DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MRP and mrp-1

DIOPT Version :9

Sequence 1:	NP_723772.2	Gene:	MRP / 34686	FlyBaseID:	FBgn0032456	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	NP_001024719.2	Gene:	mrp-1 / 180409	WormBaseID:	WBGene00003407	Length:	1534	Species:	Caenorhabditis elegans

Alignment Length:	1597	Identity:	713/1597 - (44%)
Similarity:	997/1597 - (62%)	Gaps:	132/1597 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 CGSTFWNATETWYTND--PDFTPCFEQTALVWTPCAFYWAFVIFDFYYLKASLDRNIPWNKLN-V 74
            |||.:......|..|.  |..|.|.:.|.....|..|...|....||.|..|  ||......: :
Worm    10 CGSDYELLETGWRNNSNIPQVTNCGQHTDFSTIPTLFLVIFSPILFYELYKS--RNSYLRSFSAI 72

  Fly    75 SKALVNLGLLVI--TA---LDLIMALVKKGGDSELPLYD-LDVWGPIIKFATFLLLFIFIPLNRK 133
            |..::...|||:  ||   .|..:...|.      |||: :..:|.::::|.|.|..:.....|.
Worm    73 SLRIIFCCLLVVDLTATVIYDFYLLFTKS------PLYNAIHFYGDLVQYAGFCLALVLTIACRN 131

  Fly   134 YGVQTTGCQFIFWFLLTVLSIPRCRTEV--RLDAERQKILNSQQPSEQDFSWEEYQF----VSFF 192
            .|:.|:|...::|.|:.|..:|..|..:  ||                   ::||:.    .:.:
Worm   132 RGIITSGVITLYWLLVVVCGVPELRYYITGRL-------------------YKEYEIHSCRAALY 177

  Fly   193 IF-FTFTSIMLILNCFADGMPRQTKYQRGENEIPELSASFLSRITYQWFDKMALKGYRNPLEEKD 256
            :| :..:::.|.|:||||   ..:....|:|..||.:||||:::|:|||..:|..|.:..||::|
Worm   178 VFAYVCSALELFLSCFAD---TPSNGYIGKNSCPEYTASFLNQLTFQWFSGLAYLGNKKSLEKED 239

  Fly   257 LWDLRPQDSCSEVMPIFAHHWNQNVRKNYKNKARVEPKAQFSNGNVTFENPHGEKNGRKKGMASI 321
            ||||..:|....::|.|..:....| :.|:.|.:..|:|..                 .|...||
Worm   240 LWDLNERDKAENIIPSFIENLIPEV-EGYRRKIKKNPEAAI-----------------PKNHPSI 286

  Fly   322 MPPIYKSFGGVFLFGALMKLFTDTLTFAQPQVLSLIISFVEAQDAEPEWKGILYAVLLFVLAAAQ 386
            :.||:|::....|.|...||..|.|.|..|::|..:|||:|.:: :|.|.|:..|:|:|:.:..|
Worm   287 LIPIFKTYKFTLLAGGCYKLMFDLLQFVAPELLRQLISFIEDKN-QPMWIGVSIALLMFLSSLLQ 350

  Fly   387 TFILGQYFHRMFIVGLRIRTALINAIYRKALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLN 451
            :.||.||||.||.:|:.||:.|.:|:|.|.|.:||..:|..|.|.|||||:||.||..::||::.
Worm   351 SMILHQYFHEMFRLGMNIRSVLTSAVYTKTLNLSNEARKGKTTGAIVNLMSVDIQRIQDMTTFIM 415

  Fly   452 MIWSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNE 516
            :.|||||||.|:|||||:.||.|||||..::|:|||.|..|:.:::..|:.|||:||||:|:|:|
Worm   416 LFWSAPLQILLSLYFLWKLLGVSVLAGFVILILLIPFNSFISVKMRNCQMEQMKFKDERIKMMSE 480

  Fly   517 VLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVL-T 580
            :|:|:||||||:||.|.||.||::|:|||..|:..:||||.|:..|:||||||:::||..||| .
Worm   481 ILNGMKVLKLYSWEKSMEKMVLEVREKEIRVLKKLSYLNAATTLSWACAPFLVAVLTFGLYVLWD 545

  Fly   581 SEANQLSVEKVLVSIALFDLMKLPLTILPMLSVDIAETQVSVNRINKFLNSEELDPNSVLHDSSK 645
            .|.|.|:.:...|::|||::::.||.:..|:.....:...|..|:.:|..:||:.|.:.:.....
Worm   546 PENNVLTPQITFVALALFNILRFPLAVFAMVFSQAVQCSASNTRLKEFFAAEEMSPQTSIAYGGT 610

  Fly   646 PHPMSIENGEFSWG---DEITLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVVNT 707
            ...:.::.|.|:||   ::..|.:|...:|:|.|||:||.|||||||::.|.||||.||:|.|..
Worm   611 DSAIKMDGGSFAWGSKEEDRKLHDITFNIKRGQLVAIVGRVGSGKSSLLHALLGEMNKLSGSVQV 675

  Fly   708 VGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLS 772
            .|.:|||||.|||||.::|:||||.:.||.|.|..||:.|||..|::.|.|.|.|||||||||||
Worm   676 NGSVAYVPQLAWIQNLSLRNNILFNRPYDAKLYQNVIENCALVQDLESLPAEDRTEIGEKGINLS 740

  Fly   773 GGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIG-PKGILARKSRVLVTHGVTFLP 836
            ||||||:|||||||.:|::.||||||||||:||||||||.||. ..|.|..|:|||:|||:|:|.
Worm   741 GGQKQRVSLARAVYQNAEIVLLDDPLSAVDSHVGKHIFENVISTATGCLGTKTRVLLTHGLTYLK 805

