DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MRP and mrp-2

DIOPT Version :9

Sequence 1:	NP_723772.2	Gene:	MRP / 34686	FlyBaseID:	FBgn0032456	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	NP_508121.1	Gene:	mrp-2 / 180408	WormBaseID:	WBGene00003408	Length:	1525	Species:	Caenorhabditis elegans

Alignment Length:	1570	Identity:	704/1570 - (44%)
Similarity:	972/1570 - (61%)	Gaps:	121/1570 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 PDFTPCFEQTALVWTPCAFYWAFVIFDFYYLKASL-DRNIPWNKLNVSKALVNLGLLVITALDLI 92
            |..|.|.:.|.....|..|   .|:|.|..:...| .|.......:.....:.||.|::  :|||
Worm    28 PHVTKCGQHTDFSTIPTLF---LVVFSFIVIYQLLHTRTAQLRCFSPISFRIILGCLLV--VDLI 87

  Fly    93 MALVKKGGDSELPLYDL-------------DVWGPIIKFATFLLLFIFIPLNRKYGVQTTGCQFI 144
            ..::          |||             ..:|.:::|....|..|.....:..|:.|:|...:
Worm    88 ATVI----------YDLYLYVSQSPNFEVVHFYGDLVQFGGICLALILTVACKNKGIITSGVITL 142

  Fly   145 FWFLLTVLSIPRCRTEVRLDAERQKILNSQQPSEQDFSWEEY-----QFVSFFIFFTFTSIMLIL 204
            :|.|:.|..||..|..:                 ..|.:.||     :...:.|.|||:::.|.|
Worm   143 YWLLVVVCGIPEFRFYL-----------------SGFIYNEYALEGIRATLYIIAFTFSALELFL 190

  Fly   205 NCFADGMPRQTKYQRGENEIPELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEV 269
            .|||| :|  :...:.|:..||.:|||::|:|:|||..:|..|.:..||.:|||||...|....:
Worm   191 CCFAD-VP--SDMYKSESSCPEYTASFINRLTFQWFTGLAYLGNKKSLENEDLWDLNEIDKAENL 252

  Fly   270 MPIFAHH-------WNQNVRKNYKNKARVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYK 327
            :|.|..:       ::||::|        :|.|..                 .|...|.:.||:|
Worm   253 IPSFMQNLKPRIDEYHQNIKK--------DPSAAL-----------------PKNHPSFVIPIFK 292

  Fly   328 SFGGVFLFGALMKLFTDTLTFAQPQVLSLIISFVEAQDAEPEWKGILYAVLLFVLAAAQTFILGQ 392
            ::....|.|...||..|.|.|..||:|..:|.|:|.:: :|.|.|.....::|..:..|:..|.|
Worm   293 TYKYTLLAGFFYKLCFDMLQFLAPQLLKQLIGFIEDKN-QPVWIGCSIVGIMFFSSFLQSMFLHQ 356

  Fly   393 YFHRMFIVGLRIRTALINAIYRKALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAP 457
            |:|.||.:|:.:|:.|.:|:|.|||.:||..:|..|:|.|||||:||.|:..::...:.:.||||
Worm   357 YYHSMFRLGMHVRSVLTSAVYSKALNLSNEARKGKTIGAIVNLMSVDIQKIQDMAPTIMLFWSAP 421

  Fly   458 LQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIK 522
            |||.|::||||:.||.:.||||.|:|:.:||||:||.:::..|..|||.||||:|:|:|:|:|:|
Worm   422 LQIFLSIYFLWKFLGVAALAGLVVLILALPVNGLIAIQMRKCQTEQMKLKDERIKMMSEILNGMK 486

  Fly   523 VLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYV-LTSEANQL 586
            |||||:||.|.|..||.||::|:..|:..:|..|...|.|.|||||.|:::|..|| |..|.|.|
Worm   487 VLKLYSWERSMENMVLKIRERELHILKKLSYFMAAIVFSWICAPFLASVISFVVYVYLDPENNVL 551

  Fly   587 SVEKVLVSIALFDLMKLPLTILPMLSVDIAETQVSVNRINKFLNSEELDPNSVLHDSSKPHPMSI 651
            :.|...|:::|||::::||.::.|:..:..:..||..|:.:|..:||:.|.:.:........:.:
Worm   552 TPEITFVALSLFDILRMPLAMVAMVYGEAVQCSVSNTRLKEFFAAEEMSPQTSISHGETDSAIEV 616

  Fly   652 ENGEFSWG--DEITLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVVNTVGKLAYV 714
            |||.|||.  ::.|||.|:.:::||.|||:||.|||||||::.|.||||.||:|.|...|.:|||
Worm   617 ENGLFSWSSDEDPTLREISFKIQKGQLVAIVGKVGSGKSSLLHALLGEMNKLSGSVQINGNIAYV 681

  Fly   715 PQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRI 779
            ||||||||.::|:||||.:.||.:.|..|:..|||:.|:..|.|||.|||||||||||||||||:
Worm   682 PQQAWIQNMSLRNNILFNKPYDLENYEDVVKNCALKEDLANLPAGDRTEIGEKGINLSGGQKQRV 746

  Fly   780 SLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPK-GILARKSRVLVTHGVTFLPQVDSIYV 843
            |||||||.:.|:.||||||||||:||||||||.||... |.||.|:|||||||:|:|...|.:.|
Worm   747 SLARAVYQNPDIILLDDPLSAVDSHVGKHIFENVISSSTGCLASKTRVLVTHGLTYLKHCDQLIV 811

