..|||.:..:....||..:||.|.|:.||:..|...||.:.:||:.:||:.||:|...:
 Worm   350 AGEILNHAAVDIEIIVHSVPYLQNMWSVPFQVTLAMTMLAITLGWAAMAGVCIMILFIPLNLCTS 414

  Fly   494 SRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGT 558
            ..||..|.:|||.||||.||.||:|:||||:||||||.|||.|:..:|.||:..||:...|:...
 Worm   415 RFIKLSQQKQMKIKDERTKLSNEMLNGIKVVKLYAWEESFEDQINRLRAKEVKMLRNVCILSRIV 479

  Fly   559 SFLWSCAPFLVSLVTFATYVLTS-EANQLSVEKVLVSIALFDLMKLPLTILPMLSVDIAETQVSV 622
            ....:.:||||::.:|..|||.| :.|.|:.....|::.:|:.::.|:.::..|...:.:.:||.
 Worm   480 DVANAASPFLVAIGSFTCYVLWSPDENGLTPSVAFVALTIFNQLRQPMRMVANLINTLVQARVSN 544

  Fly   623 NRINKFLNSEELDPNSVLHDSSKPHPMSIENGEFSW---GDEITLRNINIEVKKGSLVALVGTVG 684
            .|:.:|||.||::..:   :.:..:.:..:|...:|   .:...|::::..:|.|.|:|:||:||
 Worm   545 KRLRQFLNDEEMERKT---EVALGNAIVFKNASLNWKGPQNPPVLKDLSATIKPGQLIAIVGSVG 606

  Fly   685 SGKSSVVQAFLGEMEKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACAL 749
            .||||::.|.|.||..|.|.|...|.:|||||.:||.|.|:::|||||.......|::|:.:|.|
 Worm   607 GGKSSLLSAVLDEMVLLDGRVKVGGSIAYVPQHSWIFNKTIKENILFGNELSNYFYDQVVGSCQL 671

  Fly   750 RADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVI 814
            :.|......|:.|.:||.||.||||||.|||||||||.|.|:|||||||||||||||:.:|::||
 Worm   672 KTDFRHFQQGENTMVGENGITLSGGQKARISLARAVYQDKDIYLLDDPLSAVDAHVGRALFDKVI 736

  Fly   815 GPKGILARKSRVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFADFIIQHLQEGNEE 879
            ||.|:|..|:||||||.:.:...||:||||:.|:|.:.|:|:.:....|.|.. :....:..:|:
 Worm   737 GPDGLLRSKTRVLVTHNLQYTKYVDTIYVIEDGQIVQHGSFEDIAYVDGPFGR-LWSECENSDED 800

  Fly   880 EEELNQIKRQISSTADVPEL----LGTVEKAIKLARTESLSDSISVTSADSLMGGGGSLRRRTKR 940
            ..:......:.|.|..||.|    .|.:||:.::.||
 Worm   801 VADEEAESSEASVTPPVPVLENGDNGAIEKSSQIDRT---------------------------- 837

  Fly   941 QDSHDSVASAASLKKKQEVEGKLIETEKSQTGGVEFAVYKHYIKSVGIFLSVATLVLNFVFQAFQ 1005
             :||.|..|..|.:|.|:||..:   |..|.|.|:.:||:.|||::|||.|.|.|:.........
 Worm   838 -NSHFSEKSRKSEEKPQKVEKNV---ENVQLGRVKKSVYQLYIKTMGIFNSSAFLIFFIAHFTVM 898

  Fly  1006 IGSNLWLTQWANDQNVANDTGLRDM-YLG----------------VYGAFGFGQGVLAYFAVVIV 1053
            |..:|||:.|:|:........|..: ||.                ||..||..:.:|...|..::
 Worm   899 IMRSLWLSDWSNENAAIKKATLSSVDYLNSTSSVDGPVSVETRLIVYAGFGGLEMLLLALAFTVL 963

  Fly  1054 YLGGFQAAKTIHNELLAVIIRGSVCRFFDITPIGRLLNSFSGDMDVVDEELPATMDSFMTFIFMV 1118
            .:|..:|:..:|:.|:..::...: .|||.||.||::|..|.|:||:| :|...:......:...
 Worm   964 TIGSLRASYGLHSPLIHALLVAPI-SFFDTTPTGRIINRLSRDLDVID-KLQDNIRMCTQTLLNA 1026

  Fly  1119 LATIVVISLSTPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIR 1183
            ...:|:||:||||||....|:..:|||...:|:.|||||.||||.:||||.|..:|::.|||:||
 Worm  1027 CMILVLISISTPIFLVCAAPLILIYYFVMIYYIPTSRQLKRLESANRSPILSTIAESIHGASSIR 1091

  Fly  1184 AYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAVLG----GQTNPG 1244
            |::..:|........|||...|:|.|.::|||||.|||::||..:|||||.|.|.    |.| ||
 Worm  1092 AFDKTERTTTALSTNVDKFAQCRYLSHMSNRWLATRLELLGNTCVLFASLSATLSTKYFGLT-PG 1155

  Fly  1245 LVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKNKPKNWPQEGR 1309
            :.||||||||.:|:.||..||..|:||:|||||||:.||.:.:.||||.:|:.....:.||.:|:
 Worm  1156 MAGLSVSYALTITEVLNICVRSVSEIESNIVSVERVNEYQKLEPEAPWRIEKSLENEEKWPVKGK 1220

  Fly  1310 VEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVD 1374
            :|...|.:|||:.|.|||:.:...|:|||::|::||||:||||||:||:|:||...|.|.||.|:
 Worm  1221 IELDGFSMRYRKNLPLVLKNIDLKIEGGERIGVIGRTGSGKSSLTMALYRMIEGESGTIKIDDVE 1285

  Fly  1375 IASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHE 1439
            |.::|||.|||:|.||||:||:|||:||.|||||...:||:||..||:..||.|.:.....|:..
 Worm  1286 IDTIGLHQLRSKLIIIPQEPVVFSGTLRFNLDPFNQYSDDQIWNCLEICQLKQFAQEDDKTLDRY 1350

  Fly  1440 IAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHR 1504
            |||||:|:|||:|||:||.|||||..::::||||||:||..||.::|:.||..|.:.|.::||||
 Worm  1351 IAEGGKNMSVGERQLLCLCRALLRGARIVILDEATASVDTVTDGIVQRAIRQHFPQSTTISIAHR 1415

  Fly  1505 LNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAFYSMAKDAN 1547
            |:||:|||:::|||.|::.||.:|:.||.||.|.:..:..:.|
 Worm  1416 LDTIVDSDRIVVLDAGRVAEFDTPSNLLLNPDSLYSQLLNEKN 1458

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	565/1538 (37%)
		ABC_membrane	338..601	CDD:279056	98/263 (37%)
		ABCC_MRP_domain1	649..848	CDD:213217	100/201 (50%)
		ABC_membrane	988..1260	CDD:279056	110/292 (38%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	119/219 (54%)
mrp-8	NP_499598.2	CFTR_protein	173..1459	CDD:273530	528/1356 (39%)
		ABC_membrane	259..527	CDD:294371	98/268 (37%)
		ABCC_MRP_domain1	568..770	CDD:213217	100/201 (50%)
		ABC_membrane	887..1168	CDD:294371	105/283 (37%)
		ABCC_MRP_domain2	1219..1439	CDD:213211	119/219 (54%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D27645at33208
OrthoFinder	1	1.000	-	-		FOG0000087
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	O	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X177
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.790