DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MRP and mrp-5

DIOPT Version :9

Sequence 1:	NP_723772.2	Gene:	MRP / 34686	FlyBaseID:	FBgn0032456	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	NP_510479.1	Gene:	mrp-5 / 181587	WormBaseID:	WBGene00003411	Length:	1427	Species:	Caenorhabditis elegans

Alignment Length:	1385	Identity:	405/1385 - (29%)
Similarity:	663/1385 - (47%)	Gaps:	173/1385 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   229 ASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHHWNQNVRKNYKNKARVEP 293
            |...|.:||.|......:..|..|:...:|.....|||.                  .|.||:|
Worm    73 AGLFSFVTYSWVFPYLYQAVRGKLDRNQVWGCSFYDSCG------------------LNMARLE- 118

  Fly   294 KAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQ-VLSLI 357
                    |.:|:   ||....|. .|:...||:.......|...:..|.....|..|. .:..:
Worm   119 --------VLWED---EKKANAKS-PSLFKVIYRFISTRLWFSCAVFFFCLIFGFIGPTCFIRRL 171

  Fly   358 ISFVEAQDAEPEWK-----GILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKAL 417
            |:|.|..:.:.:.:     ||.....:.|:..|:....|..:...:..|:|:|.|::..:|:..|
Worm   172 IAFAENPERDEQSRIVYSYGIALVAAISVVEFARVLSYGATWAVSYRTGIRVRGAVLALLYKNVL 236

  Fly   418 RISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVM 482
            ...:...|  |..:::|:.|.|.||..:..|:..::...||.:...:.:|...:|...|.|:.|.
Worm   237 NSKDLCGK--TESDVINIFANDGQRLFDAVTFAPLVLVGPLVLVGGIGYLLMVIGRWSLLGILVF 299

  Fly   483 IILIPV-----NGVIASR----IKTYQIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVL 538
            .:...:     ..::|.|    :||         ::|:.:|.|::..|:::|:..||..|..::.
Worm   300 FVFDVIQFGLGKSMVACRNLAIVKT---------EKRISMMAEIIKYIRIVKMNGWEQIFSAKID 355

  Fly   539 DIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVLTSEANQLSVEKVLVSIALFDLMKL 603
            ..|.:|...:|.:.|..:.........|.:.:::||...||.  .|.|.......:|.::.:|..
Worm   356 QFRKEEKVQIRKSGYAQSLAIACGPVVPVVAAILTFVGVVLA--GNDLLASDAFSAITVYFVMLF 418

  Fly   604 PLTILPMLSVDIAETQVSVNRINKFLNSEELDPNSV-------------------------LHDS 643
            .:.::|..|..:||..|::.||.::|..|:..|..|                         :.::
Worm   419 GIRMIPYGSRYLAEAVVAMRRIQEYLLLEQYAPYPVTNAEDVVLDCQGATYTYQPKAAKAPVDET 483

  Fly   644 SKP---HPMSIENGEFSWGDEITLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVV 705
            .:|   ..:.:|...|:...:      .:.:|:|..:|::|.||.|||::::|..|.|......:
Worm   484 KEPTENEVIVVETPVFTCSFD------KLSIKRGEHIAVIGAVGCGKSAILKAISGHMFTTDDAL 542

  Fly   706 NT-VGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGI 769
            :. ..:..||||:|||.|.||:||||||...:.:||.|.::.|.|..|:..||.||.||:||:|.
Worm   543 SVDRSQTVYVPQKAWIFNGTVQDNILFGDKMNSERYYKAVNGCQLTEDLTTLSVGDRTEVGERGA 607

  Fly   770 NLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGVTF 834
            .||||||.|::|||||:...:|||.||..:::|..|...|.||:|  :.:|.:|:.::||:.:..
Worm   608 TLSGGQKARVALARAVFQTKNLYLFDDIFASLDKKVANKIHEEII--QKLLKKKALMMVTNNMEL 670

  Fly   835 LPQVDSIYVIKMGEISESGTFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKRQISSTADVPEL 899
            |...|.:..::.|.|...|..|.|.:...|:..|:        :..|.........|...|.|
Worm   671 LHHFDRVLFVEGGNIVADGNHDILYEKNDAYKTFV--------DACETYQATSGATSPCGDGP-- 725