  Fly   837 QVDSIYVIKMGEISESGTFDQLVKNKGAFADFIIQHLQEGN----------EEEEELNQIKRQIS 891
            ..|.:.|:|...|||.||:.:|:.:.|||::|:.:.|.|.:          |:.:|:|::.|.
Worm   806 HCDQVIVLKDETISEMGTYQELMNSNGAFSEFLEEFLLEESKHKGRSVSFGEDSKEVNELLRD-- 868

  Fly   892 STADVPELLGTVEKAIKLARTESLSDSISVT---SADSLMGGGGSLRRRTKRQDSHDSVA----- 948
                    |..|..||:......:|..|..|   :|:.:..|     .....|.:|.|:.
Worm   869 --------LDQVSPAIRQRIQSQMSQEIEKTDDKNAEIIRNG-----LHKDEQTAHSSIGKSEEK 920

  Fly   949 ----SAASLKKK-----QEVEGKLIETEKSQTGGVEFAVYKHYIKSVGIFLSVATLVLNFVFQAF 1004
                .|.|.|:|     ::.:.:|||.|..:||.|:|.||..|.:::||.:::...::.......
Worm   921 ESLLGAISPKEKTPEPPKQTKTQLIEKEAVETGKVKFEVYMSYFRAIGIKIALVFFLVYVASSML 985

  Fly  1005 QIGSNLWLTQWAND--------QNVANDTGLRDMYLGVYGAFGFGQGVLAYFAVVIVYLGGFQAA 1061
            .:.|||:|.:|::|        ...:::|.:|   ||:|...|.||......|.:|:.||...|:
Worm   986 GVFSNLYLARWSDDAKEIALSGNGSSSETQIR---LGIYAVLGMGQATSVCAASIIMALGMVCAS 1047

  Fly  1062 KTIHNELLAVIIRGSVCRFFDITPIGRLLNSFSGDMDVVDEELPATMDSFMTFIFMVLATIVVIS 1126
            :.:|..||..|:| |...|||:||:||:||.|..|:|.||.::|.||..|:......:..|.:|.
Worm  1048 RLLHATLLENIMR-SPMAFFDVTPLGRILNRFGKDVDGVDTDIPRTMSMFIRTAVSSIEIIAIIL 1111

  Fly  1127 LSTPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRF 1191
            .:||:.:::::|:..:|:...||||:|||||.||||.|||||||||.|::.|||:||||.|.|:|
Worm  1112 WATPLAISLLLPLFIVYFVVLRFYVSTSRQLKRLESASRSPIYSHFQESIQGASSIRAYGVVDKF 1176

  Fly  1192 IEESDAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAVLGGQTNP----GLVGLSVSY 1252
            |.||..:||:|....|||::||||||:|||||||||:| :|..|.:..:.:|    |||||||||
Worm  1177 IRESQHRVDENLATYYPSIVANRWLAVRLEMVGNLIVL-SSAGAAVYFRDSPGLSAGLVGLSVSY 1240

  Fly  1253 ALQVTQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKNKPKNWPQEGRVEFQNFQV 1317
            ||.:||||||.|||:|::|||||:||||.||..|..|..   ......||:||:.|.:..:||.|
Worm  1241 ALNITQTLNWAVRMTSELETNIVAVERINEYTITPTEGN---NSQSLAPKSWPENGEISIKNFSV 1302

  Fly  1318 RYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHM 1382
            |||.||||||.||:.:|...||:|||||||||||||||||||||||.||.|.|||.:||.:.|..
Worm  1303 RYRPGLDLVLHGVTAHISPCEKIGIVGRTGAGKSSLTLALFRIIEADGGCIEIDGTNIADLLLEQ 1367

  Fly  1383 LRSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENL 1447
            |||||||:|||||||||::|:|||||...:||:||:||..:||.||||||..||:|.|:||||||
Worm  1368 LRSRLTIVPQDPVLFSGTMRMNLDPFFAFSDDQIWEALRNAHLDSFVKSLQEGLHHHISEGGENL 1432

  Fly  1448 SVGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSD 1512
            |||||||:||||||||||||||||||.||||:|||.|:|||||.:||:||||||||||||::|||
Worm  1433 SVGQRQLICLARALLRKTKVLVLDEAAAAVDVETDSLLQKTIREQFKDCTVLTIAHRLNTVMDSD 1497

  Fly  1513 KVIVLDKGQIIEFASPTELLDNPKSAFYSMAKDANLV 1549
            :::|||||.:.||.:|.:||.||...|||||||||:|
Worm  1498 RLLVLDKGCVAEFDTPKKLLSNPDGIFYSMAKDANVV 1534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	710/1593 (45%)
		ABC_membrane	338..601	CDD:279056	131/263 (50%)
		ABCC_MRP_domain1	649..848	CDD:213217	117/202 (58%)
		ABC_membrane	988..1260	CDD:279056	124/283 (44%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	158/219 (72%)
mrp-1	NP_001024719.2	MRP_assoc_pro	23..1531	CDD:188098	705/1579 (45%)
		ABC_membrane	309..570	CDD:294371	129/261 (49%)
		ABCC_MRP_domain1	614..815	CDD:213217	116/200 (58%)
		ABC_membrane	976..1248	CDD:279056	123/276 (45%)
		ABCC_MRP_domain2	1293..1513	CDD:213211	158/219 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	292	1.000	Domainoid score	I822
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1273	1.000	Inparanoid score	I76
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0000087
OrthoInspector	1	1.000	-	-		otm14183
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8
SonicParanoid	1	1.000	-	-		X177
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.910