  Fly   844 IKMGEISESGTFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKRQISSTADVPEL---LGTVEK 905
            :|.|.|||.||:.:|:.|.||||:|:.:.|   .||.:...::......:.:|.|:   ||.|:.
Worm   812 LKEGTISELGTYQELLNNSGAFAEFLEEFL---IEESKTRGRVASIGDGSGEVDEILRDLGQVKP 873

  Fly   906 AIKLARTES-LSDSISV--TSADSLMGGGGSLRRRT------KRQDSHDSVASAASLKKKQEVEG 961
            .| |.|.|| ||.....  |||.::.....|.||..      .:.:.::::..|.|.....:...
Worm   874 GI-LKRLESHLSQESDKEDTSARAIEYSRDSSRRSVLLHSPRSQHEENEALLGAISEDVPAQENT 937

  Fly   962 KLIETEKSQTGGVEFAVYKHYIKSVGIFLSVATLVLNFVF---QAFQIGSNLWLTQWANDQNVAN 1023
            :|||.|..:||.|:|.||..|.:::.|.:   ||:..|::   ....|.||.:|.:.::.....|
Worm   938 QLIEKETVETGKVKFEVYIAYFQAISIPI---TLLFFFLYVGSSGLGILSNFYLAKLSDHAKSGN 999

  Fly  1024 DTGL-RDMYLGVYGAFGFGQGVLAYFAVVIVYLGGFQAAKTIHNELLAVIIRGSVCRFFDITPIG 1087
            .|.. ..|.||:|...|.||..:...|.:|:.:|..:|::.:|..||..|:| |...|||:||||
Worm  1000 RTSSDAKMELGIYAVLGMGQSFVVLIASIILTIGVLRASRILHAGLLGNIMR-SPMAFFDVTPIG 1063

  Fly  1088 RLLNSFSGDMDVVDEELPATMDSFMTFIFMVLATIVVISLSTPIFLAVIVPIAFLYYFAQRFYVA 1152
            |:||....|::.:|..||..:......||.|:||:|||..:||........::.:|:...|||::
Worm  1064 RILNRIGKDIEAIDRTLPDVIRHMSMTIFNVVATLVVIMWATPWAGIAFAILSVIYFIVLRFYIS 1128

  Fly  1153 TSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLA 1217
            |||||.||||.|||||||||.|::.|||:|||:.|.|.||::|..:||.:.:..|||::||||||
Worm  1129 TSRQLKRLESASRSPIYSHFQESIQGASSIRAFGVVDNFIKQSQQRVDDHLIAYYPSIVANRWLA 1193

  Fly  1218 IRLEMVGNLIILFASLFAVLGGQT---NPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVER 1279
            :|||||||||:|.|:..||....:   :.|||||||||||.:||||||.|||:|::|||||||||
Worm  1194 VRLEMVGNLIVLSAAGAAVYFRDSPGLSAGLVGLSVSYALNITQTLNWAVRMTSELETNIVSVER 1258

  Fly  1280 IKEYGETKQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVG 1344
            ||||..|..|..   ...:...|:||::|.:..:||.||||.||||||.|:|.:|...|||||||
Worm  1259 IKEYTVTPTEGN---NSRRLAAKSWPEKGEISIKNFSVRYRPGLDLVLHGISAHIAPSEKVGIVG 1320

  Fly  1345 RTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFE 1409
            |||||||||||||||||||.||.|.|||::||::.|..|||.|||:|||||||||::::|||||.
Worm  1321 RTGAGKSSLTLALFRIIEADGGSIEIDGINIANLQLEQLRSCLTIVPQDPVLFSGTMKMNLDPFS 1385

  Fly  1410 IKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEAT 1474
            ..:|.::|:|||.:|||.|||||..||.|:|:|||||||||||||:||||||||||||||||||.
Worm  1386 AYSDSQVWEALENAHLKPFVKSLQDGLEHKISEGGENLSVGQRQLICLARALLRKTKVLVLDEAA 1450

  Fly  1475 AAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAF 1539
            ||||:|||.|||||||.:|||||||||||||||::|||:::|||||::.||.||..||.||...|
Worm  1451 AAVDVETDSLIQKTIREQFKECTVLTIAHRLNTVMDSDRLLVLDKGRVAEFDSPKNLLANPDGIF 1515

  Fly  1540 YSMAKDANLV 1549
            ||||||||:|
Worm  1516 YSMAKDANVV 1525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	702/1567 (45%)
		ABC_membrane	338..601	CDD:279056	120/263 (46%)
		ABCC_MRP_domain1	649..848	CDD:213217	123/201 (61%)
		ABC_membrane	988..1260	CDD:279056	122/278 (44%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	158/219 (72%)
mrp-2	NP_508121.1	MRP_assoc_pro	25..1522	CDD:188098	700/1565 (45%)
		ABC_membrane	309..570	CDD:294371	118/261 (45%)
		ABCC_MRP_domain1	614..816	CDD:213217	123/201 (61%)
		ABC_membrane	971..1239	CDD:279056	119/268 (44%)
		ABCC_MRP_domain2	1284..1504	CDD:213211	158/219 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	292	1.000	Domainoid score	I822
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1273	1.000	Inparanoid score	I76
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0000087
OrthoInspector	1	1.000	-	-		otm14183
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X177
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.740