  Fly   900 LGTVEKAIKLARTESLSDSISVTSADSLMGGGGSLRRRTKRQDSHDSVASAASLKKKQEVEGKLI 964
                      |:...|...|...|::.|.|..                             .|||
Worm   726 ----------AQPAPLDAEILRNSSEDLKGDA-----------------------------DKLI 751

  Fly   965 ETEKSQ-TGGVEFAVYKHYIKSVGIFLSVATLVLNFVFQAF-QIGSNLWLTQW---ANDQ--NVA 1022
            ..|:.. ...:.:.:||.||.:.|.:.....||:.|:.... .|.|..||::|   .:|:  .:.
Worm   752 SDEEDMGNSTIAWRIYKQYIHAAGGWPIWTCLVIGFIVNVVSNIFSTYWLSRWLKKGHDETTTIT 816

  Fly  1023 NDTGLRDMYLGVYGA--FGFGQGVLAYFAVVIVYLGGFQ----------AAKTIHNELLAVIIRG 1075
            |.|...:|...:..:  .||...|.....||:...|.|:          ||..:|:.:...:|.|
Worm   817 NGTEFLEMKTSLADSPVTGFYAAVYLVALVVLTISGLFKACVFVKVSLTAATRLHDRMFQAVIHG 881

  Fly  1076 SVCRFFDITPIGRLLNSFSGDMDVVDEELPATMDSFMTFIFMVLATIVVISLSTPIFLAVIVPIA 1140
            :. .|||.||.||:||.||.|||.:|.:||.|.:.|:..:...|..:|||:...|.||...:|:.
Worm   882 AT-SFFDSTPTGRILNRFSKDMDEIDVKLPFTAEVFLQNMITCLGFLVVITSVFPYFLLFAIPLF 945

  Fly  1141 FLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVC 1205
            .::......:.|..|.|.|.|.:||||:|.|.|.::.|.:||..:...:||:|.....:|.|...
Worm   946 VVFVVFVSCFRAGIRNLKRSEHISRSPLYDHVSASLEGITTIHTFQQSNRFLEVLKKHLDCNSGA 1010

  Fly  1206 KYPSVIANRWLAIRLEMVGNLIILFASLFA----VLGGQTNPGLVGLSVSYALQVTQTLNWLVRM 1266
            .:....|.||||:.|::   |:::..::.|    :|.|..:|...|:::::|:|::....:.||.
Worm  1011 IFMFQSAMRWLAVWLDL---LVVVMTAIVALLTVMLTGTVSPADAGMAIAFAVQMSGIFQFAVRT 1072

  Fly  1267 SSDIETNIVSVERIKEYGET-KQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYREGLDLVLRGV 1330
            .:::|..:.||||:..|.:. .::..|...|..:...:||..|::.|....:|||:...|.|..:
Worm  1073 QTELEAKMTSVERVSYYADNIPEDGEWNTRQGLDIESSWPANGQINFSEVNLRYRKSHPLALNDI 1137

  Fly  1331 SFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPV 1395
            :|.|:|||||||:||||:|||||...:||:.....|.|.||||||.::||..||..::.|.|||.
Worm  1138 TFEIKGGEKVGIIGRTGSGKSSLANLIFRLYPVTNGTIYIDGVDIRTVGLVKLRRGISAIAQDPS 1202

  Fly  1396 LFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARA 1460
            ||||::|.||||....:|..||:|||..|||:.|:||...|..:::.||.|.|||:|||.|||||
Worm  1203 LFSGTVRFNLDPSLEYSDSMIWEALEKCHLKTLVQSLDKKLEADVSHGGNNFSVGERQLFCLARA 1267

  Fly  1461 LLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEF 1525
            ||.|:::::||||||:||..||.|||:.|:|.|.:.||:.|||||:.:.:.|:::.|..|::|.|
Worm  1268 LLMKSRIVILDEATASVDAGTDKLIQEVIKTVFADATVIIIAHRLDNVRNMDRIMHLKNGKLINF 1332

  Fly  1526 ASPTELLDNPKSAFYSMAKD 1545
            .:|.|:..:..|.:....||
Worm  1333 TTPQEMFKDDWSVYKLEDKD 1352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	405/1385 (29%)
		ABC_membrane	338..601	CDD:279056	56/277 (20%)
		ABCC_MRP_domain1	649..848	CDD:213217	74/199 (37%)
		ABC_membrane	988..1260	CDD:279056	85/293 (29%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	110/219 (50%)
mrp-5	NP_510479.1	MRP_assoc_pro	90..1340	CDD:188098	397/1354 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.830